Dr Fabio Squina is Pharmacist, MS in Food Science and Ph.D. in Molecular and Cell Biology. He has the background on Biochemistry, Molecular Biology and Omics Sciences. Fabio Squina?s scientific interests focus on biocatalyst discovery and development of biotechnological routes for lignocellulose conversion into high value products. Dr Fabio Squina?s research group has made contributions on metagenomics-based enzyme discovery field, establishing discovery platform, based on targeted community enrichment protocols and 'Omics' approaches. FS?s group has also successfully engagement on the development of enzymatic routes for the production of natural probiotics, phenolic compounds, and antioxidant molecules. These biotechnological initiatives are aligned to bio-refinery interests based on the potential of adding value to lignocellulose, such as sugarcane bagasse. Dr. Squina received the prestigious Young Investigator Award from São Paulo Research Foundation (FAPESP) on 2009. From 2013 to 2017, Dr. Squina coordinated Industrial Innovation project with Eli Lilly Brazil as co-Financier. Since July 2017, Dr. Squina coordinates FAPESP thematic grant entitled: Lignin valorization in cellulosic ethanol plants: biocatalytic conversion via ferulic acid to high-value chemicals. Dr. Squina has published more than a hundred papers and disclosed eight certificates of patents. (Source: Lattes Curriculum)
| Articles published in Pesquisa para Inovação FAPESP about the researcher: |
| Novel biotechnological route developed to obtain fine chemicals from agricultural waste |
| News published in Agência FAPESP Newsletter about the researcher |
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The sustainable production of chemicals and biofuels from lignocellulosic biomass is an alternative to mitigating the emission of greenhouse gases and dependence on oil industries. Besides, the transition from a fossil fuel-based economy to a renewable bioeconomy should promote job creation and economic growth. Biotechnologies for the valorization of lignocelluloses are a great challenge,…
Lignin can be obtained as a by-product of cellulosic ethanol production, and is a potential source of renewable chemicals, if methods for lignin valorization can be developed. Efficient valorisation of lignin is a major unsolved problem in the development of sustainable biorefineries. The proposal builds upon an existing BBSRC partnership award, and brings together expertise in biocatalys…
Termites are considered one of the most efficient decomposers of lignocelluloses on Earth due to their ability to produce, along with its microbial symbionts, a repertoire of carbohydrate-active enzymes (CAZymes). Recently, a set of Pro-oxidant, Antioxidant, and Detoxification enzymes (PAD) were also correlated with the metabolism of carbohydrates and lignin in termites. The lower termite…
The ultimate aims of this project are i) to utilize a microbial metagenomics platform to enable novel enzyme building block discovery and identification, ii) to assess the capabilities and of the bacteriallignin peroxidase treatment against sugarcane bagasse lignin, iii) to integrate these building blocks into suitably engineered host chassis using synthetic biology principies and to engi…
(Only some records are available in English at this moment)
The 'biorefinery' concept emerges as an alternative for the sustainable production of fuels and chemicals from abundant plant biomass resources. These initiatives are beneficial not only to address global warming reduction, but also because they can promote economic opportunities and stimulate job growth. There are well-established methods for biomass pre-treatment and fractionation into …
(Only some records are available in English at this moment)
Lignin streams derived from biomass processing plants represent an untapped source of aromatic compounds that can be converted into high value molecules. The lignin-degrading bacterium Rhodococcus jostii RHA1 (hereinafter named RHA1) depolymerizes lignin using the peroxidase DypB into oxidized, lower molecular weight aromatic compounds, which are catabolized. Although the metabolism under…
Aroma compounds represent a substantial fraction of the world's market for food additives and are mainly produced by petroleum-derived chemical synthesis. There is an increasing demand to replace compounds derived from fossil fuels; thus, renewable lignocellulosic biomass can be an attractive alternative for aroma production. In this sense, the physicochemical pretreatment is an important…
Lignocellulosic biomass is a renewable and sustainable resource for production of fuels and value-added chemicals. In this context, we have devised an experimental approach to combine lignocellulosic biomass breakdown with direct conversion of the released monomers into fine chemicals. We hypothesize that by mimicking natural cellulosomes, we could design a mini-cellulosome, which will ac…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 8 / 6 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 33 / 31 | Completed scholarships in Brazil |
| 9 / 9 | Completed scholarships abroad |
| 53 / 49 | All research grants and scholarships |
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