graduation at Farmácia Bioquímica from Universidade Estadual Paulista Júlio de Mesquita Filho (2001), master's at Biochemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (2003) and doctorate at Pharmacy from Universidade de São Paulo (2007). Has experience in Biochemistry, focusing on Molecular Biology (Source: Lattes Curriculum)
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The cell wall is essential for fungal cell survival, exerting protection against osmotic damage. In addition, it is also a component of the mammalian host immune system recognition during the infection caused by fungal pathogens. Understanding the mechanisms whereby fungal cell builds and remodels the cell wall under stress conditions is relevant given the high morbidity and mortality rat…
Invasive Pulmonary Aspergillosis (IPA), mainly caused by Aspergillus fumigatus, is a major infectious complication with mortality rates as high as 90% depending on the immunological status of the host. Azoles are fungicidal drugs for A. fumigatus and the main antifungal agents recommended for IPA. Echinocandins, such as caspofungin (CSP), represent a second line therapy and target the fun…
The cell wall is essential for the survival of the fungal cell and is also a protective element against environmental stresses preventing osmotic damage to the cell. The underlying mechanisms whereby the fungal cells build and remodel the cell wall under stressing conditions are of great relevance considering the high mortality rates caused by the human opportunistic fungal pathogen Asper…
MAP kinases and phosphatases are the main signaling pathways of tolerance to different kinds of stresses in eukaryotes. The multifactorial nature of A. fumigatus virulence and pathogenicity program in the mammalian host places the response to different kinds of stresses as one of the most important responses in the process of establishment of this organism as a pathogen. These signaling p…
Aspergillus fumigatus is a saprophytic fungus and also an aggressive opportunistic pathogen responsible for the vast majority of cases of invasive pulmonary aspergillosis, the life threatening form of infection caused by this fungus. The relative resistance of fungi to mammals is attributed to a combination of the immune system activity and endothermy. The higher temperature of the blood …
(Only some records are available in English at this moment)
Invasive Pulmonary Aspergillosis (IPA), mainly caused by the saprophyte Aspergillus fumigatus, is a clinical condition associated with high mortality rates depending on the immunological status of the host. Caspofungin (CSP), yet the second choice of therapy, is an important echinocandin for the treatment of IPA, targeting the fungal cell wall, promoting growth inhibition but favoring an …
MAP kinases and phosphatases are the main signaling pathways of tolerance to different kinds of stresses in eukaryotes. The multifactorial nature of A. fumigatus virulence and pathogenicity program in the mammalian host places the response to different kinds of stresses as one of the most important responses in the process of establishment of this organism as a pathogen. These signaling p…
(Only some records are available in English at this moment)
Invasive pulmonary aspergillosis (IPA) is the life-threatening form of infection caused by the filamentous fungus Aspergillus fumigatus which affects immunocompromised individuals. The cell wall is essential for the survival of the fungal cell and is a protective barrier against environmental stresses including osmotic damage to the cell. Understanding the mechanisms whereby the fungal ce…
Aspergillus fumigatus is a major opportunistic pathogen of mammals and the main causative pathogen of invasive pulmonary aspergillosis (IPA) in immunocompromised individuals. Thermotolerance is one of the key virulence determinants of this fungus, being a prerequisite for the establishment of infection and persistence of the pathogen inside the host. The data obtained so far in our labora…
| 2 / 2 | Ongoing research grants |
| 7 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 15 / 9 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 28 / 19 | All research grants and scholarships |
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CV Lattes
ORCID