CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Medicina from Faculdade de Medicina de Santo Amaro (1975) and doctorate at Patologia from Faculdade de Medicina da USP (1986). Has experience in Medicine, acting on the following subjects: morphometry, lung, electron microscopy, lung cancer and pulmão. (Source: Lattes Curriculum)
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Background: Previous studies have described, through genomic analysis in tumor tissue, the investigation for the applicability of biomarkers associated with metastatic progression and death from cancer is mainly based on observations of the behavior of primary tumors. However, the studies do not prioritize the evaluation of biomarkers capable of identifying the effects of the stroma-assoc…
The prevalence and social cost of respiratory diseases such as lung cancer, acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease, asthma, silicosis, and pulmonary arterial hypertension are high and some of them have few therapeutic alternatives. The therapy of most of these diseases is based on symptomatic control and not on effective cure. The present proposa…
Lung cancer remains the main cause of cancer deaths in the Brazilian population. Even suspecting that the numbers are under-estimated, this neoplasia occupies a place among the most prevalent. In the last decades, several changes have occurred in diagnosis and treatment of this disease. Better therapeutic results and preventive strategies depend on the constant increase on the knowledge…
Adenocarcinomas represent the most common histologic subtype in most countries, contributing to almost half of cases of lung cancer. How huge sources have been spent on trials involving therapeutic aspects in adenocarcinomas, there is need to develop standard criteria to improve behavior, therapy and prognosis of patients. Important changes begin to occur in the treatment of metastatic di…
(Only some records are available in English at this moment)
Background: Previous studies have described, through genomic analysis in tumor tissue, the investigation for the applicability of biomarkers associated with metastatic progression and death from cancer is mainly based on observations of the behavior of primary tumors. However, the studies do not prioritize the evaluation of biomarkers capable of identifying the effects of the stroma-assoc…
Lung cancer (LC) is a serious global health problem, as it remains the most common cause of cancer-related deaths worldwide. Most LC cases are diagnosed late, with a large portion of cases treated surgically progressing to an advanced stage. Therefore, there is great importance regarding systemic therapy in the clinical management of these patients, seeking a better clinical outcome. Syst…
Malignant mesothelioma (MM) is a rare tumor affecting the mesothelial regions, mainly the pleura (73-85%) and peritoneum (7-18%). This tumor is commonly associated with occupational or environmental exposure to asbestos, and predominantly affects males. Unfortunately, MM is highly lethal, with poor prognosis, and still presents few therapeutic options. In this context, the extracellular m…
Recent studies have identified that the EGFR T790M mutation is responsible for acquired resistance to EGFR inhibitors in up to 50% of cases and that NSCLC strains that display wild-type EGFR exhibit sensitivity to EGFR inhibitors dependent on the degree to which they have been subjected to EMT. In contrast, EGFR inhibitor-resistant NSCLC strains with mesenchymal phenotype showed decreased…
(Only some records are available in English at this moment)
Previous studies have shown that the level of hyaluronic acid (HA) in the lung tumor stroma correlates with tumor aggressiveness; supporting the hypothesis that HA promotes cell migration and invasion. The lack of information regarding HA and its relation with lung cancer, in addition to the possible role of this extracellular matrix molecule in the development of neoplasias, encouraged u…
In the proposed project the hypothesis is that myofibroblast differentiation is a key factor in driving fibrosis and its de novo emergence is regulated by a complex mechanism involving transcriptional and epigenetic regulation of gene expression by both local and bone marrow derived cells. Two specific directions are proposed, namely analysis of transcriptional and epigenetic regulation o…
| 2 / 2 | Ongoing grants |
| 23 / 14 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 87 / 30 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 115 / 49 | All research grants and scholarships |
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