Arthur Henrique Cavalcante de Oliveira

• Abstract

  The macrophage migration inhibitory factor (MIF), originally described as a cytokine of human T cells, inhibits the migration of macrophages. MIF is considered an important factor in the control of infection by parasites. Resistant mice deficient in MIF-/ - became more susceptible to infection by L. major and Trypanosoma cruzi. The description in the literature of the homologous MIF secre…

  Characterization of the Macrophage migration Inhibitory Factor of Leishmania major (LmjMIF2): contribuition of the oligomeric state for structure and function, AP.R

• Abstract

  Nucleoside diphosphate kinase (NDK) is a housekeeping enzyme that plays key roles in nucleotide recycling and homeostasis in trypanosomatids. It is also secreted by the intracellular parasite Leishmania to modulate the host response. These functions make NDK an attractive target for drug design and for studies aiming at a better understanding of the mechanisms mediating host-pathogen inte…

  Crystal structure and biophysical characterization of the nucleoside diphosphate kinase from Leishmania braziliensis, PUB.ART

• Abstract

  The nucleoside diphosphate kinase b (NDKb) is an enzyme responsible for production of nucleoside triphosphates which is involved in various cellular processes. The NDKb is secreted to the extracellular medium and has been considered a pathogenic factor produced by intracellular pathogens such as Mycobacterium tuberculosis, Vibrio cholerae and L. amazonensis. This project aims to character…

  Role of amino acids of the active site and interface in oligomeric in the structure and function of the nucleoside diphosphate kinase of Leishmania major, AP.R

(Only some records are available in English at this moment)

• Abstract

  The nucleoside diphosphate kinase (NDK) is an enzyme responsible for the production of nucleoside triphosphates and is involved in various cellular processes. The NDK is secreted into the extracellular environment and is considered a pathogenic factor in intracellular pathogens such as Mycobacterium tuberculosis, Vibrio cholerae and Leishmania amazonensis. This project aims to characteriz…

  Kinetic characterization and effect of mutations in the oligomeric interface of the Nucleoside Diphosphate Kinase from Leishmania major., BP.MS

• Abstract

  The macrophage migration inhibitory factor (MIF), originally described as a cytokine of human T cells, inhibits the migration of macrophages. MIF is considered an important factor in the control of infection by parasites. Resistant mice deficient in MIF-/ - became more susceptible to infection by L. major and Trypanosoma cruzi. The description in the literature of the homologous MIF secre…

  Site-directed Mutations in the Active-Site Oligomeric Interface Regions of the macrophage migration inhibitory factor of Leishmania major (LmjMIF2), BP.MS