CV Lattes
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Ministério da Ciência, Tecnologia e Inovações (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Bacharelado em Ciências Biológicas from Universidade Estadual de Campinas (1996), master's at Genetics from Universidade Estadual de Campinas (1999) and ph.d. at Physics from Universidade de São Paulo (2004). Has experience in Byophysics, focusing on Molecular Biophysics (Source: Lattes Curriculum)
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Cancer is a disease that has as main characteristic the continuous cellular proliferation. To support the high proliferative rate, tumor cells have increased demand for biosynthetic precursors used in the synthesis of macromolecules that will make up the daughter cells. For that, tumors consume a lot of glucose and glutamine, mainly. The increase in glutamine consumption, in addition to c…
Molecular mechanisms related to the tumorigenic process are traditionally related to oncogenes and tumor supressors deregulation, which control the signaling pathways responsible for the cell cycle regulation, cell growth, cell proliferation and cell death. On the other hand, new evidences point to an alternative mechanism where the primary role of the oncogenes and tumor supressors are t…
Cell proliferation is a crucial process for the embryogenesis and organism growth, being also essential for the proper function of several adult tissues. Although important for the homeostasis of the organism, its deregulation composes the driving force of tumor development. In the past twenty years the relationship between the processes of signal transduction stimulated by growth factors…
An emerging area in cancer biology is pointing to the fact that the already characterized genes responsible for the control of the growing process, cellular division, adhesion, metastasis and programmed cell death are also involved on the metabolism control. Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all macromolecular components during each pass…
Lymphocytes and macrophages infiltrated in the tumor microenvironment reflect the biology of the tumor and impact its prognosis. However, these cells are challenged with a hostile microenvironment and, during the process of tumor development, multiple mechanisms of suppression of the immune system come into play, favoring the growth of the tumor and gaining malignancy. In conjunction with…
Cancer cells have increased glycolytic and glutaminolytic pathways and consume glucose and glutamine at accelerated rates. The intensification of the glycolytic pathway, coined as the Warburg Effect, and the glutaminolytic pathway, provide several intermediates for different synthesis routes and are a hallmark of malignant transformation. Glutamine, in addition to providing biosynthetic i…
Breast Cancer is the second most common Cancer in incidence and mortality among females and according to national and international health organizations, this number has increased in recent years. The development of new therapies for the treatment of Cancer is necessary because of this increasing number of cases and the difficulty of effective treatments. Among the molecular mechanisms in…
Breast cancer is the most diagnosed type of cancer in women, with an estimated incidence of approximately 3.2 million cases a year by 2050. The triple-negative subtype (Triple Negative Breast Cancer, TNBC), characterized by low expression / no detection of hormone receptors estrogen (ER), progesterone (PR) and growth factors (Her2) is the most common among young women, whose characteristi…
Cancer is a disease in which its main characteristic is the continuous cell proliferation. To sustain the high proliferative rate, tumor cells have an increased demand for biosynthetic precursors used in the synthesis of macromolecules that compose the daughter cells. Therefore, tumors consume a large amount of glucose and glutamine, mainly. The increase in glutamine consumption, besides …
Because of its importance in metabolic adaptation and progression of cancer, obtain functional information about the HIFs that may answer their mechanisms of action is of paramount importance for the understanding of the disease. Of particular interest is the least studied isoform, HIF-3±, and its different variants by alternative splicing. Three variants (-3±1, -3±1 and -±9) have bHLH do…
(Only some records are available in English at this moment)
Our main goal is to understand the role of GLS2 on breast cancer progression. For such, we want to answer the following questions:Do M1 and M2 macrophages influence in vitro metastasis of GLS2 expressing cells? GLS2 has been more often linked to anti-tumorigenic effects, mainly in hepatocarcinomas and gliomas. We found a link between GLS2 expression and diminished breast cancer patient s…
Cancer is a major public health problem in many parts of the world, and is the leading cause of death in developed countries and the second leading cause of death in developing countries. Understanding the mechanisms related to tumor development and progression is essential for the improvement of therapeutic approaches to cancer and mobilizes scientific community worldwide. Different huma…
Tumor cells are exposed to multiple nutrients simultaneously, but it is the intensive consumption of glucose and glutamine, the most abundant amino acid in blood plasma, one of the hallmarks of tumor transformation. The uptake and metabolism of glucose with significant secretion of lactate even in the presence of oxygen, known as aerobic glycolysis or Warburg effect, as well as increased …
| 1 / 1 | Ongoing research grants |
| 5 / 3 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 27 / 19 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 39 / 29 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 13 |
| Citations | 288 |
| Cit./Article | 22.2 |
| Data from Web of Science | |
NASCIMENTO, ALESSANDRO S.; DIAS, SANDRA MARTHA GOMES; NUNES, FÁBIO M.; APARÍCIO, RICARDO; AMBROSIO, ANDRE L. B.; BLEICHER, LUCAS; FIGUEIRA, ANA CAROLINA M.; SANTOS, MARIA AUXILIADORA M.; OLIVEIRA NETO, MÁRIO DE; FISCHER, HANNES; et al. Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function. Journal of Molecular Biology, v. 360, n. 3, p. 586-598, July 2006. (06/00182-8)
DE GUZZI CASSAGO, CAROLINA APARECIDA; DIAS, MARILIA MEIRA; PINHEIRO, MATHEUS PINTO; PASQUALI, CAMILA CRISTINA; SILVA BASTOS, ALLINY CRISTINY; ISLAM, ZEYAUL; CONSONNI, SILVIO ROBERTO; DE OLIVEIRA, JULIANA FERREIRA; GOMES, EMERSON MACHI; RODRIGUES ASCENCAO, CAROLLINE FERNANDA; et al. Glutaminase Affects the Transcriptional Activity of Peroxisome Proliferator-Activated Receptor gamma (PPAR gamma) via Direct Interaction. BIOCHEMISTRY, v. 57, n. 44, p. 6293-6307, NOV 6 2018. Web of Science Citations: 1. (14/20673-2, 11/10127-2, 14/19518-2, 15/25832-4, 10/13992-3, 17/11766-5, 11/13981-4, 16/22246-0)
FALA, ANGELA M.; OLIVEIRA, JULIANA F.; ADAMOSKI, DOUGLAS; ARICETTI, JULIANA A.; DIAS, MARILIA M.; DIAS, MARCIO V. B.; SFORCA, MAURCIO L.; LOPES-DE-OLIVEIRA, PAULO S.; ROCCO, SILVANA A.; CALDANA, CAMILA; et al. Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3 alpha. SCIENTIFIC REPORTS, v. 5, AUG 3 2015. Web of Science Citations: 7. (14/20673-2, 14/04927-4, 14/15968-3, 12/14298-9, 10/13739-6)
CIOCAN-CARTITA, CRISTINA ALEXANDRA; JURJ, ANCUTA; ZANOAGA, OANA; COJOCNEANU, ROXANA; POP, LAURA-ANCUTA; MOLDOVAN, ALIN; MOLDOVAN, CRISTIAN; ZIMTA, ALINA ANDREEA; RADULY, LAJOS; POP-BICA, CECILIA; et al. New insights in gene expression alteration as effect of doxorubicin drug resistance in triple negative breast cancer cells. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, v. 39, n. 1, NOV 13 2020. Web of Science Citations: 0. (19/16351-3)
DRAGOMIR, MIHNEA; MAFRA, ANA CAROLINA P.; DIAS, SANDRA M. G.; VASILESCU, CATALIN; CALIN, GEORGE A.. Using microRNA Networks to Understand Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 19, n. 7, JUL 2018. Web of Science Citations: 15. (15/25832-4)
DIAS, MARILIA M.; ADAMOSKI, DOUGLAS; DOS REIS, LARISSA M.; ASCENCAO, CAROLLINE F. R.; DE OLIVEIRA, KRISHINA R. S.; PASCHOALINI MAFRA, ANA CAROLINA; DA SILVA BASTOS, ALLINY CRISTINY; QUINTERO, MELISSA; CASSAGO, CAROLINA DE G.; FERREIRA, IGOR M.; et al. GLS2 is protumorigenic in breast cancers. Oncogene, v. 39, n. 3, p. 690-702, JAN 2020. Web of Science Citations: 0. (13/05668-0, 14/18061-9, 12/14298-9, 13/23510-4, 14/17820-3, 14/06512-6, 14/15968-3, 15/25832-4, 12/09452-9, 14/20673-2, 16/06625-0, 12/11577-4, 11/10127-2)
MARTINEZ, LEANDRO; NASCIMENTO, ALESSANDRO S.; NUNES, FABIO M.; PHILLIPS, KEVIN; APARICIO, RICARDO; DIAS, SANDRA MARTHA G.; FIGUEIRA, ANA CAROLINA M.; LIN, JEAN H.; NGUYEN, PHUONG; APRILETTI, JAMES W.; et al. Gaining ligand selectivity in thyroid hormone receptors via entropy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 106, n. 49, p. 20717-20722, DEC 8 2009. Web of Science Citations: 50. (06/00182-8)
DOS REIS, LARISSA MENEZES; ADAMOSKI, DOUGLAS; OLIVEIRA SOUZA, RODOLPHO ORNITZ; RODRIGUES ASCENCAO, CAROLLINE FERNANDA; SOUSA DE OLIVEIRA, KRISHINA RATNA; CORREA-DA-SILVA, FELIPE; DE SA PATRONI, FABIO MALTA; DIAS, MARILIA MEIRA; CONSONNI, SILVIO ROBERTO; MENDES DE MORAES-VIEIRA, PEDRO MANOEL; et al. Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition-resistant triple-negative breast cancer cells. Journal of Biological Chemistry, v. 294, n. 24, p. 9342-9357, JUN 14 2019. Web of Science Citations: 3. (16/06034-2, 15/15626-8, 14/17820-3, 17/06225-5, 14/06512-6, 15/26059-7, 15/25832-4, 14/18061-9, 13/23510-4, 14/15968-3)
KRISHNA NAGAMPALLI, RAGHAVENDRA SASHI; NECIOSUP QUESNAY, JOSE EDWIN; ADAMOSKI, DOUGLAS; ISLAM, ZEYAUL; BIRCH, JAMES; SEBINELLI, HEITOR GOBBI; BRUNO MOREIRA GIRARD, RICHARD MARCEL; RODRIGUES ASCENCAO, CAROLLINE FERNANDA; FALA, ANGELA MARIA; PAULETTI, BIANCA ALVES; et al. Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter. SCIENTIFIC REPORTS, v. 8, FEB 22 2018. Web of Science Citations: 6. (17/02391-8, 14/20673-2, 16/06034-2, 15/02734-7, 15/25832-4, 14/17820-3, 14/12663-7, 14/06954-9)
SANTOS, CARLA C. F.; PARADELA, LUCIANA S.; NOVAES, LUIZ F. T.; DIAS, SANDRA M. G.; PASTRE, JULIO C.. Design and synthesis of cenocladamide analogues and their evaluation against breast cancer cell lines. MedChemComm, v. 8, n. 4, p. 755-766, APR 1 2017. (15/08199-6, 14/26378-2, 14/15968-3, 14/25770-6)
QUINTERO, MELISSA; ADAMOSKI, DOUGLAS; DOS REIS, LARISSA MENEZES; RODRIGUES ASCENCAO, CAROLLINE FERNANDA; SOUSA DE OLIVEIRA, KRISHINA RATNA; GONCALVES, KALIANDRA DE ALMEIDA; DIAS, MARILIA MEIRA; CARAZZOLLE, MARCELO FALSARELLA; GOMES DIAS, SANDRA MARTHA. Guanylate-binding protein-1 is a potential new therapeutic target for triple-negative breast cancer. BMC CANCER, v. 17, NOV 7 2017. (12/11577-4, 14/17820-3, 14/06512-6, 09/53853-5, 15/25832-4, 14/18061-9, 13/23510-4, 14/15968-3, 12/09452-9)
REDIS, ROXANA S.; VELA, LUZ E.; LU, WEIQIN; DE OLIVEIRA, JULIANA FERREIRA; IVAN, CRISTINA; RODRIGUEZ-AGUAYO, CRISTIAN; ADAMOSKI, DOUGLAS; PASCULLI, BARBARA; TAGUCHI, AYUMU; CHEN, YUNYUN; et al. Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2. MOLECULAR CELL, v. 61, n. 4, p. 520-534, FEB 18 2016. (14/17820-3, 14/20673-2, 14/15968-3)
SCOTA FERREIRA, AMANDA PETRINA; CASSAGO, ALEXANDRE; GONCALVES, KALIANDRA DE ALMEIDA; DIAS, MARILIA MEIRA; ADAMOSKI, DOUGLAS; RODRIGUES ASCENCAO, CAROLLINE FERNANDA; HONORATO, RODRIGO VARGAS; DE OLIVEIRA, JULIANA FERREIRA; FERREIRA, IGOR MONTEZE; FORNEZARI, CAMILA; et al. Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor. Journal of Biological Chemistry, v. 288, n. 39, p. 28009-28020, SEP 27 2013. (11/06654-7, 10/05003-0, 12/14298-9, 10/05987-0, 09/10875-9, 09/54067-3)
COSTA, RENNA K. E.; RODRIGUES, CAMILA T.; CAMPOS, JEAN C. H.; PARADELA, LUCIANA S.; DIAS, MARILIA M.; DA SILVA, BIANCA NOVAES; DE VALEGA NEGRAO, CYRO VON ZUBEN; GONCALVES, KALIANDRA DE ALMEIDA; ASCENCAO, CAROLLINE F. R.; ADAMOSKI, DOUGLAS; et al. High-Throughput Screening Reveals New Glutaminase Inhibitor Molecules. ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, v. 4, n. 6, p. 1849-1866, DEC 10 2021. Web of Science Citations: 0. (14/15968-3, 13/23510-4, 16/09077-4, 13/07600-3, 14/17820-3, 15/25832-4, 19/16351-3)
AMBROSIO, ANDRE L. B.; DIAS, SANDRA M. G.; POLIKARPOV, IGOR; ZURIER, ROBERT B.; BURSTEIN, SUMNER H.; GARRATT, RICHARD C.. Ajulemic acid, a synthetic nonpsychoactive cannabinoid acid, bound to the ligand binding domain of the human peroxisome proliferator-activated receptor gamma. Journal of Biological Chemistry, v. 282, n. 25, p. 18625-18633, June 2007. (06/00182-8, 98/14138-2, 99/03387-4)
CASSAGO, ALEXANDRE; FERREIRA, AMANDA P. S.; FERREIRA, IGOR M.; FORNEZARI, CAMILA; GOMES, EMERSON R. M.; GREENE, KAI SU; PEREIRA, HUMBERTO M.; GARRATT, RICHARD C.; DIAS, SANDRA M. G.; AMBROSIO, ANDRE L. B.. Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 109, n. 4, p. 1092-1097, JAN 24 2012. (09/10875-9, 10/05987-0, 10/05003-0)
(References retrieved automatically from State of São Paulo Research Institutions)
REIS, Larissa Menezes dos. Aumento de beta-oxidação confere resistência à inibição de glutaminase em células de câncer de mama triplo-negativo = Enhanced fatty acid oxidation confers resistance to glutaminase inhibition in triple-negative breast cancer cells. Tese (Doutorado) - Universidade Estadual de Campinas, Instituto de Biologia. (14/18061-9)
ESCOBAR, Melissa Quintero. Transcriptômica e metabolômica como ferramentas para o entendimento do processo de adaptação metabólica tumoral dos tumores de mama triplo-negativo. Tese (Doutorado) - Universidade Estadual de Campinas, Instituto de Biologia. (12/09452-9)
MEIRA, Douglas Adamoski. Regulação pós-transcricional da enzima glutaminase por HuR e sua relação com os altos níveis glutaminolíticos tumorais = Post-transcriptional regulation of glutaminase enzyme by HuR and its relationship with high glutaminolytic levels in tumors. Tese (Doutorado) - Universidade Estadual de Campinas, Instituto de Biologia. (14/17820-3)
DIAS, Sandra Martha Gomes. Estudos estruturais dos receptores nucleares humanos para os hormônios tireoidianos Isoforma ß1 (hTRß1) e para o ácido retinóico 9-cis Isoforma a (hRXRa). Tese (Doutorado) - Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos. (00/00021-8)
CASSAGO, Carolina Aparecida de Guzzi. Avaliação da interação da glutaminase isoforma "kidney-type" (KGA) com o receptor nuclear "peroxisome proliferator-activated receptor gamma" (PPAR -gama). Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (11/10127-2)
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GOMES, Emerson Rodrigo Machi. Caracterização bioquímica e celular da glutaminase isoforma Kidney-type com seus parceiros de interação. Dissertação (Mestrado) - Faculdade de Ciências Médicas. Universidade Estadual de Campinas (UNICAMP). (10/13992-3)
DIAS, Sandra Martha Gomes. Identificação, clonagem, estrutura e transcrição do loco genico mitocondrial nad3-rps12 de Coix lacryma-job L. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas. (97/01840-8)