graduate at Faculdade de Odontologia from Universidade Estadual Paulista Júlio de Mesquita Filho (1985), master's at Odontology from Universidade Estadual de Campinas (1991) and ph.d. at Odontology from Universidade Estadual de Campinas (1996). Has experience in Odontology, acting on the following subjects: ciclosporina, aumento gengival, cyclosporin, doença periodontal and gingival overgrowth. (Source: Lattes Curriculum)
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We recently found that erythritrine (ERIOC) has anti-inflammatory, antioxidant properties and has been shown to stimulate pro-resolving factors. Therefore, information on the impact of ERIOC in stimulating markers and pro-resolving mechanisms requires careful clearance, which will contribute to the solid construction of more comprehensive and eventually applied scientific content. This pr…
Hesperidin is a glycoside belonging to the subclass of flavonones, found abundantly in citrus fruits, and has multiple biological properties, and its pharmacological actions are often reviewed as they appear to have beneficial effects on the prevention and complications of diabetes mellitus and dyslipidemias as well as to show anti-inflammatory and antioxidant properties. This potential, …
The aim of the project will be evaluated in vivo the supra and sub physiological effects of testosterone, as well as pharmacological inhibition of androgen receptor, estrogen and aromatase enzyme on the tissue repair (wound healing and scarring), and on induced bone resorption using a model resorption by Porphyromonas gingivalis calvaria injection. It will be used 80 rats (Rattus norvegic…
The etiopathogenesis of the immune-inflammatory responses associated with periodontal disease is a strictly regulated and complex process that involves many molecules related with different cell signaling pathways. In this context, the interaction of hormones and their receptors, including sex hormones, plays an important role. It is plausible that androgenic hormones role on immune-infla…
(Only some records are available in English at this moment)
Drugs that modulate the immune response are constantly being investigated in the treatment and prevention of immune-inflammatory diseases, however, they can have a variety of disadvantages, including side effects and low efficacy. Natural products such as flavonoids have gained the interest of researchers due to their beneficial pharmacological and therapeutic activities. This project aim…
New knowledge about how inflammation is resolved signals opportunities for the development of new therapeutic approaches complementary or superior to those traditionally used. Eriocitrin (ERIOC), a citrus flavonoid known for its potent anti-inflammatory and antioxidant properties, may be a candidate to act in this process. This proposal aims to lay the foundations for the development of t…
Wound healing is conducted by sequential phases, and among the complex network of humoral and cellular events can be highlighted the activity of fibroblasts, which secrete cytokines and growth factors, actively participating in the development of new tissue and the regulation of the repair process. Several factors can compromise the mechanisms involved in the repair process, delaying and/…
(Only some records are available in English at this moment)
New knowledge about the ways in which inflammation is resolved signals opportunities for the development of new therapeutic approaches complementary or superior to those traditionally used. Currently, we are investigating the influence of eriocitrin on pro-resolutive events and in macrophage polarization (FAPESP 2020/11672-3). We hypothesized that eriocitrin favors macrophage polarization…
Recently, we have screened several natural compounds in an attempt to identify one that is capable of promoting bone formation, blocking bone resorption and reducing inflammation utilizing several in vitro assays. One type of natural product is remarkably promising in promoting osteogenesis while improving bone matrix quality and stability and forming bone in vivo. Others have reported th…
Periodontitis and gingivitis are characterized by increased levels of both host and bacterial proteolytic enzymes A diverse range of endogenous chemical mediators orchestrates the host response and controls the inflammatory response. The coagulation cascade is intimately related to inflammation. The coagulation cascade is divided in two ways that converge, culminating in the activation of…
| 1 / 1 | Ongoing research grants |
| 11 / 7 | Completed research grants |
| 16 / 11 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 31 / 22 | All research grants and scholarships |
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CV Lattes
ORCID