Sandra Martha Gomes Dias
CV Lattes
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Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Bacharelado em Ciências Biológicas from Universidade Estadual de Campinas (1996), master's at Genetics from Universidade Estadual de Campinas (1999) and ph.d. at Physics from Universidade de São Paulo (2004). Has experience in Byophysics, focusing on Molecular Biophysics (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| Study reveals how production of enzyme with key role in cancer is regulated |
- The glutaminase role on tumor progression, AP.R
Abstract
Cancer is a disease that has as main characteristic the continuous cellular proliferation. To support the high proliferative rate, tumor cells have increased demand for biosynthetic precursors used in the synthesis of macromolecules that will make up the daughter cells. For that, tumors consume a lot of glucose and glutamine, mainly. The increase in glutamine consumption, in addition to...
- Metabolic regulation of genetic and epigenetic control of gene expression, AP.R
Abstract
Molecular mechanisms related to the tumorigenic process are traditionally related to oncogenes and tumor supressors deregulation, which control the signaling pathways responsible for the cell cycle regulation, cell growth, cell proliferation and cell death. On the other hand, new evidences point to an alternative mechanism where the primary role of the oncogenes and tumor supressors are...
- Understanding the glutaminase functional regulation and the development of inhibitors as new approaches to cancer therapy, AP.R
Abstract
Cell proliferation is a crucial process for the embryogenesis and organism growth, being also essential for the proper function of several adult tissues. Although important for the homeostasis of the organism, its deregulation composes the driving force of tumor development. In the past twenty years the relationship between the processes of signal transduction stimulated by growth facto...
- Cellular and biochemical studies of the glutaminase enzyme and its relation with cancer, AP.JP
Abstract
An emerging area in cancer biology is pointing to the fact that the already characterized genes responsible for the control of the growing process, cellular division, adhesion, metastasis and programmed cell death are also involved on the metabolism control. Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all macromolecular components during each pa...
- Evaluation of synergy between immune checkpoint blockade therapy with anti-PD-1 and glutaminase inhibition in the treatment of Triple-Negative Breast Cancer, BP.PD
Abstract
Cancer cells have increased glycolytic and glutaminolytic pathways and consume glucose and glutamine at accelerated rates. The intensification of the glycolytic pathway, coined as the Warburg Effect, and the glutaminolytic pathway, provide several intermediates for different synthesis routes and are a hallmark of malignant transformation. Glutamine, in addition to providing biosynthetic...
- Developing new glutaminase inhibitors with potential anti-tumor activity, BP.DD
Abstract
Breast cancer is the most diagnosed type of cancer in women, with an estimated incidence of approximately 3.2 million cases a year by 2050. The triple-negative subtype (Triple Negative Breast Cancer, TNBC), characterized by low expression / no detection of hormone receptors estrogen (ER), progesterone (PR) and growth factors (Her2) is the most common among young women, whose characteris...
- The mechanisms underlying the GLS2 pro-tumorigenic role, BP.DD
Abstract
Cancer is a disease in which its main characteristic is the continuous cell proliferation. To sustain the high proliferative rate, tumor cells have an increased demand for biosynthetic precursors used in the synthesis of macromolecules that compose the daughter cells. Therefore, tumors consume a large amount of glucose and glutamine, mainly. The increase in glutamine consumption, beside...
- Identification of genes regulated by the several HIF-3a isoforms: development of tumor patients transcriptomics data analysis tool, BP.MS
Abstract
Because of its importance in metabolic adaptation and progression of cancer, obtain functional information about the HIFs that may answer their mechanisms of action is of paramount importance for the understanding of the disease. Of particular interest is the least studied isoform, HIF-3±, and its different variants by alternative splicing. Three variants (-3±1, -3±1 and -±9) have bHLH ...
- Study of alternative anaplerotic sources of the TCA as new targets against triple-negative breast cancer, BP.DD
Abstract
The triple-negative breast cancer disease is characterized by the absence of progesterone and estrogen hormone receptors and HER2 membrane receptor, therefore is unresponsive to conventional treatments of disease. Among others, changes in the cellular metabolism are the molecular basis for the emergence and progression of the triple-negative phenotype, indicating that these alterations ...
- Post-transcriptional regulation of glutaminase enzyme by HuR and its relationship with high glutaminolytic levels in tumors, BP.DD
Abstract
The genetic and metabolic particularities of tumor cells are crucial to their high rates of cell division, normally associated with an increase on glutamine consumption used for energy and cellular biosynthetic blocks (lipids, proteins and nucleic acids) production. The first step on the glutamine metabolism is performed by the glutaminase enzyme and produces glutamate. The glutaminase ...
(Only some records are available in English at this moment)
- Glutaminase 2 influence on tumor - macrophage interaction and metastasis, BE.EP.DD
Abstract
Our main goal is to understand the role of GLS2 on breast cancer progression. For such, we want to answer the following questions:Do M1 and M2 macrophages influence in vitro metastasis of GLS2 expressing cells? GLS2 has been more often linked to anti-tumorigenic effects, mainly in hepatocarcinomas and gliomas. We found a link between GLS2 expression and diminished breast cancer patient...
- Metabolomic analyzis of cells with PI3K-Akt pathway and Ras oncogene co-activation, BE.EP.PD
Abstract
Cancer is a major public health problem in many parts of the world, and is the leading cause of death in developed countries and the second leading cause of death in developing countries. Understanding the mechanisms related to tumor development and progression is essential for the improvement of therapeutic approaches to cancer and mobilizes scientific community worldwide. Different hu...
- Cell-based toxicity assays using high throughput and high content screening, BE.EP.PD
Abstract
Tumor cells are exposed to multiple nutrients simultaneously, but it is the intensive consumption of glucose and glutamine, the most abundant amino acid in blood plasma, one of the hallmarks of tumor transformation. The uptake and metabolism of glucose with significant secretion of lactate even in the presence of oxygen, known as aerobic glycolysis or Warburg effect, as well as increase...
| 1 / 1 | Ongoing research grants |
| 5 / 3 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 25 / 17 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 37 / 27 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 11 |
| Citations | 238 |
| Cit./Article | 21.6 |
| Data from Web of Science | |
CASSAGO, ALEXANDRE; FERREIRA, AMANDA P. S.; FERREIRA, IGOR M.; FORNEZARI, CAMILA; GOMES, EMERSON R. M.; GREENE, KAI SU; PEREIRA, HUMBERTO M.; GARRATT, RICHARD C.; DIAS, SANDRA M. G.; AMBROSIO, ANDRE L. B.. Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 109, n. 4, p. 1092-1097, JAN 24 2012. Web of Science Citations: 102. (10/05987-0, 10/05003-0, 09/10875-9)
QUINTERO, MELISSA; ADAMOSKI, DOUGLAS; DOS REIS, LARISSA MENEZES; RODRIGUES ASCENCAO, CAROLLINE FERNANDA; SOUSA DE OLIVEIRA, KRISHINA RATNA; GONCALVES, KALIANDRA DE ALMEIDA; DIAS, MARILIA MEIRA; CARAZZOLLE, MARCELO FALSARELLA; GOMES DIAS, SANDRA MARTHA. Guanylate-binding protein-1 is a potential new therapeutic target for triple-negative breast cancer. BMC CANCER, v. 17, NOV 7 2017. Web of Science Citations: 8. (14/18061-9, 13/23510-4, 14/17820-3, 14/06512-6, 14/15968-3, 15/25832-4, 12/09452-9, 09/53853-5, 12/11577-4)
SANTOS, CARLA C. F.; PARADELA, LUCIANA S.; NOVAES, LUIZ F. T.; DIAS, SANDRA M. G.; PASTRE, JULIO C.. Design and synthesis of cenocladamide analogues and their evaluation against breast cancer cell lines. MedChemComm, v. 8, n. 4, p. 755-766, APR 1 2017. Web of Science Citations: 5. (14/15968-3, 15/08199-6, 14/25770-6, 14/26378-2)
DOS REIS, LARISSA MENEZES; ADAMOSKI, DOUGLAS; OLIVEIRA SOUZA, RODOLPHO ORNITZ; RODRIGUES ASCENCAO, CAROLLINE FERNANDA; SOUSA DE OLIVEIRA, KRISHINA RATNA; CORREA-DA-SILVA, FELIPE; DE SA PATRONI, FABIO MALTA; DIAS, MARILIA MEIRA; CONSONNI, SILVIO ROBERTO; MENDES DE MORAES-VIEIRA, PEDRO MANOEL; et al. Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition-resistant triple-negative breast cancer cells. Journal of Biological Chemistry, v. 294, n. 24, p. 9342-9357, JUN 14 2019. Web of Science Citations: 3. (14/18061-9, 15/26059-7, 13/23510-4, 14/17820-3, 14/06512-6, 14/15968-3, 15/25832-4, 15/15626-8, 16/06034-2, 17/06225-5)
KRISHNA NAGAMPALLI, RAGHAVENDRA SASHI; NECIOSUP QUESNAY, JOSE EDWIN; ADAMOSKI, DOUGLAS; ISLAM, ZEYAUL; BIRCH, JAMES; SEBINELLI, HEITOR GOBBI; BRUNO MOREIRA GIRARD, RICHARD MARCEL; RODRIGUES ASCENCAO, CAROLLINE FERNANDA; FALA, ANGELA MARIA; PAULETTI, BIANCA ALVES; et al. Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter. SCIENTIFIC REPORTS, v. 8, FEB 22 2018. Web of Science Citations: 6. (14/12663-7, 14/06954-9, 14/17820-3, 17/02391-8, 15/25832-4, 14/20673-2, 15/02734-7, 16/06034-2)
REDIS, ROXANA S.; VELA, LUZ E.; LU, WEIQIN; DE OLIVEIRA, JULIANA FERREIRA; IVAN, CRISTINA; RODRIGUEZ-AGUAYO, CRISTIAN; ADAMOSKI, DOUGLAS; PASCULLI, BARBARA; TAGUCHI, AYUMU; CHEN, YUNYUN; et al. Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2. MOLECULAR CELL, v. 61, n. 4, p. 520-534, FEB 18 2016. Web of Science Citations: 63. (14/15968-3, 14/17820-3, 14/20673-2)
SCOTA FERREIRA, AMANDA PETRINA; CASSAGO, ALEXANDRE; GONCALVES, KALIANDRA DE ALMEIDA; DIAS, MARILIA MEIRA; ADAMOSKI, DOUGLAS; RODRIGUES ASCENCAO, CAROLLINE FERNANDA; HONORATO, RODRIGO VARGAS; DE OLIVEIRA, JULIANA FERREIRA; FERREIRA, IGOR MONTEZE; FORNEZARI, CAMILA; et al. Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor. Journal of Biological Chemistry, v. 288, n. 39, p. 28009-28020, SEP 27 2013. Web of Science Citations: 28. (09/10875-9, 10/05987-0, 10/05003-0, 11/06654-7, 12/14298-9, 09/54067-3)
DE GUZZI CASSAGO, CAROLINA APARECIDA; DIAS, MARILIA MEIRA; PINHEIRO, MATHEUS PINTO; PASQUALI, CAMILA CRISTINA; SILVA BASTOS, ALLINY CRISTINY; ISLAM, ZEYAUL; CONSONNI, SILVIO ROBERTO; DE OLIVEIRA, JULIANA FERREIRA; GOMES, EMERSON MACHI; RODRIGUES ASCENCAO, CAROLLINE FERNANDA; et al. Glutaminase Affects the Transcriptional Activity of Peroxisome Proliferator-Activated Receptor gamma (PPAR gamma) via Direct Interaction. BIOCHEMISTRY, v. 57, n. 44, p. 6293-6307, NOV 6 2018. Web of Science Citations: 1. (10/13992-3, 11/13981-4, 17/11766-5, 16/22246-0, 15/25832-4, 14/19518-2, 14/20673-2, 11/10127-2)
DRAGOMIR, MIHNEA; MAFRA, ANA CAROLINA P.; DIAS, SANDRA M. G.; VASILESCU, CATALIN; CALIN, GEORGE A.. Using microRNA Networks to Understand Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 19, n. 7, JUL 2018. Web of Science Citations: 15. (15/25832-4)
FALA, ANGELA M.; OLIVEIRA, JULIANA F.; ADAMOSKI, DOUGLAS; ARICETTI, JULIANA A.; DIAS, MARILIA M.; DIAS, MARCIO V. B.; SFORCA, MAURCIO L.; LOPES-DE-OLIVEIRA, PAULO S.; ROCCO, SILVANA A.; CALDANA, CAMILA; et al. Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3 alpha. SCIENTIFIC REPORTS, v. 5, AUG 3 2015. Web of Science Citations: 7. (14/15968-3, 14/04927-4, 12/14298-9, 10/13739-6, 14/20673-2)
KRISHNA NAGAMPALLI, RAGHAVENDRA SASHI; NECIOSUP QUESNAY, JOSE EDWIN; ADAMOSKI, DOUGLAS; ISLAM, ZEYAUL; BIRCH, JAMES; SEBINELLI, HEITOR GOBBI; BRUNO MOREIRA GIRARD, RICHARD MARCEL; RODRIGUES ASCENCAO, CAROLLINE FERNANDA; FALA, ANGELA MARIA; PAULETTI, BIANCA ALVES; et al. Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter. SCIENTIFIC REPORTS, v. 8, FEB 22 2018. Web of Science Citations: 6. (14/12663-7, 14/06954-9, 14/17820-3, 17/02391-8, 15/25832-4, 14/20673-2, 15/02734-7, 16/06034-2)
(References retrieved automatically from State of São Paulo Research Institutions)
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DIAS, Sandra Martha Gomes. Identificação, clonagem, estrutura e transcrição do loco genico mitocondrial nad3-rps12 de Coix lacryma-job L. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas. (97/01840-8)
GOMES, Emerson Rodrigo Machi. Caracterização bioquímica e celular da glutaminase isoforma Kidney-type com seus parceiros de interação. Dissertação (Mestrado) - Faculdade de Ciências Médicas. Universidade Estadual de Campinas (UNICAMP). (10/13992-3)
CASSAGO, Carolina Aparecida de Guzzi. Avaliação da interação da glutaminase isoforma "kidney-type" (KGA) com o receptor nuclear "peroxisome proliferator-activated receptor gamma" (PPAR -gama). Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (11/10127-2)
DIAS, Sandra Martha Gomes. Estudos estruturais dos receptores nucleares humanos para os hormônios tireoidianos Isoforma ß1 (hTRß1) e para o ácido retinóico 9-cis Isoforma a (hRXRa). Tese (Doutorado) - Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos. (00/00021-8)
REIS, Larissa Menezes dos. Aumento de beta-oxidação confere resistência à inibição de glutaminase em células de câncer de mama triplo-negativo = Enhanced fatty acid oxidation confers resistance to glutaminase inhibition in triple-negative breast cancer cells. Tese (Doutorado) - Universidade Estadual de Campinas, Instituto de Biologia. (14/18061-9)
ESCOBAR, Melissa Quintero. Transcriptômica e metabolômica como ferramentas para o entendimento do processo de adaptação metabólica tumoral dos tumores de mama triplo-negativo. Tese (Doutorado) - Universidade Estadual de Campinas, Instituto de Biologia. (12/09452-9)
MEIRA, Douglas Adamoski. Regulação pós-transcricional da enzima glutaminase por HuR e sua relação com os altos níveis glutaminolíticos tumorais = Post-transcriptional regulation of glutaminase enzyme by HuR and its relationship with high glutaminolytic levels in tumors. Tese (Doutorado) - Universidade Estadual de Campinas, Instituto de Biologia. (14/17820-3)