CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor in Physical Education from Universidade of Ribeirão Preto (1998). Ph.D. in Physiology by School of Medicine University of São Paulo (2004) under the mentorship of Dr Renato Migliorini (1999-2004). Research Scholar at the lab of Dr Timothy Bartness in Atlanta GA, USA (2002-2003). Post-doctoral training at the Quebec Institute of Cardiology and Pneumology, Quebec, Canada, under mentorship of Dr Yves Deshaies (2005-2009). Visiting Scientist at the laboratory of Dr David Sabatini at the Whitehead Institute For Biomedical Research associated to the MIT (Massachusetts Institute of Technology), Cambridge, USA (2009-2010). Currrently, works as a Associated Professor at the Institute of Biomedical Sciences, University of São Paulo and head of the Rodent Metabolic Phenotyping Center (RPMC). Investigate the regulation of lipid and glucose metabolism by nutrient sensors. (Source: Lattes Curriculum)
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We propose herein to investigate the role of adipocyte Rictor/mTORC2 as mediator of the beneficial and protective effects of polyunsaturated omega 3 fatty acids (n-3 fatty acids) against obesity and associated metabolic diseases. More specifically, we will investigate whether adipocyte Rictor/mTORC2 deficiency (adipocyte Rictor deletion) affects the pro-energy expenditure, insulin sensiti…
Approximately 80-90% of primary HCC cases occur as a progression from steatohepatitis (NASH), namely, in livers displaying chronic inflammation. In this study, we will address how chronic liver inflammation modulates the microenvironment favoring immune evasion and NASH progression to HCC with a special focus on the role of liver resident Kupffer cells and recruited macrophages as major d…
The main goal of this proposal is to obtain funding to acquire equipment for the creation of a Multiuser Facility for Metabolic, Cardiovascular and Respiratory Phenotyping of rodents in different ambient temperatures and light-dark cycles. The funding will be destined for the acquisition of the Promethium Core (Sable Systems) and climate ambient chambers (4 chambers) coupled to a system o…
(Only some records are available in English at this moment)
We propose herein to investigate the role of peroxisomes as mediators of the beneficial and protective effects of n-3 long chain polyunsaturated fatty acids (omega 3 FA) against obesity and associated metabolic diseases. More specifically, we will investigate whether hepatocyte and adipocyte peroxisome deficiency (Pex5 deletion) affects the pro-energy expenditure, insulin sensitizing and …
Lipodystrophy comprises a group of diseases characterized by either a partial or a complete reduction in adipose mass that is associated with the development of several metabolic diseases such as insulin resistance, dyslipidemia, hypertension, hepatic steatosis and atherosclerosis, among others. In this proposal, we will investigate in 3 integrated research programs the molecular mechanis…
We propose herein to investigate the mechanisms by which n-3 fatty acids protect from obesity and associated metabolic diseases. More specifically, we will investigate in two integrated research programs the mechanisms underlying the pro-energy expenditure (Aim 1) and anti-inflammatory (Aim 2) actions of n-3 fatty acids. In Aim 1, the following processes will be investigated as possible u…
(Only some records are available in English at this moment)
There are three types of adipocytes, the white one, which has low mitochondrial density, reduced oxidative capacity and stores energy in the form of lipids; brown, which has high mitochondrial and peroxisomal density and oxidizes fatty acids, glucose and amino acids to produce heat; and beige, which, depending on the current stimulus, can behave as a white adipocyte (high-fat diet) or bro…
Futile metabolic cycles composed of antagonic processes such as fatty acids de novo synthesis and ²-oxidation are activated simutaneoulsy with brown adipose tissue UCP-1 and thermogenesis. Thus, it is our goal in this proposal to invetigate the signaling pathways regulating fatty acids de novo synthesis and ²-oxidation in brown adipose tissue with a special focus on the role of mTORC2 and…
(Only some records are available in English at this moment)
Omega 3 polyunsaturated fatty acids (n-3 PUFAs), found in the fish oil, attenuate obesity and associated metabolic complications such as inflammation, insulin resistance and hyperlipidemia in rodents. In a pilot study performed in diet induced obese mice, intake a diet produced with fish oil (HFn3) reduced body weight gain and improved glucose homeostasis. To elucidate the mechanisms unde…
White adipose tissue major roles are to store excess of energy from diet as triacylglycerol and secrete hormones. Brown adipose tissue, on the other hand, expresses the uncopling protein 1 (UCP1) that when properly activated uncouples proton gradient at inner mitochondrial membrane releasing energy as heat. Fenofibrate is a ligand for the peroxisome proliferator activated receptor alpha …
(Only some records are available in English at this moment)
The activin receptor (ActR - type I and II) signaling pathways play critical roles in regulating a wide range of physiological and pathological activities across tissues. ActRII mediates the actions of ligands such activins, growth differentiation factors (GDFs), and bone morphogenetic proteins (BMPs) by activating downstream signaling cascades including canonical (Smads2,3,4) and non-can…
Despite recent advances, the molecular mechanisms and signaling pathways that contribute to metabolic dysfunction-associated steatotic liver disease (MASLD) onset and progression are not completely understood. Several pieces of evidence indicate that elevated serum lipopolysaccharides (LPS) levels (endotoxemia) due to intestinal dysbiosis play a major role in MASLD development exacerbatin…
Signaling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway is increased in hepatocellular carcinoma (HCC), but paradoxically, genetic inhibition of mTORC1 via Raptor deletion in hepatocytes also promotes HCC development in conditions of liver lipid overload. We found during my postdoc (FAPESP Process 2020/16656-6) that HCC in hepatocyte mTORC1 deficient mice is in pa…
The central regulators of autophagy are the serine/threonine kinases unc-51 like autophagy activating kinase 1/2 (ULK1 and ULK2) that participate in the onset of the autophagic cellular process. These kinases in addition to initiate the autophagic cascade, seem to have interesting secondary roles in energy metabolism to coordinate the cellular response to starvation, such as increasing gl…
The thiazolidinediones (TZDs) are anti-diabetic drugs whose use in treating type 2 diabetes is limited by adverse side effects. The goal of this proposal is a biochemical investigation into a mechanism that separates the positive metabolic effects of TZDs from their side effects. PPAR³, the molecular target of the TZDs, is a key regulator of systemic insulin sensitivity, adipogenesis, inf…
(Only some records are available in English at this moment)
| 5 / 5 | Ongoing grants |
| 8 / 6 | Completed research grants |
| 11 / 11 | Ongoing scholarships in Brazil |
| 33 / 30 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 7 / 7 | Completed scholarships abroad |
| 66 / 61 | All research grants and scholarships |
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