Daisy Maria Favero Salvadori

• Abstract

  Cancer is characterized as a serious public health problem. Particularly, bladder cancer has a high cost to health system, especially because the necessity of routine clinical monitoring (urine cytology and cystoscopy) and its high recurrence rate. Due to the complexity of biological systems, little is known about the molecular mechanisms responsible for urothelial carcinomas. Literature …

  Bladder transitional cell carcinoma: a study of pos-transcriptional modifications and RNA binding proteins, AP.R

• Abstract

  Currently, the most widely used procedure in the treatment of coronary lesions is angioplasty with stent-implantation procedure. However, despite the breakthroughs and developments associated with this procedure, acute and chronic complications can emerge, being restenosis the major limiting factor for this therapy. It is known that restenosis is a multifactorial and multigenic process, w…

  Genomic alterations associated to restenosis after coronary angioplasty with stent, AP.R

• Abstract

  Obesity, considered by the World Health Organization (WHO) as a worldwide epidemic disease, is a multifactorial disorder which involves inherited and environmental factors and life style, with not only social or psychological consequences, but also associated with the development of co-morbidities such as hypertension, cardiovascular diseases and cancer. Therefore, obesity has become a ch…

  Genetic biomarkers of morbid obesity: gene expression and polymorphisms, cytogenetics alterations and their relationship with the plasmatic micronutrients, AP.R

(Only some records are available in English at this moment)

• Abstract

  Doxorubicin (DOX) is an anthracycline isolated from the actinobacteria Streptomyces peucetius and is widely used in anticancer therapy. However, despite its effectiveness, DOX can promote cardiotoxicity that limits chemotherapy and reduces the quality of life of patients. Scientific literature suggests that DOX-induced toxicity may be associated with mitochondrial dysfunction, which resul…

  Doxorubicin-induced mitochondial changes and Alda-1 protective potential in cardiac cells, BP.IC

• Abstract

  Reproductive health has received special attention due to the increased incidence of infertility in the human population. Among the main risk factors, especially for male infertility, are smoking, obesity, stress and occupational or environmental exposure to xenobiotics. Although there are some data demonstrating the deleterious action of these factors on gametogenesis, the molecular mech…

  Impact of environmental pollutant on sperm and offspring of exposed animals, BP.IC

• Abstract

  Worldwide, bladder cancer is the seventh most common neoplasia in men and the seventeenth in women, and the urothelial cell carcinoma (UCC) is responsible for approximately 90% of these malignant tumors. The most used and successful chemotherapies for UCC include combinations of methotrexate, vinblastine, doxorubicin and cisplatin (MVAC), or combination of gemcitabine and cisplatin. Commo…

  Antiproliferative and toxicogenetic effects of simultaneous treatment with alila isothiocyanate and cisplatin in bladder carcinoma cells, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Cardiotoxicity induced by doxorubicin (DOX) is one of the main secondary pathophisiological events related to this antineoplasic compound, and the excessive reactive oxygen species (ROS) generation is a widely accepted mechanistic explanation. The chemical structure of DOX is particularly prone to undergo reversible reduction to semiquinone radicals, process that occurs predominantly in m…

  In vitro cardiotoxicity induced by doxorubicin and cardioprotective potential of Alda-1, BE.EP.DR

• Abstract

  Bladder cancer has a high cost to health system, especially because of routine clinical monitoring (urine cytology and cystoscopy) and high recurrence rates. Due to the complexity of biological systems, the knowledge about the molecular mechanisms responsible for urothelial carcinomas is scarce. Literature shows that there is involvement of a complex network of pathways linking a large nu…

  Functional analysis of 14 RNA binding proteins (RBPs) in two bladder urothelial carcinoma cell lines, BE.EP.DR