Abstract
Paracoccidioidomycosis (PCM), caused by Paracoccidioides brasiliensis, is the most prevalent systemic mycosis in Brazil. The main clinical forms of PCM are the acute or juvenile form (JF) characterized by a Th2 immune response and chronic or adult form (AF), with a Th1 and Th17 profile. In spite of significant improvement in the antifungal therapy in last years, its efficacy is still lim…