CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Holds a B.Sc. degree in Pharmacy - by the University of Sao Paulo, M.Sc. and Ph.D. (1996) in Biological Sciences (Pharmacology, FMRP) by the University of Sao Paulo. Held internships at the Albert Einstein College of Medicine, NY - USA, University of Montreal - Clinical Research Institute of Montreal - Canada and Augusta University (Medical College of Georgia), GA - USA. Professor and Chair of Pharmacology Department of the Ribeirao Preto Medical School (FMRP) - University of Sao Paulo, member of the Sao Paulo Research Foundation (FAPESP) and member of The Brazilian Academy of Sciences. Has experience in Cardiovascular Pharmacology and Physiology and interest directed to signaling pathways that control vascular function and its changes in arterial hypertension, diabetes and obesity. Member of the Editorial Board of Circulation Research and Hypertension, and Associate Editor of The American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. Specific Interests: glycosylation with N-acetilglucosamine (O-GlcNAc) and vascular (dys)function, involvement of cytokines, endothelins, aldosterone and sexual hormones in target-organ damage in cardiovascular diseases. (Source: Lattes Curriculum)
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Transgender individuals - who have a gender identity different from the one assigned to them at birth - seek medical assistance to undergo gender transition, a multidisciplinary process that encompasses physical, biological and social changes. Hormone therapy is a primary strategy for obtaining secondary sexual characteristics aligned with an individual's gender identity. Testosterone, us…
Testosterone is the main pharmacological approach used by transmasculine individuals during gender-affirming hormone therapy (GAHT-T). Although presenting a safe profile, it can increase cardiovascular risk in this population. Of note, the literature lacks studies addressing the effects of testosterone, and related mechanisms, in the cardiovascular system of biological female organisms, e…
Inflammatory diseases are a complex and heterogeneous group of diseases that affect more than 10% of the word population. The current options for the treatment of these diseases are still limited and in some cases, inefficient due to limited understanding of the mechanisms underlying these diseases. The development of translational research by a center that can generate scientific knowled…
Recent data from Prof. Hiromi Yangisawa's laboratory suggest that endothelial dysfunction may play an important role in progression of aortic aneurysms (unpublished data) and both teams have come to enter into collaboration with a goal to investigate the contribution of endothelial dysfunction in the progression of aortic aneurysm. Two aims were set to achieve this goal, as follows: 1) To…
The present project focuses on vascular oxidative stress as a mechanistic link between macrophage infiltration, matrix metalloproteinase activation and VSMC dysregulation (apoptosis) in atherosclerotic plaque instability. We aim to determine how the vascular redox environment impacts the atherosclerotic plaque phenotype. In particular we will unravel the role of PTPs in this process. (AU)
O-GlcNAcylation (O-GlcNAc) is an unusual form of glycosylation, where a simple sugar N-acetyl-glucosamine (GlcNAc) is added to the hydroxyl group (O) of serine (Ser) and threonine (Thr) residues in nuclear and cytoplasmic proteins. Increased O-GlcNAc reduces the release of inflammatory mediators as interleukin1² (IL-1²), interleukin-6 (IL-6) and tumor necrosis factor (TNF-±) as well as th…
(Only some records are available in English at this moment)
Transgender individuals - who have a gender identity different from the one assigned to them at birth - seek medical assistance to undergo gender transition, a multidisciplinary process that encompasses physical, biological and social changes. Hormone therapy is a primary strategy for obtaining secondary sexual characteristics aligned with an individual's gender identity. Testosterone, us…
Testosterone is used in the gender transition process by transmasculine people and, although considered safe, it can increase cardiovascular risk for this population. Testosterone, in supraphysiological doses, exerts deleterious effects on the cardiovascular system of men and male animal models, but its effects on the vasculature of women, especially in gender-affirming hormone therapy (T…
Obesity is a global epidemic associated with a range of cardiovascular complications, including dysfunction of perivascular adipose tissue (PVAT), which plays a crucial role in modulating vasoconstrictor responses. In obesity, PVAT undergoes pathological changes characterized by increased production of vasoconstrictor and pro-inflammatory molecules, along with a reduction in its anti-cont…
(Only some records are available in English at this moment)
Arterial hypertension is a pathophysiological condition that affects a large part of the world's population and is one of the main causes of early mortality. It is characterized by persistent elevation in blood pressure, which may be related to genetic and environmental factors, such as excessive consumption of sodium chloride (NaCl). Excess NaCl induces water retention, increased periphe…
Testosterone is used in the gender transition process by transmasculine people and, although considered safe, may increase cardiovascular risk for this population. In pathophysiological contexts, testosterone exerts deleterious effects in the cardiovascular system, but its effects on PVAT, especially in the gender-affirming hormone therapy, are not known. Considering that immune system ce…
Diabetes Mellitus (DM) is one of the main risk factors for several cardiovascular diseases such as high blood pressure, atherosclerosis, stroke, coronary artery disease and heart failure. DM also promotes macro and microvascular complications, such as peripheral arterial disease, retinopathy, ischemia and limb amputation, which are largely responsible for reducing the life expectancy of p…
(Only some records are available in English at this moment)
Testosterone is used in gender-affirming hormone therapy (GAHT) by transmasculine people and, although considered safe, it increases cardiovascular risk for this population. In pathophysiological contexts, testosterone causes cardiac hypertrophy and alters lipid metabolism. Changes in energy metabolism, particularly increased glycolytic metabolism, favor the differentiation of CD4+ T cell…
Primary Aldosteronism (PA) is a pathological condition in which the adrenal glands increase the production of aldosterone. In the vasculature, the deleterious effects of high aldosterone concentrations comprise its pro-oxidant, pro-inflammatory, and pro-proliferative properties. The post-translational modification (PTM) O-GlcNAc changes the function, stability, and subcellular location of…
Cardiovascular diseases (CVDs), a group of disorders that affect the heart and blood vessels, represent the leading cause of mortality and disability worldwide. Excessive ethanol consumption is an important public health concern, and it is a risk factor for CVDs. Despite extensive investigation, mechanisms underlying cardiovascular dysfunction induced by ethanol are not fully known. Eubio…
Perivascular adipose tissue (PVAT) is recognized as an endocrine organ that releases a wide variety of adipokines, which negatively modulate vascular contraction. In comorbidities and cardiometabolic diseases, changes in PVAT morphology and function are observed. Aldosterone, a mineralocorticoid hormone that increases cardiovascular risk, induces PVAT dysfunction. The mechanisms that just…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing grants |
| 15 / 10 | Completed research grants |
| 7 / 7 | Ongoing scholarships in Brazil |
| 44 / 31 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 13 / 13 | Completed scholarships abroad |
| 83 / 65 | All research grants and scholarships |
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