bachelor's at Medicina from Universidade Estadual de Campinas (1995) and doctorate at Biochemistry from Universidade Federal do Rio de Janeiro (1997). Has experience in Metabolism, Bioenergetics and Neurobiology, acting on the following subjects: cell death, mitochondria, oxidative stress, calcium and mitochondrial permeability transition. (Source: Lattes Curriculum)
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Proton-translocating NAD(P)+ transhydrogenase (NNT) is a transmembrane protein located in the inner mitochondrial membrane that catalyzes the reversible reduction reaction of NADP+ by NADH, with generation of NADPH and NAD+, coupled to the entry of a proton from the intermembrane space to the mitochondrial matrix. NNT is ubiquitously expressed in mammals and its function is related to the…
In the last 40 years, it has become evident that mitochondria are involved in many cell functions besides energy conversion, such as the control of cell death via calcium and oxygen and nitrogen reactive species signaling. Elevated levels of calcium in the mitochondrial matrix stimulate the generation of reactive oxygen which promote the opening of an unspecific pore in the inner mitochon…
In the last 40 years, it has become evident that mitochondria are involved in many cell functions besides energy conversion, such as the control of cell death via calcium and oxygen and nitrogen reactive species signaling. Elevated levels of calcium in the mitochondrial matrix stimulate the generation of reactive oxygen which promote the opening of an unspecific pore in the inner mitochon…
In addition to be the cell’s powerhouse, mitochondria also contains a cell death machinery. Indeed, after a number of new mitochondrial proteins and modulator metabolites have been discovered, this organelle has emerged as a center of attention in processes of cell signaling, cell injury and cell death. Evidence has been provided that mitochondria comprise one of the main pathways for cel…
Alterations in the energetic metabolism associated with modifications in the offer of nutrients and oxygen, ionic transport, inhibition of components of the transport chain of electrons or increase in the production of reactive oxygen species can lead to cell death. This cell death caused by failures of the energetic metabolism is a possible cause of several disorders, including arteriosc…
(Only some records are available in English at this moment)
The mitochondrial NAD(P)+ transhydrogenase (NNT) is a transmembrane protein that catalyzes the transfer of hydride between NAD(H) and NADP(H) coupled with proton transport between the intermembrane space and the mitochondrial matrix. This process can occur in both directions and generate either NADPH or NADH (i.e., forward and reverse reactions). Although both reactions are physiologicall…
The mitochondrial transmembrane protein NAD(P)+ transhydrogenase (NNT) catalyzes the transfer of a hydride between NAD(H) and NADP(H), coupled with the transport of a proton between the intermembrane space and the mitochondrial matrix. This process can occur in the direction of generation of NADPH or NADH (i.e., direct and reverse reactions). The NADPH generated by NNT activity stands out…
Previous studies have shown that NAD(P)+ transhydrogenase (NNT) is relevant to maintenance of mitochondrial redox balance in mouse brain, especially under physiologically challenging conditions, such as after treatment with a high-fat diet. In this sense, this project aims at study the role of NNT activity in the development of age-related changes in the central nervous system using a mou…
The nicotinamide nucleotide transhydrogenase (NNT) is a transmembrane protein located in the inner mitochondrial membrane that catalyzes the reduction of NADP+ by NADH producing NADPH and NAD+, coupled to the transport of protons from the intermembrane space to the mitochondrial matrix. This protein is expressed in all mammalian and its function is related to the maintenance of mitochondr…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 5 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 14 / 7 | Completed scholarships in Brazil |
| 22 / 14 | All research grants and scholarships |
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CV Lattes
ORCID