Edmar Zanoteli

• Abstract

  The neuraminidase-1 (Neu1) regulates the catabolism of sialoglycoconjugates in lysosomes. Congenital deficiency of Neu1 is the basis of sialidosis, severe neurosomatic disease associated with osteoskeletal deformities, hypotonia and weakness. Neu1 deficient mice develop an atypical form of muscle degeneration characterized by abnormal proliferation of fibroblasts, expansion of extracellul…

  The role of neuraminidase 1 on regulation of muscle mass and of proliferative cell potential, AP.R

• Abstract

  Neuraminidase-1 (Neu1) regulates the catabolism of sialoglycoconjugates in lysosomes. Congenital Neu1 deficiency in children is the basis of sialidosis, a neurosomatic disorder whose symptoms include hypotonia, muscle weakness and osteoskeletal deformities. Mice with Neu1 deficiency develop an atypical form of muscle degeneration characterized by abnormal fibroblast proliferation and expa…

  The role of neuraminidase 1 on muscle atrophy and regeneration, AP.R

• Abstract

  Muscle atrophy corresponds to a loss of muscle tissue related to pathological or physiological conditions such as cancer, septicemia, immobility, fasting, and the use of glucocorticoids. Exogenous glucocorticoids are one of the most prescribed therapeutic compounds in medical practice. However, they have negative effects on several tissues, including skeletal muscle tissue, acting negativ…

  Evaluation of Calpaine and Caspase-3 expression in skeletal muscle tissue of rats submitted to administration of different glucocorticoids and after supplementation of omega-3 fatty acid (EPA/DHA) associated or not with dexamethasone administration, BP.IC

• Abstract

  Skeletal muscular atrophy can occur through numerous physiological or pathological processes of the organism, such as aging, prolonged fasting, cancer, septicemia or even by the use of glucocorticoids. Synthetic glucocorticoids are widely used in clinical practice and are one of the most common causes of drug myopathy, activating various systems of muscle degradation, mainly the proteasom…

  Evaluation of the lysosomal autophagic process in the skeletal muscle tissue of rats submitted to supplementation of omega-3 fatty acid (EPA / DHA) associated or not with dexamethasone administration, BP.IC

• Abstract

  The mass muscle regulation depends essentially on two regulatory processes dynamic that are opposite: the synthesis and protein degradation. The molecular evaluation pathways responsible for this balance is of great interest to the medical practice as it opens up possibilities for therapeutic and various pathologies including side effects of drugs such as, for example, glucocorticoids (my…

  IGF-1 receptor evaluation on dexamethasone-induced muscle atrophy associated and non-associated to previous omega-3 fatty acid supplementation, BP.IC

(Only some records are available in English at this moment)