graduation at Ciências Biológicas Modalidade Médica from Universidade Estadual Paulista Júlio de Mesquita Filho (1974), master's at Microbiology from Universidade Federal de São Paulo (1978) and doctorate at Microbiology from Universidade Federal de São Paulo (1986). Has experience in Imunologia, focusing on Imunologia Aplicada, acting on the following subjects: maternal fetal interaction, cytokines, monocytes, preeclampsia, pregnancy. (Source: Lattes Curriculum)
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Pregnant women with pre-eclampsia (PE) have an exacerbated immune response, with no clinical signs of infection, which can be called sterile inflammation. This activation state of innate and adaptive immunity cells results in an increase in the production of inflammatory cytokines as tumor necrosis factor alpha (TNF-alpha), and in decrease of the anti-inflammatory cytokine, interleukin-1…
The literature has been suggesting that the exacerbated systemic inflammatory response detected in pregnant women with preeclampsia (PE) is harmful to the pregnancy progress and may have its origin in placenta. Both innate and adaptive immunity may be involved in this process. Systemic inflammation is a key feature in PE and is represented by excessive concentrations of pro-inflammatory c…
Preeclampsia (PE) is an obstetric pathology which affects between 3% and 8% of pregnancies and is considered as a major cause of morbidity and mortality, both maternal and fetal. The literature suggests that PE is characterized by a state of maladaptive immune tolerance in maternal-fetal interface, determining low uteroplacental blood flow that results in placental hypoxia / ischemia, oxi…
(Only some records are available in English at this moment)
Pregnant women with preeclampsia (PE) present a shift in the immune response to an inflammatory profile, resulting from the endogenous activation of innate and adaptive immunity cells. The activation of peripheral blood monocytes, with exacerbated production of inflammatory cytokines such as TNF-± and other inflammatory mediators, can cause activation of adaptive immune cells, generating …
Preeclampsia is a specific manifestation of pregnancy characterized by an intense systemic inflammatory response, arteriolar spasm and endothelial dysfunction, resulting from genetic, immunological and endocrine factors. Between 10 and 15% of maternal deaths are associated with hypertensive diseases of pregnancy, 10% of which are associated with eclampsia, defined as manifestation of gene…
Pregnancies complicated by preeclampsia (PE) are associated with placental ischemia/hypoxia, oxidative stress, and elevated levels of proinflammatory cytokines. These physiological changes can trigger cell death due to apoptosis, an essential process for the maintenance of homeostasis in human tissues, including the placenta and considered an intermediate event in the generation of pregna…
(Only some records are available in English at this moment)
Pregnant women with preeclampsia (PE) present a shift in the immune response to an inflammatory profile, resulting from the endogenous activation of innate and adaptive immunity cells. TNF-± can exert different functional effects on CD4+ T lymphocyte subsets through interaction with TNFR1 and TNFR2 receptors. The binding of TNF-± to these two receptors activates different signaling pathwa…
Preeclampsia (PE) is a gestational specific syndrome associated with endothelial celldysfunction, elevated serum levels of inflammatory cytokines and oxidative stress. Previousresults from our research group showed that PE is marked by oxidative stress and the monocytesfrom maternal peripheral blood might be an important source of free radicals and inflammatorycytokines in this disease. N…
Preeclampsia (PE) is an exclusive syndrome of human gestation that is beginning withlocal placental dysfunction and develops into a disease identified by maternal hypertension and/or proteinuria. Nitric oxide (NO) is a biological mediator able to participate in the process related to gestation, representing the main vasodilator in theplacenta.Disturbances in NO system is responsible for t…
Autophagy is an intracellular catabolic process which removes damaged organelles and cytoplasmatic proteins in order to maintain cellular homeostasis. However, autophagy is also involved in the regulation of immune function and inflammation. Two distinct maternal diseases, antiphospholipid syndrome (APS) and diabetes, are associated with placental inflammation and are clinical risk factor…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 6 / 4 | Completed research grants |
| 34 / 19 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 48 / 31 | All research grants and scholarships |
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CV Lattes
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