Sergio Alberto Rupp de Paiva

• Abstract

  Doxorubicin is an effective chemotherapy used for decades in the treatment of solid and hematologic malignancies. However, its cardiotoxicity represents the most severe side effect, limiting treatment and worsening patients' quality of life. There is not a highly effective treatment to prevent cardiotoxicity. Recently, changes in gut microbiota have been related to increased risk of cardi…

  Influence of GLP-1 analogue on intestinal microbiota and attenuation of doxorubicin-induced cardiotoxicity in rats, AP.R

• Abstract

  Vitamin D deficiency/insufficient has become public health problem. Additionally, it has encouraged the indiscriminate use of this vitamin. Vitamin D supplementation causes oxidative stress, inflammation, apoptosis, change energy metabolism and morphology and cardiac function. In addition, vitamin D supplementation increases serum phosphorus and hyperphosphatemia stimulates the release of…

  Participation of fibroblast growth factor-23 (FGF -23) on oxidative stress, inflammatory mediators, energy metabolism, apoptosis and cardiac morphological and functional changes associated with vitamin D supplementation in rats, AP.R

• Abstract

  Cardiac remodeling has a key role in ventricular dysfunction after myocardial infarction. Some cellular mechanisms such as oxidative stress, inflammation and fibrosis modulate this process. Thus, treatment or repair of post-infarction changes has great clinical relevance. There is great interest in natural products with antioxidant properties, especially rosemary. Objective: To analyze th…

  Influence of diet supplementation of rosemary (Rosmarinus oficinalis L.) on cardiac remodeling in rats subjected to acute myocardial infarction, AP.R

(Only some records are available in English at this moment)

• Abstract

  Vitamin D deficiency has been considered a public health problem. Concerns about this deficiency increase every day due to new findings that associate it with the development of chronic diseases, including cardiovascular diseases. Because of this, several professionals have been encouraging vitamin D supplementation indiscriminately. However, recent studies have shown that vitamin D has b…

  Influence of gender and time on cardiac remodeling induced by vitamin D supplementation, BP.MS

• Abstract

  Chronic Obstructive Pulmonary Disease (COPD) is a progressive disorder characterized by airflow limitation associated with chronic inflammatory response. It is one of the main causes of mortality in Brazil, representing an important public health problem. On the other hand, consumption of food sources of bioactive compounds (CBAs) as flavonoids, are associated with lower risk of chronic d…

  In vivo analysis of the inflammatory response of patients with Chronic Obstructive Pulmonary Disease (COPD) in orange juice and orange juice with lycopene intake, BP.PD
• Influence of diet rosemary supplementation (Rosmarinus officinalis L.) on cardiac remodeling in rats subjected to acute myocardial infarction, BP.DR

• Abstract

  An increased oxidative status is described after myocardial infarction. On the other hand, many beneficial effects have been attributed to constituents of plant foods, especially antioxidants. Rosemary is one of the most widely used herbs, known for its antioxidant effect. To support its use, it is of great relevance to characterize its compounds and its antioxidant actions. Objectives: i…

  Identification of phenolic compounds and protective action of Rosmarinus officinallis supplementation on oxidative stress in rats submitted to myocardial infarction, BE.EP.DR