CV Lattes
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ORCID
Ministério da Ciência, Tecnologia e Inovação (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Bacharelado em Ciências Biológicas from Universidade Estadual de Campinas (1996), master's at Genetics from Universidade Estadual de Campinas (1999) and ph.d. at Physics from Universidade de São Paulo (2004). Has experience in Byophysics, focusing on Molecular Biophysics (Source: Lattes Curriculum)
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To sustain the high proliferative rate, tumor cells have an increased demand for biosynthetic precursors used in the synthesis of macromolecules that will compose the daughter cells. For this, tumors consume a large amount of glucose and glutamine, mainly. The alteration in nutrient metabolism has been related to enzyme filamentation, a process conserved from yeast to mammalian cells, but…
Cancer is a disease that has as main characteristic the continuous cellular proliferation. To support the high proliferative rate, tumor cells have increased demand for biosynthetic precursors used in the synthesis of macromolecules that will make up the daughter cells. For that, tumors consume a lot of glucose and glutamine, mainly. The increase in glutamine consumption, in addition to c…
Molecular mechanisms related to the tumorigenic process are traditionally related to oncogenes and tumor supressors deregulation, which control the signaling pathways responsible for the cell cycle regulation, cell growth, cell proliferation and cell death. On the other hand, new evidences point to an alternative mechanism where the primary role of the oncogenes and tumor supressors are t…
Cell proliferation is a crucial process for the embryogenesis and organism growth, being also essential for the proper function of several adult tissues. Although important for the homeostasis of the organism, its deregulation composes the driving force of tumor development. In the past twenty years the relationship between the processes of signal transduction stimulated by growth factors…
(Only some records are available in English at this moment)
The relationship between tumor cells and their microenvironment governs essential aspects of tumor biology, including the success of therapeutic responses and clinical prognosis. Immune cells, whether myeloid or lymphoid, interact with tumor cells but their actions can be inhibited by potent immunosuppressive mechanisms. The performance of immune functions is also affected by tumor metabo…
Cellular biology has experienced a revolution in the past decade, largely driven by technological advances in microscopy techniques. The ability to visualize cellular structures in unprecedented detail has provided profound insights into the complexity and dynamics of the living cell. With the recent advances in expansion microscopy, especially techniques like proExM (Protein-retention Ex…
(Only some records are available in English at this moment)
Lymphocytes and macrophages infiltrated in the tumor microenvironment reflect the biology of the tumor and impact its prognosis. However, these cells are challenged with a hostile microenvironment and, during the process of tumor development, multiple mechanisms of suppression of the immune system come into play, favoring the growth of the tumor and gaining malignancy. In conjunction with…
Cancer cells have increased glycolytic and glutaminolytic pathways and consume glucose and glutamine at accelerated rates. The intensification of the glycolytic pathway, coined as the Warburg Effect, and the glutaminolytic pathway, provide several intermediates for different synthesis routes and are a hallmark of malignant transformation. Glutamine, in addition to providing biosynthetic i…
Breast Cancer is the second most common Cancer in incidence and mortality among females and according to national and international health organizations, this number has increased in recent years. The development of new therapies for the treatment of Cancer is necessary because of this increasing number of cases and the difficulty of effective treatments. Among the molecular mechanisms in…
(Only some records are available in English at this moment)
Our main goal is to understand the role of GLS2 on breast cancer progression. For such, we want to answer the following questions:Do M1 and M2 macrophages influence in vitro metastasis of GLS2 expressing cells? GLS2 has been more often linked to anti-tumorigenic effects, mainly in hepatocarcinomas and gliomas. We found a link between GLS2 expression and diminished breast cancer patient s…
Cancer is a major public health problem in many parts of the world, and is the leading cause of death in developed countries and the second leading cause of death in developing countries. Understanding the mechanisms related to tumor development and progression is essential for the improvement of therapeutic approaches to cancer and mobilizes scientific community worldwide. Different huma…
Tumor cells are exposed to multiple nutrients simultaneously, but it is the intensive consumption of glucose and glutamine, the most abundant amino acid in blood plasma, one of the hallmarks of tumor transformation. The uptake and metabolism of glucose with significant secretion of lactate even in the presence of oxygen, known as aerobic glycolysis or Warburg effect, as well as increased …
| 1 / 1 | Ongoing research grants |
| 6 / 4 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 30 / 22 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 45 / 35 | All research grants and scholarships |
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