CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Prof. Carlota Rangel Yagui is a full professor at the Department of Biochemical and Pharmaceutical Technology of the School of Pharmaceutical Sciences, University of São Paulo (FCF-USP) and a Visiting Professor at the Institute of Pharmaceutical Sciences of King's College London (2022-2027). She has a Bachelor's Degree in Pharmacy and Biochemistry (1997) from USP and a PhD. in Biochemical and Pharmaceutical Technology from the same institution (2003), with an 18 months period as a visiting student a the Massachusetts Institute of Technology (MIT-USA) from July 2001 to December 2002. Prof. Rangel-Yagui has coordinated the Graduate Program in Biochemical and Pharmaceutical Technology for five years (2015-2019 and 2021-2022) and was the vice-president of the Graduate Committee at FCF/USP from 2018-2020). Currently, she is the Editor in Chief of the Brazilian Journal of Pharmaceutical Sciences, a member of the Brazilian Association of Pharmaceutical Sciences, member of the Controlled Release Society and the vice-president of the Controlled Release Society Brazilian Local Chapter. Prof. Rangel-Yagui coordinates the Laboratory of Nanobiotechnology of the University of São Paulo (@nanobio.Lab), focused on nanobiotechnology, self-aggregated nanostructure, protein PEGylation and aqueous biphasic systems for protein purification. (Source: Lattes Curriculum)
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The increasing exposition to ultraviolet (UV) radiation has been causing health and aesthetic problems, both acutely (hyperpigmentation, sunburn, inflammatory reactions, photoallergy and photosensitivity) and chronically (skin cancer, immunosuppression and photoaging). Chronic effects are in part related to UV-induced damage to DNA and enzymes such as photolyase, capable of increasing the…
Cutaneous aging is a natural biologic process, however it can be accelerated by several factor such as exposition to ultraviolet (UV) A radiation. Among the factors leading to aging, one can highlight oxidative stress and the enzyme catalase is one of the endogenous mechanisms to prevent this process by reactive oxygen species neutralization. In this sense, an additional supply of catalas…
Biological medicines represent an important breakthrough of the pharmaceutical industry that generated considerable income to patent holders of the recent marketed biomolecules. Nonetheless, the need to keep competitive and to solve intrinsic problems of protein-based biodrugs, such as immunogenicity and biological instability, has led to the development of biobetters as follow-on biodrug…
Chemotherapeutic treatment of cancer with drugs such as alkylating agents, antimetabolites and antimitotics is associated to severe toxicity, damaging health cells and compromising many organs. Alkylphosphocholines (APCs), on the other hand, are a promising class of antitumor agents since they act in the cell membrane and in protein kinases inhibition. APCs prototype corresponds to Miltef…
(Only some records are available in English at this moment)
Cancer is responsible for a large proportion of diseases in the Americas, second only to cardiovascular diseases. Among them, skin cancer accounts for 30% of malignant tumors registered in Brazil. Excessive exposure to ultraviolet ligth from the sun is one of the main causes responsible for the development of skin cancer, as it causes oxidative stressin the cells, favoring changes in DNA …
The area of nanotechnology has been actively explored for the purposes of prevention, diagnosis and treatment of different diseases. The development of new drug delivery systems accounts for around 75% of product sales in the field of nanomedicine. Although revolutionary and growing in the current market, drug delivery systems still offer challenges, especially when it comes to encapsulat…
Skin is the first barrier against chemical, physical and biological aggression; it is constantly exposed to the sunlight and therefore to ultraviolet (UV) radiation that can cause premature aging and skin cancer. As a consequence, there is a search for novel alternatives to protect the skin against UV radiation. Once photoaging is partially related to UV- induced damage to DNA, enzymes su…
PEGylation of therapeutic proteins has been employed to improve biopharmaceuticals clinical performance (considering immunogenicity and plasma half-life). Despite the advantages of PEGylated biopharmaceuticals, the parallel reactions between reactive PEG and the functional amino acids of proteins result in heterogeneity of PEGylated species. This problem associated with the hydrolysis of …
Cancer is of the main causes of mortality in the world. Among them, acute lymphoblastic leukemia has a high incidence in children. Its treatment includes the enzyme L-asparagine, which is the focus of this project. In order to tackle problems such as high immunogenicity and low biodisponibility, Nanotechnology principles are being used to target the tumor cells improving the treatment sig…
This proposal is a sub-project of the thematic project Fapesp No 2013/086 17-7 entitled "Production of extracellular L-asparaginase: from bioprospecting to the engineering of an antileukemic biopharmaceutical" headed by Prof. Adalberto Pessoa Jr., and is included in the workplan "Nanotechnological development of L- asparaginase for pharmaceutical formulation", under the responsibility of …
(Only some records are available in English at this moment)
Skin exposition to sun might result in deleterious effects, accute ones (sunburn, phototoxic reactions, photoalergy and photosensitivity) and chronic ones (skin cancer, immunosuppression, photoaging). The cascade of events related to skin exposition to UV radiation is extremely complex and involves free radicals' production, oxidative damage to DNA and direct photolesions to DNA. In this …
The present proposal is included in the context of project Fapesp 2016/16221-4, in which a research internship abroad was planned at University College London (UCL) under supervision of Prof. Giuseppe Battaglia. The focus of this project is the development of novel nanocarriers containing the enzyme L-asparaginase (ASNase). This enzyme has been used to treat acute lymphoblastic leukaemia …
Nanostructures for L-Asparaginase (ASNase) drug delivery could overcome its fast plasma clearance by encapsulating this enzyme in an internal compartment. Additionally, this strategy allows either the stealth and/or controlled release of the protein. Among different nanotechnological approaches for proteins delivery, polymersomes appear to be very promising. Polymersomes are formed throug…
| 1 / 1 | Ongoing grants |
| 6 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 16 / 14 | Completed scholarships in Brazil |
| 4 / 3 | Completed scholarships abroad |
| 30 / 27 | All research grants and scholarships |
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