graduate at Odontologia from Universidade de São Paulo (2002), master's at Odontology from Universidade de São Paulo (2005) and ph.d. at Odontology from Universidade Estadual Paulista Júlio de Mesquita Filho (2008). Has experience in Odontology, focusing on Odontology, acting on the following subjects: bebês, prevenção, cárie, odontologia, erosão dentária, bebidas, odontopediatria and erosão de dente, abrasão dentária, bebidas. (Source: Lattes Curriculum)
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The aim of this proposal will be to evaluate the antimicrobial, anti-biofilm and anti-caries potential of Malva sylvestris extract on enamel and dentin, as well as its chemical composition, the capacity to change the tooth enamel color of and its cytotoxicity in human fibroblasts. This proposal will be performed in two phases, as follows: A) In vitro phase: Chemical fingerprint of the com…
The presence of the acquired enamel pellicle (AEP) is one of the protective factors against erosive tooth wear (ETW) and dental caries. Among the AEP proteins with enamel binding potential and acid-resistant properties, cystatin, hemoglobin (Hb) and statherin have been recently identified by our group. Modification of the protein profile of the AEP by the incorporation of some proteins ca…
Radiation-related root dental caries is one of the adverse effects found in patients submitted to a head and neck radiation therapy. The first objective of this work will be to verify the influence of biofilm from irradiated patient and tooth that has undergone radiation on the development of root caries as well as to test new formulations of artificial saliva with respect to the preventi…
The present study aims to evaluate the antimicrobial and anticaries effect of different commercial agents (natural toothpastes and natural mouthrinses) and alternative (natural extracts and experimental fluoride varnish) in respect to the following parameters: minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), minimum biofilm inhibitory concentration (MBIC),…
The aim of the project is to evaluate the citoxicity of titanium tetrafluoride (TiF4) compared with sodium fluoride (NaF) varnishes, regardless the fluoride concentration and time of treatment, by analyzing the cell viability, morphology and the death type (apoptosis or necrosis). NIH3T3 will be cultured in DMEM supplemented with 10% fetal bovine serum, at 37oC in a humidified atmosphere …
(Only some records are available in English at this moment)
This work aims to compare an experimental toothpaste containing Chitosan, with TiF4 or NaF, to a specific commercial fluoride toothpaste and their effects on the development of dental caries under a microcosm biofilm model. A hundred and ninety-two bovine enamel samples (4x4mm) will be prepared and divided into the following groups of toothpastes: 1) TiF4 (1400 ppm F-) + 0.5% Chitosan (75…
The aim of this proposal will be to evaluate the antimicrobial, anti-biofilm and anti-caries potential of Malva sylvestris extract on enamel and dentin, as well as its chemical composition, the capacity to change the tooth enamel color of and its cytotoxicity in human fibroblasts. This proposal will be performed in two phases, as follows: A) In vitro phase: Chemical fingerprint of the com…
Although previous in vitro and in situ studies have shown that TiF4/NaF solution (daily application) and TiF4 varnish (single application) can reduce tooth enamel erosion, no in vivo studies have been performed to confirm their protective role. Thus, the objectives of this study are: 1 - to develop an animal model that can facilitate understanding the development of erosive tooth wear; 2 …
This in vitro work aims to evaluate the abrasive effect of toothpaste containing activated carbon on the erosive dentin wear. For this, 132 dentin samples will be prepared from bovine incisors, which will be distributed into the following groups: Group 1 - Colgate Triple Action (positive control); Group 2 - Colgate Natural Extracts; Group 3 - Colgate Luminous White Activated Carbon; Group…
The aim of this study will be to evaluate the effect of solutions containing different concentrations of Malva sylvestris on the CFU counts for cariogenic microorganisms present in microcosm biofilm as well as on the prevention of enamel demineralization. Firstly, we will determine MIC and MBC, testing different concentrations of Malva sylvestris extract on Streptococcus mutans. The MIC a…
The aim of this work will be to evaluate the salivary protein profile of adults with Parkinson's disease and control adults, before and after high intensity physical exercise, to identify possible biomarkers for monitoring disease progression. Twenty adults with Parkinson's disease and twenty adults, matched by age and gender, without Parkinson's disease, will participate. These participa…
(Only some records are available in English at this moment)
Although previous in vitro and in situ studies have shown that TiF4 varnish (single application) can reduce tooth enamel erosion, no in vivo studies have been performed to confirm their protective role. Thus, the objectives of this study were to develop an animal model that can facilitate understanding the development of erosive tooth wear and to evaluate the role of TiF4 on the preventio…
This study will analyze the protective effect of experimental solutions containing TiF4/NaF and chitosan (at different viscosities) on early enamel erosion (by reflectometry) and erosive enamel wear (by profilometry) in vitro. For this, bovine enamel samples (n=15) will be distributed to the following treatment groups: (1) commercial solution with SnCl2/NaF (800 ppm Sn+2, 500 ppm F, pH 4.…
This work aims to evaluate the effect of experimental toothpastes and mouthrinses containing different natural extracts on the relative metabolic activity (%) of total bacteria, Streptococcus mutans, Streptococcus sobrinus, Lactobacilli (genus), Bifidobacterium dentium, Scardovia wiggsiae and Fusobacteria (genus) using analyses of qPCR and the enamel demineralization by TMR. For the micro…
The present study aims 1) to evaluate the effect of 4% TiF4 varnish compared to 5.42% NaF and 2% chlorexidine on the prevention of dentin demineralization under a cariogenic microcosm biofilm and 2) to validate the use of Micro-CT to measure dentin demineralization. For the microcosm biofilm formation, saliva will be collected from 2 healthy subjects, who must have not brush their teeth f…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 14 / 12 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 42 / 40 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 67 / 63 | All research grants and scholarships |
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CV Lattes
ORCID