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Roger Frigério Castilho

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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas (FCM)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

bachelor's at Medicina from Universidade Estadual de Campinas (1995) and doctorate at Biochemistry from Universidade Federal do Rio de Janeiro (1997). Has experience in Metabolism, Bioenergetics and Neurobiology, acting on the following subjects: cell death, mitochondria, oxidative stress, calcium and mitochondrial permeability transition. (Source: Lattes Curriculum)

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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Data from Web of Science

ARANDA-SOUZA, MARY A.; ROSSATO, FRANCO A.; COSTA, RUTE A. P.; FIGUEIRA, TIAGO R.; CASTILHO, ROGER F.; GUARNIERE, MIRIAM C.; NUNES, ERIKA S.; COELHO, LUANA C. B. B.; CORREIA, MARIA T. S.; VERCESI, ANIBAL E.. A lectin from Bothrops leucurus snake venom raises cytosolic calcium levels and promotes B16-F10 melanoma necrotic cell death via mitochondrial permeability transition. Toxicon, v. 82, p. 97-103, . Web of Science Citations: 20. (11/51800-1, 12/07424-8, 11/50400-0)

MICHELINI, LUIZ G. B.; FIGUEIRA, TIAGO R.; SIQUEIRA-SANTOS, EDILERIE S.; CASTILHO, ROGER F.. Rotenone exerts similar stimulatory effects on H2O2 production by isolated brain mitochondria from young-adult and old rats. Neuroscience Letters, v. 589, p. 25-30, . Web of Science Citations: 4. (11/51800-1, 11/50400-0, 11/14229-4)

MICHELINI, LUIZ G. B.; BENEVENTO, CARLOS E.; ROSSATO, FRANCO A.; SIQUEIRA-SANTOS, EDILENE S.; CASTILHO, ROGER F.. Effects of Partial Inhibition of Respiratory Complex I on H2O2 Production by Isolated Brain Mitochondria in Different Respiratory States. Neurochemical Research, v. 39, n. 12, p. 2419-2430, . Web of Science Citations: 5. (11/50400-0, 11/14229-4)

FIGUEIROA, EVELLYNE DE OLIVEIRA; ARANDA-SOUZA, MARY ANGELA; VAREJAO, NATHALIA; ROSSATO, FRANCO APARECIDO; PEREIRA COSTA, RUTE ALVES; FIGUEIRA, TIAGO REZENDE; NASCIMENTO DA SILVA, LUIS CLAUDIO; CASTILHO, ROGER FRIGERIO; VERCESI, ANIBAL EUGENIO; DOS SANTOS CORREIA, MARIA TEREZA. pCramoll and rCramoll lectins induce cell death in human prostate adenocarcinoma (PC-3) cells by impairment of mitochondrial homeostasis. TOXICOLOGY IN VITRO, v. 43, p. 40-46, . Web of Science Citations: 1. (11/51800-1, 11/50400-0)

NAVARRO, CLAUDIA D. C.; FIGUEIRA, TIAGO R.; FRANCISCO, ANNELISE; DAL'BO, GENOEFA A.; RONCHI, JULIANA A.; ROVANI, JULIANA C.; ESCANHOELA, CECILIA A. F.; OLIVEIRA, HELENA C. F.; CASTILHO, ROGER F.; VERCESI, ANIBAL E.. Redox imbalance due to the loss of mitochondrial NAD(P)-transhydrogenase markedly aggravates high fat diet-induced fatty liver disease in mice. Free Radical Biology and Medicine, v. 113, p. 190-202, . Web of Science Citations: 12. (14/02819-0, 11/50400-0, 13/07607-8, 15/22063-0)

RONCHI, JULIANA APARECIDA; FRANCISCO, ANNELISE; CORREA PASSOS, LUIZ AUGUSTO; FIGUEIRA, TIAGO REZENDE; CASTILHO, ROGER FRIGERIO. The Contribution of Nicotinamide Nucleotide Transhydrogenase to Peroxide Detoxification Is Dependent on the Respiratory State and Counterbalanced by Other Sources of NADPH in Liver Mitochondria. Journal of Biological Chemistry, v. 291, n. 38, p. 20173-20187, . Web of Science Citations: 24. (11/50400-0, 15/22063-0)

FRANCISCO, ANNELISE; ENGEL, DAIANE F.; FIGUEIRA, TIAGO R.; ROGERIO, FABIO; DE BEM, ANDREZA F.; CASTILHO, ROGER F.. Mitochondrial NAD(P)(+) Transhydrogenase is Unevenly Distributed in Different Brain Regions, and its Loss Causes Depressive-like Behavior and Motor Dysfunction in Mice. Neuroscience, v. 440, p. 210-229, . Web of Science Citations: 0. (17/17728-8, 15/22063-0, 18/01360-4, 20/05202-4)

FRANCISCO, ANNELISE; RONCHI, JULIANA A.; NAVARRO, CLAUDIA D. C.; FIGUEIRA, TIAGO R.; CASTILHO, ROGER F.. Nicotinamide nucleotide transhydrogenase is required for brain mitochondrial redox balance under hampered energy substrate metabolism and high-fat diet. Journal of Neurochemistry, v. 147, n. 5, p. 663-677, . Web of Science Citations: 0. (17/17728-8, 15/22063-0)

FIGUEIRA, TIAGO R.; FRANCISCO, ANNELISE; RONCHI, JULIANA A.; DOS SANTOS, GUILHERME R. R. M.; DOS SANTOS, WILLIAM; TREBERG, JASON R.; CASTILHO, ROGER F.. NADPH supply and the contribution of NAD(P)(+) transhydrogenase (NNT) to H2O2 balance in skeletal muscle mitochondria. Archives of Biochemistry and Biophysics, v. 707, . Web of Science Citations: 0. (11/51800-1, 20/05202-4, 18/04559-6, 17/17728-8)

CHWEIH, HANAN; CASTILHO, ROGER F.; FIGUEIRA, TIAGO R.. Tissue and sex specificities in Ca2+ handling by isolated mitochondria in conditions avoiding the permeability transition. Experimental Physiology, v. 100, n. 9, p. 1073-1092, . Web of Science Citations: 10. (11/51800-1, 11/50400-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SOUSA, Solange Carvalho de. Estresse oxidativo mitocondrial, morte celular e efeito de ligantes de imunofilinas em modelos para a doença de Parkinson.  161 f. Tese (Doutorado) -  Faculdade de Ciências Médicas.  Universidade Estadual de Campinas (UNICAMP).  Campinas.  (00/10036-2

MELO, Daniela Rodrigues de. Alterações do metabolismo oxidativo mitocondrial e neurodegeneração por metilmalonato. Tese (Doutorado) -  Faculdade de Ciências Médicas.  Universidade Estadual de Campinas (UNICAMP).  (08/58358-0

MACIEL, Evelise Neves. Permeabilidade mitocondrial transitoria na excitotoxicidade e na lesão neuronal da acidemia metilmalonica. Tese (Doutorado) -  Faculdade de Ciências Médicas.  Universidade Estadual de Campinas (UNICAMP).  (00/04865-6

BUENO, Luiz Guilherme Michelini. Caracterização do estímulo da produção mitocondrial de H2O2 por inibição parcial do Complexo I da cadeia respiratória = : Stimulatory effects of a partial respiratory Complex I inhibition on mitochondrial H2O2 generation. Dissertação (Mestrado) -  Faculdade de Ciências Médicas.  Universidade Estadual de Campinas.  (11/14229-4

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