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Carsten Wrenger

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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB)  (Institutional affiliation for the last research proposal)
Birthplace: Alemanha

He obtained a Bachelor degree in Biology from the Bielefeld University, Germany (1996) and a Master degree in Biology from the Bielefeld University (1999). He performed doctoral studies (PhD) in Biology/Biochemistry at the Bernhard Nocht Institute for Tropical Medicine (2002) and was Wellcome International Postdoctoral Fellow at the Wellcome Trust Biocentre, University of Dundee, UK (2002-2004) as well as Principal Investigator at the Bernhard Nocht Institute for Tropical Medicine (2004-2010). He did Habilitation and Venia-legendi in Zoology at the University of Hamburg, Germany (2007) which was also accredited as Livre-docência from the University of São Paulo (2013). He was Jovem Pesquisador em Centros Emergentes at the Institute of Biomedical Sciences, University of São Paulo (ICB-USP) and is currently Associate Professor for Molecular Parasitology at ICB-USP. He has experience in molecular parasitology, biochemistry and cell biology and is working on the vitamin B1 and B6 metabolism in Plasmodium falciparum and Staphylococcus aureus MRSA. (Source: Lattes Curriculum)

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FAPESP support in numbers * Updated November 16, 2019
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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (28)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications28
Citations170
Cit./Article6.1
Data from Web of Science

BOSCH, SORAYA S.; KRONENBERGER, THALES; MEISSNER, KAMILA A.; ZIMBRES, FLAVIA M.; STEGEHAKE, DIRK; IZUI, NATALIA M.; SCHETTERT, ISOLMAR; LIEBAU, EVA; WRENGER, CARSTEN. Oxidative Stress Control by Apicomplexan Parasites. BIOMED RESEARCH INTERNATIONAL, . Web of Science Citations: 10. (09/54325-2, 11/19703-6, 12/12807-3, 11/13706-3, 13/17577-9, 10/20647-0, 13/10288-1)

KRONENBERGER, THALES; LINDNER, JASMIN; MEISSNER, KAMILA A.; ZIMBRES, FLAVIA M.; CORONADO, MONIKA A.; SAUER, FRANK M.; SCHETTERT, ISOLMAR; WRENGER, CARSTEN. Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum: A Druggable Target?. BIOMED RESEARCH INTERNATIONAL, . Web of Science Citations: 9. (09/54325-2, 11/19703-6, 12/12807-3, 11/13706-3, 10/20647-0, 12/12790-3, 13/10288-1)

PEREIRA, C. A.; SAYE, M.; WRENGER, C.; MIRANDA, M. R.. Metabolite Transporters in Trypanosomatid Parasites: Promising Therapeutic Targets But... How to Deal with Them?. Current Medicinal Chemistry, v. 21, n. 15, p. 1707-1712, . Web of Science Citations: 3. (10/20647-0, 09/54325-2)

DREBES, JULIA; KUENZ, MADELEINE; PEREIRA, CLAUDIO A.; BETZEL, CHRISTIAN; WRENGER, CARSTEN. MRSA Infections: From Classical Treatment to Suicide Drugs. Current Medicinal Chemistry, v. 21, n. 15, p. 1809-1819, . Web of Science Citations: 12. (09/54325-2, 13/10288-1)

KRONENBERGER, THALES; LUNEV, SERGEY; WRENGER, CARSTEN; GROVES, MATTHEW R.. Purification, crystallization and preliminary X-ray diffraction analysis of pyridoxal kinase from Plasmodium falciparum (PfPdxK). ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, v. 70, n. 11, p. 1550-1555, . Web of Science Citations: 0. (11/13706-3, 09/54325-2, 13/10288-1)

MALTAROLLO, VINICIUS GONCALVES; KRONENBERGER, THALES; WINDSHUEGEL, BJOERN; WRENGER, CARSTEN; GOULART TROSSINI, GUSTAVO HENRIQUE; HONORIO, KATHIA MARIA. Advances and Challenges in Drug Design of PPAR delta Ligands. CURRENT DRUG TARGETS, v. 19, n. 2, p. 144-154, . Web of Science Citations: 0. (14/03644-9, 14/27313-1)

LUNEV, SERGEY; BOSCH, SORAYA S.; BATISTA, FERNANDO DE ASSIS; WRENGER, CARSTEN; GROVES, MATTHEW R.. Crystal structure of truncated aspartate transcarbamoylase from Plasmodium falciparum. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, v. 72, n. 7, p. 523-533, . Web of Science Citations: 2. (13/17577-9, 13/10288-1)

CANDIDO-FERREIRA, IVAN LAVANDER; KRONENBERGER, THALES; ROSA SAYEGH, RAPHAEL SANTA; CORREIA BATISTA, ISABEL DE FATIMA; DA SILVA JUNIOR, PEDRO ISMAEL. Evidence of an Antimicrobial Peptide Signature Encrypted in HECT E3 Ubiquitin Ligases. FRONTIERS IN IMMUNOLOGY, v. 7, . Web of Science Citations: 4. (13/07467-1, 14/03644-9)

LUNEV, SERGEY; BUTZLOFF, SABINE; ROMERO, ATILIO R.; LINZKE, MARLEEN; BATISTA, FERNANDO A.; MEISSNER, KAMILA A.; MUELLER, INGRID B.; ADAWY, ALAA; WRENGER, CARSTEN; GROVES, MATTHEW R.. Oligomeric interfaces as a tool in drug discovery: Specific interference with activity of malate dehydrogenase of Plasmodium falciparum in vitro. PLoS One, v. 13, n. 4, . Web of Science Citations: 2. (12/12807-3, 14/23330-9, 13/10288-1, 16/24790-9, 15/26722-8)

LUNEV, SERGEY; BOSCH, SORAYA S.; BATISTA, FERNANDO A.; WANG, CHAO; LI, JINGYAO; LINZKE, MARLEEN; KRUITHOF, PAUL; CHAMOUN, GEORGE; DOMLING, ALEXANDER S. S.; WRENGER, CARSTEN; et al. Identification of a non-competitive inhibitor of Plasmodium falciparum aspartate transcarbamoylase. Biochemical and Biophysical Research Communications, v. 497, n. 3, p. 835-842, . Web of Science Citations: 0. (15/26722-8, 13/17577-9, 14/23330-9)

BURK, OLIVER; KUZIKOV, MARIA; KRONENBERGER, THALES; JESKE, JUDITH; KEMINER, OLIVER; THASLER, WOLFGANG E.; SCHWAB, MATTHIAS; WRENGER, CARSTEN; WINDSHUEGEL, BJOERN. Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles. ARCHIVES OF TOXICOLOGY, v. 92, n. 4, p. 1435-1451, . Web of Science Citations: 1. (14/03644-9, 14/27313-1)

BORGES-PEREIRA, LUCAS; MEISSNER, KAMILA ANNA; WRENGER, CARSTEN; GARCIA, CELIA R. S.. Plasmodium falciparum GFP-E-NTPDase expression at the intraerythrocytic stages and its inhibition blocks the development of the human malaria parasite. PURINERGIC SIGNALLING, v. 13, n. 3, p. 267-277, . Web of Science Citations: 2. (12/12807-3, 11/51295-5, 15/26722-8, 13/10288-1, 10/51593-3)

SCARPELLI, PEDRO H.; TESSARIN-ALMEIDA, GIULLIANA; VICOSO, KENIA LOPES; LIMA, WANIA REZENDE; BORGES-PEREIRA, LUCAS; MEISSNER, KAMILA ANNA; WRENGER, CARSTEN; RAFAELLO, ANNA; RIZZUTO, ROSARIO; POZZAN, TULLIO; et al. Melatonin activates FIS1, DYN1, and DYN2 Plasmodium falciparum related-genes for mitochondria fission: Mitoemerald-GFP as a tool to visualize mitochondria structure. Journal of Pineal Research, v. 66, n. 2, . Web of Science Citations: 4. (11/51295-5, 14/14347-5, 15/26722-8, 12/12807-3)

DE AZEVEDO, ERIKA CHANG; NASCIMENTO, ALESSANDRO S.. Energy landscape of the domain movement in Staphylococcus aureus UDP-N-acetylglucosamine 2-epimerase. Journal of Structural Biology, v. 207, n. 2, p. 158-168, . Web of Science Citations: 0. (15/13684-0, 17/18173-0, 15/26722-8)

DREBES, JULIA; KUENZ, MADELEINE; WINDSHUEGEL, BJOERN; KIKHNEY, ALEXEY G.; MUELLER, INGRID B.; EBERLE, RAPHAEL J.; OBERTHUER, DOMINIK; CANG, HUAIXING; SVERGUN, DMITRI I.; PERBANDT, MARKUS; et al. Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus - Insights into a novel pro-drug approach addressing MRSA infections. SCIENTIFIC REPORTS, v. 6, . Web of Science Citations: 3. (13/10288-1)

KRONENBERGER, THALES; ASSE, JR., LEONARDO RANDER; WRENGER, CARSTEN; GOULART TROSSINI, GUSTAVO HENRIQUE; HONORIO, KATHIA MARIA; MALTAROLLO, VINICIUS GONCALVES. Studies of Staphylococcus aureus FabI inhibitors: fragment-based approach based on holographic structure-activity relationship analyses. Future Medicinal Chemistry, v. 9, n. 2, p. 135-151, . Web of Science Citations: 4. (14/03644-9, 13/10288-1)

ZIMBRES, FLAVIA M.; TARNOK, ATTILA; ULRICH, HENNING; WRENGER, CARSTEN. Aptamers: Novel Molecules as Diagnostic Markers in Bacterial and Viral Infections?. BIOMED RESEARCH INTERNATIONAL, . Web of Science Citations: 22. (12/50393-6, 10/20647-0, 09/54325-2, 11/19703-6)

KRONENBERGER, THALES; SCHETTERT, ISOLMAR; WRENGER, CARSTEN. Targeting the vitamin biosynthesis pathways for the treatment of malaria. Future Medicinal Chemistry, v. 5, n. 7, p. 769-779, . Web of Science Citations: 4. (11/13706-3, 10/20647-0, 09/54325-2)

BEGUM, AFSHAN; DREBES, JULIA; KIKHNEY, ALEXEY; MUELLER, INGRID B.; PERBANDT, MARKUS; SVERGUN, DMITRI; WRENGER, CARSTEN; BETZEL, CHRISTIAN. Staphylococcus aureus thiaminase II: oligomerization warrants proteolytic protection against serine proteases. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, v. 69, n. 12, p. 2320-2329, . Web of Science Citations: 1. (09/54325-2)

NDJONKA, DIEUDONNE; RAPADO, LUDMILA NAKAMURA; SILBER, ARIEL M.; LIEBAU, EVA; WRENGER, CARSTEN. Natural Products as a Source for Treating Neglected Parasitic Diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 14, n. 2, p. 3395-3439, . Web of Science Citations: 76. (09/54325-2)

KRUGER, ARNE; ZIMBRES, FLAVIA M.; KRONENBERGER, THALES; WRENGER, CARSTEN. Molecular Modeling Applied to Nucleic Acid-Based Molecule Development. BIOMOLECULES, v. 8, n. 3, . Web of Science Citations: 3. (18/08820-0, 17/03966-4, 15/26722-8)

MINARI, KARINE; DE AZEVEDO, ERIKA CHANG; RODRIGUES KIRALY, VANESSA THOMAZ; HELENO BATISTA, FERNANDA APARECIDA; DE MORAES, FABIO ROGERIO; DE MELO, FERNANDO ALVES; NASCIMENTO, ALESSANDRO SILVA; GAVA, LISANDRA MARQUES; INACIO RAMOS, CARLOS HENRIQUE; BORGES, JULIO CESAR. Thermodynamic analysis of interactions of the Hsp90 with adenosine nucleotides: A comparative perspective. International Journal of Biological Macromolecules, v. 130, p. 125-138, . Web of Science Citations: 0. (09/53989-4, 13/25646-0, 14/07206-6, 11/23110-0, 15/26722-8, 12/50161-8, 17/18173-0, 17/07335-9)

MEISSNER, KAMILA ANNA; KRONENBERGER, THALES; MALTAROLLO, VINICIUS GONCALVES; GOULART TROSSINI, GUSTAVO HENRIQUE; WRENGER, CARSTEN. Targeting the Plasmodium falciparum plasmepsin V by ligand-based virtual screening. CHEMICAL BIOLOGY & DRUG DESIGN, v. 93, n. 3, p. 300-312, . Web of Science Citations: 1. (17/03966-4, 15/26722-8, 16/24790-9, 14/03644-9)

MEISSNER, KAMILA A.; LUNEV, SERGEY; WANG, YUAN-ZE; LINZKE, MARLEEN; BATISTA, FERNANDO DE ASSIS; WRENGER, CARSTEN; GROVES, MATTHEW R.. Drug Target Validation Methods in Malaria - Protein Interference Assay (PIA) as a Tool for Highly Specific Drug Target Validation. CURRENT DRUG TARGETS, v. 18, n. 9, p. 1069-1085, . Web of Science Citations: 4. (13/10288-1, 12/12807-3, 14/23330-9)

KRONENBERGER, THALES; WINDSHUGEL, BJORN; WRENGER, CARSTEN; HONORIO, KATHIA M.; MALTAROLLO, VINICIUS G.. On the relationship of anthranilic derivatives structure and the FXR (Farnesoid X receptor) agonist activity. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, v. 36, n. 16, p. 4378-4391, . Web of Science Citations: 2. (14/03644-9, 14/27313-1)

VASCONCELOS, STANLEY N. S.; MEISSNER, KAMILA A.; FERRAZ, WITOR R.; TROSSINI, GUSTAVO H. G.; WRENGER, CARSTEN; STEFANI, HELIO A.. Indole-3-glyoxyl tyrosine: synthesis and antimalarial activity against Plasmodium falciparum. Future Medicinal Chemistry, v. 11, n. 6, p. 525-538, . Web of Science Citations: 1. (16/24790-9, 17/25543-8, 12/00424-2, 12/12807-3, 15/26722-8, 13/17960-7)

SARTORI, GERALDO RODRIGUES; NASCIMENTO, ALESSANDRO S.. Comparative Analysis of Electrostatic Models for Ligand Docking. FRONTIERS IN MOLECULAR BIOSCIENCES, v. 6, . Web of Science Citations: 0. (15/13684-0, 17/18173-0, 15/26722-8)

BATISTA, FERNANDO A.; BOSCH, SORAYA S.; BUTZLOFF, SABINE; LUNEV, SERGEY; MEISSNER, KAMILA A.; LINZKE, MARLEEN; ROMERO, ATILIO R.; WANG, CHAO; MUELLER, INGRID B.; DOMLING, ALEXANDER S. S.; et al. Oligomeric protein interference validates druggability of aspartate interconversion in Plasmodium falciparum. MICROBIOLOGYOPEN, v. 8, n. 7, . Web of Science Citations: 0. (16/24790-9, 17/03966-4, 15/26722-8, 13/17577-9, 14/23330-9)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

KRONENBERGER, Thales. Implicações estruturais de mutantes da piridoxal quinase de Plasmodium falciparum. 2014. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (11/13706-3)

ZIMBRES, Flávia Menezes. Identificação e interferência de proteínas integradas na superfície do eritrócito infectado por Plasmoidum falciparum.. 2016. Tese (Doutorado) – Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (11/19703-6)

MEISSNER, Kamila Anna. Análise do estado redox e seu efeito sobre a proliferação de Plasmodium falciparum em eritrócitos geneticamente diferentes.. 2017. Tese (Doutorado) – Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (12/12807-3)

LINDNER, Jasmin. Análise do catabolismo da hemoglobina de Plasmodium falciparum.. 2017. Tese (Doutorado) – Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (12/12790-3)

KRONENBERGER, Thales. Sítios de interação alternativos em receptores nucleares e sua viabilidade como alvos terapêuticos usando triagem computacional e experimental.. 2017. Tese (Doutorado) – Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (14/03644-9)

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