William Tadeu Lara Festuccia
CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Physical Education by the Universidade of Ribeirão Preto (1998) Obtained Ph.D. at Physiology Department from University of São Paulo (2004) under the mentorship of Dr Renato Migliorini (1999-2004). Worked as a Research Scholar at the lab of Dr Timothy Bartness in Atlanta GA, USA (2002-2003). Received Post-doctoral training at the Quebec Institute of Cardiology and Pneumology, Quebec, Canada, under supervision of Dr Yves Deshaies (2005-2009). Worked as a Visiting Scientist at the laboratory of Dr David Sabatini at the Whitehead Institute For Biomedical Research associated to the MIT (Massachusetts Institute of Technology), Cambridge, USA (2009-2010). Currrently, work as Associated Professor at the Institute of Biomedical Sciences, University of São Paulo. Has experience in Human Physiology, focusing on neural, hormonal and molecular control of lipids, carbohydrates and protein metabolism and intracellular signaling via mTOR. (Source: Lattes Curriculum)
- Characterization of the molecular mechanisms determining the energy balance, glucose homeostasis and hepatomegaly in mice with severe lipodystrophy, AP.R
Abstract
Lipodystrophy comprises a group of diseases characterized by either a partial or a complete reduction in adipose mass that is associated with the development of several metabolic diseases such as insulin resistance, dyslipidemia, hypertension, hepatic steatosis and atherosclerosis, among others. In this proposal, we will investigate in 3 integrated research programs the molecular mechan...
- Mechanisms underlying the antiinflammatory and thermogenic effects of fish oil in obesity and associated metabolic diseases, AP.R SPRINT
Abstract
We propose herein to investigate the mechanisms by which n-3 fatty acids protect from obesity and associated metabolic diseases. More specifically, we will investigate in two integrated research programs the mechanisms underlying the pro-energy expenditure (Aim 1) and anti-inflammatory (Aim 2) actions of n-3 fatty acids. In Aim 1, the following processes will be investigated as possible...
- Involvement of the nutrient sensor mTOR in the development of obesity associated chronic metabolic diseases, AP.TEM
Abstract
The exponential growth of obesity worldwide is increasing the prevalence of several chronic diseases commonly associated to excessive adiposity such as type 2 diabetes, hepatic steatosis and some types of cancer. Despite of its major impact worldwide, little is known about the mechanisms that link obesity to the development of its associated chronic diseases. Being obesity a condition c...
- Polyphenol enriched fruit extracts as alternative therapy against adipocyte dysfunctions associated with obesity and metabolic disorders, AP.R
Abstract
Role of adipose tissue in the development of obesity and associated co-morbidities: investigation of molecular mechanism and search for alternative therapies. The exponential growth of obesity in the world is associated with a marked increase in the prevalence of several morbidities directly associated with excessive adiposity as Type 2 Diabetes (T2D), Metabolic Syndrome (MS), atheroscl...
- Role of adipose tissue in the development of obesity and associated co-morbidities: investigation of molecular mechanism and search for alternative therapies, AP.JP
Abstract
The exponential growth of obesity in the world is associated with a marked increase in the prevalence of several morbidities directly associated with excessive adiposity as Type 2 Diabetes (T2D), Metabolic Syndrome (MS), atherosclerosis, hypertension, stroke, hepatic steatosis and some types of cancer. The main goal of the current research proposal is to investigate the molecular mechan...
- Discovery of new transcription factors involved in the development of steatosis, steatopatite and hepatocarcinome, BP.PD
Abstract
The exponential growth of obesity worldwide is increasing the prevalence of several chronic diseases commonly associated to excessive adiposity such as type 2 diabetes, hepatic steatosis and some types of cancer. Despite of its major impact worldwide, little is known about the mechanisms that link obesity to the development of its associated chronic diseases. Being obesity a condition c...
- UCP1-independent mechanisms involved in the increased energy expenditure and protection against Obesity induced by fish oil in mice, BP.DR
Abstract
Intake of a high fat diet rich in fish oil and omega 3 fatty acids (n-3 fatty acids) protects mice from body weight gain and Obesity by increasing energy expenditure in an UCP1-independent manner. We will investigate herein the involvement skeletal muscle, heart and liver peroxisomal and mitochondrial oxidative metabolism, as well as SERCA-mediated calcium cycling as mediators of the in...
- Characterization of mTORC2 role in the hepatic steatosis, steatohepatitis and hepatocellular carcinoma progression induced by PTEN deletion in hepatocytes, BP.DR
Abstract
Visceral obesity is associated with the development of several chronic metabolic diseases such as non-alcoholic fatty liver disease (NAFLD), a group of progressive liver complications that comprises steatosis (NAFL), steatohepatitis (NASH), cirrhosis and hepatocarcinoma (HCC). Several studies indicate that lipogenesis, inflammation, oxidative stress and insulin resistance contribute sig...
(Only some records are available in English at this moment)
- Effects of obesity and severe lipodystrophy on oxidation and peroxidation of lipids: involvement of these molecules on inflammation and insulin resistance, BP.PD
Abstract
Several lines of evidence suggest that obesity and lipodystrophy share common properties related to the buffering capacity of adipose tissue (AT) to adequately store fat, leading to redistribution and deposition of lipids in skeletal muscle, liver and pancreas (Snel et al., 2012). Since those organs and tissues do not possess the proper enzymatic machinery for fat storage, the local acc...
- Training in the maintenance and genotyping of genetically modified mice, BP.TT
- Characterization of the molecular mechanisms by which TSC1 deletion in adipocytes increases oxidative metabolism and UCP1 content in white adipose tissue, BP.IC
Abstract
The exponential increase in obesity worldwide is an alarming problem as it increases the chances of developing other diseases associated with excessive adipose mass, such as Type II diabetes and insulin resistance. Currently in Brazil, about half of the population is overweight, progressing to a possible obesity. Therefore, a deeper understanding of the molecular mechanisms that determi...
(Only some records are available in English at this moment)
- ULK1/2 mediated autophagy: effects in hepatocyte energetic metabolism, BE.EP.DD
Abstract
The central regulators of autophagy are the serine/threonine kinases unc-51 like autophagy activating kinase 1/2 (ULK1 and ULK2) that participate in the onset of the autophagic cellular process. These kinases in addition to initiate the autophagic cascade, seem to have interesting secondary roles in energy metabolism to coordinate the cellular response to starvation, such as increasing ...
- ERK kinase regulation of insulin signaling and inflammation: honing the antidiabetic effects of PPARgamma activation, BE.EP.PD
Abstract
The thiazolidinediones (TZDs) are anti-diabetic drugs whose use in treating type 2 diabetes is limited by adverse side effects. The goal of this proposal is a biochemical investigation into a mechanism that separates the positive metabolic effects of TZDs from their side effects. PPAR³, the molecular target of the TZDs, is a key regulator of systemic insulin sensitivity, adipogenesis, i...
- Genomic and epigenomic analysis of insulin action, BE.EP.DR
Abstract
In this project, we will continue to collect human adipocyte samples and generate RNA-seq and histone modification ChIP-seq libraries to assess genome-wide transcriptional and epigenomic states. We have identified key cis-regulatory elements with altered activity in the IR state and have determined the candidate transcription factors (TFs) that bind them. We will validate the importanc...
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing research grants |
| 4 / 2 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 17 / 14 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 36 / 31 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 24 |
| Citations | 358 |
| Cit./Article | 14.9 |
| Data from Web of Science | |
DONADO-PESTANA, CARLOS M.; BELCHIOR, THIAGO; FESTUCCIA, WILLIAM T.; GENOVESE, MARIA INES. Phenolic compounds from cambuci (Campomanesia phaea O. Berg) fruit attenuate glucose intolerance and adipose tissue inflammation induced by a high-fat, high-sucrose diet. Food Research International, v. 69, p. 170-178, MAR 2015. Web of Science Citations: 9. (13/50394-5, 13/19797-6)
YAMASHITA, ALEX S.; BELCHIOR, THIAGO; LIRA, FABIO S.; BISHOP, NICOLETTE C.; WESSNER, BARBARA; ROSA, JOSE C.; FESTUCCIA, WILLIAM T.. Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors. Mediators of Inflammation, 2018. Web of Science Citations: 7. (13/15825-5, 15/22983-1, 15/19530-5)
OLIVEIRA, TIAGO E.; CASTRO, ERIQUE; BELCHIOR, THIAGO; ANDRADE, MAYNARA L.; CHAVES-FILHO, ADRIANO B.; PEIXOTO, ALBERT S.; MORENO, MAYARA F.; ORTIZ-SILVA, MILENE; MOREIRA, RAFAEL J.; INAGUE, ALEX; et al. Fish Oil Protects Wild Type and Uncoupling Protein 1-Deficient Mice from Obesity and Glucose Intolerance by Increasing Energy Expenditure. MOLECULAR NUTRITION & FOOD RESEARCH, v. 63, n. 7, APR 2019. Web of Science Citations: 4. (17/23040-9, 15/13508-8, 16/07062-0, 15/22983-1, 15/19530-5, 17/17582-3, 18/11156-5, 16/23169-9, 17/12260-8)
PAHLAVANI, MANDANA; RAMALINGAM, LATHA; MILLER, EMILY K.; SCOGGIN, SHANE; MENIKDIWELA, KALHARA R.; KALUPAHANA, NISHAN S.; FESTUCCIA, WILLIAM T.; MOUSTAID-MOUSSA, NAIMA. Eicosapentaenoic Acid Reduces Adiposity, Glucose Intolerance and Increases Oxygen Consumption Independently of Uncoupling Protein 1. MOLECULAR NUTRITION & FOOD RESEARCH, v. 63, n. 7, APR 2019. Web of Science Citations: 3. (15/19530-5)
MOREIRA, RAFAEL J.; CASTRO, ERIQUE; OLIVEIRA, TIAGO E.; BELCHIOR, THIAGO; PEIXOTO, ALBERT S.; CHAVES-FILHO, ADRIANO B.; MORENO, MAYARA F.; LIMA, JANAYNA D.; YOSHINAGA, MARCOS; MIYAMOTO, SAYURI; et al. Lipoatrophy-Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids. MOLECULAR NUTRITION & FOOD RESEARCH, v. 64, n. 7, FEB 2020. Web of Science Citations: 0. (13/07937-8, 17/17943-6, 14/06863-3, 15/19530-5, 16/04000-3, 18/15549-1, 13/07467-1)
LAPLANTE‚ M.; HORVAT‚ S.; FESTUCCIA‚ W.T.; BIRSOY‚ K.; PREVORSEK‚ Z.; EFEYAN‚ A.; SABATINI‚ D.M.. DEPTOR Cell-Autonomously Promotes Adipogenesis, and Its Expression Is Associated with Obesity. Cell Metabolism, v. 16, n. 2, p. 202-212, 2012. Web of Science Citations: 62. (09/15354-7, 10/10909-8)
LABBE, SEBASTIEN M.; MOUCHIROUD, MATHILDE; CARON, ALEXANDRE; SECCO, BLANDINE; FREINKMAN, ELIZAVETA; LAMOUREUX, GUILLAUME; GELINAS, YVES; LECOMTE, ROGER; BOSSE, YOHAN; CHIMIN, PATRICIA; et al. mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold. SCIENTIFIC REPORTS, v. 6, NOV 23 2016. Web of Science Citations: 11. (15/19530-5)
CHIMIN, PATRICIA; ANDRADE, MAYNARA L.; BELCHIOR, THIAGO; PASCHOAL, VIVIAN A.; MAGDALON, JULIANA; YAMASHITA, ALEX S.; CASTRO, ERIQUE; CASTOLDI, ANGELA; CHAVES-FILHO, ADRIANO B.; YOSHINAGA, MARCOS Y.; et al. Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis. Journal of Lipid Research, v. 58, n. 9, p. 1797-1807, SEP 2017. Web of Science Citations: 11. (12/02270-2, 15/13508-8, 12/25317-4, 15/19530-5, 09/15354-7)
BLANCHARD, PIERRE-GILLES; MOREIRA, RAFAEL J.; CASTRO, ERIQUE; CARON, ALEXANDRE; COTE, MARIE; ANDRADE, MAYNARA L.; OLIVEIRA, TIAGO E.; ORTIZ-SILVA, MILENE; PEIXOTO, ALBERT S.; DIAS, FRANCE ANNE; et al. PPAR gamma is a major regulator of branched-chain amino acid blood levels and catabolism in white and brown adipose tissues. METABOLISM-CLINICAL AND EXPERIMENTAL, v. 89, p. 27-38, DEC 2018. Web of Science Citations: 5. (15/13508-8, 16/07062-0, 15/19530-5, 16/23169-9, 17/12260-8)
BIRSOY, KIVANC; FESTUCCIA, WILLIAM T.; LAPLANTE, MATHIEU. A comparative perspective on lipid storage in animals. Journal of Cell Science, v. 126, n. 7, p. 1541-1552, APR 1 2013. Web of Science Citations: 36. (09/15354-7)
PASCHOAL, VIVIAN A.; AMANO, MARIANE T.; BELCHIOR, THIAGO; MAGDALON, JULIANA; CHIMIN, PATRICIA; ANDRADE, MAYNARA L.; ORTIZ-SILVA, MILENE; CASTRO, ERIQUE; YAMASHITA, ALEX S.; ROSA NETO, JOSE CESAR; et al. mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function. Immunobiology, v. 222, n. 2, p. 261-271, FEB 2017. Web of Science Citations: 18. (11/10783-7, 09/15354-7, 12/02270-2, 15/19530-5)
CASTRO, ERIQUE; SILVA, TIAGO E. OLIVEIRA; FESTUCCIA, WILLIAM T.. Critical review of beige adipocyte thermogenic activation and contribution to whole-body energy expenditure. HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION, v. 31, n. 2, SI, AUG 2017. Web of Science Citations: 7. (16/07062-0, 15/19530-5, 16/23169-9)
PASCHOAL, VIVIAN A.; BELCHIOR, THIAGO; AMANO, MARIANE T.; BURGOS-SILVA, MARINA; PEIXOTO, ALBERT S.; MAGDALON, JULIANA; VIEIRA, THAYNA S.; ANDRADE, MAYNARA L.; MORENO, MAYARA F.; CHIMIN, PATRICIA; et al. Constitutive Activation of the Nutrient Sensor mTORC1 in Myeloid Cells Induced by Tsc1 Deletion Protects Mice from Diet-Induced Obesity. MOLECULAR NUTRITION & FOOD RESEARCH, v. 62, n. 17, SEP 2018. Web of Science Citations: 2. (11/10783-7, 09/15354-7, 12/02270-2, 15/19530-5)
LAPLANTE‚ M.; HORVAT‚ S.; FESTUCCIA‚ W.T.; BIRSOY‚ K.; PREVORSEK‚ Z.; EFEYAN‚ A.; SABATINI‚ D.M.. DEPTOR Cell-Autonomously Promotes Adipogenesis, and Its Expression Is Associated with Obesity. Cell Metabolism, v. 16, n. 2, p. 202-212, 2012. Web of Science Citations: 62. (09/15354-7, 10/10909-8)
LABBE, SEBASTIEN M.; MOUCHIROUD, MATHILDE; CARON, ALEXANDRE; SECCO, BLANDINE; FREINKMAN, ELIZAVETA; LAMOUREUX, GUILLAUME; GELINAS, YVES; LECOMTE, ROGER; BOSSE, YOHAN; CHIMIN, PATRICIA; et al. mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold. SCIENTIFIC REPORTS, v. 6, NOV 23 2016. Web of Science Citations: 11. (15/19530-5)
CHIMIN, PATRICIA; ANDRADE, MAYNARA L.; BELCHIOR, THIAGO; PASCHOAL, VIVIAN A.; MAGDALON, JULIANA; YAMASHITA, ALEX S.; CASTRO, ERIQUE; CASTOLDI, ANGELA; CHAVES-FILHO, ADRIANO B.; YOSHINAGA, MARCOS Y.; et al. Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis. Journal of Lipid Research, v. 58, n. 9, p. 1797-1807, SEP 2017. Web of Science Citations: 11. (12/02270-2, 15/13508-8, 12/25317-4, 15/19530-5, 09/15354-7)
YAMASHITA, ALEX S.; BELCHIOR, THIAGO; LIRA, FABIO S.; BISHOP, NICOLETTE C.; WESSNER, BARBARA; ROSA, JOSE C.; FESTUCCIA, WILLIAM T.. Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors. Mediators of Inflammation, 2018. Web of Science Citations: 7. (13/15825-5, 15/22983-1, 15/19530-5)
DONADO-PESTANA, CARLOS M.; BELCHIOR, THIAGO; FESTUCCIA, WILLIAM T.; GENOVESE, MARIA INES. Phenolic compounds from cambuci (Campomanesia phaea O. Berg) fruit attenuate glucose intolerance and adipose tissue inflammation induced by a high-fat, high-sucrose diet. Food Research International, v. 69, p. 170-178, MAR 2015. Web of Science Citations: 9. (13/50394-5, 13/19797-6)
BLANCHARD, PIERRE-GILLES; MOREIRA, RAFAEL J.; CASTRO, ERIQUE; CARON, ALEXANDRE; COTE, MARIE; ANDRADE, MAYNARA L.; OLIVEIRA, TIAGO E.; ORTIZ-SILVA, MILENE; PEIXOTO, ALBERT S.; DIAS, FRANCE ANNE; et al. PPAR gamma is a major regulator of branched-chain amino acid blood levels and catabolism in white and brown adipose tissues. METABOLISM-CLINICAL AND EXPERIMENTAL, v. 89, p. 27-38, DEC 2018. Web of Science Citations: 5. (15/13508-8, 16/07062-0, 15/19530-5, 16/23169-9, 17/12260-8)
MOREIRA, RAFAEL J.; CASTRO, ERIQUE; OLIVEIRA, TIAGO E.; BELCHIOR, THIAGO; PEIXOTO, ALBERT S.; CHAVES-FILHO, ADRIANO B.; MORENO, MAYARA F.; LIMA, JANAYNA D.; YOSHINAGA, MARCOS; MIYAMOTO, SAYURI; et al. Lipoatrophy-Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids. MOLECULAR NUTRITION & FOOD RESEARCH, v. 64, n. 7, FEB 2020. Web of Science Citations: 0. (13/07937-8, 17/17943-6, 14/06863-3, 15/19530-5, 16/04000-3, 18/15549-1, 13/07467-1)
CHIMIN, PATRICIA; ANDRADE, MAYNARA L.; BELCHIOR, THIAGO; PASCHOAL, VIVIAN A.; MAGDALON, JULIANA; YAMASHITA, ALEX S.; CASTRO, ERIQUE; CASTOLDI, ANGELA; CHAVES-FILHO, ADRIANO B.; YOSHINAGA, MARCOS Y.; et al. Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis. Journal of Lipid Research, v. 58, n. 9, p. 1797-1807, SEP 2017. Web of Science Citations: 11. (12/02270-2, 15/13508-8, 12/25317-4, 15/19530-5, 09/15354-7)
BLANCHARD, PIERRE-GILLES; MOREIRA, RAFAEL J.; CASTRO, ERIQUE; CARON, ALEXANDRE; COTE, MARIE; ANDRADE, MAYNARA L.; OLIVEIRA, TIAGO E.; ORTIZ-SILVA, MILENE; PEIXOTO, ALBERT S.; DIAS, FRANCE ANNE; et al. PPAR gamma is a major regulator of branched-chain amino acid blood levels and catabolism in white and brown adipose tissues. METABOLISM-CLINICAL AND EXPERIMENTAL, v. 89, p. 27-38, DEC 2018. Web of Science Citations: 5. (15/13508-8, 16/07062-0, 15/19530-5, 16/23169-9, 17/12260-8)
BIRSOY, KIVANC; FESTUCCIA, WILLIAM T.; LAPLANTE, MATHIEU. A comparative perspective on lipid storage in animals. Journal of Cell Science, v. 126, n. 7, p. 1541-1552, APR 1 2013. Web of Science Citations: 36. (09/15354-7)
DE CASTRO, GABRIELA S.; SIMOES, ESTEFANIA; LIMA, JOANNA D. C. C.; ORTIZ-SILVA, MILENE; FESTUCCIA, WILLIAM T.; TOKESHI, FLIVIO; ALCANTARA, PAULO S.; OTOCH, JOSE P.; COLETTI, DARIO; SEELAENDER, MARILIA. Human Cachexia Induces Changes in Mitochondria, Autophagy and Apoptosis in the Skeletal Muscle. CANCERS, v. 11, n. 9, SEP 2019. Web of Science Citations: 0. (16/02780-1, 12/50079-0, 16/13810-9, 16/12508-7, 17/12260-8)
(References retrieved automatically from State of São Paulo Research Institutions)
PASCHOAL, Vivian Almeida. mTOR complexo 1 atenua a resposta pró-inflamatória de macrófagos e inflamação do tecido adiposo associadas à obesidade.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (11/10783-7)
MAGDALON, Juliana. A ativação constitutiva de mTORC1 em adipócitos aumenta a capacidade oxidativa mitocondrial e reduz a adiposidade visceral em camundongos.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (11/03972-8)
SILVA, Tiago Eugênio Oliveira da. Ingestão de dieta hiperlipídica rica em óleo de peixe aumenta o gasto energético independentemente de UCP1.. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (16/07062-0)
OLIVEIRA, Thiago Belchior de. Envolvimento dos PPARγ nas ações metabólicas dos ácidos graxos ômega-3.. Tese (Doutorado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (11/14172-2)