Associate professor of Neurology at UNICAMP. Research areas: Neuromuscular diseases, Clinical neurophysiology and Neurogenetics. (Source: Lattes Curriculum)
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Motor neuronopathies and axonopathies represent a large and heterogeneous group of neurological disorders characterized by primary damage either to the cell bodies or to the axonal extensions of Motor Neurons (MN). They may affect upper or lower MN. On clinical grounds, these conditions may affect children and adults, but in general follow a chronic course and deeply impact morbi-mortalit…
The central biological questions of our RIDC is the investigation of basic mechanisms that lead to epilepsy and stroke and the injury mechanisms that follow the disease onset and progression, and are related to prevention, treatment and rehabilitation. Our goals are to develop new methods and techniques to improve the understanding of mechanisms of damage, plasticity and repair in epileps…
Sensory neuronopathies (SN) represent a specific subgroup of peripheral nervous system disorders characterized by selective damage to dorsal root ganglia neurons. In contrast to polyneuropathies, SN usually present with multifocal non-length-dependent sensory deficits, ataxia and normal muscle strength. In the last few years, SN have been increasingly recognized in clinical practice assoc…
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease that causes destruction of motor neurons, both superior (SMN) and inferior (IMN), and that causes progressive paralysis of the somatic muscles. The disease is presented in two forms: sporadic (sALS), more frequent, around 90% of cases; and familial (fALS), 5-10% of cases. Regarding fALS, several genetic alterations …
Duchenne Muscular Dystrophy (DMD) is the most frequent muscular dystrophy in children, segregating as an X-linked recessive trait, in which the dystrophin gene is mutated. As a result, there is a progressive degeneration of skeletal muscles. Metabolic syndrome, in turn, is determined from risk factors for cardiovascular diseases, such as dyslipidemia, abnormal glucose regulation, central …
Friedreich s Ataxia (FRDA) is the most common autosomal recessive inheritance ataxia in the world, and spinal cord atrophy is a classic finding in this disease. Magnetic resonance imaging studies, based on manual or semi-automatic methods, already confirm this finding in vivo. However, with the advancement of computational methods, automated segmentation techniques and new imaging sequenc…
Amyotrophic Lateral Sclerosis is the third most frequent neurodegenerative disorder in adults and may have a familial or sporadic origin. This disease affects the motor neurons of the brain and spinal cord, causing progressive and irreversible motor paralysis. Death usually occurs in approximately 3 to 5 years after diagnosis due to respiratory insufficiency and yet, there is no preventio…
(Only some records are available in English at this moment)
Inherited cerebellar ataxias (ICA) represent a heterogeneous group of neurodegenerative disorders that share cerebellar ataxia as the core clinical finding. Pathologically, this group of diseases is characterized by severe neuronal loss in the cerebellum and brainstem. Cervical spinal cord atrophy is a hallmark of these disorders. This is indeed confirmed by quantitative neuroimaging data…
Sensory neuron diseases (SND) constitute a subgroup of peripheral nervous system diseases whose most striking feature is the primary degeneration of dorsal root ganglia. SND patients have sensory deficits in many parts of the body, which leads to impairment of motor coordination, although their primary motor brain areas remain intact. The effects of SND on the central nervous system have …
Voxel-based analyses of MRI datasets are widely used for quantitative analyses in neuroscience. This technique, unfortunately, has poor statistical power and high noise level leading to a low sensitivity for detection of abnormalities. In contrast, ROI-based analyses attenuate these shortcomings by grouping the voxels corresponding to the same anatomical structure, reducing, thereby, the …
| 2 / 2 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 16 / 13 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 24 / 21 | All research grants and scholarships |
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CV Lattes
ORCID