CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Medicine from the State University of Rio de Janeiro (1977), Master's in Microbiology and Immunology from the Federal University of Rio de Janeiro (1981) and Ph.D. in Internal Medicine from the University of São Paulo (1992). Currently AssociateProfessor of Immunology at the Department of Biochemistry and Immunology of the Ribeirão Preto School of Medicine, University of São Paulo. Has experience in Immunology, focusing on Applied Imunology, acting on the following subjects: Rhipicephalus microplus, ticks, functional genomics, antigen discovery, vaccines, immunoparasitology, immunogenetics of host responses, visceral leishmanisis. (Source: Lattes Curriculum)
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Vaccines formulated with 4 to 10 among 13 tick salivary antigens are validated in cattle and dogs, however, their manufacturing with good cost-benefit is unfeasible due to the large number of their components. Furthermore, some targets are poor immunogens because they contain insufficient T helper cell epitopes (HTLs) and thus provide weak coverage of bovine class II alleles. This project…
Visceral leishmaniasis (VL) is characterized by a "cytokine storm" and can be lethal if left untreated. Most infections with the etiologic agent are, however, asymptomatic. Malnutrition and co-infections with invasive helminths are known risk factors for VL. The current unhealthy human diet and the new concept of environmental enteric dysfunction (EED) justify reevaluating these factors. …
(Only some records are available in English at this moment)
In livestock, we can highlight the tick in cattle as one of the main problems affecting health and productivity. To control these parasites, acaricides are widely used which, in addition to directly killing ticks, also affect the environment and contaminate meat and milk. In this context, vaccines to combat infestation by ticks emerged, however, limitations and variations in effectiveness…
The frequent and indiscriminate use of acaricides has led ticks to become resistant to almost all chemical classes available for their control. Thus, new technologies to control ticks must be developed, such as vaccines and biological control with entomopathogens. The cattle tick is a monoxene ectoparasite. Consequently, its bovine host has enough time to develop an adaptive immune respon…
Ticks are obligatory hematophagous arthropods and very important disease carriers. Besides the diseases transmitted by ticks, the infestation on bovines generates significant loss in livestock profits, in Brazil and over the world. The current control of this parasite employs acaricides, which present problems by selecting resistant ticks besides contaminating meat and milk. Thus, severa…
(Only some records are available in English at this moment)
Vaccines prime barriers of the immune system to hinder progress of infection to disease. However, traditional strategies have not been successful against certain pathogens. Regarding the control of the cattle tick Rhipicephalus microplus, an ectoparasite with multiple mechanisms of parasitism based on highly varied antigens that evade its hosts' defenses, so far, no vaccine has achieved a…
While visceral leishmaniasis (VL) presents high mortality if left untreated, most infections with the agent of the disease, Leishmania infantum, remain asymptomatic. The risk factors for developing VL are still not well known. VL is prevalent in middle and low-income populations and is characterized by a "cytokine storm". Inflammation affects IgG Fc N-glycosylation profiles, which, in tur…
The rational vaccine design depends on the understanding of immunological mechanisms stimulated by vaccination. The emerging field of Systems Vaccinology uses high-throughput data analysis (e.g. microarray and RNA-seq) for the identification of gene signatures that predict the immunogenicity of vaccines and consequently, the identification of potential mechanisms involved in vaccine effic…
| 20 / 16 | Completed research grants |
| 23 / 13 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 46 / 32 | All research grants and scholarships |
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