Carlota de Oliveira Rangel Yagui
CV Lattes
GoogleMyCitations
ResearcherID
ORCID
Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Carlota de Oliveira Rangel Yagui in research grants and scholarships supported by FAPESP.
| News published in Agência FAPESP Newsletter about the researcher |
| Alternative process purifies proteins used as biosensors |
- N-terminal pegylation of proteins and purification by aqueous two-phase systems, AP.R
Abstract
Biological medicines represent an important breakthrough of the pharmaceutical industry that generated considerable income to patent holders of the recent marketed biomolecules. Nonetheless, the need to keep competitive and to solve intrinsic problems of protein-based biodrugs, such as immunogenicity and biological instability, has led to the development of biobetters as follow-on biodr...
- Synthesis and nanotechnological development of miltefosine homocholinic analogs, AP.R
Abstract
Chemotherapeutic treatment of cancer with drugs such as alkylating agents, antimetabolites and antimitotics is associated to severe toxicity, damaging health cells and compromising many organs. Alkylphosphocholines (APCs), on the other hand, are a promising class of antitumor agents since they act in the cell membrane and in protein kinases inhibition. APCs prototype corresponds to Milt...
- Development of alkylphosphocholines as potential antineoplastic molecules, AP.R
- 3rd conference on drug discovery & therapy, AR.EXT
(Only some records are available in English at this moment)
- Development of novel platforms for pegylation of proteins with therapeutic potential using microfluidics, BP.PD
Abstract
PEGylation of therapeutic proteins has been employed to improve biopharmaceuticals clinical performance (considering immunogenicity and plasma half-life). Despite the advantages of PEGylated biopharmaceuticals, the parallel reactions between reactive PEG and the functional amino acids of proteins result in heterogeneity of PEGylated species. This problem associated with the hydrolysis o...
- Production and characterization of lyposomes and polymersomes for encapsulation of L-asparaginase, BP.IC
Abstract
Cancer is of the main causes of mortality in the world. Among them, acute lymphoblastic leukemia has a high incidence in children. Its treatment includes the enzyme L-asparagine, which is the focus of this project. In order to tackle problems such as high immunogenicity and low biodisponibility, Nanotechnology principles are being used to target the tumor cells improving the treatment s...
- Development of polymersomes permeable to L-asparagine for encapsulation of L-asparaginase, BP.PD
Abstract
This proposal is a sub-project of the thematic project Fapesp No 2013/086 17-7 entitled "Production of extracellular L-asparaginase: from bioprospecting to the engineering of an antileukemic biopharmaceutical" headed by Prof. Adalberto Pessoa Jr., and is included in the workplan "Nanotechnological development of L- asparaginase for pharmaceutical formulation", under the responsibility o...
- Development and evaluation of pre-clinical safety of polymeric nanostructures for encapsulation of photolyase, BP.PD
Abstract
In 2015, non-melanoma skin cancer (basal cell carcinoma and squamous cell carcinoma) was the highest incidence in the Brazilian population. Ultraviolet (UV) radiation is the main cause of this cancer and estimates point that 182,000 people in Brazil received this diagnosis in 2015, reinforcing the problem. Topical application of DNA repair enzymes, such as photolyase, is a convenient s...
- Development and characterization of poly(ethylene glycol) methyl ether-Block-Poly (D,L-Lactide) (PEG-PLA) Polymersomes for the release of recombinant L-asparaginase, BP.DR
Abstract
This proposal is a subproject of the thematic project Fapesp No 2013/08617-7, entitled "Production of extracellular L-asparaginase: from bioprospecting to the engineering of an antileukemic biopharmaceutical" conceived by a multidisciplinary group of researchers headed by Prof. Adalberto Pessoa Jr., and is included in the workplan "Nanotechnological development of L- asparaginase for ph...
(Only some records are available in English at this moment)
- Development of porous polymersomes with amphotericin B channels for L-asparaginase encapsulation, BE.EP.PD
Abstract
The present proposal is included in the context of project Fapesp 2016/16221-4, in which a research internship abroad was planned at University College London (UCL) under supervision of Prof. Giuseppe Battaglia. The focus of this project is the development of novel nanocarriers containing the enzyme L-asparaginase (ASNase). This enzyme has been used to treat acute lymphoblastic leukaemi...
- Encapsulation of L-asparaginase in polymersomes by pH-switch method and electroporation, BE.EP.DR
Abstract
Nanostructures for L-Asparaginase (ASNase) drug delivery could overcome its fast plasma clearance by encapsulating this enzyme in an internal compartment. Additionally, this strategy allows either the stealth and/or controlled release of the protein. Among different nanotechnological approaches for proteins delivery, polymersomes appear to be very promising. Polymersomes are formed thro...
| 1 / 1 | Ongoing research grants |
| 4 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 14 / 12 | Completed scholarships in Brazil |
| 3 / 2 | Completed scholarships abroad |
| 24 / 21 | All research grants and scholarships |
| Associated processes | |
- Alexsandra Conceição Apolinário
- Cecilia Zorzi Bueno
- Leoberto Costa Tavares
- Raquel Brandão Haga
- Lívia Regina Brandeburski
- Letícia Costa Tomazelli
- Ellen Muniz Shergue
- Marcela de Siqueira Cardoso Silva
- Arthur Bonfá Fernandes
- Nathália Barros Militão dos Santos
- João Pedro Nunes Gonçalves
- Gustavo Muneo Takata
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 16 |
| Citations | 91 |
| Cit./Article | 5.7 |
| Data from Web of Science | |
CARDOSO SILVA, MARCELA DE SIQUEIRA; SANTOS-EBINUMA, VALERIA DE CARVALHO; LOPES, ANDRE MORENI; RANGEL-YAGUI, CARLOTA DE OLIVEIRA. Dextran sulfate/Triton X two-phase micellar systems as an alternative first purification step for clavulanic acid. Fluid Phase Equilibria, v. 399, p. 80-86, AUG 15 2015. Web of Science Citations: 5. (10/02324-0, 11/18088-6)
DE SA, MATHEUS M.; RANGEL-YAGUI, CARLOTA O.. Molecular Determinants for the Binding Mode of Alkylphosphocholines in the C2 Domain of PKC alpha. MOLECULAR INFORMATICS, v. 34, n. 2-3, p. 84-96, FEB 2015. Web of Science Citations: 1. (11/02189-8)
PACHIONI, JULIANA DE ALMEIDA; MAGALHAES, JULIANA GALLOTTINI; CARDOSO LIMA, ELYS JULIANE; BUENO, LUCIANA DE MOURA; BARBOSA, JOYCE FERREIRA; DE SA, MATHEUS MALTA; RANGEL-YAGUI, CARLOTA DE OLIVEIRA. Alkylphospholipids - A Promising Class of Chemotherapeutic Agents with a Broad Pharmacological Spectrum. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, v. 16, n. 5, p. 742-759, 2013. Web of Science Citations: 35. (11/02189-8)
APOLINARIO, ALEXSANDRA CONCEICAO; MAGON, MONIKA S.; PESSOA JR, ADALBERTO; RANGEL-YAGUI, CARLOTA DE OLIVEIRA. Challenges for the Self-Assembly of Poly(Ethylene Glycol)-Poly(Lactic Acid) (PEG-PLA) into Polymersomes: Beyond the Theoretical Paradigms. NANOMATERIALS, v. 8, n. 6, JUN 2018. Web of Science Citations: 3. (13/08617-7, 14/10456-4)
SANTOS, JOAO H. P. M.; CARRETERO, GUSTAVO; VENTURA, SONIA P. M.; CONVERTI, ATTILIO; RANGEL-YAGUI, CARLOTA O.. PEGylation as an efficient tool to enhance cytochrome c thermostability: a kinetic and thermodynamic study. JOURNAL OF MATERIALS CHEMISTRY B, v. 7, n. 28, p. 4432-4439, JUL 28 2019. Web of Science Citations: 0. (16/22065-5)
HERRERA BELEN, LISANDRA; BELTRAN LISSABET, JORGE; RANGEL-YAGUI, CARLOTA DE OLIVEIRA; EFFER, BRIAN; MONTEIRO, GISELE; PESSOA, ADALBERTO; FARIAS AVENDANO, JORGE G.. A structural in silico analysis of the immunogenicity of L-asparaginase from Escherichia coli and Erwinia carotovora. BIOLOGICALS, v. 59, p. 47-55, MAY 2019. Web of Science Citations: 1. (16/22065-5)
PACHIONI-VASCONCELOS, JULIANA DE ALMEIDA; LOPES, ANDRE MORENI; APOLINARIO, ALEXSANDRA CONCEICAO; VALENZUELA-OSES, JOHANNA KARINA; RIBEIRO COSTA, JULIANA SOUZA; NASCIMENTO, LAURA DE OLIVEIRA; PESSOA, JR., ADALBERTO; SOUZA BARBOSA, LEANDRO RAMOS; RANGEL-YAGUI, CARLOTA DE OLIVEIRA. Nanostructures for protein drug delivery. BIOMATERIALS SCIENCE, v. 4, n. 2, p. 205-218, 2016. Web of Science Citations: 26. (13/16588-7, 13/08617-7, 14/01983-0, 14/10456-4)
VALENZUELA-OSES, JOHANNA K.; GARCIA, MONICA C.; FEITOSA, VALKER A.; PACHIONI-VASCONCELOS, JULIANA A.; GOMES-FILHO, SANDRO M.; LOURENCO, FELIPE R.; CERIZE, NATALIA N. P.; BASSERES, DANIELA S.; RANGEL-YAGUI, CARLOTA O.. Development and characterization of miltefosine-loaded polymeric micelles for cancer treatment. Materials Science & Engineering C-Materials for Biological Applications, v. 81, p. 327-333, DEC 1 2017. Web of Science Citations: 7. (14/01983-0)
ALEXSANDRA CONCEIÇÃO APOLINÁRIO; JULIANA DE ALMEIDA PACHIONI-VASCONCELOS; ADALBERTO PESSOA JR.; CARLOTA DE OLIVEIRA RANGEL-YAGUI. POLIMEROSSOMOS VERSUS LIPOSSOMOS: A EVOLUÇÃO DA “BALA MÁGICA”. Química Nova, v. 40, n. 7, p. -, Ago. 2017. (13/08617-7, 14/10456-4)
SANTOS, JOAO H. P. M.; CARRETERO, GUSTAVO; COUTINHO, JOAO A. P.; RANGEL-YAGUI, CARLOTA O.; VENTURA, SONIA P. M.. Multistep purification of cytochrome c PEGylated forms using polymer-based aqueous biphasic systems. GREEN CHEMISTRY, v. 19, n. 24, p. 5800-5808, DEC 21 2017. Web of Science Citations: 4. (16/22065-5)
MEDEIROS DE BRITO, ANNA EMMANUELA; PESSOA, JR., ADALBERTO; CONVERTI, ATTILIO; RANGEL-YAGUI, CARLOTA DE OLIVEIRA; DA SILVA, JOSE ALEXSANDRO; APOLINARIO, ALEXSANDRA CONCEICAO. Poly (lactic-co-glycolic acid) nanospheres allow for high L-asparaginase encapsulation yield and activity. Materials Science & Engineering C-Materials for Biological Applications, v. 98, p. 524-534, MAY 2019. Web of Science Citations: 1. (17/08123-5, 13/08617-7, 14/10456-4)
APOLINARIO, ALEXSANDRA CONCEICAO; FERRARO, RAFAEL BERTELLI; DE OLIVEIRA, CAMILA AREIAS; PESSOA, JR., ADALBERTO; RANGEL-YAGUI, CARLOTA DE OLIVEIRA. Quality-by-Design Approach for Biological API Encapsulation into Polymersomes Using ``Off-the-Shelf{''} Materials: a Study on L-Asparaginase. AAPS PHARMSCITECH, v. 20, n. 6, AUG 2019. Web of Science Citations: 0. (17/03811-0, 13/08617-7, 16/03887-4, 14/10456-4)
FEITOSA, VALKER ARAUJO; DE ALMEIDA, VINICIUS CORDEIRO; MALHEIROS, BARBARA; DE CASTRO, RAPHAEL DIAS; SOUZA BARBOSA, LEANDRO RAMOS; PEREIRA CERIZE, NATALIA NETO; RANGEL-YAGUI, CARLOTA DE OLIVEIRA. Polymeric micelles of pluronic F127 reduce hemolytic potential of amphiphilic drugs. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 180, p. 177-185, AUG 1 2019. Web of Science Citations: 0. (15/15822-1, 14/01983-0)
TORRES-OBREQUE, KARIN; MENEGUETTI, GIOVANNA PASTORE; CUSTODIO, DEBORA; MONTEIRO, GISELE; PESSOA-JUNIOR, ADALBERTO; DE OLIVEIRA RANGEL-YAGUI, CARLOTA. Production of a novel N-terminal PEGylated crisantaspase. Biotechnology and Applied Biochemistry, v. 66, n. 3, p. 281-289, MAY-JUN 2019. Web of Science Citations: 1. (16/22065-5, 13/08617-7)
PICADO MADALENA SANTOS, JOAO HENRIQUE; TORRES-OBREQUE, KARIN MARIANA; MENEGUETTI, GIOVANNA PASTORE; AMARO, BEATRIZ PANICHI; RANGEL-YAGUI, CARLOTA OLIVEIRA. Protein PEGylation for the design of biobetters: from reaction to purification processes. Brazilian Journal of Pharmaceutical Sciences, v. 54, n. SI, 2018. Web of Science Citations: 2. (16/22065-5)
MENEGUETTI, GIOVANNA PASTORE; PICADO MADALENA SANTOS, JOAO HENRIQUE; TORRES OBREQUE, KARIN MARIANA; VAZ BARBOSA, CHRISTIANO MARCELLO; MONTEIRO, GISELE; POLISELLI FARSKY, SANDRA HELENA; DE OLIVEIRA, ADRIANO MARIM; ANGELI, CLAUDIA BLANES; PALMISANO, GIUSEPPE; MARQUES VENTURA, SONIA PATRICIA; et al. Novel site-specific PEGylated L-asparaginase. PLoS One, v. 14, n. 2, FEB 12 2019. Web of Science Citations: 2. (16/22065-5, 13/08617-7)
BRUMANO, LARISSA PEREIRA; SANTOS DA SILVA, FRANCISCO VITOR; COSTA-SILVA, TALES ALEXANDRE; APOLINARIO, ALEXSANDRA CONCEICAO; PICADO MADALENA SANTOS, JOAO HENRIQUE; KLEINGESINDS, EDUARDO KREBS; MONTEIRO, GISELE; RANGEL-YAGUI, CARLOTA DE OLIVEIRA; BENYAHIA, BRAHIM; PESSOA JUNIOR, ADALBERTO. Development of L-Asparaginase Biobetters: Current Research Status and Review of the Desirable Quality Profiles. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, v. 6, JAN 10 2019. Web of Science Citations: 3. (17/21819-9, 15/07749-2, 18/03734-9, 13/08617-7, 14/10456-4)