Ricardo Ambrósio Fock
CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Farmácia Bioquímica from Faculdades Oswaldo Cruz (2000) and ph.d. at Análises Clínicas from Faculdades de Ciências Farmacêuticas (2005). Has experience in Pharmacy (Source: Lattes Curriculum)
- Effect of protein malnutrition on hematopoiesis. marrow endothelial cell involvement and action of granulocytic colony stimulating factor (G-CSF), AP.R
Abstract
Hematopoiesis occurs in the bone marrow in regions named microenvironments, which modulate the processes of differentiation, proliferation and self-renewal of the hematopoietic stem cell (HSC). In recent years the literature has given attention to the role of medullary endothelial cells in the ability to modulate and sustain hematopoiesis associated with endothelial cells. The role of m...
- The role of age-associated endothelial dysfunction in hematopoiesis, AP.R SPRINT
Abstract
Increase in life expectancy has been associated with high risk of development of age-associated diseases. Anemia and endothelial dysfunction are a common finding in the elderly and can lead to serious conditions such as heart failure. The causes of anemia in the elderly are multifactorial and commonly associate to micronutrient and/or macronutrient insufficiency. Endothelial cells play ...
- Evaluation of modulatory effects and mechanisms of the synthetic fragment of leptin LEP5 in the hematopoiesis regulaton in mice submitted to protein malnutrition, AP.R
Abstract
Malnutrition is considered a disease responsible for 55% of children deaths worldwide, mainly under five years old. The FAO (Food and Agriculture Organization) says that in 2012 there were about 86 million malnourished people worldwide and protein malnutrition (PM) is the most common. It is known that the PM causes hematological disorders such as anemia and histological changes in the b...
- Evaluation of hematopoietic regulatory aspects in protein malnutrition: the role of bone marrow endothelial-like cells derived from mesenchymal stem cells, AP.R
Abstract
Malnutrition remains a major public health problem affecting millions of people worldwide. Previous studies have shown that protein-energy malnutrition (PEM) leads to anemia as a result of the depletion of progenitor hemopoietic populations, changes in cellular development, and also structural and ultrastructural changes in the extracellular matrix. Hematopoiesis occurs in bone marrow (...
(Only some records are available in English at this moment)
- Evaluation of the combined action of EPO, G-CSF, GM-CSF and IL-3 in the modulation of hematopoiesis in malnourished mice, BP.IC
Abstract
Hematopoietic tissue, such as tissues that have a high rate of cell turnover, require a broad source of nutrients and can be altered by deficient nutritional states. Protein malnutrition (PM) compromises lymphohematopoietic organs and modifies the immune response. Our work shows that malnutrition causes anemia and leukopenia. In addition to quantitative changes, we observed qualitative ...
- Assessment of modulatory effects and mechanisms of the synthetic fragment of leptin LEP5 in the regulation of hematopoiesis of mice subjected to protein malnutrition, BP.DR
Abstract
Malnutrition is responsible for 55% of child deaths worldwide and is considered the most deadly disease for children under five years of age. The FAO (Food and Agriculture Organization) says that in 2012 there were about 86 million malnourished people worldwide. Protein-energy malnutrition (PEM) is the most prevalent form of malnutrition and is defined by the WHO (World Health Organizat...
- Evaluation of glutamine as modulator of c-Rel and NFkB factors in macrophages and lymphocytes in a dietary restriction model, BP.DR
Abstract
The development of an appropriate immune response is very important for the maintenance of homeostasis, a series of processes are triggered from the first contact with pathogenic microorganisms to the effectiveness of the immune memory response. For these processes occur properly, nutrients are necessary, including glutamine that plays roles as a substrate for energy supply, and nitroge...
(Only some records are available in English at this moment)
- Evaluation of the DNA damage in response to radiation-induced bystander effects on mesenchymal stem cells, BE.EP.PD
Abstract
Accidental and occupational exposure to ionizing radiation (IR) can induces cellular damage in many living organisms at sub-lethal doses. The energy deposited on the cells leads to the breakage of chemical bonds, damaging both basic structures and the DNA, resulting in a range of lesions in which DNA double strand breaks (DSB) have a pivotal role in determining whether cells survive rad...
- Evaluation of glutamine as modulator of the transcription factor NF-kB and c-Rel in macrophages and lymphocytes from IL-10 knock out mice subjected to dietary restriction, BE.EP.DR
Abstract
Dietary restriction modify the innate and adaptive immune response, exerting effects on inflammatory and regulatory cytokine production also modifying the expression of genes directly involved in immune response. Macrophages and lymphocytes play key roles in innate and specific immune response and have high utilization rate of the amino acid glutamine, which is essential for energy and ...
| 1 / 1 | Ongoing research grants |
| 7 / 4 | Completed research grants |
| 9 / 8 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 19 / 15 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 11 |
| Citations | 48 |
| Cit./Article | 4.4 |
| Data from Web of Science | |
APARECIDA HASTREITER, ARACELI; MAKIYAMA, EDSON NAOTO; BORELLI, PRIMAVERA; FOCK, RICARDO AMBROSIO. Impairment of G-CSF receptor on granulocytic progenitor cells causes neutropenia in protein malnutrition. NUTRITION, v. 69, JAN 2020. Web of Science Citations: 0. (18/25813-8)
ANTUNES SANTOS, ANDRESSA CRISTINA; HEBEBA, CRISTINA BICHELS; HASTREITER, ARACELI APARECIDA; DE OLIVEIRA, DALILA CUNHA; MAKIYAMA, EDSON NAOTO; POLISELLI FARSKY, SANDRA HELENA; BORELLI, PRIMAVERA; FOCK, RICARDO AMBROSIO. Exogenous glutamine impairs neutrophils migration into infections sites elicited by lipopolysaccharide by a multistep mechanism. Amino Acids, v. 51, n. 3, p. 451-462, MAR 2019. Web of Science Citations: 0. (16/16463-8)
CONAWAY, EVAN A.; DE OLIVEIRA, DALILA C.; MCINNIS, CHRISTINE M.; SNAPPER, SCOTT B.; HORWITZ, BRUCE H.. Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation. JOURNAL OF IMMUNOLOGY, v. 198, n. 7, p. 2906-2915, APR 1 2017. Web of Science Citations: 9. (15/02610-6)
DE OLIVEIRA, DALILA C.; SANTOS, ED WILSON; NOGUEIRA-PEDRO, AMANDA; XAVIER, JOSE GUILHERME; BORELLI, PRIMAVERA; FOCK, RICARDO AMBROSIO. Effects of short-term dietary restriction and glutamine supplementation in vitro on the modulation of inflammatory properties. NUTRITION, v. 48, p. 96-104, APR 2018. Web of Science Citations: 1. (16/16463-8)
LIMA, FABIANA DA SILVA; DA ROCHA ROMERO, AMANDA BATISTA; HASTREITER, ARACELI; NOGUEIRA-PEDRO, AMANDA; MAKIYAMA, EDSON; COLLI, CELIA; FOCK, RICARDO AMBROSIO. An insight into the role of magnesium in the immunomodulatory properties of mesenchymal stem cells. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 55, p. 200-208, MAY 2018. Web of Science Citations: 2. (16/16463-8)
RAMOS CUNHA, MAYARA CALDAS; LIMA, FABIANA DA SILVA; RAMIREZ VINOLO, MARCO AURELIO; HASTREITER, ARACELI; CURI, RUI; BORELLI, PRIMAVERA; FOCK, RICARDO AMBROSIO. Protein Malnutrition Induces Bone Marrow Mesenchymal Stem Cells Commitment to Adipogenic Differentiation Leading to Hematopoietic Failure. PLoS One, v. 8, n. 3, MAR 14 2013. Web of Science Citations: 23.
SARTORI, TALITA; DOS SANTOS, GUILHERME GALVAO; NOGUEIRA-PEDRO, AMANDA; MAKIYAMA, EDSON; ROGERO, MARCELO MACEDO; BORELLI, PRIMAVERA; FOCK, RICARDO AMBROSIO. Effects of glutamine, taurine and their association on inflammatory pathway markers in macrophages. INFLAMMOPHARMACOLOGY, v. 26, n. 3, p. 829-838, JUN 2018. Web of Science Citations: 3. (16/16463-8)
DOS SANTOS, GUILHERME GALVAO; BATOOL, SHAFQAT; HASTREITER, ARACELI; SARTORI, TALITA; NOGUEIRA-PEDRO, AMANDA; BORELLI, PRIMAVERA; FOCK, RICARDO AMBROSIO. The influence of protein malnutrition on biological and immunomodulatory aspects of bone marrow mesenchymal stem cells. Clinical Nutrition, v. 36, n. 4, p. 1149-1157, AUG 2017. Web of Science Citations: 1. (14/06872-2)
HASTREITER, ARACELI APARECIDA; DOS SANTOS, GUILHERME GALVAO; SANTOS, ED WILSON CAVALCANTE; MAKIYAMA, EDSON NAOTO; BORELLI, PRIMAVERA; FOCK, RICARDO AMBROSIO. Protein malnutrition impairs bone marrow endothelial cells affecting hematopoiesis. Clinical Nutrition, v. 39, n. 5, p. 1551-1559, MAY 2020. Web of Science Citations: 0. (18/25813-8, 14/06872-2)
OLIVEIRA, DALILA CUNHA; NOGUEIRA-PEDRO, AMANDA; SANTOS, ED WILSON; HASTREITER, ARACELI; SILVA, GRAZIELA BATISTA; BORELLI, PRIMAVERA; FOCK, RICARDO AMBROSIO. A review of select minerals influencing the haematopoietic process. NUTRITION RESEARCH REVIEWS, v. 31, n. 2, p. 267-280, DEC 2018. Web of Science Citations: 4. (16/16463-8)
ANTUNES SANTOS, ANDRESSA CRISTINA; HEBEBA, CRISTINA BICHELS; HASTREITER, ARACELI APARECIDA; DE OLIVEIRA, DALILA CUNHA; MAKIYAMA, EDSON NAOTO; POLISELLI FARSKY, SANDRA HELENA; BORELLI, PRIMAVERA; FOCK, RICARDO AMBROSIO. Exogenous glutamine impairs neutrophils migration into infections sites elicited by lipopolysaccharide by a multistep mechanism. Amino Acids, v. 51, n. 3, p. 451-462, MAR 2019. Web of Science Citations: 0. (16/16463-8)