Graduated from the Faculty of Medicine of the University of São Paulo (FMUSP) in 1989, with a Medical Residency in Psychiatry at the Institute of Psychiatry (IPq) of the Hospital das Clínicas of FMUSP (1990-1992). He completed his Master's degree (1995) and Doctorate (2000) from the Psychiatry Program at the Faculty of Medicine of the University of São Paulo. Specialization in Geriatric Psychiatry from the University of London (Institute of Psychiatry, Section of Old Age Psychiatry) (1996-1997). In May 2010, he obtained the title of Free Professor from FMUSP. He is currently a Full Professor in the Department of Psychiatry at FMUSP, carrying out assistance, teaching and research activities with a focus on Geriatric Psychiatry and Neurosciences. Lines of research focus on the following themes: (1) Clinical and clinical-laboratory research: dementia and cognitive disorders in the elderly (Alzheimer's disease and mild cognitive impairment), delirium, mood disorders in the elderly (depression and bipolar disorder); (2) Basic and translational research: pathophysiological mechanisms, experimental models (neuronal cultures), molecular biology, biomarkers. He is currently Head of the Department of Psychiatry at FMUSP. Member of the Coordinating Committee and advisor of the Postgraduate Program in Psychiatry at FMUSP. (Source: Lattes Curriculum)
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The COVID-19 pandemic originated a giant challenge for the health system inorder to handle the treatment of the acute phase of the disease. After few months of pandemic, it became clear that there was another enormous challenge, the follow-up and management of the frequent persistent median and long-term consequences of the COVID-19, which full magnitude its is far to be acknowledged. The…
The Center for Research and Innovation in Mental Health (Centro Nacional de Pesquisa e Inovação em Saúde Mental, CISM) represents a partnership between the University of São Paulo (USP), the Federal University of São Paulo (UNIFESP), the Federal University of Rio Grande do Sul (UFRGS), private investors (Banco Industrial do Brasil), and two City Halls from the state of São Paulo (Indaiatu…
The search for drugs with neuroprotective effects and disease-modifying properties for Alzheimer's disease (AD) is an area of major interest, since the incidence and prevalence of this disorder are predicted to rise exponentially. Thus, new interventions that prevent or delay the emergence of AD would have an enormous impact on clinical practice and public health, particularly in view of …
The search for the biological substrate of neuropsychiatric disorders is a pre-requisite for the development of more efficacious therapies and mainly of preventive strategies by means of early diagnosis. The experimental attempts to identify specific markers for the different diseases remain unsuccessful to date. At least partially, these negative results derive from a probable lack of sp…
The pathogenic process in Alzheimer's disease (AD) is present several years before the onset of clinical symptoms; therefore, diagnosis of AD should ideally be established at pre-dementia stages. New technologies based on the use of biomarkers (particularly CSF and neuroimaging) provide in vivo evidence of the pathogenic process in patients with mild cognitive impairment (MCI). However, t…
(Only some records are available in English at this moment)
Alzheimer's disease (AD) is considered a major challenge in medical care and is the main cause of dementia characterized by neuronal loss associated with senile plaques and neurofibrillary tangles (NFT). In addition, mitochondrial dysfunction and anomalous GSK-3² activity have also been observed in AD. Therefore, lithium has been suggested as an important therapeutic strategy because it h…
As a result of improvements in living conditions, life expectancy as well as the pace of population aging has increased dramatically in the world. This scenario is not far from the reality of adults with Down Syndrome (DS). Currently, it is estimated that 1 in 1000 live births worldwide has SD. In addition to the close relationship with intellectual disability, DS is directly associated w…
The Alzheimer's disease (AD) is characterized by ²-amyloid (²A) and hyperphosphorilated Tau protein deposition in the nervous tissue, which compromises cognitive functions, with repercussions over cognition and behavior. One of the physiopathological hypothesis to explain this injury involves the increase in the oxidative stress and in the following decrease of telomere length. Telomeres …
Background: The study of subtle cognitive alterations previous to the onset of dementia in Alzheimer's disease (AD), a field of intensive research, and the "classic" episodic and semantic memory impairments are being questioned as the only early signals of the disease to be considered. Recent data shows that changes in executive functioning may be present at predementia stages of AD, name…
(Only some records are available in English at this moment)
Background: Eye movement analysis has proved to be a very accurate and cost/time effective method in the detection and classification of cognitive decline in many neurodegenerative conditions, specifically in Alzheimer's disease (AD) and in Mild Cognitive Impairment (MCI). However, little is known about eye movement patterns as a result of executive impairments in these conditions. Recent…
| 2 / 2 | Ongoing research grants |
| 5 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 9 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 18 / 16 | All research grants and scholarships |
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CV Lattes
ORCID