María Sol Brassesco Annichini

• Abstract

  Osteosarcoma is the most common pediatric bone tumor primarily found in long bone metaphyses. Current treatment consists of surgical removal and neoadjuvant multimodal chemotherapy. About one third of patients are affected by post-surgery recurrence and distant metastases in the lungs and bones. Only 20% of patients with metastases survive after 5 years. Therefore, it is essential to eluc…

  Functional analysis of HOXD10 in pediatric osteosarcoma with emphasis on invasion and metastasis, AP.R

• Abstract

  The treatment of childhood cancer has evolved significantly in recent decades. However, the cure rates obtained for certain histological subtypes, such as malignant high-grade brain tumors, aggressive subtypes of leukemias and sarcomas are mostly lagging behind. Ewing's sarcoma and osteosarcoma represent the most frequent malignant bone tumors , representing 5-7 % of all cancers affecting…

  Evaluation of rock kinases and their interaction with microRNAs in bone sarcomas of childhood: implications for tumor progression and invasion, AP.R

• Abstract

  Glioblastoma (GBM) is the most biologically aggressive primary brain tumor that accounts for about 50% of gliomas. Despite the improvements in neurosurgery, radiation treatment techniques, and the advent of temozolomide, GBM remains the most common and least curable brain cancer with a median survival of only 14 months. The major contributors to malignancy are the ability of glioma cells …

  NF-Kb inhibition in glioblastoma: in vitro and in vivo effects of DHMEQ in tumor chemoresistence, invasion and progression, AP.JP

• Abstract

  Ependymoma (EPN) is a primary tumor of the Central Nervous System that presents a reddish-gray and well-defined coloration, being categorized as a solid tumor. Even though its origin is still under discussion, it is believed that it originates from glial ependymal cells, while it has also been suggested that an origin is from glial stem cells. EPN has a wide possibility of distribution wi…

  NFkB inhibition as a therapeutic alternative for ZFTA/RELA positive ependymoma, BP.IC

• Abstract

  Childhood cancer is among the leading causes of death in children and adolescents between 0 and 19 years and among them, Ewing's sarcoma is responsible for the death of 2.4 children on average every 1,000,000 every year. This is a very aggressive cancer with high relapse rates. Current treatment is mainly based on a cocktail of chemotherapy drugs, but in many cases the tumor has resistanc…

  Comparative evaluation of antitumor effects of NF-ºB inhibitors DHMEQ, DTCM-g and SEMBL in Ewing's Sarcoma, BP.MS

• Abstract

  Medulloblastoma (MB) is the most common malignant brain tumor in childhood, with its highest peak of incidence at 8 years of age. Currently, MB is classified not only according to prognosis and histological features, but also as a result of its altered molecular pathways. In this way, MB is currently divided into 4 subgroups: WNT (wingless), Shh (sonic hedgehog), Group 3 and Group 4. The …

  Investigation of anti-proliferative and anti-invasive effects of perillyl alcohol on medulloblastoma-SHH and its influence on the modulation Ras and its effectors, BP.MS

(Only some records are available in English at this moment)