Full Professor at Pharmacology Department of Ribeirão Preto Medical School (University of São Paulo, FMRP - USP). He has experience in Immunopharmacology, focusing on inflammatory diseases, working primarily in sepsis, rheumatoid arthritis, tisular lesion mechanisms, leukocytes migration, innate immune response. He is a member of The World Academy of Sciences (TWAS), Brazilian Academy of Sciences (ABC) and The Academy of Sciences of the State of São Paulo (Aciesp). He is also a member of Brazilian Society for Immunology (SBI), Brazilian Society of Pharmacology (SBFTE) and Brazilian Society of Inflammation. He currently coordinates CRID - Center of Research in Inflammatory Diseases. Ad hoc consultant to the Brazilian National Council for Scientific and Technological Development (CNPq), of The São Paulo Research Foundation (FAPESP) and of CAPES Foundation. He published more than 600 papers in international journals, which received more than 30,000 citations, ensuring an h-index of 86 (Scopus) (Source: Lattes Curriculum)
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Inflammatory diseases are a complex and heterogeneous group of diseases that affect more than 10% of the word population. The current options for the treatment of these diseases are still limited and, in some cases, inefficient due to limited understanding of the mechanisms underlying these diseases. The development of translational research by a center that can generate scientific knowle…
The disease caused by coronavirus in 2019 (Covid-19) is caused by coronavirus-2 of severe acute respiratory syndrome (SARS-CoV-2) and has become an important health problem worldwide. The pulmonary changes observed in patients with Covid-19 are characterized by intense damage to epithelial and endothelial cells, viral replication in pulmonary tissue and extensive inflammatory process char…
The purpose of the Single Cell Genetic Analysis Laboratory (AGCU) is to characterize genetic heterogeneity at the genomic scale of special cells. FMRP's research desk hours from other Campus units can be accessed privately and with availability from private institutions. Also, teaching functions, dependency training, academic and technical training. (AU)
(Only some records are available in English at this moment)
Rheumatoid Arthritis (RA) is an inflammatory systemic disease that affects joints. There is a similarity between pathways that induce tissue destruction in RA and Periodontal Disease (PD), a chronic inflammatory condition that affect tooth surrounding structures. One of mechanisms that link RA and PD evolve dysbiosis of oral microbiome, which is partially reversed after treatment with syn…
Sepsis is a major cause of mortality in hospitalized patients worldwide. Medically is defined as Systemic Inflammatory Response Syndrome (SIRS) resulting from an infectious process, which commonly, can develop into a multiple organ dysfunction followed by death. It is noteworthy that sepsis mortality rate in pediatric patients is significantly higher than in adults. In addition to the sev…
(Only some records are available in English at this moment)
Inflammatory diseases are a complex and heterogeneous group of diseases, which are a major cause of morbidity and mortality and an important socioeconomic problem. Despite recent scientific and technological advances, the current treatment options for inflammatory diseases are still limited and, in some cases, inefficient. The mission of the Center of Research in Inflammatory Diseases (CR…
(Only some records are available in English at this moment)
The initial proposal of the Aristides Pacheco Leão Program for Stimulating Scientific Vocations is to allow undergraduate students to work in a research institution, under the guidance of a Brazilian Academy of Sciences member, promoting scientific development and stimulating scientific interest in undergraduates. Therefore, with this project we aim to enable the student to induce and id…
(Only some records are available in English at this moment)
Rheumatoid arthritis (RA) is an autoimmune disease that affects 0.5 to 1% of adult world population, and it is characterized by bone loss. Osteoblasts are bone cells that synthetize bone matrix and stimulate osteoclasts, that degrade which in turn degrade matrix, though the release of the receptor activator of nuclear factor ºB ligand (RANKL), that interacts with its receptor (RANK) on th…
Although primary resistance to anti-PD1/PD-L1 inhibitors is a common clinical event, the biological pathways underlying mechanisms are not fully understood. Currently, the potential correlation between the tumor glycolytic metabolism reprogramming, known as Warburg effect, and primary resistance to immune checkpoint inhibitors (ICIs) remains unknown. We propose that tumors with high glyco…
Sepsis is a life-threatening multi-organ dysfunction caused by a dysregulated host response to infection. Sepsis-surviving patients commonly develop a late immunosuppression which is associated with increased susceptibility to secondary infections. The mechanisms involved in this immunosuppressive state include increased IL-33 production in the lung tissue homogenates and bronchial lavage…
TH17 subset of helper T cells are characterized by the production of interleukin 17 (IL-17), IL-17F, and IL-22 and have emerged as a subset of effector CD4+ T cells that participates in the development of autoimmune diseases. The aryl hydrocarbon receptor (AHR) is highly expressed on TH17 cells and has an important role in the in vivo and in vitro generation of these cells. Under TH17-cel…
(Only some records are available in English at this moment)
| 6 / 6 | Ongoing research grants |
| 13 / 12 | Completed research grants |
| 9 / 9 | Ongoing scholarships in Brazil |
| 73 / 48 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 7 / 6 | Completed scholarships abroad |
| 109 / 82 | All research grants and scholarships |
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