José Luiz Laus

• Abstract

  The cornea is the most important refractive element of the eye. The corneal tissue is transparent by the present features such as the absence of blood vessels in the epithelium, spacing and regular organization of stromal collagen fibers and the pump and barrier functions exerted by the endothelium. Endothelial lesions are an important indication to the corneal transplantation, once the c…

  Effects of fucoidan from Fucus vesiculosus on the morphology, ploidy and metabolism of corneal endothelium in rabbits, AP.R

• Abstract

  At the end 1990, the transplantation of substrates colonized by corneal limbal epithelial stem cells emerged as a promising therapeutic option for reconstructing the ocular surface and restoring the vision in patients with limbal deficiency. After 15 years of clinical practice, several aspects related to the security and the standardization of the procedures used for manipulating these su…

  Chromatin supraorganization, DNA content, nuclear glycoprotein amount, and immunophenotypic characterization of limbal epithelial cells cultured on intact or denuded amniotic membrane versus scaffold composed of fucoidan-alginate-chitosan, AP.R

• Abstract

  As millions of glaucoma patients lose sight, it is evident that there is a need to develop neuroprotective therapies that can be used to prevent retinal ganglion cell (RGC) death. Advances in understanding of the glaucoma make it evident that perfusion abnormalities are a key factor in the pathogenesis of glaucomatous neuropathy. Based on findings in similar diseases, we hypothesize that …

  Preserving vision in glaucoma: preventing optic neuropathy through neuroprotective, vasodilative treatment, AP.R

(Only some records are available in English at this moment)

• Abstract

  Polymers, in ophthalmology, have been used for building biomaterials (membranes, hydrogels, micelles, liposomes and other devices), for drugs or cells delivery systems, or for corneal inlays and onlays. There is an interest in expanding the range of polymeric materials capable of integrating the cornea without risk of rejection, and to promote rearrangements in the supramolecular organiza…

  Anisotropic and refractive properties of the cornea of rabbits following implantation of type I collagen inlays extracted from bovine digital flexor tendon, BP.DR

• Abstract

  Quali-quantitative characteristics relative to the rigidity of canine health eyes will be assessed through ARFI elastography (Acoustic Radiaton Force Impulse) aiming to establish standards for the species. For this study 42 brachycephalic canines within 1 to 6 years old, male and female will be evaluated. . The subjects will undergo to physical, laboratorial and ophthalmic examinations. F…

  ARFI elastography (Acoustic Radiation Force Impulse) of ocular healthy canines, BP.MS

• Abstract

  This project was designed aiming the study of a technique for epithelial limbal stem cells culture and its therapeutic use. Limbal explants will be collected from 20 New Zealand rabbits and processed as cell suspensions, they will be used in two groups: Group I - epithelial cells expanded on a single layer of amniotic membrane. Group II - epithelial cells cultured in a tridimensional syst…

  Transplantation of amniotic membrane with limbal epithelial cells cultivated in sandwich configuration: clinical study and viability in rabbit corneas, BP.DR

(Only some records are available in English at this moment)