CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas from Universidade de São Paulo (1996) and doctorate at Biochemistry from Universidade de São Paulo (2002). Has experience in Biochemistry, acting on the following subjects: pancreatic beta cells, apoptosis, cytokines, er stress and fator de transcricao nf-kappab. (Source: Lattes Curriculum)
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Diabetes Mellitus (DM) is characterized by chronic hyperglycemia that can compromise life quality and span. Since preservation of beta-cell functional mass is a central point for prevention of DM it is of extreme importance a better understanding of the mechanisms involved in this dysfunction. In the past few year our group have being studding the transcription factor HNF4alpha in beta-ce…
Diabetes Mellitus (DM) is a disease characterized by chronic hyperglycemia and alteration in the metabolism of carbohydrate, lipids and protein. There are different forms of the disease, that differ on its etiology, however they have in common the induction of dysfunction and cell death of the pancreatic beta cells. Thus, it is of extreme importance a better understanding of the molecular…
Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the selective destruction of the insulin producing pancreatic beta cells. A better understanding of the molecular mechanisms that regulate apoptosis in beta cells could open new strategies for the treatment (prevention or cure) of this devastating disease. Cytokines such as interleukin (IL)-1b, tumor necrosis factor…
Reactive Oxygen Species (ROS) have an important role as physiological signaling elements of the pancreatic beta cells, as they are relevant in the Glucose-Stimulated Insulin Secretion. NOX enzymes (NADPH Oxidase) are part of a 7-member family in the human genome and they are generators of ROS. Because of its highly reactive nature, which ispotentially dangerous to the cell components, ROS…
Diabetes mellitus (DM) is a group of diseases characterized by chronic hyperglycemia, whose incidence increases every year around the world. In different types of DM, there is a progressive dysfunction and loss of ² cells, resulting from different mechanisms. Among them, the main one is UPR (Unfolded Protein Response), an Endoplasmic Reticulum (ER) stress response that initially aims at r…
Type 1 Diabetes mellitus (DM1) is a pathology that occurs due to autoimmune destruction of pancreatic ß cells, initially without clinical manifestations. This autoimmune response is mediated by different proinflammatory cytokines secreted by an islet immune cell infiltrate, such as interleukin (IL) 1ß, interferon (IFN) and tumor necrosis factor (TNF), in process known as insulitis. In res…
(Only some records are available in English at this moment)
| 4 / 3 | Completed research grants |
| 8 / 5 | Completed scholarships in Brazil |
| 12 / 8 | All research grants and scholarships |
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