CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas from Universidade de São Paulo (1996) and doctorate at Biochemistry from Universidade de São Paulo (2002). Has experience in Biochemistry, acting on the following subjects: pancreatic beta cells, apoptosis, cytokines, er stress and fator de transcricao nf-kappab. (Source: Lattes Curriculum)
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Diabetes mellitus (DM) is a group of metabolic diseases characterized by chronic hyperglycemia that frequently leads to decrease in the quality of life, presenting a significant increase in the number of cases in the last years. Although there are different types of DM, differing by its etiology, beta cell mass loss is a crucial phenomenon for its development. Thus, a better understanding…
Diabetes Mellitus (DM) is characterized by chronic hyperglycemia that can compromise life quality and span. Since preservation of beta-cell functional mass is a central point for prevention of DM it is of extreme importance a better understanding of the mechanisms involved in this dysfunction. In the past few year our group have being studding the transcription factor HNF4alpha in beta-ce…
Diabetes Mellitus (DM) is a disease characterized by chronic hyperglycemia and alteration in the metabolism of carbohydrate, lipids and protein. There are different forms of the disease, that differ on its etiology, however they have in common the induction of dysfunction and cell death of the pancreatic beta cells. Thus, it is of extreme importance a better understanding of the molecular…
A programação científica contará com 5 sessões temáticas, divididas em dois dias (3-4/11), discutindo diferentes aspectos da morte celular, cada apresentação será de 30 min e ao final da sessão teremos 20 min para discussões sobre o tema com os participantes. Essas sessões contarão com palestrantes de importantes universidades internacionais especialistas nos temas abordados. No Simpósio …
(Only some records are available in English at this moment)
Type 1 diabetes mellitus (TDM1) is characterized by pancreatic ¿ cell autoimmune destruction, leading to total insulin absence and consequently chronic hyperglycemia. During this autoimmune process, pancreatic islets are invaded by immune cells, in a process known as insulite. In this pro-inflammatory environment, pro-inflammatory cytokines, such as IL-1¿, TNF e IFN-¿, are secreted. Expos…
Reactive Oxygen Species (ROS) have an important role as physiological signaling elements of the pancreatic beta cells, as they are relevant in the Glucose-Stimulated Insulin Secretion. NOX enzymes (NADPH Oxidase) are part of a 7-member family in the human genome and they are generators of ROS. Because of its highly reactive nature, which ispotentially dangerous to the cell components, ROS…
Diabetes mellitus (DM) is a group of diseases characterized by chronic hyperglycemia, whose incidence increases every year around the world. In different types of DM, there is a progressive dysfunction and loss of ² cells, resulting from different mechanisms. Among them, the main one is UPR (Unfolded Protein Response), an Endoplasmic Reticulum (ER) stress response that initially aims at r…
Type 1 Diabetes mellitus (DM1) is a pathology that occurs due to autoimmune destruction of pancreatic ß cells, initially without clinical manifestations. This autoimmune response is mediated by different proinflammatory cytokines secreted by an islet immune cell infiltrate, such as interleukin (IL) 1ß, interferon (IFN) and tumor necrosis factor (TNF), in process known as insulitis. In res…
(Only some records are available in English at this moment)