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Maria Cristina Nonato Costa

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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

graduation at Física São Carlos from Universidade de São Paulo (1990), master's at Física Aplicada - Sâo Carlos from Universidade de São Paulo (1993), doctorate at Chemical Biology from University of Manchester (1996) and doctorate at Física Aplicada São Carlos from Universidade de São Paulo (1997). He is currently professor doutor at Faculdade de Ciências Farmacêuticas de Ribeirão Preto-USP. Has experience in Byophysics, focusing on Byophysics, acting on the following subjects: trypanosoma cruzi, leishmania major, diidroorotato desidrogenase, cristalografia and proteínas. (Source: Lattes Curriculum)

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FAPESP support in numbers * Updated October 12, 2019
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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (27)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications26
Citations176
Cit./Article6.8
Data from Web of Science

PADUA, RICARDO A. P.; TOMALERI, GIOVANI P.; REIS, RENATA A. G.; DAVID, JULIANA S.; SILVA, VALERIA C.; PINHEIRO, MATHEUS P.; NONATO, MARIA CRISTINA. ThermoFMN - A Thermofluor Assay Developed for Ligand-Screening as an Alternative Strategy for Drug Discovery. Journal of the Brazilian Chemical Society, v. 25, n. 10, p. 1864+, . Web of Science Citations: 7. (08/11644-8, 11/14269-6, 07/08703-0, 12/25075-0, 11/23504-9)

PINHEIRO, MATHEUS PINTO; EMERY, FLAVIO DA SILVA; CRISTINA NONATO, M.. Target Sites for the Design of Anti-trypanosomatid Drugs Based on the Structure of Dihydroorotate Dehydrogenase. CURRENT PHARMACEUTICAL DESIGN, v. 19, n. 14, p. 2615-2627, . Web of Science Citations: 18. (09/14184-0, 07/08703-0)

PEREIRA DE PADUA, RICARDO AUGUSTO; NONATO, MARIA CRISTINA. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of recombinant human fumarase. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, v. 70, n. 1, p. 120-122, . Web of Science Citations: 4. (08/11644-8, 08/08262-6)

COUTO‚ S.G.; NONATO‚ M.C.; COSTA-FILHO‚ A.J.. Defects in vesicle core induced by Escherichia coli dihydroorotate dehydrogenase. BIOPHYSICAL JOURNAL, v. 94, n. 5, p. 1746-1753, . (03/09859-2)

FELICIANO, PATRICIA R.; DRENNAN, CATHERINE L.; CRISTINA NONATO, M.. Crystal structure of an Fe-S cluster-containing fumarate hydratase enzyme from Leishmania major reveals a unique protein fold. Proceedings of the National Academy of Sciences of the United States of America, v. 113, n. 35, p. 9804-9809, . Web of Science Citations: 7. (08/08262-6, 11/19674-6, 09/10454-3)

FELICIANO, PATRICIA R.; RUSTIGUEL, JOANE K.; SOARES, RICARDO O. S.; SAMPAIO, SUELY V.; CRISTINA NONATO, M.. Crystal structure and molecular dynamics studies of L-amino acid oxidase from Bothrops atrox. Toxicon, v. 128, p. 50-59, . Web of Science Citations: 6. (13/14988-8, 09/10454-3, 15/24010-0)

PERES, RAPHAEL S.; SANTOS, GABRIELA B.; CECILIO, NERRY T.; JABOR, VALQURIA A. P.; NIEHUES, MICHAEL; TORRES, BRUNA G. S.; BUQUI, GABRIELA; SILVA, CARLOS H. T. P.; DALLA COSTA, TERESA; LOPES, NORBERTO P.; et al. Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis. ARTHRITIS RESEARCH & THERAPY, v. 19, . Web of Science Citations: 5. (09/54014-7, 14/50265-3, 12/20990-2, 12/25075-0, 13/08216-2)

SARTIM, MARCO A.; PINHEIRO, MATHEUS P.; DE PADUA, RICARDO A. P.; SAMPAIO, SUELY V.; CRISTINA NONATO, M.. Structural and binding studies of a C-type galactose-binding lectin from Bothrops jararacussu snake venom. Toxicon, v. 126, p. 59-69, . Web of Science Citations: 5. (11/23236-4, 14/19127-3, 14/11266-4)

REIS, RENATA A. G.; CALIL, FELIPE ANTUNES; FELICIANO, PATRICIA ROSA; PINHEIRO, MATHEUS PINTO; NONATO, M. CRISTINA. The dihydroorotate dehydrogenases: Past and present. Archives of Biochemistry and Biophysics, v. 632, n. SI, p. 175-191, . Web of Science Citations: 14. (11/23504-9, 07/08703-0, 12/25075-0)

GARCIA REIS, RENATA ALMEIDA; LORENZATO, JR., EDER; SILVA, VALERIA CRISTINA; NONATO, MARIA CRISTINA. Recombinant production, crystallization and crystal structure determination of dihydroorotate dehydrogenase from Leishmania (Viannia) braziliensis. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, v. 71, n. 5, SI, p. 547-552, . Web of Science Citations: 2. (11/23504-9, 12/25075-0, 14/01257-8)

AZEREDO, LUIS FELIPE S. P.; COUTINHO, JULIA P.; JABOR, VALQUIRIA A. P.; FELICIANO, PATRICIA R.; NONATO, MARIA CRISTINA; KAISER, CARLOS R.; MENEZES, CARLA MARIA S.; HAMMES, AMANDA S. O.; CAFFARENA, ERNESTO RAUL; HOELZ, LUCAS V. B.; et al. Evaluation of 7-arylaminopyrazolo[1,5-a]pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 126, p. 72-83, . Web of Science Citations: 16. (12/25075-0)

MAETANI, MICAH; KATO, NOBUTAKA; JABOR, VALQUIRIA A. P.; CALIL, FELIPE A.; NONATO, MARIA CRISTINA; SCHERER, CHRISTINA A.; SCHREIBER, STUART L.. Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P-falciparum Dihydroorotate Dehydrogenase. ACS Medicinal Chemistry Letters, v. 8, n. 4, p. 438-442, . Web of Science Citations: 15. (12/25075-0)

RUSTIGUEL, JOANE K.; KUMAGAI, PATRICIA S.; DIAS-BARUFFI, MARCELO; COSTA-FILHO, ANTONIO J.; NONATO, MARIA CRISTINA. Recombinant expression, purification and preliminary biophysical and structural studies of C-terminal carbohydrate recognition domain from human galectin-4. Protein Expression and Purification, v. 118, p. 39-48, . Web of Science Citations: 3. (10/17662-8, 10/16153-2, 11/21811-1, 11/21767-2)

REIS, RENATA A. G.; FERREIRA, PATRICIA; MEDINA, MILAGROS; NONATO, M. CRISTINA. The mechanistic study of Leishmania major dihydro-orotate dehydrogenase based on steady- and pre-steady-state kinetic analysis. Biochemical Journal, v. 473, n. 5, p. 651-660, . Web of Science Citations: 5. (11/23504-9, 12/25075-0)

RUSTIGUEL, JOANE K.; SOARES, RICARDO O. S.; MEISBURGER, STEVE P.; DAVIS, KATHERINE M.; MALZBENDER, KRISTINA L.; ANDO, NOZOMI; DIAS-BARUFFI, MARCELO; NONATO, MARIA CRISTINA. Full-length model of the human galectin-4 and insights into dynamics of inter-domain communication. SCIENTIFIC REPORTS, v. 6, . Web of Science Citations: 3. (11/21811-1, 10/16153-2)

DE PADUA, RICARDO A. P.; KIA, ALI MARTIN; COSTA-FILHO, ANTONIO J.; WILKINSON, SHANE R.; NONATO, M. CRISTINA. Characterisation of the fumarate hydratase repertoire in Trypanosoma cruzi. International Journal of Biological Macromolecules, v. 102, p. 42-51, . Web of Science Citations: 3. (08/08262-6, 08/11644-8, 15/18390-5)

LEWIS, TIMOTHY A.; SYKES, DAVID B.; LAW, JASON M.; MUNOZ, BENITO; RUSTIGUEL, JOANE K.; NONATO, MARIA CRISTINA; SCADDEN, DAVID T.; SCHREIBER, STUART L.. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Medicinal Chemistry Letters, v. 7, n. 12, p. 1112-1117, . Web of Science Citations: 15. (12/25075-0)

CORDEIRO, ARTUR T.; FELICIANO, PATRICIA R.; PINHEIRO, MATHEUS P.; CRISTINA NONATO, M.. Crystal structure of dihydroorotate dehydrogenase from Leishmania major. Biochimie, v. 94, n. 8, p. 1739-1748, . Web of Science Citations: 23.

FELICIANO, PATRICIA R.; GUPTA, SHREEDHARA; DYSZY, FABIO; DIAS-BARUFFI, MARCELO; COSTA-FILHO, ANTONIO J.; MICHELS, PAUL A. M.; NONATO, M. CRISTINA. Fumarate hydratase isoforms of Leishmania major: Subcellular localization, structural and kinetic properties. International Journal of Biological Macromolecules, v. 51, n. 1-2, p. 25-31, . Web of Science Citations: 15. (08/08262-6, 09/10454-3, 09/15810-2, 06/05538-5)

ALVES, RAQUEL MELO; FELICIANO, PATRICIA ROSA; SAMPAIO, SUELY VILELA; NONATO, MARIA CRISTINA. A rational protocol for the successful crystallization of l-amino-acid oxidase from Bothrops atrox. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, v. 67, n. 4, p. 475-478, . Web of Science Citations: 2. (05/54855-0, 09/10454-3)

RUSTIGUEL, JOANE KATHELEN; PINHEIRO, MATHEUS PINTO; ULIAN ARAUJO, ANA PAULA; NONATO, MARIA CRISTINA. Crystallization and preliminary X-ray diffraction analysis of recombinant chlorocatechol 1,2-dioxygenase from Pseudomonas putida. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, v. 67, n. 4, p. 507-509, . Web of Science Citations: 3. (08/01743-9, 08/07077-0)

CALIL, FELIPE A.; DAVID, JULIANA S.; CHIAPPETTA, ESTELA R. C.; FUMAGALLI, FERNANDO; MELLO, RODRIGO B.; LEITE, FRANCO H. A.; CASTILHO, MARCELO S.; EMERY, FLAVIO S.; CRISTINA NONATO, M.. Ligand-based design, synthesis and biochemical evaluation of potent and selective inhibitors of Schistosoma mansoni dihydroorotate dehydrogenase. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 167, p. 357-366, . Web of Science Citations: 0. (15/25099-5, 17/21146-4, 15/06588-5)

WIEZEL, GISELE A.; RUSTIGUEL, JOANE K.; MORGENSTERN, DAVID; ZOCCAL, KARINA E.; FACCIOLI, LUCIA H.; CRISTINA NONATO, M.; UEBERHEIDE, BEATRIX; ARANTES, ELIANE C.. Insights into the structure, function and stability of bordonein-L, the first L-amino acid oxidase from Crotalus durissus terrificus snake venom. Biochimie, v. 163, p. 33-49, . Web of Science Citations: 0. (14/03332-7, 11/23236-4, 15/24010-0, 14/23285-3, 14/06170-8, 14/07125-6)

CHIBLI, LUCAS A.; SCHMIDT, THOMAS J.; CRISTINA NONATO, M.; CALIL, FELIPE A.; DA COSTA, FERNANDO B.. Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 157, p. 852-866, . Web of Science Citations: 3. (15/25099-5, 14/26866-7, 14/01443-6, 16/18579-3)

FELICIANO, PATRICIA R.; DRENNAN, CATHERINE L.; NONATO, MARIA CRISTINA. Crystal Structures of Fumarate Hydratases from Leishmania major in a Complex with Inhibitor 2-Thiomalate. ACS Chemical Biology, v. 14, n. 2, p. 266-275, . Web of Science Citations: 0. (13/14988-8, 08/08262-6, 14/22246-4)

NONATO, M. CRISTINA; DE PADUA, RICARDO A. P.; DAVID, JULIANA S.; REIS, RENATA A. G.; TOMALERI, GIOVANI P.; PEREIRA, HUMBERTO D'MUNIZ; CALIL, FELIPE A.. Structural basis for the design of selective inhibitors for Schistosoma mansoni dihydroorotate dehydrogenase. Biochimie, v. 158, p. 180-190, . Web of Science Citations: 2. (15/25099-5, 11/14269-6)

AJALLA ALEIXO, MARIANA A.; RANGEL, VICTOR L.; RUSTIGUEL, JOANE K.; DE PADUA, RICARDO A. P.; NONATO, MARIA CRISTINA. Structural, biochemical and biophysical characterization of recombinant human fumarate hydratase. FEBS Journal, v. 286, n. 10, p. 1925-1940, . Web of Science Citations: 0. (12/25075-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FELICIANO, Patrícia Rosa. Clonagem, expressão heteróloga e caracterização do gene LmjF24.0320 que codifica a enzima fumarato hidratase em Leishmania major. 2009. Dissertação (Mestrado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (06/05538-5)

PINHEIRO, Matheus Pinto. Estudos cristalográficos da enzima diidroorotato desidrogenase de \'Trypanosoma Cruzi\'. 2008. Dissertação (Mestrado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (05/58008-0)

BONALUMI, Joane Kathelen Rustiguel. Estudos cristalográficos da enzima clorocatecol 1,2-dioxigenase de Pseudomonas putida. 2010. Dissertação (Mestrado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (08/01743-9)

PINHEIRO, Matheus Pinto. Planejamento de inibidores das enzimas diidroorotato desidrogenase de Trypanosoma cruzi e Leishmania major. 2012. Tese (Doutorado) – Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (07/08703-0)

BONALUMI, Joane Kathelen Rustiguel. Caracterização estrutural e avaliação de aspectos funcionais de galectinas humanas do grupo tandem-repeat. 2014. Tese (Doutorado) – Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (10/16153-2)

JUNIOR, Eder Lorenzato. Desenvolvimento de uma plataforma modelo para a busca de ligantes com potencial leishmanicida baseado na inibição seletiva da enzima diidroorotato desidrogenase. 2016. Dissertação (Mestrado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (14/01257-8)

REIS, Renata Almeida Garcia. Estudo do mecanismo e inibição da enzima diidroorotato desidrogenase de Leishmania major. 2016. Tese (Doutorado) – Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (11/23504-9)

PÁDUA, Ricardo Augusto Pereira de. Caracterização estrutural e funcional das isoformas da enzima fumarato hidratase de Trypanosoma cruzi. 2014. Tese (Doutorado) – Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (08/11644-8)

FELICIANO, Patrícia Rosa. Estudos da correlação entre estrutura e função da enzima fumarato hidratase em Leishmania major. 2013. Tese (Doutorado) – Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (09/10454-3)

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