Abstract
Myelodysplastic syndrome (MDS) is a heterogeneous group of hematological neoplasms characterized by ineffective hematopoiesis, cytopenias and risk of progression to acute myeloid leukemia and which mainly affects the elderly population. Mitochondrial dysfunction and stem cell exhaustion are two hallmarks of aging commonly found in MDS. Clonal hematopoiesis is perpetuated by inflammation a…