Bachelor in Physical Education from Universidade of Ribeirão Preto (1998). Ph.D. in Physiology by School of Medicine University of São Paulo (2004) under the mentorship of Dr Renato Migliorini (1999-2004). Research Scholar at the lab of Dr Timothy Bartness in Atlanta GA, USA (2002-2003). Post-doctoral training at the Quebec Institute of Cardiology and Pneumology, Quebec, Canada, under mentorship of Dr Yves Deshaies (2005-2009). Visiting Scientist at the laboratory of Dr David Sabatini at the Whitehead Institute For Biomedical Research associated to the MIT (Massachusetts Institute of Technology), Cambridge, USA (2009-2010). Currrently, works as a Associated Professor at the Institute of Biomedical Sciences, University of São Paulo and head of the Rodent Metabolic Phenotyping Center (RPMC). Investigate the regulation of lipid and glucose metabolism by nutrient sensors. (Source: Lattes Curriculum)
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Approximately 80-90% of primary HCC cases occur as a progression from steatohepatitis (NASH), namely, in livers displaying chronic inflammation. In this study, we will address how chronic liver inflammation modulates the microenvironment favoring immune evasion and NASH progression to HCC with a special focus on the role of liver resident Kupffer cells and recruited macrophages as major d…
The main goal of this proposal is to obtain funding to acquire equipment for the creation of a Multiuser Facility for Metabolic, Cardiovascular and Respiratory Phenotyping of rodents in different ambient temperatures and light-dark cycles. The funding will be destined for the acquisition of the Promethium Core (Sable Systems) and climate ambient chambers (4 chambers) coupled to a system o…
Evidence gathered in the last decades suggests that lipotoxicity and inflammation, through still not completed defined molecular mechanisms, are the main factors connecting adipose tissue dysfunction to the development nonalcoholic fatty liver disease (NAFLD), a group of liver diseases that comprises from a simple hepatic steatosis (NAFL) to more severe steatohepatitis (NASH), cirrhosis a…
(Only some records are available in English at this moment)
We propose herein to investigate the role of peroxisomes as mediators of the beneficial and protective effects of n-3 long chain polyunsaturated fatty acids (omega 3 FA) against obesity and associated metabolic diseases. More specifically, we will investigate whether hepatocyte and adipocyte peroxisome deficiency (Pex5 deletion) affects the pro-energy expenditure, insulin sensitizing and …
Lipodystrophy comprises a group of diseases characterized by either a partial or a complete reduction in adipose mass that is associated with the development of several metabolic diseases such as insulin resistance, dyslipidemia, hypertension, hepatic steatosis and atherosclerosis, among others. In this proposal, we will investigate in 3 integrated research programs the molecular mechanis…
We propose herein to investigate the mechanisms by which n-3 fatty acids protect from obesity and associated metabolic diseases. More specifically, we will investigate in two integrated research programs the mechanisms underlying the pro-energy expenditure (Aim 1) and anti-inflammatory (Aim 2) actions of n-3 fatty acids. In Aim 1, the following processes will be investigated as possible u…
(Only some records are available in English at this moment)
Evidence obtained in recent decades suggests that lipotoxicity and inflammation, through still undefined molecular mechanisms, are the main factors that link adipose tissue dysfunction to the development of non-alcoholic fatty liver disease (NAFLD), which comprises steatosis (NAFL), steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). Although mTORC1 and mTORC2, from both…
Approximately 80-90% of primary HCC cases occur as a progression from steatohepatitis (NASH), namely, in livers displaying chronic inflammation. In this study, we will address how chronic liver inflammation modulates the microenvironment favoring immune evasion and NASH progression to HCC with a special focus on the role of liver resident Kupffer cells and recruited macrophages as major d…
Lipodystrophy is defined as a heterogeneous group of diseases characterized by a partial or complete reduction in body fat mass. It is associated, by unknown mechanisms, with the development of various metabolic complications such as insulin resistance, dyslipidemia, hypertension, hepatic steatosis and atherosclerosis. Previous studies have shown that adiponectin and leptin administration…
(Only some records are available in English at this moment)
White adipose tissue major roles are to store excess of energy from diet as triacylglycerol and secrete hormones. Brown adipose tissue, on the other hand, expresses the uncopling protein 1 (UCP1) that when properly activated uncouples proton gradient at inner mitochondrial membrane releasing energy as heat. Fenofibrate is a ligand for the peroxisome proliferator activated receptor alpha …
Obesity is a risk factor for several non-communicable chronic diseases such as type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). Intake of a high-fat, high caloric diet increases the storage of fatty acids as triacylglycerol in adipocytes promoting firstly hypertrophy, followed by hyperplasia and expansion of white adipose tissue mass. Several studies have observed that obesit…
(Only some records are available in English at this moment)
Despite recent advances, the molecular mechanisms and signaling pathways that contribute to metabolic dysfunction-associated steatotic liver disease (MASLD) onset and progression are not completely understood. Several pieces of evidence indicate that elevated serum lipopolysaccharides (LPS) levels (endotoxemia) due to intestinal dysbiosis play a major role in MASLD development exacerbatin…
The activin receptor (ActR - type I and II) signaling pathways play critical roles in regulating a wide range of physiological and pathological activities across tissues. ActRII mediates the actions of ligands such activins, growth differentiation factors (GDFs), and bone morphogenetic proteins (BMPs) by activating downstream signaling cascades including canonical (Smads2,3,4) and non-can…
Signaling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway is increased in hepatocellular carcinoma (HCC), but paradoxically, genetic inhibition of mTORC1 via Raptor deletion in hepatocytes also promotes HCC development in conditions of liver lipid overload. We found during my postdoc (FAPESP Process 2020/16656-6) that HCC in hepatocyte mTORC1 deficient mice is in pa…
The central regulators of autophagy are the serine/threonine kinases unc-51 like autophagy activating kinase 1/2 (ULK1 and ULK2) that participate in the onset of the autophagic cellular process. These kinases in addition to initiate the autophagic cascade, seem to have interesting secondary roles in energy metabolism to coordinate the cellular response to starvation, such as increasing gl…
The thiazolidinediones (TZDs) are anti-diabetic drugs whose use in treating type 2 diabetes is limited by adverse side effects. The goal of this proposal is a biochemical investigation into a mechanism that separates the positive metabolic effects of TZDs from their side effects. PPAR³, the molecular target of the TZDs, is a key regulator of systemic insulin sensitivity, adipogenesis, inf…
In this project, we will continue to collect human adipocyte samples and generate RNA-seq and histone modification ChIP-seq libraries to assess genome-wide transcriptional and epigenomic states. We have identified key cis-regulatory elements with altered activity in the IR state and have determined the candidate transcription factors (TFs) that bind them. We will validate the importance …
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing research grants |
| 8 / 6 | Completed research grants |
| 9 / 9 | Ongoing scholarships in Brazil |
| 31 / 28 | Completed scholarships in Brazil |
| 3 / 3 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 62 / 57 | All research grants and scholarships |
| Associated processes | |
CV Lattes
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