Full Professor - Institute of Biomedical Sciences and School of Medicine at University of Sao Paulo, Brazil. Visiting Professor - Stanford University School of Medicine CA-USA. Founder and director - SPARK-Brasil. Research interest - cell metabolism. Member - Brazilian Academy of Sciences, São Paulo Academy of Sciences and Global Young Academy. (Source: Lattes Curriculum)
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Peripheral arterial disease (PAD) affects over 200 million people worldwide, causing significant disability and death. Typically, PAD is due to atherosclerosis, with obstruction of the iliac, femoral, and/or infrapopliteal arteries, and consequent reduction of blood supply to the lower extremities. Most of medical interventions of PAD stemmed from a vascular disease perspective. Although …
Mitochondria are organelles that continually undergo fission and fusion (mitochondrial dynamics). These opposing processes work together to maintain mitochondrial shape, size, number and function. Disruption of mitochondrial dynamics results in the accumulation of fragmented and dysfunctional mitochondria, contributing to the establishment and progression of several degenerative diseases.…
Mitochondria are organelles that continually undergo fusion and fission. These opposite processes work together to maintain the shape, size, number and function of mitochondria. Recently, our group demonstrated that reestablishing mitochondrial fusion-fission balance through exercise or drug therapy is sufficient to restore mitochondrial bioenergetics and improves the prognosis of heart f…
Mitochondria are key organelles involved in ATP production and regulation of several signaling cascades that ultimately affect cell death and survival. Mitochondrial dysfunction plays a critical role in the development and progression of cardiovascular diseases, such as myocardial infarction. Therefore, mitochondria have become an attractive therapeutic target for the treatment of cardiov…
4-hydroxy-2-nonenal (4-HNE) is a major by-product of lipid peroxidation, a process that is exacerbated under oxidative stress conditions. This aldehyde is highly reactive with proteins, lipids and DNA, causing target loss of function and degradation in most cases. For this reason, accumulation of 4-HNE has been correlated with the establishment and progression of many diseases, including …
(Only some records are available in English at this moment)
It is currently known that the pathophysiology of amyotrophic lateral sclerosis (ALS) is associated with mitochondrial dysfunction, excessive lipid peroxidation and consequent accumulation of cytotoxic aldehydes. Among these aldehydes, acetaldehyde can be highlighted, an electrophilic aldehyde produced in the mitochondria capable of attacking nucleophilic amino acids and forming adducts w…
Amyotrophic lateral sclerosis (ALS) is a progressive and lethal neuromuscular degenerative disease that affects 0.01% (~10/100,000) of the population worldwide. Most ALS patients (familial or sporadic) display a progressive motor disorder after the disease onset; therefore, characterizing it as a degenerative syndrome triggered by a major disruption of the neuromuscular axis. However, ~50…
Mitochondria are organelles that continually undergo fusion and fission. These opposite processes work together to maintain the shape, size, number and function of mitochondria. Recently, our group demonstrated that reestablishing mitochondrial fusion-fission balance through exercise or drug therapy is sufficient to restore mitochondrial bioenergetics and improves the prognosis of heart f…
Recently, knowledge about the pathophysiology of amyotrophic lateral sclerosis (ALS) has established that the formation and accumulation of aldehydes resulting from mitochondrial dysfunction and consequent excessive lipid peroxidation are extremely neurotoxic and are associated with the appearance of symptoms and progression of ALS in preclinical models. Among the various aldehydes, 4-hyd…
Mitochondria are organelles that continually undergo fission and fusion (mitochondrial dynamics). These opposing processes work together to maintain mitochondrial shape, size, number and function. Disruption of mitochondrial dynamics results in the accumulation of fragmented and dysfunctional mitochondria, contributing to the establishment and progression of several degenerative diseases.…
Doxorubicin is a chemotherapeutic agent widely used in the treatment of carcinomas, sarcomas, and hematological tumors. However, 40% of treated display liver dysfunction, the main organ responsible for doxorubicin metabolism. The mechanisms involved in doxorubicin-induced hepatotoxicity are still unknown. It is known that doxorubicin accumulates in the liver in a dose-dependent manner, pr…
(Only some records are available in English at this moment)
Mitochondrial myopathy is a devastating disorder with no treatment available. The pathology of mitochondrial myopathy is characterized by an initial skeletal muscle degeneration due to mitochondrial dysfunction followed by a multi systemic effect such as lipolysis, gluconeogenesis, starvation-like response, among others, which contributes to disease progression and lethality. Targeting th…
Mitochondria are organelles that continually undergo fusion and fission. These opposite processes work together to maintain the shape, size, number and function of mitochondria. Mitochondrial fusion proteins (mitofusins 1 and 2) also play key role in the mitochondria-endo/sarcoplasmic reticulum (ER) communication; therefore, affecting critical intracellular processes such as phospholipids…
Impaired mitochondrial bioenergetics and defective endo/sarcoplasmic reticulum (ER) function have been individually reported in skeletal muscle under degenerative conditions in both humans and rodents. However, the dynamic interplay between these two key organelles under physiological conditions as well as its contribution to skeletal muscle degeneration remain elusive. Our preliminary fi…
Aldehydes are known as a class of highly reactive molecules and one of the most important drivers of redox damage in living cells. Aldehyde levels are mainly controlled by enzymes from Aldehyde Dehydrogenase superfamily (ALDH), of which ALDH2 is the most well characterized member. The main acetaldehyde metabolizing enzyme is mainly known by a mutation (E540K, named ALDH2*2) present in abo…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 7 / 7 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 28 / 28 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 11 / 11 | Completed scholarships abroad |
| 52 / 52 | All research grants and scholarships |
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CV Lattes
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