Cláudio Romero Farias Marinho
CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Bacharelado Em Ciências Biológicas from Universidade de São Paulo (1994), graduate at Licenciatura Plena Em Ciências Biológicas from Universidade de São Paulo (1996), graduate at Licenciatura Em Ciências do Primeiro Grau from Universidade de São Paulo (1996), master's at Immunology from Universidade de São Paulo (1998) and ph.d. at Immunology from Universidade de São Paulo (2003). Has experience in Immunology, acting on the following subjects: trypanosoma cruzi, chagas disease, doença de chagas, clone sylvio x10/4 and malária. (Source: Lattes Curriculum)
- Recrudescence of the malaria during pregnancy: effects and mechanisms, AP.R
Abstract
It is estimated that approximately 125 million women in endemic plasmodium countries get pregnant every year and, therefore, face an increased risk of acquiring malaria followed by its complications. Frequently is observed a recrudescence of the infection during pregnancy, suggesting a complex pathogenic mechanism linked to an imbalance of the immune response responsible for infection c...
- A novel approach to identify the specific antibody characteristics important for protection from malaria in pregnant women, AP.R
Abstract
Over 100 million pregnant women are at risk of malaria each year. Effects include maternal anemia, miscarriage and low birth weight, and central to their pathogenesis is the placental sequestration of Plasmodium falciparum- infected erythrocytes (IE), termed placental malaria, and mediated by a parasite protein called VAR2CSA. First-time mothers are at greatest risk, as they lack antibo...
- Characterization of autophagic activity and inflammasome in placental malaria, AP.R
Abstract
Malaria in pregnancy is a major public health problem in countries where the disease is endemic, causing maternal and infant morbidity and mortality. It remains unclear why pregnant women are more susceptible to malaria. However, it is known that the placenta provides a favorable environment to the development of certain parasite subpopulations, triggering an intense inflammatory infilt...
- The role of inflammasomes in the pathogenesis of malaria during pregnancy: effects and mechanisms, AV.EXT
Abstract
Malaria is a serious parasitic disease that affects about 500 million people annually. In endemic regions, malaria in pregnancy (MiP) is a major cause of maternal and infant mortality. The severity of the disease may be explained by the fact that placenta is an appropriated environment to the development of subpopulations of parasites, and by the immune profile developed by pregnant wom...
- The role of inflammasomes in the pathogenesis of malaria during pregnancy: effects and mechanisms, AP.R
Abstract
Malaria is a serious parasitic disease that affects about 500 million people annually. In endemic regions, malaria in pregnancy (MiP) is a major cause of maternal and infant mortality. The severity of the disease may be explained by the fact that placenta is an appropriated environment to the development of subpopulations of parasites, and by the immune profile developed by pregnant wom...
(Only some records are available in English at this moment)
- Impact of autophagy and inflammasome on the pathogenesis of Placental Malaria, BP.DR
Abstract
Malaria is a severe public health problem around the world, especially in developing countries where it is responsible for approximately 500 000 deaths every year. Pregnant women are more prone to develop severe infection than non-pregnant counterparts due to the existence are of the placenta. Erythrocytes infected with Plasmodium spp. accumulate inside this organ leading to the develop...
- Autophagy in placental malaria: effects and mechanisms, BP.PD
Abstract
Malaria in pregnancy is a major public health problem in countries where the disease is endemic, causing maternal and infant morbidity and mortality. It remains unclear why pregnant women are more susceptible to malaria. However, it is known that the placenta provides a favorable environment to the development of certain parasite subpopulations, triggering an intense inflammatory infilt...
- Characterization of the role of dendritic cells in the recrudescence of malaria in pregnancy, BP.DD
Abstract
Each year at least 50 million pregnant women are exposed to Plasmodium. Malaria during pregnancy (MiP, the English "Malaria in Pregnancy") is characterized by the sequestration of parasites in the placenta, and consequent maternal anemia, intrauterine growth retardation and decreased fetal viability. Frequently is observed a recrudescence of the infection during pregnancy, suggesting a ...
- Role of the adaptor protein MyD88 on the placental malaria, BP.IC
Abstract
Each year at least 50 million pregnant women are exposed to malaria and this represents a high risk of death for the mother and growing fetus. The placental malaria (PM) is characterized by sequestration of parasites in the placenta, and consequent maternal anemia, intrauterine growth retardation and decreased fetal viability. The large number of factors that are potentially involved in...
(Only some records are available in English at this moment)
- Plasmodium vivax genomic analysis: identification of relapses and association with pregnancy adverse outcome in women From the Brazilian Amazon, BE.EP.DD
Abstract
Malaria in pregnancy is a serious public health problem and is characterized by the presence of Plasmodium spp. in the peripheral blood or the placenta, impacting on maternal and foetal health. Although P. vivax burden in pregnancy is less described than P. falciparum, recent studies indicate that both species represent a threaten to mother and foetus. Nevertheless, several hypotheses h...
| 2 / 2 | Ongoing research grants |
| 4 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 9 / 9 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 17 / 17 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 21 |
| Citations | 188 |
| Cit./Article | 9.0 |
| Data from Web of Science | |
ATAIDE, RICARDO; MURILLO, OSCAR; DOMBROWSKI, JAMILLE G.; SOUZA, RODRIGO M.; LIMA, FLAVIA A.; LIMA, GISELLE F. M. C.; HRISTOV, ANGELICA D.; VALLE, SUIANE C. N.; DI SANTI, SILVIA M.; EPIPHANIO, SABRINA; et al. Malaria in Pregnancy Interacts with and Alters the Angiogenic Profiles of the Placenta. PLoS Neglected Tropical Diseases, v. 9, n. 6, JUN 2015. Web of Science Citations: 10. (09/53889-0, 11/20921-8, 09/53256-7, 12/04755-3)
PEREIRA, MARCELO L. M.; ORTOLAN, LUANA S.; SERCUNDES, MICHELLE K.; DEBONE, DANIELA; MURILLO, OSCAR; LIMA, FLAVIA A.; MARINHO, CLAUDIO R. F.; EPIPHANIO, SABRINA. Association of Heme Oxygenase 1 with Lung Protection in Malaria-Associated ALI/ARDS. Mediators of Inflammation, 2016. Web of Science Citations: 1. (14/09964-5, 12/10081-5, 09/53256-7, 14/20451-0)
DOMBROWSKI, JAMILLE G.; SOUZA, RODRIGO M.; CURRY, JONATHAN; HINTON, LAURA; SILVA, NATERCIA R. M.; GRIGNARD, LYNN; GONCALVES, LIGIA A.; GOMES, ANA RITA; EPIPHANIO, SABRINA; DRAKELEY, CHRIS; et al. G6PD deficiency alleles in a malaria-endemic region in the Western Brazilian Amazon. Malaria Journal, v. 16, JUN 15 2017. Web of Science Citations: 5. (14/09964-5, 12/04755-3, 15/06106-0, 16/13465-0, 14/20451-0)
SERCUNDES, MICHELLE K.; ORTOLAN, LUANA S.; DEBONE, DANIELA; SOEIRO-PEREIRA, PAULO V.; GOMES, ELIANE; AITKEN, ELIZABETH H.; NETO, ANTONIO CONDINO; RUSSO, MOMTCHILO; D' IMPERIO LIMA, MARIA R.; ALVAREZ, JOSE M.; et al. Targeting Neutrophils to Prevent Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome in Mice. PLOS PATHOGENS, v. 12, n. 12, DEC 2016. Web of Science Citations: 23. (09/53889-0, 09/53256-7, 13/20718-3, 10/11925-7, 11/19525-0, 10/19439-4)
BARBOZA, RENATO; REIS, ARAMYS SILVA; DA SILVA, LEANDRO GUSTAVO; HASENKAMP, LUTERO; BENEVIDES PEREIRA, KEITTY RAQUEL; SARAIVA CAMARA, NIELS OLSEN; MARANHAO COSTA, FABIO TRINDADE; D'IMPERIO LIMA, MARIA REGINA; ALVAREZ, JOSE MARIA; BOSCARDIN, SILVIA BEATRIZ; et al. MyD88 Signaling Is Directly Involved in the Development of Murine Placental Malaria. Infection and Immunity, v. 82, n. 2, p. 830-838, FEB 2014. Web of Science Citations: 8. (09/53889-0, 09/53256-7, 11/17880-8, 12/02270-2)
ORTOLAN, LUANA S.; SERCUNDES, MICHELLE K.; BARBOZA, RENATO; DEBONE, DANIELA; MURILLO, OSCAR; HAGEN, STEFANO C. F.; RUSSO, MOMTCHILO; D' IMPERIO LIMA, MARIA REGINA; ALVAREZ, JOSE M.; AMAKU, MARCOS; et al. Predictive Criteria to Study the Pathogenesis of Malaria-Associated ALI/ARDS in Mice. Mediators of Inflammation, 2014. Web of Science Citations: 4. (09/53889-0, 09/53256-7)
MEDEIROS, MARCIA M.; DA SILVA, HENRIQUE B.; REIS, ARAMYS S.; BARBOZA, RENATO; THOMPSON, JOANNE; D'IMPERIO LIMA, MARIA REGINA; MARINHO, CLAUDIO R. F.; TADOKORO, CARLOS E.. Liver Accumulation of Plasmodium chabaudi-Infected Red Blood Cells and Modulation of Regulatory T Cell and Dendritic Cell Responses. PLoS One, v. 8, n. 11, NOV 27 2013. Web of Science Citations: 11. (09/53889-0)
RIBEIRO, BRUNO DE PAULO; CASSIANO, GUSTAVO CAPATTI; DE SOUZA, RODRIGO MEDEIROS; CYSNE, DALILA NUNES; GRIGOLIN GRISOTTO, MARCOS AUGUSTO; SILVA DE AZEVEDO DOS SANTOS, ANA PAULA; FARIAS MARINHO, CLAUDIO ROMERO; DANTAS MACHADO, RICARDO LUIZ; FERNANDES NASCIMENTO, FLAVIA RAQUEL. Polymorphisms in Plasmodium vivax Circumsporozoite Protein (CSP) Influence Parasite Burden and Cytokine Balance in a Pre-Amazon Endemic Area from Brazil. PLoS Neglected Tropical Diseases, v. 10, n. 3, MAR 2016. Web of Science Citations: 6. (09/53889-0)
SOUZA, RODRIGO M.; ATAIDE, RICARDO; DOMBROWSKI, JAMILLE G.; IPPOLITO, VANESSA; AITKEN, ELIZABETH H.; VALLE, SUIANE N.; ALVAREZ, JOSE M.; EPIPHANIO, SABRINA; MARINHO, CLAUDIO R. F.. Placental Histopathological Changes Associated with Plasmodium vivax Infection during Pregnancy. PLoS Neglected Tropical Diseases, v. 7, n. 2, FEB 2013. Web of Science Citations: 33. (11/20921-8, 09/53256-7, 11/19525-0)
BARBOZA, RENATO; SARAIVA CAMARA, NIELS OLSEN; GOMES, ELIANE; SA-NUNES, ANDERSON; FLORSHEIM, ESTHER; MIROTTI, LUCIANA; LABRADA, ALEXIS; ALCANTARA-NEVES, NEUZA MARIA; RUSSO, MOMTCHILO. Endotoxin Exposure during Sensitization to Blomia tropicalis Allergens Shifts TH2 Immunity Towards a TH17-Mediated Airway Neutrophilic Inflammation: Role of TLR4 and TLR2. PLoS One, v. 8, n. 6, JUN 21 2013. Web of Science Citations: 22. (11/17880-8)
COSTA, FABIO T. M.; LOPES, STEFANIE C. P.; ALBRECHT, LETUSA; ATAIDE, RICARDO; SIQUEIRA, ANDRE M.; SOUZA, RODRIGO M.; RUSSELL, BRUCE; RENIA, LAURENT; MARINHO, CLAUDIO R. F.; LACERDA, MARCUS V. G.. On the pathogenesis of Plasmodium vivax malaria: Perspectives from the Brazilian field. International Journal for Parasitology, v. 42, n. 12, SI, p. 1099-1105, NOV 2012. Web of Science Citations: 30. (09/53889-0)
AITKEN, ELIZABETH H.; NEGRI, ELNARA M.; BARBOZA, RENATO; LIMA, MARIA RI; ALVAREZ, JOSE M.; MARINHO, CLAUDIO R. F.; CALDINI, ELIA G.; EPIPHANIO, SABRINA. Ultrastructure of the lung in a murine model of malaria-associated acute lung injury/acute respiratory distress syndrome. Malaria Journal, v. 13, JUN 13 2014. Web of Science Citations: 10. (09/53889-0, 09/53256-7)
LIMA, FLAVIA A.; GOMEZ-CONDE, IVAN; VIDEIRA, PAULA A.; MARINHO, CLAUDIO R. F.; OLIVIERI, DAVID N.; TADOKORO, CARLOS E.. Intravital microscopy technique to study parasite dynamics in the labyrinth layer of the mouse placenta. Parasitology International, v. 63, n. 1, p. 254-259, FEB 2014. Web of Science Citations: 5. (09/53889-0)
DOMBROWSKI, JAMILLE GREGORIO; DE SOUZA, RODRIGO MEDEIROS; MENDES SILVA, NATERCIA REGINA; BARATEIRO, ANDRE; EPIPHANIO, SABRINA; GONCALVES, LIGIA ANTUNES; FARIAS MARINHO, CLAUDIO ROMERO. Malaria during pregnancy and newborn outcome in an unstable transmission area in Brazil: A population-based record linkage study. PLoS One, v. 13, n. 6, JUN 21 2018. Web of Science Citations: 1. (09/53889-0, 14/09964-5, 14/20451-0, 17/03939-7, 12/04755-3, 15/06106-0)
BARBOZA, RENATO; HASENKAMP, LUTERO; BARATEIRO, ANDRE; MURILLO, OSCAR; MACHADO PEIXOTO, ERIKA PAULA; LIMA, FLAVIA AFONSO; REIS, ARAMYS SILVA; GONCALVES, LIGIA ANTUNES; EPIPHANIO, SABRINA; MARINHO, CLAUDIO R. F.. Fetal-Derived MyD88 Signaling Contributes to Poor Pregnancy Outcomes During Gestational Malaria. FRONTIERS IN MICROBIOLOGY, v. 10, JAN 29 2019. Web of Science Citations: 1. (09/53889-0, 09/53256-7, 12/14715-9, 15/10892-1, 11/19048-8, 13/16417-8, 16/07030-0, 17/03939-7, 11/17880-8, 15/06106-0)
BASTOS, MARCELE F.; KAYANO, ANA CAROLINA A. V.; SILVA-FILHO, JOAO LUIZ; DOS-SANTOS, JOAO CONRADO K.; JUDICE, CARLA; BLANCO, YARA C.; SHRYOCK, NATHANIEL; SERCUNDES, MICHELLE K.; ORTOLAN, LUANA S.; FRANCELIN, CAROLINA; et al. Inhibition of hypoxia-associated response and kynurenine production in response to hyperbaric oxygen as mechanisms involved in protection against experimental cerebral malaria. FASEB JOURNAL, v. 32, n. 8, p. 4470-4481, AUG 2018. Web of Science Citations: 1. (16/07030-0, 14/20451-0, 12/16525-2, 16/12855-9)
CAMPOS, MONICA C.; DOMBROWSKI, JAMILLE G.; PHELAN, JODY; MARINHO, CLAUDIO R. F.; HIBBERD, MARTIN; CLARK, TAANE G.; CAMPINO, SUSANA. Zika might not be acting alone: Using an ecological study approach to investigate potential co-acting risk factors for an unusual pattern of microcephaly in Brazil. PLoS One, v. 13, n. 8, AUG 15 2018. Web of Science Citations: 6. (16/07030-0, 12/04755-3)
DOMBROWSKI, JAMILLE GREGORIO; DE SOUZA, RODRIGO MEDEIROS; LIMA, FLAVIA AFONSO; BANDEIRA, CARLA LETICIA; MURILLO, OSCAR; COSTA, DOUGLAS DE SOUSA; MACHADO PEIXOTO, ERIKA PAULA; CUNHA, MARIELTON DOS PASSOS; DE ANDRADE ZANOTTO, PAOLO MARINHO; BEVILACQUA, ESTELA; et al. Association of Malaria Infection During Pregnancy With Head Circumference of Newborns in the Brazilian Amazon. JAMA NETWORK OPEN, v. 2, n. 5, MAY 2019. Web of Science Citations: 0. (09/53889-0, 14/09964-5, 14/20451-0, 14/17766-9, 13/21728-2, 16/08204-2, 13/16417-8, 12/04755-3, 15/06106-0, 13/00981-1, 18/20468-0)
BARATEIRO, ANDRE; PEREIRA, MARCELO L. M.; EPIPHANIO, SABRINA; MARINHO, CLAUDIO R. F.. Contribution of Murine Models to the Study of Malaria During Pregnancy. FRONTIERS IN MICROBIOLOGY, v. 10, JUN 19 2019. Web of Science Citations: 0. (17/05782-8, 17/03939-7, 12/10081-5, 18/20468-0)
BARBOZA, RENATO; LIMA, FLAVIA AFONSO; REIS, ARAMYS SILVA; MURILLO, OSCAR JAVIER; MACHADO PEIXOTO, ERIKA PAULA; BANDEIRA, CARLA LETICIA; FOTORAN, WESLEY LUZETTI; SARDINHA, LUIS ROBERTO; WUNDERLICH, GERHARD; BEVILACQUA, ESTELA; et al. TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria. SCIENTIFIC REPORTS, v. 7, AUG 17 2017. Web of Science Citations: 9. (09/53889-0, 14/09964-5, 14/20451-0, 11/19048-8, 13/16417-8, 12/16525-2, 13/00981-1, 11/17880-8, 15/06106-0)
PEREIRA, MARCELO L. M.; MARINHO, CLAUDIO R. F.; EPIPHANIO, SABRINA. Could Heme Oxygenase-1 Be a New Target for Therapeutic Intervention in Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome?. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 8, MAY 16 2018. Web of Science Citations: 2. (16/07030-0, 12/10081-5, 14/20451-0)