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William Tadeu Lara Festuccia

CV Lattes ResearcherID ORCID


Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Graduated in Physical Education by the Universidade of Ribeirão Preto (1998) Obtained Ph.D. at Physiology Department from University of São Paulo (2004) under the mentorship of Dr Renato Migliorini (1999-2004). Worked as a Research Scholar at the lab of Dr Timothy Bartness in Atlanta GA, USA (2002-2003). Received Post-doctoral training at the Quebec Institute of Cardiology and Pneumology, Quebec, Canada, under supervision of Dr Yves Deshaies (2005-2009). Worked as a Visiting Scientist at the laboratory of Dr David Sabatini at the Whitehead Institute For Biomedical Research associated to the MIT (Massachusetts Institute of Technology), Cambridge, USA (2009-2010). Currrently, work as Associated Professor at the Institute of Biomedical Sciences, University of São Paulo. Has experience in Human Physiology, focusing on neural, hormonal and molecular control of lipids, carbohydrates and protein metabolism and intracellular signaling via mTOR. (Source: Lattes Curriculum)

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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (31)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BOLSONI-LOPES, ANDRESSA; FESTUCCIA, WILLIAM T.; FARIAS, TALITA S. M.; CHIMIN, PATRICIA; TORRES-LEAL, FRANCISCO L.; DEROGIS, PRISCILLA B. M.; DE ANDRADE, PAULA B.; MIYAMOTO, SAYURI; LIMA, FABIO B.; CURI, RUI; et al. Palmitoleic acid (n-7) increases white adipocyte lipolysis and lipase content in a PPAR alpha-dependent manner. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, v. 305, n. 9, p. E1093-E1102, . (10/10909-8, 11/51627-8, 09/15354-7)

FESTUCCIA, WILLIAM T.; BLANCHARD, PIERRE-GILLES; OLIVEIRA, THIAGO B.; MAGDALON, JULIANA; PASCHOAL, VIVIAN A.; RICHARD, DENIS; DESHAIES, YVES. PPAR gamma activation attenuates cold-induced upregulation of thyroid status and brown adipose tissue PGC-1 alpha and D2. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 303, n. 12, p. R1277-R1285, . (10/10909-8, 09/15354-7)

MAGDALON, JULIANA; CHIMIN, PATRICIA; BELCHIOR, THIAGO; NEVES, RODRIGO X.; VIEIRA-LARA, MARCEL A.; ANDRADE, MAYNARA L.; FARIAS, TALITA S.; BOLSONI-LOPES, ANDRESSA; PASCHOAL, VIVIAN A.; YAMASHITA, ALEX S.; et al. Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v. 1861, n. 5, p. 430-438, . (11/03972-8, 13/14203-0, 10/51906-1, 12/25317-4, 09/15354-7, 15/19530-5)

YAMASHITA, ALEX SHIMURA; ROSA, MARINA DA COSTA; BORODOVSKY, ALEXANDRA; FESTUCCIA, WILLIAM T.; CHAN, TIMOTHY; RIGGINS, GREGORY J.. Demethylation and epigenetic modification with 5-azacytidine reduces IDH1 mutant glioma growth in combination with temozolomide. NEURO-ONCOLOGY, v. 21, n. 2, p. 189-200, . (15/05828-2)

HALL, JESSICA A.; RAMACHANDRAN, DEEPTI; ROH, HYUN C.; DISPIRITO, JOANNA R.; BELCHIOR, THIAGO; ZUSHIN, PETER-JAMES H.; PALMER, COLIN; HONG, SHANGYU; MINA, I, AMIR; LIU, BINGYANG; et al. Obesity-Linked PPAR gamma S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3. Cell Metabolism, v. 32, n. 4, p. 665+, . (17/25881-0)

GUERRA, BEATRIZ A.; BRANDAO, BRUNA B.; PINTO, SILAS S.; SALGUEIRO, WILLIAN G.; DE-SOUZA, EVANDRO A.; REIS, FELIPE C. G.; BATISTA, THIAGO M.; CAVALCANTE-SILVA, VANESSA; D'ALMEIDA, VANIA; CASTILHO, BEATRIZ A.; et al. Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects. MOLECULAR METABOLISM, v. 29, p. 124-135, . (15/03292-8, 17/22057-5, 10/52557-0, 16/02207-0, 17/01184-9, 15/01316-7, 15/19530-5, 12/07259-7, 17/07975-8)

FESTUCCIA, WILLIAM T.. Regulation of Adipocyte and Macrophage Functions by mTORC1 and 2 in Metabolic Diseases. MOLECULAR NUTRITION & FOOD RESEARCH, v. 65, n. 1, SI, . (15/19530-5)

SOUZA, CAMILA O.; TEIXEIRA, ALEXANDRE A. S.; BIONDO, LUANA AMORIM; SILVEIRA, LOREANA SANCHES; DE SOUZA BREDA, CRISTIANE N.; BRAGA, TARCIO T.; CAMARA, NIELS O. S.; BELCHIOR, THIAGO; FESTUCCIA, WILLIAM T.; DINIZ, TIEGO A.; et al. Palmitoleic acid reduces high fat diet-induced liver inflammation by promoting PPAR-gamma-independent M2a polarization of myeloid cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v. 1865, n. 10, . (13/04765-1, 19/06172-4, 19/24112-9, 15/19530-5, 16/01409-8)

BELCHIOR, THIAGO; PASCHOAL, VIVIAN A.; MAGDALON, JULIANA; CHIMIN, PATRICIA; FARIAS, TALITA M.; CHAVES-FILHO, ADRIANO B.; GORJAO, RENATA; ST-PIERRE, PHILIPPE; MIYAMOTO, SAYURI; KANG, JING X.; et al. Omega-3 fatty acids protect from diet-induced obesity, glucose intolerance, and adipose tissue inflammation through PPAR gamma-dependent and PPAR gamma-independent actions. MOLECULAR NUTRITION & FOOD RESEARCH, v. 59, n. 5, p. 957-967, . (11/14172-2, 09/15354-7)

BLANCHARD, P. G.; TURCOTTE, V.; COTE, M.; GELINAS, Y.; NILSSON, S.; OLIVECRONA, G.; DESHAIES, Y.; FESTUCCIA, W. T.. Peroxisome proliferator-activated receptor activation favours selective subcutaneous lipid deposition by coordinately regulating lipoprotein lipase modulators, fatty acid transporters and lipogenic enzymes. ACTA PHYSIOLOGICA, v. 217, n. 3, p. 227-239, . (09/15354-7)

FESTUCCIA, WILLIAM T.; BLANCHARD, PIERRE-GILLES; BELCHIOR, THIAGO; CHIMIN, PATRICIA; PASCHOAL, VIVIAN A.; MAGDALON, JULIANA; HIRABARA, SANDRO M.; SIMOES, DANIEL; ST-PIERRE, PHILIPPE; CARPINELLI, ANGELO; et al. PPAR gamma activation attenuates glucose intolerance induced by mTOR inhibition with rapamycin in rats. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, v. 306, n. 9, p. E1046-E1054, . (09/15354-7)

BLANCHARD, PIERRE-GILLES; FESTUCCIA, WILLIAM T.; HOUDE, VANESSA P.; ST-PIERRE, PHILIPPE; BRULE, SOPHIE; TURCOTTE, VERONIQUE; COTE, MARIE; BELLMANN, KERSTIN; MARETTE, ANDRE; DESHAIES, YVES. Major involvement of mTOR in the PPAR gamma-induced stimulation of adipose tissue lipid uptake and fat accretion. Journal of Lipid Research, v. 53, n. 6, p. 1117-1125, . (10/10909-8, 09/15354-7)

PASCHOAL, VIVIAN A.; BELCHIOR, THIAGO; AMANO, MARIANE T.; BURGOS-SILVA, MARINA; PEIXOTO, ALBERT S.; MAGDALON, JULIANA; VIEIRA, THAYNA S.; ANDRADE, MAYNARA L.; MORENO, MAYARA F.; CHIMIN, PATRICIA; et al. Constitutive Activation of the Nutrient Sensor mTORC1 in Myeloid Cells Induced by Tsc1 Deletion Protects Mice from Diet-Induced Obesity. MOLECULAR NUTRITION & FOOD RESEARCH, v. 62, n. 17, . (11/10783-7, 12/02270-2, 09/15354-7, 15/19530-5)

CASTRO, ERIQUE; SILVA, TIAGO E. OLIVEIRA; FESTUCCIA, WILLIAM T.. Critical review of beige adipocyte thermogenic activation and contribution to whole-body energy expenditure. HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION, v. 31, n. 2, SI, . (16/07062-0, 16/23169-9, 15/19530-5)

PASCHOAL, VIVIAN A.; AMANO, MARIANE T.; BELCHIOR, THIAGO; MAGDALON, JULIANA; CHIMIN, PATRICIA; ANDRADE, MAYNARA L.; ORTIZ-SILVA, MILENE; CASTRO, ERIQUE; YAMASHITA, ALEX S.; ROSA NETO, JOSE CESAR; et al. mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function. Immunobiology, v. 222, n. 2, p. 261-271, . (11/10783-7, 12/02270-2, 09/15354-7, 15/19530-5)

CHAAR, LAIALI J.; COELHO, ALINE; SILVA, NATALIA M.; FESTUCCIA, WILLIAM L.; ANTUNES, VAGNER R.. High-fat diet-induced hypertension and autonomic imbalance are associated with an upregulation of CART in the dorsomedial hypothalamus of mice. PHYSIOLOGICAL REPORTS, v. 4, n. 11, . (13/06206-0, 11/13563-8, 09/15354-7, 10/19018-9, 15/19530-5)

CASTRO, ERIQUE; VIEIRA, THAYNA S.; OLIVEIRA, TIAGO E.; ORTIZ-SILVA, MILENE; ANDRADE, MAYNARA L.; TOMAZELLI, CAROLINE A.; PEIXOTO, ALBERT S.; SOBRINHO, CLEYTON R.; MORENO, MAYARA F.; GILIO, GUSTAVO R.; et al. Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in cold-acclimated mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, v. 321, n. 5, p. E592-E605, . (16/23169-9, 19/25943-1, 17/23040-9, 15/13508-8, 17/17582-3, 18/03418-0, 17/17403-1, 17/12260-8, 19/01763-4, 19/17660-0, 15/19530-5, 20/09399-7, 19/04271-5, 12/25317-4)

YAMASHITA, ALEX S.; BELCHIOR, THIAGO; LIRA, FABIO S.; BISHOP, NICOLETTE C.; WESSNER, BARBARA; ROSA, JOSE C.; FESTUCCIA, WILLIAM T.. Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors. Mediators of Inflammation, . (15/22983-1, 15/19530-5, 13/15825-5)

DE CASTRO, GABRIELA S.; SIMOES, ESTEFANIA; LIMA, JOANNA D. C. C.; ORTIZ-SILVA, MILENE; FESTUCCIA, WILLIAM T.; TOKESHI, FLIVIO; ALCANTARA, PAULO S.; OTOCH, JOSE P.; COLETTI, DARIO; SEELAENDER, MARILIA. Human Cachexia Induces Changes in Mitochondria, Autophagy and Apoptosis in the Skeletal Muscle. CANCERS, v. 11, n. 9, . (16/02780-1, 12/50079-0, 16/13810-9, 16/12508-7, 17/12260-8)

BIRSOY, KIVANC; FESTUCCIA, WILLIAM T.; LAPLANTE, MATHIEU. A comparative perspective on lipid storage in animals. Journal of Cell Science, v. 126, n. 7, p. 1541-1552, . (09/15354-7)

LAPLANTE‚ M.; HORVAT‚ S.; FESTUCCIA‚ W.T.; BIRSOY‚ K.; PREVORSEK‚ Z.; EFEYAN‚ A.; SABATINI‚ D.M.. DEPTOR Cell-Autonomously Promotes Adipogenesis, and Its Expression Is Associated with Obesity. Cell Metabolism, v. 16, n. 2, p. 202-212, . (10/10909-8, 09/15354-7)

CHIMIN, PATRICIA; ANDRADE, MAYNARA L.; BELCHIOR, THIAGO; PASCHOAL, VIVIAN A.; MAGDALON, JULIANA; YAMASHITA, ALEX S.; CASTRO, ERIQUE; CASTOLDI, ANGELA; CHAVES-FILHO, ADRIANO B.; YOSHINAGA, MARCOS Y.; et al. Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis. Journal of Lipid Research, v. 58, n. 9, p. 1797-1807, . (12/25317-4, 15/13508-8, 12/02270-2, 09/15354-7, 15/19530-5)

LABBE, SEBASTIEN M.; MOUCHIROUD, MATHILDE; CARON, ALEXANDRE; SECCO, BLANDINE; FREINKMAN, ELIZAVETA; LAMOUREUX, GUILLAUME; GELINAS, YVES; LECOMTE, ROGER; BOSSE, YOHAN; CHIMIN, PATRICIA; et al. mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold. SCIENTIFIC REPORTS, v. 6, . (15/19530-5)

BLANCHARD, PIERRE-GILLES; MOREIRA, RAFAEL J.; CASTRO, ERIQUE; CARON, ALEXANDRE; COTE, MARIE; ANDRADE, MAYNARA L.; OLIVEIRA, TIAGO E.; ORTIZ-SILVA, MILENE; PEIXOTO, ALBERT S.; DIAS, FRANCE ANNE; et al. PPAR gamma is a major regulator of branched-chain amino acid blood levels and catabolism in white and brown adipose tissues. METABOLISM-CLINICAL AND EXPERIMENTAL, v. 89, p. 27-38, . (16/07062-0, 16/23169-9, 15/13508-8, 17/12260-8, 15/19530-5)

OLIVEIRA, TIAGO E.; CASTRO, ERIQUE; BELCHIOR, THIAGO; ANDRADE, MAYNARA L.; CHAVES-FILHO, ADRIANO B.; PEIXOTO, ALBERT S.; MORENO, MAYARA F.; ORTIZ-SILVA, MILENE; MOREIRA, RAFAEL J.; INAGUE, ALEX; et al. Fish Oil Protects Wild Type and Uncoupling Protein 1-Deficient Mice from Obesity and Glucose Intolerance by Increasing Energy Expenditure. MOLECULAR NUTRITION & FOOD RESEARCH, v. 63, n. 7, . (16/07062-0, 16/23169-9, 15/13508-8, 17/23040-9, 17/12260-8, 15/22983-1, 18/11156-5, 17/17582-3, 15/19530-5)

PAHLAVANI, MANDANA; RAMALINGAM, LATHA; MILLER, EMILY K.; SCOGGIN, SHANE; MENIKDIWELA, KALHARA R.; KALUPAHANA, NISHAN S.; FESTUCCIA, WILLIAM T.; MOUSTAID-MOUSSA, NAIMA. Eicosapentaenoic Acid Reduces Adiposity, Glucose Intolerance and Increases Oxygen Consumption Independently of Uncoupling Protein 1. MOLECULAR NUTRITION & FOOD RESEARCH, v. 63, n. 7, . (15/19530-5)

FONSECA, MONIQUE T.; MORETTI, EDUARDO H.; MARQUES, LUCAS M. M.; MACHADO, BIANCA F.; BRITO, CAMILA F.; GUEDES, JADY T.; KOMEGAE, EVILIN N.; VIEIRA, THAYNA S.; FESTUCCIA, WILLIAM T.; LOPES, NORBERTO P.; et al. A leukotriene-dependent spleen-liver axis drives TNF production in systemic inflammation. Science Signaling, v. 14, n. 679, . (16/23540-9, 18/03418-0, 17/17403-1, 17/13350-0, 15/19530-5, 16/04921-1, 20/09399-7, 14/50265-3, 14/03719-9, 18/00849-0)

MOREIRA, RAFAEL J.; CASTRO, ERIQUE; OLIVEIRA, TIAGO E.; BELCHIOR, THIAGO; PEIXOTO, ALBERT S.; CHAVES-FILHO, ADRIANO B.; MORENO, MAYARA F.; LIMA, JANAYNA D.; YOSHINAGA, MARCOS; MIYAMOTO, SAYURI; et al. Lipoatrophy-Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids. MOLECULAR NUTRITION & FOOD RESEARCH, v. 64, n. 7, . (17/17943-6, 18/15549-1, 13/07467-1, 16/04000-3, 14/06863-3, 13/07937-8, 15/19530-5)

ANDRADE, MAYNARA L.; GILIO, GUSTAVO R.; PERANDINI, LUIZ A.; PEIXOTO, ALBERT S.; MORENO, MAYARA F.; CASTRO, ERIQUE; OLIVEIRA, TIAGO E.; VIEIRA, THAYNA S.; ORTIZ-SILVA, MILENE; THOMAZELLI, CAROLINE A.; et al. PPAR gamma-induced upregulation of subcutaneous fat adiponectin secretion, glyceroneogenesis and BCAA oxidation requires mTORC1 activity. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v. 1866, n. 8, . (19/17660-0, 16/23169-9, 18/11156-5, 17/17403-1, 17/17582-3, 17/23040-9, 15/22983-1, 13/07937-8, 19/04271-5, 15/13508-8, 19/01763-4, 15/19530-5, 17/12260-8)

DONADO-PESTANA, CARLOS M.; PESSOA, ERIKA V. M.; RODRIGUES, LARISSA; ROSSI, RAFAELA; MOURA, MARCIO H. C.; DOS SANTOS-DONADO, PRISCILA R.; CASTRO, ERIQUE; FESTUCCIA, WILLIAM T.; GENOVESE, MARIA INES. Polyphenols of cambuci (Campomanesia phaea (O. Berg.)) fruit ameliorate insulin resistance and hepatic steatosis in obese mice. Food Chemistry, v. 340, . (15/19530-5, 18/24477-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PASCHOAL, Vivian Almeida. mTOR complexo 1 atenua a resposta pró-inflamatória de macrófagos e inflamação do tecido adiposo associadas à obesidade.. Tese (Doutorado) -  Instituto de Ciências Biomédicas.  Universidade de São Paulo (USP).  São Paulo.  (11/10783-7

MAGDALON, Juliana. A ativação constitutiva de mTORC1 em adipócitos aumenta a capacidade oxidativa mitocondrial e reduz a adiposidade visceral em camundongos.. Tese (Doutorado) -  Instituto de Ciências Biomédicas.  Universidade de São Paulo (USP).  São Paulo.  (11/03972-8

OLIVEIRA, Thiago Belchior de. Envolvimento dos PPARγ nas ações metabólicas dos ácidos graxos ômega-3.. Tese (Doutorado) -  Instituto de Ciências Biomédicas.  Universidade de São Paulo (USP).  São Paulo.  (11/14172-2

SILVA, Tiago Eugênio Oliveira da. Ingestão de dieta hiperlipídica rica em óleo de peixe aumenta o gasto energético independentemente de UCP1.. Dissertação (Mestrado) -  Instituto de Ciências Biomédicas.  Universidade de São Paulo (USP).  São Paulo.  (16/07062-0

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