Graduated in Physical Education by the Universidade of Ribeirão Preto (1998) Obtained Ph.D. at Physiology Department from University of São Paulo (2004) under the mentorship of Dr Renato Migliorini (1999-2004). Worked as a Research Scholar at the lab of Dr Timothy Bartness in Atlanta GA, USA (2002-2003). Received Post-doctoral training at the Quebec Institute of Cardiology and Pneumology, Quebec, Canada, under supervision of Dr Yves Deshaies (2005-2009). Worked as a Visiting Scientist at the laboratory of Dr David Sabatini at the Whitehead Institute For Biomedical Research associated to the MIT (Massachusetts Institute of Technology), Cambridge, USA (2009-2010). Currrently, work as Associated Professor at the Institute of Biomedical Sciences, University of São Paulo. Has experience in Human Physiology, focusing on neural, hormonal and molecular control of lipids, carbohydrates and protein metabolism and intracellular signaling via mTOR. (Source: Lattes Curriculum)
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We propose herein to investigate the role of peroxisomes as mediators of the beneficial and protective effects of n-3 long chain polyunsaturated fatty acids (omega 3 FA) against obesity and associated metabolic diseases. More specifically, we will investigate whether hepatocyte and adipocyte peroxisome deficiency (Pex5 deletion) affects the pro-energy expenditure, insulin sensitizing and …
Evidence gathered in the last decades suggests that lipotoxicity and inflammation, through still not completed defined molecular mechanisms, are the main factors connecting adipose tissue dysfunction to the development nonalcoholic fatty liver disease (NAFLD), a group of liver diseases that comprises from a simple hepatic steatosis (NAFL) to more severe steatohepatitis (NASH), cirrhosis a…
Evidence gathered in the last decades suggests that lipotoxicity and inflammation, through still not completed defined molecular mechanisms, are the main factors connecting adipose tissue dysfunction to the development nonalcoholic fatty liver disease (NAFLD), a group of liver diseases that comprises from a simple hepatic steatosis (NAFL) to more severe steatohepatitis (NASH), cirrhosis a…
Lipodystrophy comprises a group of diseases characterized by either a partial or a complete reduction in adipose mass that is associated with the development of several metabolic diseases such as insulin resistance, dyslipidemia, hypertension, hepatic steatosis and atherosclerosis, among others. In this proposal, we will investigate in 3 integrated research programs the molecular mechanis…
We propose herein to investigate the mechanisms by which n-3 fatty acids protect from obesity and associated metabolic diseases. More specifically, we will investigate in two integrated research programs the mechanisms underlying the pro-energy expenditure (Aim 1) and anti-inflammatory (Aim 2) actions of n-3 fatty acids. In Aim 1, the following processes will be investigated as possible u…
The exponential growth of obesity worldwide is increasing the prevalence of several chronic diseases commonly associated to excessive adiposity such as type 2 diabetes, hepatic steatosis and some types of cancer. Despite of its major impact worldwide, little is known about the mechanisms that link obesity to the development of its associated chronic diseases. Being obesity a condition cha…
(Only some records are available in English at this moment)
Obesity is a risk factor for several non-communicable chronic diseases such as type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). Intake of a high-fat, high caloric diet increases the storage of fatty acids as triacylglycerol in adipocytes promoting firstly hypertrophy, followed by hyperplasia and expansion of white adipose tissue mass. Several studies have observed that obesit…
Nonalcoholic fatty liver disease (NAFLD) is a group of diseases characterized by an excess of lipids in the liver, comprising from simple hepatic steatosis (NAFL) to an eventual progression to more serious diseases such as steatohepatitis (NASH) and hepatocellular carcinoma (HCC). The constitutive activation of PI3K-mTORC2-Akt-mTORC1 pathway induced by Pten deletion in hepatocytes promote…
NAFLD comprises a wide spectrum of liver diseases varying from a simple hepatic lipid accumulation denominated as steatosis (nonalcoholic fatty liver [NAFL]), to a much more serious form of chronic liver disease denominated as nonalcoholic steatohepatitis (NASH). NASH is characterized by liver inflammation, hepatocyte damage and fibrosis. The mechanisms involved in NAFLD include excessive…
(Only some records are available in English at this moment)
Preliminary results obtained at undergraduated scientific training suggest that constitutive mTORC1 activation induced by Tsc1 deletion in adipocytes increases adipose tissue BCAA oxidation and lipolysis. Considering these findings, in this master proposal, we will test the hypothesis that mTORC1 is a major regulator of adipose tissue BCAAmetabolismo and lipolysis in visceral, subcutaneou…
The exponential growth of obesity worldwide is increasing the prevalence of several chronic diseases commonly associated to excessive adiposity such as type 2 diabetes, hepatic steatosis and some types of cancer. Despite of its major impact worldwide, little is known about the mechanisms that link obesity to the development of its associated chronic diseases. Being obesity a condition cha…
Intake of a high fat diet rich in fish oil and omega 3 fatty acids (n-3 fatty acids) protects mice from body weight gain and Obesity by increasing energy expenditure in an UCP1-independent manner. We will investigate herein the involvement skeletal muscle, heart and liver peroxisomal and mitochondrial oxidative metabolism, as well as SERCA-mediated calcium cycling as mediators of the incr…
(Only some records are available in English at this moment)
The central regulators of autophagy are the serine/threonine kinases unc-51 like autophagy activating kinase 1/2 (ULK1 and ULK2) that participate in the onset of the autophagic cellular process. These kinases in addition to initiate the autophagic cascade, seem to have interesting secondary roles in energy metabolism to coordinate the cellular response to starvation, such as increasing gl…
The thiazolidinediones (TZDs) are anti-diabetic drugs whose use in treating type 2 diabetes is limited by adverse side effects. The goal of this proposal is a biochemical investigation into a mechanism that separates the positive metabolic effects of TZDs from their side effects. PPAR³, the molecular target of the TZDs, is a key regulator of systemic insulin sensitivity, adipogenesis, inf…
In this project, we will continue to collect human adipocyte samples and generate RNA-seq and histone modification ChIP-seq libraries to assess genome-wide transcriptional and epigenomic states. We have identified key cis-regulatory elements with altered activity in the IR state and have determined the candidate transcription factors (TFs) that bind them. We will validate the importance …
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing research grants |
| 7 / 5 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 24 / 21 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 46 / 41 | All research grants and scholarships |
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CV Lattes
ORCID