Associate Professor, Head of the Department of Phyisology & Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil. Bachelor in Pharmaceutical Sciences, State University Paulista - UNESP - (1998), Master degree and PhD in Physiology at the School of Medicine Ribeirao Preto, Universidade de São Paulo. (2000). Head of the Neural Control of Circulation Laboratory at ICB/USP. Past-President of the Brazilian Society of Physiology (SBFis), 2015-2016, Member of the Deliberative Council of the Federation of Experimental Biology Societies (FeSBE) and Member of the Deliberative Council of the ABDC/Brazilian Journal. Member of the Council of the International Union of Physiological Sciences (IUPS) -2017-2021. Member of the Steering Committee of the Neural Control & Autonomic Regulation Section (NCAR) - American Physiological Society (APS). Reviewing Editor of The Journal of Physiology (2019-2022), Open Biology (Royal Society Journal, England), Brazilian Journal of Medical and Biological Research and Physiological Mini Reviews (2019-2022). Ad-hoc consultant for research and postgraduate funding agencies, CNPq, CAPES and FAPESP and reviewer of scientific journals with a selective editorial and peer-review system. Coordinator of the Graduate Program in Human Physiology of the Institute of Biomedical Sciences (ICB), University of São Paulo (2016 to 2019). Expertise in the integrative physiology, with an emphasis on cardiovascular and neuroscience, acting on the following topics: neurogenic hypertension of experimental animal models exposed to high salt and fat diet, autonomic nervous system, genomic interference, molecular bases and neurochemical mechanisms in the hypothalamic and brainstem nuclei involved in neural control of blood pressure. (Source: Lattes Curriculum)
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Glucose is an essential energy source for cells, and therefore, its plasma concentration must be finely controlled to avoid variations, otherwise, it can lead to serious health complications. The liver plays a crucial role in glucose regulation by producing, storing, and releasing it according to the body's needs. Besides to the liver, hormones such as glucagon and insulin act antagonisti…
Autonomic dysfunction and the consequent activation of the renin-angiotensin system are the main determinants of the deleterious effects of hypertension. Increased availability of angiotensin II (Ang II) within brain autonomic areas activates intracellular signaling pathways thus augmenting neuronal activity and resulting in sympathoexcitation that characterizes the neurogenic hypertensio…
High salt intake is one of the causes of primary hypertension as it promotes an increase in plasma osmolarity by activating different brain regions that are susceptible to changes in neurotransmission by high sodium levels, leading to increased sympathetic nerve activity (SNA) and consequently increased in blood pressure (BP). Among the hypothalamic nuclei involved in neurogenic hypertens…
By 2050 life spans in both the UK and Brazil are predicted to reach 85-90 years. This brings challenges of increased burden of age-related ill-health, especially from neurodegenerative conditions which require long-term care. A sedentary(lifestyle impairs cognitive development in early life(and is associated with cognitive(decline in later life. By contrast, maintenance of(physical activi…
Work plan - Provisional dates for project: August 1st-15th September 2017: August 1st - 3th. Blood pressure measurements. 100 mice randomized with respect to treatment. 15min for each measurement per mouse will take 3 days to complete; August 3rd -15th: Heart rate variability measurements with exercise-induced heart rate recovery and pharmacological assessment of parasympathetic tone. Est…
(Only some records are available in English at this moment)
Cardiovascular diseases (CVDs) represent one of the main causes of premature death worldwide. In Brazil, CVDs, including acute myocardial infarction (AMI) and stroke are responsible for a significant portion of deaths. Systemic arterial hypertension (SAH) is an important risk factor in the development of these conditions and is often responsible for deaths. The cause of essential SAH is m…
Among the cardiovascular diseases may be related to a high-salt diet, the neurogenic hypertension is one of them. Although there are many studies in this field, there are still gaps to fully understand the mechanisms involved in neurotransmission between hypothalamic and brainstem nuclei that participate in the neural control of circulation during hyperosmotic stimuli with salt loading. M…
Glucose is the main energetic source to the organism, including the brain, and it can be obtained by the food and by metabolic process involving the liver and pancreas. Changes on glycemia can be extremely dangerous to the body, and to avoid them there are several physiological mechanisms to keep the glucose levels at a regular range, which involves pancreatic hormones insulin and glucago…
(Only some records are available in English at this moment)
Hypertension is characterized by hyperactivation of the cerebral renin-angiotensin (SARS) system, increased oxidative stress and local inflammation, which determine impaired reflex control, autonomic dysfunction and sympathetic overactivity with consequent deleterious effects to the cardiovascular system. Recently, it has been described that the deleterious effects of hypertension could a…
Hypertension is a high-risk factor for the development of cardiovascular diseases. In 2017, circulatory diseases were responsible for 27% of the percentage of deaths, representing the leading cause of mortality in Brazil. Hyperosmolarity condition, caused by an excess of salt intake, is directly related to the development of hypertension. Although widely recognized in clinical practice as…
Glucose is the most important energy substrate for the body, so it is vital to rigorously regulate blood glucose levels. Insulin is the main anabolic hormone that regulates glucose homeostasis, being responsible for glucose uptake and decrease of glycemia in the post-prandial period. In addition to its peripheral actions, insulin exerts a range of actions on the central nervous system, li…
(Only some records are available in English at this moment)
This proposal is complementary to the report already sent of my PhD project. One major life-threatening condition driving an organism's evolution is limited food availability. This food availability must include glucose since glucose is a major source of fuel for most organisms, including all mammals. Blood glucose homeostasis must also be tightly regulated since both extreme hyper - or h…
Preliminary data from my PhD project have shown that salt-sensitive neurogenic hypertension elicits an increased in the mRNA level of the ectonucleotidase triphosphate diphosphohydrolase 3 (E-NTPD3) in the hypothalamic paraventricular nucleus (PVN). This enzyme hydrolyses ATP to ADP and ADP to AMP, and increase the concentration of a substrate of ecto-5'-nucleotidase (AMP) to produce aden…
The paraventricular nucleus of the hypothalamus (PVN) is considered an important integrative center for autonomic, respiratory and neuroendocrine regulation. It is well known that PVN neurons that project to the RVLM express P2 purinergic receptors, and thus the purinergic signaling in these neurons may contribute to modulate sympathetic activity. Moreover, several evidences indicate the …
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| 4 / 4 | Ongoing scholarships in Brazil |
| 19 / 16 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 39 / 33 | All research grants and scholarships |
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