CV Lattes
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Ministério da Ciência, Tecnologia e Inovação (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Holds a bachelor's degree in Biological Sciences (1996) and a master's degree in Genetics and Molecular Biology (1999), both from the Institute of Biology at the University of Campinas (IB/Unicamp). Earned a Ph.D. in Biomolecular Physics (2004) from the Institute of Physics of São Carlos, University of São Paulo (IFSC/USP). Completed postdoctoral research (until 2009) at the College of Veterinary Medicine at Cornell University (Ithaca, NY, USA). Achieved the title of Livre-Docente (2018) from the Department of Physics and Interdisciplinary Science (FCI) at the Institute of Physics of São Carlos, University of São Paulo (IFSC/USP). Since 2010, has been a Lead Researcher at the National Biosciences Laboratory of the National Center for Research in Energy and Materials (LNBio, CNPEM). In 2022, became the Leader of the LNBio Science Division and, in 2023, the Head of the Integrative Biology Division. In this division, oversees the work of five research groups focusing on Molecular and Cellular Sociology, Non-Membranous Condensates, Protein Design, Nuclear Structure, and Computational Biology. Research is centered on understanding metabolic alterations associated with tumorigenesis, with an emphasis on glutamine metabolism and metabolic exchanges within the tumor microenvironment. The work integrates molecular biology, protein biochemistry, conventional and in situ structural biology, 2D and 3D cellular biology (spheroids and organoids), and in vivo models. (Source: Lattes Curriculum)
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To sustain the high proliferative rate, tumor cells have an increased demand for biosynthetic precursors used in the synthesis of macromolecules that will compose the daughter cells. For this, tumors consume a large amount of glucose and glutamine, mainly. The alteration in nutrient metabolism has been related to enzyme filamentation, a process conserved from yeast to mammalian cells, but…
To sustain the high proliferative rate, tumor cells have an increased demand for biosynthetic precursors used in the synthesis of macromolecules that will compose the daughter cells. For this, tumors consume a large amount of glucose and glutamine, mainly. The alteration in nutrient metabolism has been related to enzyme filamentation, a process conserved from yeast to mammalian cells, but…
Cancer is a disease that has as main characteristic the continuous cellular proliferation. To support the high proliferative rate, tumor cells have increased demand for biosynthetic precursors used in the synthesis of macromolecules that will make up the daughter cells. For that, tumors consume a lot of glucose and glutamine, mainly. The increase in glutamine consumption, in addition to c…
Molecular mechanisms related to the tumorigenic process are traditionally related to oncogenes and tumor supressors deregulation, which control the signaling pathways responsible for the cell cycle regulation, cell growth, cell proliferation and cell death. On the other hand, new evidences point to an alternative mechanism where the primary role of the oncogenes and tumor supressors are t…
Cell proliferation is a crucial process for the embryogenesis and organism growth, being also essential for the proper function of several adult tissues. Although important for the homeostasis of the organism, its deregulation composes the driving force of tumor development. In the past twenty years the relationship between the processes of signal transduction stimulated by growth factors…
(Only some records are available in English at this moment)
One of the main contributing factors to the high mortality associated with cancer is metastasis. In this context, circulating tumor cells (CTCs) play a crucial role in understanding metastatic cancer, especially in the context of breast neoplasia, where their presence is strongly correlated with an unfavorable prognosis. Thus, early detection of CTCs emerges as a crucial tool in clinical …
When the availability of nutritional resources fails to meet cellular needs, cells activate adaptive responses to ensure their survival. The mitochondrion plays a crucial role in this process, adjusting its structure and function in response to environmental conditions. For example, the mitochondrial network can elongate in response to amino acid deficiency, ensuring adequate oxidation of…
The relationship between tumor cells and their microenvironment governs essential aspects of tumor biology, including the success of therapeutic responses and clinical prognosis. Immune cells, whether myeloid or lymphoid, interact with tumor cells but their actions can be inhibited by potent immunosuppressive mechanisms. The performance of immune functions is also affected by tumor metabo…
(Only some records are available in English at this moment)
Cellular biology has experienced a revolution in the past decade, largely driven by technological advances in microscopy techniques. The ability to visualize cellular structures in unprecedented detail has provided profound insights into the complexity and dynamics of the living cell. With the recent advances in expansion microscopy, especially techniques like proExM (Protein-retention Ex…
One of the central problems of cell biology is how cells organize biochemical reactions in space and time. Traditionally, studies of this problem have focused on reactions concentrated within membrane compartments and organelles. Recently, however, there has been a growing appreciation that the dynamic partitioning of proteins into novel non-membranous compartments can be used to regulate…
(Only some records are available in English at this moment)
Our main goal is to understand the role of GLS2 on breast cancer progression. For such, we want to answer the following questions:Do M1 and M2 macrophages influence in vitro metastasis of GLS2 expressing cells? GLS2 has been more often linked to anti-tumorigenic effects, mainly in hepatocarcinomas and gliomas. We found a link between GLS2 expression and diminished breast cancer patient s…
Cancer is a major public health problem in many parts of the world, and is the leading cause of death in developed countries and the second leading cause of death in developing countries. Understanding the mechanisms related to tumor development and progression is essential for the improvement of therapeutic approaches to cancer and mobilizes scientific community worldwide. Different huma…
Tumor cells are exposed to multiple nutrients simultaneously, but it is the intensive consumption of glucose and glutamine, the most abundant amino acid in blood plasma, one of the hallmarks of tumor transformation. The uptake and metabolism of glucose with significant secretion of lactate even in the presence of oxygen, known as aerobic glycolysis or Warburg effect, as well as increased …
| 2 / 2 | Ongoing grants |
| 6 / 4 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 33 / 25 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 48 / 38 | All research grants and scholarships |
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