Alfredo Ribeiro da Silva
CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
He has a degree in Medicine (1995), specialization in Pathology (1998), Masters (2001) and Doctorate (2002) in Human Pathology by the Medical School of Ribeirão Preto of the University of São Paulo (FMRP / USP). He has a postdoctoral degree from Stanford University, California, USA (2007). Since 2004, he has been teaching at the Department of Pathology at FMRP / USP. He is the current Deputy Chief of the Department of Pathology and Legal Medicine of FMRP / USP. He works in the area of ​​pathology, with emphasis on oncological pathology. He studies several types of cancer, including breast cancer, gynecological cancer, head and neck cancer (including salivary gland tumors) and prostate cancer. He has extensive experience with immunohistochemistry and in situ hybridization (Source: Lattes Curriculum)
- The participation of pathway phosphatidylinositol 3-kinase (PI3K) in oral squamous cell carcinoma, AP.R
Abstract
The oral squamous cell carcinoma (OSCC) have high incidence in Brazil corresponding to nearly 95% of all oral malignancies. The OSCC molecular biology is very complex because this carcinoma develops from dysfunction of many interrelated signaling pathways. The active PI3K/AKT pathway is involved in cellular growth and cell survival beyond to block apoptosis. Dysfunctions in this pathway...
- Expression of microRNAs miR-20b, miR-125b and miR-145 in breast carcinomas with MUC1 overexpression, AP.R
Abstract
Mucin 1 may behave as an oncogene and may perform an important role during breast cancer development. Recently, our research group showed that MUC1 is overexpressed in invasive breast ductal carcinoma and that this oncogene could be involved in hypoxia regulation through differential expression of HIF-1± (hypoxia-inducible factor-1±). The purpose of this study is to investigate the poss...
- The role of BMI-1 in the signaling pathways of DNA homologous recombination in breast cancer, AP.R
Abstract
Homologous recombination (HR) are one of double-strand break (DSB) repair pathways BRCA1 and BRCA2, associated with the RAD51 protein, accumulates in DNA damage foci after signaling H2AX, a DNA damage marker that accumulates in lesion foci, associated to ATM/ATR pathway, leading to DNA repair. Topoisomerase III beta (TopoIII beta) removes HR intermediates before the segregation of chro...
(Only some records are available in English at this moment)
- Fibroblast growth factor receptors status in squamous cell carcinomas and circulating tumor cells, BP.PD
Abstract
Signaling through the fibroblast growth factor (FGF) eventually became a rather complex growth signaling pathway, reflecting the wide range of physiological functions controlled via FGF-FGFR (fibroblast growth factor receptor). The FGF family in mammals consists of 18 ligands that exert their functions through 4 transmembrane receptors with tyrosine kinase activity (FGFR1, FGFR2, FGFR3 ...
- Expression of microRNAs miR-20b, miR-125b and miR-145 in breast carcinomas with MUC1 overexpression, BP.DR
Abstract
Mucin 1 may behave as an oncogene and may perform an important role during breast cancer development. Recently, our research group showed that MUC1 is overexpressed in invasive breast ductal carcinoma and that this oncogene could be involved in hypoxia regulation through differential expression of HIF-1± (hypoxia-inducible factor-1±). The purpose of this study is to investigate the poss...
- The role of BMI-1 in the signaling pathways of DNA homologous recombination in breast cancer, BP.DR
Abstract
Homologous recombination (HR) are one of double-strand break (DSB) repair pathways. BRCA1 and BRCA2, associated with the RAD51 protein, accumulates in DNA damage foci after signaling H2AX, a DNA damage marker that accumulates in lesion foci, associated to ATM/ATR pathway, leading to DNA repair. Topoisomerase III beta (TopoIII beta) removes HR intermediates before the segregation of ch...
(Only some records are available in English at this moment)
- Comprehensive portrait of FGFR expression in circulating tumor cells of head and neck cancer, BE.EP.PD
Abstract
Head and neck cancer represents 600,000 new cancers worldwide each year, and almost 90% of them are squamous cell carcinoma (HNSCC). With the exception of HPV status with its known implications, numerous molecular and clinical risk factors have been investigated over the decades. Unfortunately, these risk factors have demonstrated limited clinical utility, and prognostic biomarker resea...
| 6 / 6 | Completed research grants |
| 7 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 14 / 13 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 6 |
| Citations | 144 |
| Cit./Article | 24.0 |
| Data from Web of Science | |
OLIVEIRA, LUCINEI R.; OLIVEIRA-COSTA, JOAO P.; ARAUJO, IANA M.; SOAVE, DANILO F.; ZANETTI, JULIANA S.; SOARES, FERNANDO A.; ZUCOLOTO, SERGIO; RIBEIRO-SILVA, ALFREDO. Cancer stem cell immunophenotypes in oral squamous cell carcinoma. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 40, n. 2, p. 135-142, FEB 2011. Web of Science Citations: 23.
SOAVE, DANILO FIGUEIREDO; OLIVEIRA DA COSTA, JOAO PAULO; DA SILVEIRA, GIORGIA GOBBI; FRAGA IANEZ, RENATA CAROLINA; DE OLIVEIRA, LUCINEI ROBERTO; LOURENCO, SILVIA VANESSA; RIBEIRO-SILVA, ALFREDO. CD44/CD24 immunophenotypes on clinicopathologic features of salivary glands malignant neoplasms. DIAGNOSTIC PATHOLOGY, v. 8, FEB 18 2013. Web of Science Citations: 13.
MACHADO, JULIANA REIS; SOAVE, DANILO FIGUEIREDO; DA SILVA, MARCOS VINICIUS; DE MENEZES, LILIANA BORGES; ETCHEBEHERE, RENATA MARGARIDA; GONCALVES DOS REIS MONTEIRO, MARIA LUIZA; DOS REIS, MARLENE ANTONIA; MIRANDA CORREA, ROSANA ROSA; NUNES CELES, MARA RUBIA. Neonatal Sepsis and Inflammatory Mediators. Mediators of Inflammation, 2014. Web of Science Citations: 40.
OLIVEIRA-COSTA, JOAO PAULO; OLIVEIRA, LUCINEI ROBERTO; DA SILVEIRA, GIORGIA GOBBI; SOAVE, DANILO FIGUEIREDO; SOARES, FERNANDO AUGUSTO; RIBEIRO-SILVA, ALFREDO. Topoisomerase expression in oral squamous cell carcinoma: relationship with cancer stem cells profiles and lymph node metastasis. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 41, n. 10, p. 762-768, NOV 2012. Web of Science Citations: 6.
OLIVEIRA-COSTA, JOAO PAULO; ZANETTI, JULIANA S.; SILVEIRA, GIORGIA G.; SOAVE, DANILO F.; OLIVEIRA, LUCINEI R.; ZORGETTO, VERONICA A.; SOARES, FERNANDO A.; ZUCOLOTO, SERGIO; RIBEIRO-SILVA, ALFREDO. Differential expression of HIF-1 alpha in CD44(+)CD24(-/) (low) breast ductal carcinomas. DIAGNOSTIC PATHOLOGY, v. 6, AUG 8 2011. Web of Science Citations: 17.
OLIVEIRA-COSTA, JOAO PAULO; DE CARVALHO, ALEX FIORINI; DA SILVEIRA, GIORGIA GOBBI; AMAYA, PETER; WU, YONGQI; PARK, KYOUNG-JOO JENNY; GIGLIOLA, MABEL PINILLA; LUSTBERG, MARYAM; CAVICCHIOLI BUIM, MARCILEI ELIZA; FERREIRA, ELISA NAPOLITANO; et al. Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells. ONCOTARGET, v. 6, n. 25, p. 20902-20920, AUG 28 2015. Web of Science Citations: 45.