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Alessandro Silva Nascimento

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Universidade de São Paulo (USP). Instituto de Física de São Carlos (IFSC)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

graduate at Bacharelado Em Ciências Farmacêuticas from Universidade de Brasília (2005) and ph.d. at Physics from Universidade de São Paulo (2009). Has experience in Byophysics, acting on the following subjects: protein crystallography and structural aspects of molecular interactions. Has a position at the Sao Carlos Physics Institute. (Source: Lattes Curriculum)

Research grants
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Scholarships abroad
FAPESP support in numbers * Updated October 12, 2019
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Most frequent collaborators in research granted by FAPESP
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Use this Research Supported by FAPESP (BV/FAPESP) channel only to send messages referring to FAPESP-funded scientific projects.


 

 

 

 

Keywords used by the researcher
Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (28)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications25
Citations267
Cit./Article10.7
Data from Web of Science

BLEICHER, LUCAS; PRATES, ERICA T.; GOMES, THIAGO C. F.; SILVEIRA, RODRIGO L.; NASCIMENTO, ALESSANDRO S.; ROJAS, ADRIANA L.; GOLUBEV, ALEXANDER; MARTINEZ, LEANDRO; SKAF, MUNIR S.; POLIKARPOV, IGOR. Molecular Basis of the Thermostability and Thermophilicity of Laminarinases: X-ray Structure of the Hyperthermostable Laminarinase from Rhodothermus marinus and Molecular Dynamics Simulations. Journal of Physical Chemistry B, v. 115, n. 24, p. 7940-7949, . Web of Science Citations: 18. (10/08680-2, 10/18849-4, 09/14107-6, 10/16947-9)

MARTINEZ, LEANDRO; NASCIMENTO, ALESSANDRO S.; NUNES, FABIO M.; PHILLIPS, KEVIN; APARICIO, RICARDO; DIAS, SANDRA MARTHA G.; FIGUEIRA, ANA CAROLINA M.; LIN, JEAN H.; NGUYEN, PHUONG; APRILETTI, JAMES W.; et al. Gaining ligand selectivity in thyroid hormone receptors via entropy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 106, n. 49, p. 20717-20722, . Web of Science Citations: 51. (06/00182-8)

WATANABE, LEANDRA; DE MOURA, PATRICIA RIBEIRO; NASCIMENTO, ALESSANDRO SILVA; COLAU, DIDIER; DUMOUTIER, LAURE; RENAULD, JEAN-CHRISTOPHE; POLIKARPOV, IGOR. Crystallization and preliminary X-ray diffraction analysis of human IL-22 bound to its soluble decoy receptor IL-22BP. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, v. 65, n. 2, p. 102-104, . Web of Science Citations: 1. (06/00182-8, 06/01534-5)

MALTAROLLO, VINICIUS G.; TOGASHI, MARIE; NASCIMENTO, ALESSANDRO S.; HONORIO, KATHIA M.. Structure-Based Virtual Screening and Discovery of New PPAR delta/gamma Dual Agonist and PPAR delta and gamma Agonists. PLoS One, v. 10, n. 3, . Web of Science Citations: 14. (11/18981-2, 14/06565-2)

NASCIMENTO‚ A.; CATALANO-DUPUY‚ D.; BERNARDES‚ A.; NETO‚ M.; SANTOS‚ M.; CECCARELLI‚ E.; POLIKARPOV‚ I.. Crystal structures of Leptospira interrogans FAD-containing ferredoxin-NADP+ reductase and its complex with NADP+. BMC STRUCTURAL BIOLOGY, v. 7, n. 1, p. 69, . (06/00182-8)

GODOY, ANDRE S.; PEREIRA, CAROLINE S.; RAMIA, MARINA PAGLIONE; SILVEIRA, RODRIGO L.; CAMILO, CESAR M.; KADOWAKI, MARCO A.; LANGE, LENE; BUSK, PETER K.; NASCIMENTO, ALESSANDRO S.; SKAF, MUNIR S.; et al. Structure, computational and biochemical analysis of PcCel45A endoglucanase from Phanerochaete chrysosporium and catalytic mechanisms of GH45 subfamily C members. SCIENTIFIC REPORTS, v. 8, . Web of Science Citations: 3. (15/13684-0, 11/21608-1, 10/52362-5, 11/20505-4)

LIBERATO, MARCELO VIZONA; NASCIMENTO, ALESSANDRO S.; AYERS, STEVEN D.; LIN, JEAN Z.; CVORO, ALEKSANDRA; SILVEIRA, RODRIGO L.; MARTINEZ, LEANDRO; SOUZA, PAULO C. T.; SAIDEMBERG, DANIEL; DENG, TUO; et al. Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) gamma Activators and Pan-PPAR Partial Agonists. PLoS One, v. 7, n. 5, . Web of Science Citations: 73. (06/00182-8)

FLORINDO, RENATA N.; SOUZA, VALQUIRIA P.; MUTTI, HEMILY S.; CAMILO, CESAR; MANZINE, LIVIA REGINA; MARANA, SANDRO R.; POLIKARPOV, IGOR; NASCIMENTO, ALESSANDRO S.. Structural insights into beta-glucosidase transglycosylation based on biochemical, structural and computational analysis of two GH1 enzymes from Trichoderma harzianum. NEW BIOTECHNOLOGY, v. 40, n. B, p. 218-227, . Web of Science Citations: 6. (14/19439-5, 14/06565-2, 08/56255-9)

NASCIMENTO, ALESSANDRO S.; MUNIZ, JOAO RENATO C.; APARICIO, RICARDO; GOLUBEV, ALEXANDER M.; POLIKARPOV, IGOR. Insights into the structure and function of fungal beta-mannosidases from glycoside hydrolase family 2 based on multiple crystal structures of the Trichoderma harzianum enzyme. FEBS Journal, v. 281, n. 18, SI, p. 4165-4178, . Web of Science Citations: 11. (08/56255-9, 09/52840-7)

DA SILVA, FLAVIA M. C.; DOS SANTOS, JADEMILSON C.; CAMPOS, JESSICA L. O.; MAFUD, ANA CAROLINA; POLIKARPOV, IGOR; FIGUEIRA, ANA CAROLINA M.; NASCIMENTO, ALESSANDRO S.. Structure-based identification of novel PPAR gamma ligands. Bioorganic & Medicinal Chemistry Letters, v. 23, n. 21, p. 5795-5802, . Web of Science Citations: 16. (10/15376-8)

MUNIZ, HELOISA S.; NASCIMENTO, ALESSANDRO S.. Towards a critical evaluation of an empirical and volume-based solvation function for ligand docking. PLoS One, v. 12, n. 3, . Web of Science Citations: 1. (14/06565-2, 10/15376-8)

MUNIZ, HELOISA DOS SANTOS; NASCIMENTO, ALESSANDRO S.. Ligand- and receptor-based docking with LiBELa. Journal of Computer-Aided Molecular Design, v. 29, n. 8, p. 713-723, . Web of Science Citations: 4. (14/06565-2)

VAZ DE LIMA, LUIS ANTONIO C.; NASCIMENTO, ALESSANDRO S.. MolShaCS: A free and open source tool for ligand similarity identification based on Gaussian descriptors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 59, p. 296-303, . Web of Science Citations: 12. (10/15376-8)

GODOY, ANDRE SCHUTZER; CAMILO, CESAR MOISES; KADOWAKI, MARCO ANTONIO; MUNIZ, HELOISA DOS S.; SANTO, MELISSA ESPIRITO; MURAKAMI, MARIO TYAGO; NASCIMENTO, ALESSANDRO S.; POLIKARPOV, IGOR. Crystal structure of beta 1 -> 6-galactosidase from Bifidobacterium bifidum S17: trimeric architecture, molecular determinants of the enzymatic activity and its inhibition by alpha-galactose. FEBS Journal, v. 283, n. 22, p. 4097-4112, . Web of Science Citations: 5. (11/20505-4, 09/05328-9, 08/56255-9, 14/06565-2, 09/52840-7, 11/05712-3)

FLORINDO, RENATA N.; SOUZA, VALQUIRIA P.; MANZINE, LIVIA R.; CAMILO, CESAR M.; MARANA, SANDRO R.; POLIKARPOV, IGOR; NASCIMENTO, ALESSANDRO S.. Structural and biochemical characterization of a GH3 beta-glucosidase from the probiotic bacteria Bifidobacterium adolescentis. Biochimie, v. 148, p. 107-115, . Web of Science Citations: 3. (14/19439-5, 14/06565-2, 08/56255-9)

NASCIMENTO, ALESSANDRO S.. Structural requirement for PPAR gamma binding revealed by a meta analysis of holo-crystal structures. Biochimie, v. 92, n. 5, p. 499-506, . Web of Science Citations: 4.

GOLUBEV, ALEXANDER M.; ROJAS, ADRIANA L.; NASCIMENTO, ALESSANDRO S.; BLEICHER, LUCAS; KULMINSKAYA, ANNA A.; ENEYSKAYA, ELENA V.; POLIKARPOV, IGOR. Crystallization and Preliminary Crystallographic Analysis of Laminarinase from Rhodothermus marinus: A Case of Pseudomerohedral Twinning. PROTEIN AND PEPTIDE LETTERS, v. 15, n. 10, p. 1142-1144, . Web of Science Citations: 1. (06/00182-8)

NASCIMENTO, ALESSANDRO S.; DIAS, SANDRA MARTHA GOMES; NUNES, FÁBIO M.; APARÍCIO, RICARDO; AMBROSIO, ANDRE L. B.; BLEICHER, LUCAS; FIGUEIRA, ANA CAROLINA M.; SANTOS, MARIA AUXILIADORA M.; OLIVEIRA NETO, MÁRIO DE; FISCHER, HANNES; et al. Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function. Journal of Molecular Biology, v. 360, n. 3, p. 586-598, . (06/00182-8)

MARTINEZ, LEANDRO; SOUZA, PAULO C. T.; GARCIA, WANIUS; BATISTA, FERNANDA A. H.; PORTUGAL, RODRIGO V.; NASCIMENTO, ALESSANDRO S.; NAKAHIRA, MARCEL; LIMA, LUIS M. T. R.; POLIKARPOV, IGOR; SKAF, MUNIR S.. On the Denaturation Mechanisms of the Ligand Binding Domain of Thyroid Hormone Receptors. Journal of Physical Chemistry B, v. 114, n. 3, p. 1529-1540, . Web of Science Citations: 5. (06/00182-8)

KIM, KYOUNG-YUN; NASCIMENTO, ALESSANDRO S.; GOLUBEV, ALEXANDER M.; POLIKARPOV, IGOR; KIM, CHUNG-SEI; KANG, SU-IL; KIM, SU-IL. Catalytic mechanism of inulinase from Arthrobacter sp. S37. Biochemical and Biophysical Research Communications, v. 371, n. 4, p. 600-605, . (06/00182-8)

NASCIMENTO, ALESSANDRO S.; KRAUCHENCO, SANDRA; GOLUBEV, ALEXANDER M.; GUSTCHINA, ALLA; WLODAWER, ALEXANDER; POLIKARPOV, IGOR. Statistical coupling analysis of aspartic proteinases based on crystal structures of the Trichoderma reesei enzyme and its complex with pepstatin A. Journal of Molecular Biology, v. 382, n. 3, p. 763-778, . Web of Science Citations: 7. (99/03387-4)

WATANABE, LEANDRA; DE MOURA, PATRICIA RIBEIRO; BLEICHER, LUCAS; NASCIMENTO, ALESSANDRO S.; ZAMORANO, LAURA S.; CALVETE, JUAN J.; SANZ, LIBIA; PEREZ, ALICIA; BURSAKOV, SERGEY; ROIG, MANUEL G.; et al. Crystal structure and statistical coupling analysis of highly glycosylated peroxidase from royal palm tree (Roystonea regia). Journal of Structural Biology, v. 169, n. 2, p. 226-242, . Web of Science Citations: 31. (06/00182-8)

DE AZEVEDO, ERIKA CHANG; NASCIMENTO, ALESSANDRO S.. Energy landscape of the domain movement in Staphylococcus aureus UDP-N-acetylglucosamine 2-epimerase. Journal of Structural Biology, v. 207, n. 2, p. 158-168, . Web of Science Citations: 0. (15/13684-0, 17/18173-0, 15/26722-8)

FARRO, ERICK GIANCARLO S.; LEITE, ANA ELISA T.; SILVA, ISABELA A.; FILGUEIRAS, JEFFERSON G.; DE AZEVEDO, EDUARDO R.; POLIKARPOV, IGOR; NASCIMENTO, ALESSANDRO S.. GH43 endo-arabinanase from Bacillus licheniformis: Structure, activity and unexpected synergistic effect on cellulose enzymatic hydrolysis. International Journal of Biological Macromolecules, v. 117, p. 7-16, . Web of Science Citations: 1. (15/13684-0, 14/06565-2, 14/03768-0)

NAKAMURA, ALINE M.; SEIKI KADOWAKI, MARCO ANTONIO; GODOY, ANDRE; NASCIMENTO, ALESSANDRO S.; POLIKARPOV, IGOR. Low-resolution envelope, biophysical analysis and biochemical characterization of a short-chain specific and halotolerant carboxylesterase from Bacillus licheniformis. International Journal of Biological Macromolecules, v. 120, n. B, p. 1893-1905, . Web of Science Citations: 0. (11/20505-4)

SONODA, MILTON T.; GODOY, ANDRE S.; PELLEGRINI, VANESSA O. A.; KADOWAKI, MARCO A. S.; NASCIMENTO, ALESSANDRO S.; POLIKARPOV, IGOR. Structure and dynamics of Trichoderma harzianum Cel7B suggest molecular architecture adaptations required for a wide spectrum of activities on plant cell wall polysaccharides. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1863, n. 6, p. 1015-1026, . Web of Science Citations: 0. (15/13684-0, 14/06565-2, 17/18173-0)

MINARI, KARINE; DE AZEVEDO, ERIKA CHANG; RODRIGUES KIRALY, VANESSA THOMAZ; HELENO BATISTA, FERNANDA APARECIDA; DE MORAES, FABIO ROGERIO; DE MELO, FERNANDO ALVES; NASCIMENTO, ALESSANDRO SILVA; GAVA, LISANDRA MARQUES; INACIO RAMOS, CARLOS HENRIQUE; BORGES, JULIO CESAR. Thermodynamic analysis of interactions of the Hsp90 with adenosine nucleotides: A comparative perspective. International Journal of Biological Macromolecules, v. 130, p. 125-138, . Web of Science Citations: 0. (09/53989-4, 13/25646-0, 14/07206-6, 11/23110-0, 15/26722-8, 12/50161-8, 17/18173-0, 17/07335-9)

SARTORI, GERALDO RODRIGUES; NASCIMENTO, ALESSANDRO S.. Comparative Analysis of Electrostatic Models for Ligand Docking. FRONTIERS IN MOLECULAR BIOSCIENCES, v. 6, . Web of Science Citations: 0. (15/13684-0, 17/18173-0, 15/26722-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

NASCIMENTO, Alessandro Silva. Interações dos receptores nucleares com seus ligantes: Estudos estruturais do receptor de hormônio tireoidiano, do receptor de mineralocorticóide e do receptor ativado por proliferadores peroxissomais. 2009. Tese (Doutorado) – Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos. (04/08070-9)

FARRO, Erick Giancarlo Suclupe. Caracterização estrutural e bioquímica das arabinanases de Bacillus licheniformis. 2016. Dissertação (Mestrado) - Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos. (14/03768-0)

CUNHA, João Victor de Souza. Aplicação de Monte Carlo para a geração de ensembles e análise termodinâmica da interação biomolecular. 2016. Dissertação (Mestrado) - Instituto de Física de São Carlos. Universidade de São Paulo (USP). São Carlos. (14/01751-2)

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