Edson Roberto da Silva

• Abstract

  Over the past ten years, our group has described the interaction of natural and synthetic compounds with the enzyme Leishmania amazonensis arginase (La-Arg). To date, we have identified at least three pharmacophoric groups required for La-Arg inhibition: catechol, thiosemicarbazide, and phenylhydrazine. The first moiety identified was the catechol group from studies with the medicinal pla…

  Rational drug design, synthesis, and study of the structure-activity relationship of Leishmania amazonensis arginase enzyme inhibitors for the development of new drugs, AP.R

• Abstract

  In the last five years our group has described the interaction of natural and synthetic compounds with the enzyme arginase of Leishmania amazonensis. The first natural compound discovered was quercetin, followed by a synthetic compound containing a thiosemicarbazide functional group. These studies described for the first time the selective inhibition of L. amazonensis arginase. Recently, …

  Study of the polyamine synthesis pathway and trypanothione synthesis for the development of new drugs for the treatment of leishmaniasis, AP.R

• Abstract

  The enzyme arginase of Leishmania is a validated target for the development of drugs against the parasite. Our group works with medicinal plants that possess leishmanicidal activity in culture of promastigote forms of the parasite and that simultaneously exhibit inhibitory activity of arginase enzyme in vitro. The study we conducted with medicinal plants showed that different flavonoids i…

  Arginase enzyme as a target to development of new prototype compound against Leishmania, AP.R

(Only some records are available in English at this moment)

• Abstract

  Much has been supported by the use of secondary plant metabolites as potential leishmanicidals. Of zoonotic aspect, the leishmaniasis, caused by protozoans of the Leishmania genus, it is a worldwide disease prevalent in undeveloped and emerging countries, like Brazil. The inexistence of a universally accessible and effective drug raises the study and research of new molecules able to prev…

  Microencapsulation of Stachytarpheta cayennensis extracts and evaluation of leishmanicidal potential, BP.IC

• Abstract

  Caused by protozoans of the Leishmania genus, leishmaniasis is a group of neglected diseases that afflicts thousands of people worldwide, where its most severe form, visceral leishmaniasis if left untreated, has a high mortality rate. They have as a vector the sand flies, which inoculate the promastigote form of the parasite in the host and, within macrophages, assume the amastigote form,…

  Study of anthranil hydrazides as potential growth inhibitory activity of Leishmania amazonensis, BP.IC

• Abstract

  The arginase enzyme is the first enzyme in the polyamine synthesis pathway in Leishmania. It converts L-arginine into L-ornithine and urea. The ornithine decarboxylase (ODC) produces putrescine by L-ornithine decarboxylation. The putrescine is used as a substrate in the polyamines biosynthesis such as spermidine and spermine. Spermidine is a substrate of the trypanothione synthase that co…

  Production of mutant arginase enzyme from Leishmania (Leishmania) amazonensis for crystallization study, BP.IC

(Only some records are available in English at this moment)