CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas Modalidade Médica from Universidade Estadual Paulista Júlio de Mesquita Filho (1974), master's at Microbiology from Universidade Federal de São Paulo (1978) and doctorate at Microbiology from Universidade Federal de São Paulo (1986). Has experience in Imunologia, focusing on Imunologia Aplicada, acting on the following subjects: maternal fetal interaction, cytokines, monocytes, preeclampsia, pregnancy. (Source: Lattes Curriculum)
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Introduction: Preeclampsia (PE) is a pregnancy-specific syndrome characterized by the activation of monocytes with an inflammatory (M1) profile, as opposed to the anti-inflammatory M2 profile, leading to elevated levels of pro-inflammatory cytokines, such as tumor necrosis factor (TNF). TNF is initially produced as a transmembrane protein (mTNF) and can be cleaved by TNF converting enzyme…
Pregnant women with pre-eclampsia (PE) have an exacerbated immune response, with no clinical signs of infection, which can be called sterile inflammation. This activation state of innate and adaptive immunity cells results in an increase in the production of inflammatory cytokines as tumor necrosis factor alpha (TNF-alpha), and in decrease of the anti-inflammatory cytokine, interleukin-1…
The literature has been suggesting that the exacerbated systemic inflammatory response detected in pregnant women with preeclampsia (PE) is harmful to the pregnancy progress and may have its origin in placenta. Both innate and adaptive immunity may be involved in this process. Systemic inflammation is a key feature in PE and is represented by excessive concentrations of pro-inflammatory c…
Preeclampsia (PE) is an obstetric pathology which affects between 3% and 8% of pregnancies and is considered as a major cause of morbidity and mortality, both maternal and fetal. The literature suggests that PE is characterized by a state of maladaptive immune tolerance in maternal-fetal interface, determining low uteroplacental blood flow that results in placental hypoxia / ischemia, oxi…
(Only some records are available in English at this moment)
Preeclampsia is a pregnancy-specific syndrome, characterized by an adaptive immune response shifted towards an inflammatory profile and mediated by subpopulations of CD4+Th1 and CD4+Th17 cells to the detriment of the regulatory profile mediated by regulatory T cells (CD4+Treg). The balance between Treg and Th17 cells is critical for fetal tolerance and disease prevention. Molecules called…
Introduction: Pre-eclampsia (PE) is a pregnancy-specific syndrome characterized by high plasma levels of pro-inflammatory cytokines, such as tumor necrosis factor (TNF), which play an important role in the pathophysiology of the disease. The binding of TNF to the TNFR1 and TNFR2 receptors on the cell surface activates different signaling pathways. TNFR1 induces cell death by apoptosis or …
Introduction: Pre-eclampsia (PE) is a pregnancy-specific syndrome characterized by high levels of pro-inflammatory cytokines that play an important role in the pathophysiology of the disease. Tumor necrosis factor (TNF) has been described as the main pro-inflammatory cytokine produced by peripheral blood mononuclear cells, mainly monocytes, which are activated in PE. This cytokine is dete…
Pregnant women with preeclampsia (PE) present a shift in the immune response to an inflammatory profile, resulting from the endogenous activation of innate and adaptive immunity cells. The activation of peripheral blood monocytes, with exacerbated production of inflammatory cytokines such as TNF-± and other inflammatory mediators, can cause activation of adaptive immune cells, generating …
(Only some records are available in English at this moment)
Pregnant women with preeclampsia (PE) present a shift in the immune response to an inflammatory profile, resulting from the endogenous activation of innate and adaptive immunity cells. TNF-± can exert different functional effects on CD4+ T lymphocyte subsets through interaction with TNFR1 and TNFR2 receptors. The binding of TNF-± to these two receptors activates different signaling pathwa…
Preeclampsia (PE) is a gestational specific syndrome associated with endothelial celldysfunction, elevated serum levels of inflammatory cytokines and oxidative stress. Previousresults from our research group showed that PE is marked by oxidative stress and the monocytesfrom maternal peripheral blood might be an important source of free radicals and inflammatorycytokines in this disease. N…
Preeclampsia (PE) is an exclusive syndrome of human gestation that is beginning withlocal placental dysfunction and develops into a disease identified by maternal hypertension and/or proteinuria. Nitric oxide (NO) is a biological mediator able to participate in the process related to gestation, representing the main vasodilator in theplacenta.Disturbances in NO system is responsible for t…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 7 / 5 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 36 / 21 | Completed scholarships in Brazil |
| 7 / 7 | Completed scholarships abroad |
| 52 / 35 | All research grants and scholarships |
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