Maria Terezinha Serrão Peraçoli
CV Lattes
ResearcherID
ORCID
Universidade Estadual Paulista (UNESP). Campus de Botucatu. Faculdade de Medicina (FMB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas Modalidade Médica from Universidade Estadual Paulista Júlio de Mesquita Filho (1974), master's at Microbiology from Universidade Federal de São Paulo (1978) and doctorate at Microbiology from Universidade Federal de São Paulo (1986). Has experience in Imunologia, focusing on Imunologia Aplicada, acting on the following subjects: paracoccidioides brasiliensis, citocinas, monocytes, monócitos and paracoccidoides brasiliensis. (Source: Lattes Curriculum)
- Modulation of systemic inflammatory response in preeclampsia, AP.R
Abstract
The literature has been suggesting that the exacerbated systemic inflammatory response detected in pregnant women with preeclampsia (PE) is harmful to the pregnancy progress and may have its origin in placenta. Both innate and adaptive immunity may be involved in this process. Systemic inflammation is a key feature in PE and is represented by excessive concentrations of pro-inflammatory...
- Inflammasome and autophagy involvement in the pathophysiology of preeclampsia, AP.R
Abstract
Preeclampsia (PE) is an obstetric pathology which affects between 3% and 8% of pregnancies and is considered as a major cause of morbidity and mortality, both maternal and fetal. The literature suggests that PE is characterized by a state of maladaptive immune tolerance in maternal-fetal interface, determining low uteroplacental blood flow that results in placental hypoxia / ischemia, o...
- Involvement of innate immunity and placental factors in the pathophysiology of preeclampsia, AP.R
- Modulatory effect of silibinin on cytokines production and fungicidal activity of human monocytes challenged with Paracoccidioides brasiliensis in vitro, AP.R
Abstract
Silibinin is the major active component of silymarin (Silybum marianum), a polyphenolic plant flavonoid that has anti-inflammatory, cytoprotective, anti-fibrotic and anticarcinogenic effects. The modulatory effect of silibinin on monocyte function against P.brasiliensis (Pb18) has not yet been demonstrated. The objective of the present study is to evaluate the effect of this flavonoid o...
- Immunomodulatory effect of Vitamin D on CD4+ t cell subsets in pregnant women with preeclampsia, BP.DR
Abstract
Studies suggest that preeclampsia (PE) is characterized by abnormal activation of the innate and adaptive immune systems. Regulatory T (Treg) cells are a population of T cells responsible for maintenance of tolerance and for the control of inflammation, while Th17 cells mediate various types of inflammatory reactions, having opposite actions to Treg cells. The occurrence of a systemic i...
- Monosodium urate and silibinin modulation of monocytes from preeclamptic women and THP-1 lineage of human monocytes, BP.MS
Abstract
Preeclampsia (PE) is a gestational specific syndrome characterized by a maladaptation state of the immunological tolerance, identified by oxidative stress and abnormal activation of the innate immune system. In plasma of pregnant women with PE there are elevated levels of molecular structures associated with stress and cell death, called damage-associated molecular patterns (DAMPs) such...
- Immunomodulatory effect of vitamin D on the activation of inflammasomes in placental tissue from pregnant women with pre-eclampsia, BP.DR
Abstract
Pregnancies complicated by Pre-Eclampsia (PE) are associated with placental ischaemia/hypoxia, oxidative stress, and elevated levels of proinflammatory cytokines. These physiological changes can trigger cell death by apoptosis, an essential process for the maintenance of homeostasis in human tissues, including the placenta and considered an intermediate event in the generation of pregna...
- Modulatory effect of silibinin on NLRP3 inflammasome induced by monosodium urate in monocytes from pregnant women with preeclampsia, BP.IC
Abstract
Preeclampsia (PE) is a specific gestational syndrome, characterized by intense systemic inflammatory reaction, which contributes significantly to the pathogenesis of the disease. Monocytes of preeclamptic women are endogenously activated and produce high levels of the inflammatory cytokines interleukin-1beta (IL-1b) and tumor necrosis factor alpha (TNF-a) detected in plasma and also exp...
(Only some records are available in English at this moment)
- Effects of supernatant from monocytes of preeclamptic women treated with SILIBIN on oxidative stress and nitric oxide availability in endothelial cells, BE.EP.MS
Abstract
Preeclampsia (PE) is a gestational specific syndrome associated with endothelial celldysfunction, elevated serum levels of inflammatory cytokines and oxidative stress. Previousresults from our research group showed that PE is marked by oxidative stress and the monocytesfrom maternal peripheral blood might be an important source of free radicals and inflammatorycytokines in this disease....
- Effects of supernatant from placental explants treated with Vitamin D on oxidative stress, inflammation and nitric oxide availability in endothelial cells, BE.EP.DR
Abstract
Preeclampsia (PE) is an exclusive syndrome of human gestation that is beginning withlocal placental dysfunction and develops into a disease identified by maternal hypertension and/or proteinuria. Nitric oxide (NO) is a biological mediator able to participate in the process related to gestation, representing the main vasodilator in theplacenta.Disturbances in NO system is responsible for...
- Understanding the relationship between autophagy and inflammasome activity in the human trophoblast, BE.EP.DR
Abstract
Autophagy is an intracellular catabolic process which removes damaged organelles and cytoplasmatic proteins in order to maintain cellular homeostasis. However, autophagy is also involved in the regulation of immune function and inflammation. Two distinct maternal diseases, antiphospholipid syndrome (APS) and diabetes, are associated with placental inflammation and are clinical risk fact...
- Effect of hyperuricemia in the plasma of pregnant women with preeclampsia on autophagy in mononuclear lymphoid cells, BE.EP.MS
Abstract
Preeclampsia (PE) is a clinical complication of pregnancy characterized by hypertension and proteinuria, identified after the 20th week of gestation. This pathology is associated with hyperuricemia, elevated plasma levels of inflammatory cytokines, leukocyte activation and oxidative stress. High levels of uric acid in the plasma of pregnant women with PE have been considered not only as...
- Comparative analysis of placental lesions in early- and late-onset preeclampsia, BE.EP.MS
Abstract
Preeclampsia is a pregnancy-specific syndrome of humans, characterized by the appearance of hypertension and proteinuria after the 20th week of gestation. It is accepted that this disease originates in the placenta, probably due to factors involved in its formation and development. This project aims: a) to evaluate the histopathological lesions in placenta of pregnant women with PE comp...
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 5 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 30 / 15 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 4 / 4 | Completed scholarships abroad |
| 43 / 26 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 13 |
| Citations | 136 |
| Cit./Article | 10.5 |
| Data from Web of Science | |
TAKAHAGI-NAKAIRA, E.; SUGIZAKI, M. F.; PERACOLI, M. T. S.. MICRODILUTION PROCEDURE FOR ANTIFUNGAL SUSCEPTIBILITY TESTING OF Paracoccidioides brasiliensis TO AMPHOTERICIN B AND ITRACONAZOLE. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 15, n. 4, p. 718-731, 2009. Web of Science Citations: 2.
PEREIRA DO NASCIMENTO, MAGDA PAULA; BANNWART, CAMILA FERREIRA; NAKAIRA-TAKAHAGI, ERIKA; SERRAO PERACOLI, MARIA TEREZINHA. Granulocyte macrophage colony-stimulating factor enhances the modulatory effect of cytokines on monocyte-derived multinucleated giant cell formation and fungicidal activity against Paracoccidioides brasiliensis. Memórias do Instituto Oswaldo Cruz, v. 106, n. 6, p. 735-741, SEP 2011. Web of Science Citations: 0.
BANNWART, CAMILA FERREIRA; RODRIGUES MARTINS, ROSANA A.; NAKAIRA-TAKAHASHI, ERIKA; DIAS-MELICIO, LUCIANE A.; CAMPOS SOARES, ANGELA M. V.; PERACOLI, MARIA TEREZINHA S.. Interleukin-15 augments oxidative metabolism and fungicidal activity of human monocytes against Paracoccidioides brasiliensis. Memórias do Instituto Oswaldo Cruz, v. 105, n. 7, p. 866-872, NOV 2010. Web of Science Citations: 4.
BANNWART, C. F.; PERACOLI, J. C.; NAKAIRA-TAKAHAGI, E.; PERACOLI, M. T. S.. Inhibitory effect of silibinin on tumour necrosis factor-alpha and hydrogen peroxide production by human monocytes. NATURAL PRODUCT RESEARCH, v. 24, n. 18, p. 1747-1757, 2010. Web of Science Citations: 12.
DO NASCIMENTO‚ M.P.P.; DE CAMPOS SOARES‚ A.M.V.; DIAS-MELICIO‚ L.A.; PARISE-FORTES‚ M.R.; MARTINS‚ R.A.R.; NAKAIRA‚ E.T.; PERAÇOLI‚ M.T.S.. Fungicidal activity of human monocyte-derived multinucleated giant cells induced in vitro by Paracoccidioides brasiliensis antigen. Mycopathologia, v. 166, n. 1, p. 25-33, 2008.
BANNWART, CAMILA FERREIRA; NAKAIRA-TAKAHAGI, ERIKA; GOLIM, MARJORIE ASSIS; LOPES DE MEDEIROS, LEONARDO TEIXEIRA; ROMAO, MARIANA; WEEL, INGRID CRISTINA; SERRAO PERACOLI, MARIA TEREZINHA. Downregulation of nuclear factor-kappa B (NF-kappa B) pathway by silibinin in human monocytes challenged with Paracoccidioides brasiliensis. Life Sciences, v. 86, n. 23-24, p. 880-886, JUN 5 2010. Web of Science Citations: 17. (08/08374-9)
INNOCENTI GIORGI, VANESSA S.; PERACOLI, MARIA TEREZINHA S.; PERACOLI, JOSE C.; WITKIN, STEVEN S.; BANNWART-CASTRO, CAMILA F.. Silibinin modulates the NF-kappa b pathway and pro-inflammatory cytokine production by mononuclear cells from preeclamptic women. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, v. 95, n. 1-2, p. 67-72, SEP 2012. Web of Science Citations: 34. (10/00776-0)
SIQUEIRA, KEILA ZANIBONI; VICTORIANO DE CAMPOS SOARES, ANGELA MARIA; DIAS-MELICIO, LUCIANE ALARCAO; CALVI, SUELI APARECIDA; SERRAO PERACOLI, MARIA TEREZINHA. Interleukin-6 treatment enhances human monocyte permissiveness for Paracoccidioides brasiliensis growth by modulating cytokine production. Medical Mycology, v. 47, n. 3, p. 259-267, 2009. Web of Science Citations: 8.
NAKAIRA-TAKAHAGI, ERIKA; GOLIM, MARJORIE A.; BANNWART, CAMILA F.; PUCCIA, ROSANA; PERACOLI, MARIA T. S.. Interactions between TLR2, TLR4, and mannose receptors with gp43 from Paracoccidioides brasiliensis induce cytokine production by human monocytes. Medical Mycology, v. 49, n. 7, p. 694-703, OCT 2011. Web of Science Citations: 17.
NAKAIRA-TAKAHAGI‚ E.; GOLIM‚ M.A.; BANNWART‚ C.F.; PUCCIA‚ R.; PERAÇOLI‚ M.T.S.. Interactions between TLR2‚ TLR4‚ and mannose receptors with gp43 from Paracoccidioides brasiliensis induce cytokine production by human monocytes. Medical Mycology, n. 0, p. 1-10, 2011.
WEEL, INGRID C.; ROMAO-VEIGA, MARIANA; MATIAS, MARIANA L.; FIORATTI, EDUARDO G.; PERACOLI, JOSE C.; BORGES, VERA T.; ARAUJO, JR., JOAN P.; PERACOLI, MARIA T.. Increased expression of NLRP3 inflammasome in placentas from pregnant women with severe preeclampsia. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, v. 123, p. 40-47, SEP 2017. Web of Science Citations: 8. (12/24697-8)
MEDEIROS, LEONARDO T. L.; PERACOLI, JOSE C.; BANNWART-CASTRO, CAMILA F.; ROMAO, MARIANA; WEEL, INGRID C.; GOLIM, MARJORIE A.; DE OLIVEIRA, LEANDRO G.; KUROKAWA, CILMERY S.; MEDEIROS BORGES, VERA T.; PERACOLI, MARIA T. S.. Monocytes from Pregnant Women with Pre-Eclampsia are Polarized to a M1 Phenotype. American Journal of Reproductive Immunology, v. 72, n. 1, p. 5-13, JUL 2014. Web of Science Citations: 20. (09/11924-3)
RIBEIRO, VANESSA R.; ROMAO-VEIGA, MARIANA; ROMAGNOLI, GRAZIELA G.; MATIAS, MARIANA L.; NUNES, PRISCILA R.; BORGES, VERA THEREZINHA M.; PERACOLI, JOSE C.; PERACOLI, MARIA TEREZINHA S.. Association between cytokine profile and transcription factors produced by T-cell subsets in early- and late-onset pre-eclampsia. IMMUNOLOGY, v. 152, n. 1, p. 163-173, SEP 2017. Web of Science Citations: 12. (14/25124-7, 12/24697-8)
ROMAO-VEIGA, MARIANA; MATIAS, MARIANA LETICIA; RIBEIRO, VANESSA ROCHA; NUNES, PRISCILA REZECK; BORGES, VERA THEREZINHA M.; PERACOLI, JOSE CARLOS; PERACOLI, MARIA TEREZINHA S.. Induction of systemic inflammation by hyaluronan and hsp70 in women with pre-eclampsia. CYTOKINE, v. 105, p. 23-31, MAY 2018. Web of Science Citations: 2. (13/00534-5, 12/24697-8)
MATIAS, MARIANA LETICIA; GOMES, VIRGINIA JULIANI; ROMAO-VEIGA, MARIANA; RIBEIRO, VANESSA ROCHA; NUNES, PRISCILA REZECK; ROMAGNOLI, GRAZIELA GORETE; PERACOLI, JOSE CARLOS; SERRAO PERACOLI, MARIA TEREZINHA. Silibinin Downregulates the NF-B Pathway and NLRP1/NLRP3 Inflammasomes in Monocytes from Pregnant Women with Preeclampsia. Molecules, v. 24, n. 8, APR 2 2019. Web of Science Citations: 0. (16/18155-9, 15/26147-3, 16/22854-0)