CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Medicine from the State University of Rio de Janeiro (1977), Master's in Microbiology and Immunology from the Federal University of Rio de Janeiro (1981) and Ph.D. in Internal Medicine from the University of São Paulo (1992). Currently AssociateProfessor of Immunology at the Department of Biochemistry and Immunology of the Ribeirão Preto School of Medicine, University of São Paulo. Has experience in Immunology, focusing on Applied Imunology, acting on the following subjects: Rhipicephalus microplus, ticks, functional genomics, antigen discovery, vaccines, immunoparasitology, immunogenetics of host responses, visceral leishmanisis. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
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Visceral leishmaniasis (VL) is characterized by a "cytokine storm" and can be lethal if left untreated. Most infections with the etiologic agent are, however, asymptomatic. Malnutrition and co-infections with invasive helminths are known risk factors for VL. The current unhealthy human diet and the new concept of environmental enteric dysfunction (EED) justify reevaluating these factors. …
Ticks are important vectors of diseases to humans and animals and promote significant losses in the cattle production sector, while also induce expressive inconvenience to dogs owners. The control of tick infestations has been done with acaricides, but the selection of resistant parasites and environmental contamination point towards the need for alternative methods of control. Currently …
Visceral leishmaniasis (VL) may be fatal if not treated and, although hypergammaglobulinemia is a hallmark of VL, the actual contribution of antibodies in progression of disease remains unknown. Effector and regulatory functions of antibodies rely on their interactions with type I and II Fc receptors and these interactions are tuned by the patterns of antibody Fc N-glycosylation. We recen…
Tick salivary constituents antagonize inflammatory, immune and hemostatic host responses, favoring tick blood feeding and the establishment of tick-borne pathogens in hosts during hematophagy. Amblyomma triste, A. cajennense and A. parvum ticks are very important in veterinary and human health because they are vectors of the etiological agents for several diseases. Insights into the tick …
Vaccines are a sustainable means to control endo and ectoparasites, but their development requires knowledge about components and induction of protective immunity and on mechanisms of parasitism. Acquisition of useful knowledge would benefit from techniques to access lymph draining the host's target organs of infections and from improved functional annotation of parasite transcriptomes. S…
(Only some records are available in English at this moment)
Ticks are obligatory hematophagous arthropods and very important disease carriers. Besides the diseases transmitted by ticks, the infestation on bovines generates significant loss in livestock profits, in Brazil and over the world. The current control of this parasite employs acaricides, which present problems by selecting resistant ticks besides contaminating meat and milk. Thus, severa…
Visceral leishmaniasis (VL) may be fatal if not treated and, although hypergammaglobulinemia is a hallmark of VL, the contribution of antibodies in progression of disease remains unknown. Effector and regulatory functions of antibodies rely on their interactions with type I and II Fc receptors and these interactions are tuned by the patterns of antibody Fc N-glycosylation. We recently sho…
Visceral leishmaniasis (VL) may be fatal if not treated and although hypergammaglobulinemia is a hallmark of VL, the contribution of antibodies in progression of disease remains unknown. Effector and regulatory functions of antibodies rely on their interactions with type I and II Fc receptors and these interactions are tuned by the patterns of antibody Fc N-glycosylation. Recently, we sho…
(Only some records are available in English at this moment)
While visceral leishmaniasis (VL) presents high mortality if left untreated, most infections with the agent of the disease, Leishmania infantum, remain asymptomatic. The risk factors for developing VL are still not well known. VL is prevalent in middle and low-income populations and is characterized by a "cytokine storm". Inflammation affects IgG Fc N-glycosylation profiles, which, in tur…
The rational vaccine design depends on the understanding of immunological mechanisms stimulated by vaccination. The emerging field of Systems Vaccinology uses high-throughput data analysis (e.g. microarray and RNA-seq) for the identification of gene signatures that predict the immunogenicity of vaccines and consequently, the identification of potential mechanisms involved in vaccine effic…
| 2 / 2 | Ongoing research grants |
| 16 / 12 | Completed research grants |
| 21 / 11 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 41 / 27 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 18 |
| Citations | 227 |
| Cit./Article | 12.6 |
| Data from Web of Science | |
PORCINO, GABRIANE NASCIMENTO; SOUSA CARVALHO, KATIA SILENE; BRAZ, DEBORA CAVALCANTE; SILVA, VLADIMIR COSTA; NERY COSTA, CARLOS HENRIQUE; FERREIRA DE MIRANDA SANTOS, ISABEL KINNEY. Evaluation of methods for detection of asymptomatic individuals infected with Leishmania infantum in the state of Piaui, Brazil. PLoS Neglected Tropical Diseases, v. 13, n. 7, JUL 2019. Web of Science Citations: 1. (16/18527-3, 15/07820-9)
LIZANDRA G. MAGALHÃES; THAIS C. LIMA; RENATO G. DE PAULA; ENYARA R. MORAIS; DANIELA P. AGUIAR; LUIZ G. GARDINASSI; GUSTAVO R. GARCIA; ROSANGELA S. LAURENTIZ; VANDERLEI RODRIGUES; JAIRO K. BASTOS; et al. Effects of (-)-6,6'-dinitrohinokinin on adult worms of Schistosoma mansoni: a proteomic analyses. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 26, n. 3, p. -, Jun. 2016. (13/00382-0, 09/15207-4, 10/17378-8)
VILLA, ERIKA C.; MARUYAMA, SANDRA R.; DE MIRANDA-SANTOS, ISABEL K. F.; PALACIOS, GUSTAVO; LADNER, JASON T.. Complete Coding Genome Sequence for Mogiana Tick Virus, a Jingmenvirus Isolated from Ticks in Brazil. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 5, n. 18, MAY 2017. Web of Science Citations: 6. (12/06374-7)
GARDINASSI, LUIZ GUSTAVO; DOTZ, VIKTORIA; EDERVEEN, AGNES HIPGRAVE; DE ALMEIDA, ROQUE PACHECO; NERY COSTA, CARLOS HENRIQUE; COSTA, DORCAS LAMOUNIER; DE JESUS, AMELIA RIBEIRO; MAYBORODA, OLEG A.; GARCIA, GUSTAVO ROCHA; WUHRER, MANFRED; et al. Clinical Severity of Visceral Leishmaniasis Is Associated with Changes in Immunoglobulin G Fc N-Glycosylation. MBIO, v. 5, n. 6, NOV-DEC 2014. Web of Science Citations: 19. (11/23819-0, 13/00382-0, 12/06708-2)
CARVALHO, WANESSA ARAUJO; IANELLA, PATRICIA; ARNOLDI, FREDERICO G. C.; CAETANO, ALEXANDRE RODRIGUES; MARUYAMA, SANDRA REGINA; FERREIRA, BEATRIZ ROSSETTI; ANDREUCCI CONTI, LUIS HENRIQUE; MONTEIRO DA SILVA, MARCIA RAMOS; PAULA, JOSE OTAVIO F.; MENDES MAIA, ANTONIO AUGUSTO; et al. Haplotypes of the bovine IgG2 heavy gamma chain in tick-resistant and tick-susceptible breeds of cattle. IMMUNOGENETICS, v. 63, n. 5, p. 319-324, MAY 2011. Web of Science Citations: 8.
MARUYAMA, SANDRA R.; ANATRIELLO, ELEN; ANDERSON, JENNIFER M.; RIBEIRO, JOSE M.; BRANDAO, LUCINDA G.; VALENZUELA, JESUS G.; FERREIRA, BEATRIZ R.; GARCIA, GUSTAVO R.; SZABO, MATIAS P. J.; PATEL, SONAL; et al. The expression of genes coding for distinct types of glycine-rich proteins varies according to the biology of three metastriate ticks, Rhipicephalus (Boophilus) microplus, Rhipicephalus sanguineus and Amblyomma cajennense. BMC Genomics, v. 11, JUN 7 2010. Web of Science Citations: 33.
CARVALHO, WANESSA ARAUJO; FRANZIN, ALESSANDRA MARA; RODRIGUES ABATEPAULO, ANTONIO ROBERTO; FREIRE DE OLIVEIRA, CARLO JOSE; MORE, DANIELA DANTAS; DA SILVA, JOAO SANTANA; FERREIRA, BEATRIZ ROSSETTI; FERREIRA DE MIRANDA SANTOS, ISABEL K.. Modulation of cutaneous inflammation induced by ticks in contrasting phenotypes of infestation in bovines. Veterinary Parasitology, v. 167, n. 2-4, SI, p. 260-273, FEB 10 2010. Web of Science Citations: 22.
GARDINASSI, LUIZ GUSTAVO; GARCIA, GUSTAVO ROCHA; NERY COSTA, CARLOS HENRIQUE; SILVA, VLADIMIR COSTA; FERREIRA DE MIRANDA SANTOS, ISABEL KINNEY. Blood Transcriptional Profiling Reveals Immunological Signatures of Distinct States of Infection of Humans with Leishmania infantum. PLoS Neglected Tropical Diseases, v. 10, n. 11, NOV 2016. Web of Science Citations: 8. (11/23819-0, 13/00382-0, 12/06708-2, 14/25856-8)
GARCIA, GUSTAVO R.; RIBEIRO, JOSE MARCOS CHAVES; MARUYAMA, SANDRA REGINA; GARDINASSI, LUIZ GUSTAVO; NELSON, KRISTINA; FERREIRA, BEATRIZ R.; ANDRADE, THALES GALDINO; FERREIRA DE MIRANDA SANTOS, ISABEL K.. A transcriptome and proteome of the tick Rhipicephalus microplus shaped by the genetic composition of its hosts and developmental stage. SCIENTIFIC REPORTS, v. 10, n. 1, JUL 30 2020. Web of Science Citations: 4. (12/04087-0, 13/00382-0)
MARUYAMA, SANDRA R.; GARCIA, GUSTAVO R.; TEIXEIRA, FELIPE R.; BRANDAO, LUCINDA G.; ANDERSON, JENNIFER M.; RIBEIRO, JOSE M. C.; VALENZUELA, JESUS G.; HORACKOVA, JANA; VERISSIMO, CECLIA J.; KATIKI, LUCIANA M.; et al. Mining a differential sialotranscriptome of Rhipicephalus microplus guides antigen discovery to formulate a vaccine that reduces tick infestations. PARASITES & VECTORS, v. 10, APR 26 2017. Web of Science Citations: 8. (12/04087-0, 10/16464-8, 12/15464-0)
GARDINASSI, LUIZ GUSTAVO; DESOUZA-VIEIRA, THIAGO S.; DA SILVA, NAILA O.; GARCIA, GUSTAVO R.; BORGES, VALERIA M.; CAMPOS, ROSEANE N. S.; DE ALMEIDA, ROQUE P.; DE MIRANDA SANTOS, ISABEL K. F.; SARAIVA, ELVIRA M.. Molecular signatures of neutrophil extracellular traps in human visceral leishmaniasis. PARASITES & VECTORS, v. 10, JUN 6 2017. Web of Science Citations: 3. (11/23819-0, 13/00382-0, 14/25856-8)
GARCIA, GUSTAVO ROCHA; MARUYAMA, SANDRA REGINA; NELSON, KRISTINA T.; CHAVES RIBEIRO, JOSE MARCOS; GARDINASSI, LUIZ GUSTAVO; MENDES MAIA, ANTONIO AUGUSTO; FERREIRA, BEATRIZ ROSSETTI; KOOYMAN, FRANS N. J.; DE MIRANDA SANTOS, ISABEL K. F.. Immune recognition of salivary proteins from the cattle tick Rhipicephalus microplus differs according to the genotype of the bovine host. PARASITES & VECTORS, v. 10, MAR 14 2017. Web of Science Citations: 2. (12/04087-0, 13/00382-0, 12/15464-0)
MALARDO, THIAGO; GARDINASSI, LUIZ GUSTAVO; MOREIRA, BERNARDO PEREIRA; PADILHA, EVERTON; CETRULO LORENZI, JULIO CESAR; SOARES, LUANA SILVA; GEMBRE, ANA FLAVIA; FONTOURA, ISABELA CARDOSO; DE ALMEIDA, LUCIANA PREVIATO; FERREIRA DE MIRANDA SANTOS, ISABEL KINNEY; et al. MicroRNA expression signatures in lungs of mice infected with Mycobacterium tuberculosis. TUBERCULOSIS, v. 101, p. 151-159, DEC 2016. Web of Science Citations: 3. (11/01117-3, 14/04405-8, 14/25856-8)
FRANZIN, ALESSANDRA MARA; MARUYAMA, SANDRA REGINA; GARCIA, GUSTAVO ROCHA; OLIVEIRA, ROSANE PEREIRA; CHAVES RIBEIRO, JOSE MARCOS; BISHOP, RICHARD; MENDES MAIA, ANTONIO AUGUSTO; MORE, DANIELA DANTAS; FERREIRA, BEATRIZ ROSSETTI; DE MIRANDA SANTOS, ISABEL KINNEY FERREIRA. Immune and biochemical responses in skin differ between bovine hosts genetically susceptible and resistant to the cattle tick Rhipicephalus microplus. PARASITES & VECTORS, v. 10, JAN 31 2017. Web of Science Citations: 11. (12/04087-0)
MAGALHAES, LIZANDRA G.; LIMA, THAIS C.; DE PAULA, RENATO G.; MORAIS, ENYARA R.; AGUIAR, DANIELA P.; GARDINASSI, LUIZ G.; GARCIA, GUSTAVO R.; LAURENTIZ, ROSANGELA S.; RODRIGUES, VANDERLEI; BASTOS, JAIRO K.; et al. Effects of (-)-6,6 `-dinitrohinokinin on adult worms of Schistosoma mansoni: a proteomic analyses. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 26, n. 3, p. 334-341, MAY-JUN 2016. Web of Science Citations: 0. (10/17378-8, 09/15207-4, 13/00382-0)
GARCIA, GUSTAVO ROCHA; GARDINASSI, LUIZ GUSTAVO; RIBEIRO, JOSE MARCOS; ANATRIELLO, ELEN; FERREIRA, BEATRIZ ROSSETTI; SANTANNA MOREIRA, HIGO NASSER; MAFRA, CLAUDIO; MARTINS, MARIA MARLENE; JUAN SZABO, MATIAS PABLO; FERREIRA DE MIRANDA-SANTOS, ISABEL KINNEY; et al. The sialotranscriptome of Amblyomma triste, Amblyomma parvum and Amblyomma cajennense ticks, uncovered by 454-based RNA-seq. PARASITES & VECTORS, v. 7, SEP 8 2014. Web of Science Citations: 39. (11/23819-0)
MARUYAMA, SANDRA R.; CARVALHO, BENILTON; GONZALEZ-PORTA, MAR; RUNG, JOHAN; BRAZMA, ALVIS; GARDINASSI, LUIZ GUSTAVO; FERREIRA, BEATRIZ R.; BANIN, TAMY M.; VERISSIMO, CECILIA J.; KATIKI, LUCIANA M.; et al. Blood transcriptome profile induced by an efficacious vaccine formulated with salivary antigens from cattle ticks. NPJ VACCINES, v. 4, n. 1, DEC 18 2019. Web of Science Citations: 2. (12/06708-2, 12/04087-0, 12/15464-0)
OLIVEIRA, C. J.; ANATRIELLO, E.; DE MIRANDA-SANTOS, I. K.; FRANCISCHETTI, I. M.; SA-NUNES, A.; FERREIRA, B. R.; RIBEIRO, J. M. C.. Proteome of Rhipicephalus sanguineus tick saliva induced by the secretagogues pilocarpine and dopamine. TICKS AND TICK-BORNE DISEASES, v. 4, n. 6, p. 469-477, 2013. Web of Science Citations: 31.
RIBEIRO, JOSE MARCOS C.; LABRUNA, MARCELO B.; MANS, BEN J.; MARUYAMA, SANDRA REGINA; FRANCISCHETTI, IVO M. B.; BARIZON, GUSTAVO CANAVACI; DE MIRANDA SANTOS, ISABEL K. F.. The sialotranscriptome of Antricola delacruzi female ticks is compatible with non-hematophagous behavior and an alternative source of food. Insect Biochemistry and Molecular Biology, v. 42, n. 5, p. 332-342, MAY 2012. Web of Science Citations: 27.
(References retrieved automatically from State of São Paulo Research Institutions)
ANATRIELLO, Elen. Vacina de DNA multicomponente baseada em genes codificantes de proteínas salivares de Rhipicephalus microplus induz imunidade cruzada contra Rhipicephalus sanguineus. Tese (Doutorado) - Faculdade de Medicina de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (07/50869-2)
GARCIA, Gustavo Rocha. Estudo do proteoma e imunoproteoma salivar do carrapato de bovinos, Rhipicephalus (Boophilus) microplus, para identificação e caracterização de antígenos silenciosos. Tese (Doutorado) - Faculdade de Medicina de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (09/51212-2)
SELECTION PROCESS OF TICK ANTIGENS AND ANTI-TICK ANTIGENIC COMPOSITION 721558.0 - Office Of Technology Transfer Of National Institutes Of Health; Universidade de São Paulo (USP). Isabel Kinney Ferreira de Miranda Santos; José Marcos Chaves Ribeiro; Beatriz Rossetti Ferreira; Cecília José Veríssimo; Lucinda Giampietro Brandao; Sandra Regina Costa Maruyama; Elen Anatriello; Gustavo Rocha Garcia; Daniela Dantas Moré; Jesus Gilberto Valenzuela - June 2016, 28
METHOD FOR SELECTING TICK ANTIGENS AND ANTIGENIC COMPOSITIONS AGAINST TICKS 2014354593.0 - Office Of Technology Transfer Of National Institutes Of Health; Universidade de São Paulo (USP). Isabel Kinney Ferreira de Miranda Santos; José Marcos Chaves Ribeiro; Beatriz Rossetti Ferreira; Cecília José Veríssimo; Lucinda Giampietro Brandao; Sandra Regina Costa Maruyama; Elen Anatriello; Gustavo Rocha Garcia; Daniela Dantas Moré; Jesus Gilberto Valenzuela - September 2014, 26
PROCESSO DE SELECCIÓN Y ANTÍGENOS DE GARRAPATAS Y COMPOSICIONES ANTIGÉNICAS 16-169566 - Office Of Technology Transfer Of National Institutes Of Health; Universidade de São Paulo (USP). Isabel Kinney Ferreira de Miranda Santos; José Marcos Chaves Ribeiro; Beatriz Rossetti Ferreira; Cecília José Veríssimo; Lucinda Giampietro Brandao; Sandra Regina Costa Maruyama; Elen Anatriello; Gustavo Rocha Garcia; Daniela Dantas Moré; Jesus Gilberto Valenzuela - June 2016, 27
PROCESSO DE SELEÇÃO DE ANTÍGENOS DE CARRAPATOS E COMPOSIÇÕES ANTIGÊNICAS ANTICARAPATOS BR1020130306622 - Office Tecnology Transfer Of National Institutes Of Health (Nih-Ott); Universidade de São Paulo (USP). Isabel Kinney Ferreira de Miranda Santos; José Marcos Chaves Ribeiro; Beatriz Rossetti Ferreira; Cecília José Veríssimo; Lucinda Giampietro Brandao; Sandra Regina Costa Maruyama; Elen Anatriello; Gustavo Rocha Garcia; Daniela Dantas Moré - November 2013, 28
PROCESSO DE SELECCIÓN Y ANTÍGENOS DE GARRAPATAS Y COMPOSICIONES ANTIGÉNICAS MX/E/2016/036153 - Office Of Technology Transfer Of National Institutes Of Health; Universidade de São Paulo (USP). Isabel Kinney Ferreira de Miranda Santos; José Marcos Chaves Ribeiro; Beatriz Rossetti Ferreira; Cecília José Veríssimo; Lucinda Giampietro Brandao; Sandra Regina Costa Maruyama; Elen Anatriello; Gustavo Rocha Garcia; Daniela Dantas Moré; Jesus Gilberto Valenzuela - May 2016, 27
METHOD FOR SELECTING TICK ANTIGENS AND ANTIGENIC COMPOSITIONS AGAINST TICKS PCT/BR2014/000351 - Office Of Technology Transfer Of National Institutes Of Health; Universidade de São Paulo (USP). Isabel Kinney Ferreira de Miranda Santos; José Marcos Chaves Ribeiro; Beatriz Rossetti Ferreira; Cecília José Veríssimo; Lucinda Giampietro Brandao; Sandra Regina Costa Maruyama; Elen Anatriello; Gustavo Rocha Garcia; Daniela Dantas Moré; Jesus Gilberto Valenzuela - September 2014, 26
METHOD FOR SELECTING TICK ANTIGENS AND ANTIGENIC COMPOSITIONS AGAINST TICKS ZA2016/04334 - Office Of Technology Transfer Of National Institutes Of Health; Universidade de São Paulo (USP). Isabel Kinney Ferreira de Miranda Santos; José Marcos Chaves Ribeiro; Beatriz Rossetti Ferreira; Cecília José Veríssimo; Lucinda Giampietro Brandao; Sandra Regina Costa Maruyama; Elen Anatriello; Gustavo Rocha Garcia; Daniela Dantas Moré; Jesus Gilberto Valenzuela - June 2016, 27