- Research Grants
Luciana Amaral Haddad in research grants and scholarships supported by FAPESP.
Fragile mental retardation protein (FMRP), encoded by the FMR1 gene, has been detected in pre- and postsynaptic neuronal processes. It plays central roles in translational repression of several dendritic mRNAs, which have translation activated upon synaptic stimulation, notably by glutamate. Other DNA- and RNA-mediated roles have been assigned to FMRP. Different FMRP isoforms have been ...
Fragile Mental Retardation Protein (FMRP), the product of Fragile Mental Retardation 1 (FMR1)gene, is an RNA-binding protein with significant expression in the brain, notably in the cerebral cortex, hippocampus, and cerebellum. Fmr1 transcripts are subjected to alternative splicing yielding 20 possible, non-redundant FMRP isoforms, not yet characterized. FMRP second KH domain (KH-2) has...
(Only some records are available in English at this moment)
Alternative splicing is considered a key mechanism in the generation of transcriptomic and proteomic diversity in eukaryotes. With the ability to originate mRNA variants from a single gene, it is implicated in up to 80% of human brain expressed trancripts. Splicing is regulated both by accessory nucleotide sequences (cis elements) and various protein components (trans elements) that int...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|
(References retrieved automatically from State of São Paulo Research Institutions)
CAMPOS, Marcelo Valpeteris de. Levantamento de proteínas candidatas a ativadoras do splicing do éxon 12 do gene FMR1. Dissertação (Mestrado) - Instituto de Biociências. Universidade de São Paulo (USP). São Paulo. (11/03964-5)
VELLOSO, Juliana da Cruz Corrêa. Investigação de elementos regulatórios do éxon 14 do gene Fmr1 e análise de expressão de suas isoformas. Tese (Doutorado) - Instituto de Biociências. Universidade de São Paulo (USP). São Paulo. (09/51297-8)