CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas Modalidade Médica from Universidade Estadual Paulista Júlio de Mesquita Filho (1974), master's at Microbiology from Universidade Federal de São Paulo (1978) and doctorate at Microbiology from Universidade Federal de São Paulo (1986). Has experience in Imunologia, focusing on Imunologia Aplicada, acting on the following subjects: maternal fetal interaction, cytokines, monocytes, preeclampsia, pregnancy. (Source: Lattes Curriculum)
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Pregnant women with pre-eclampsia (PE) have an exacerbated immune response, with no clinical signs of infection, which can be called sterile inflammation. This activation state of innate and adaptive immunity cells results in an increase in the production of inflammatory cytokines as tumor necrosis factor alpha (TNF-alpha), and in decrease of the anti-inflammatory cytokine, interleukin-1…
The literature has been suggesting that the exacerbated systemic inflammatory response detected in pregnant women with preeclampsia (PE) is harmful to the pregnancy progress and may have its origin in placenta. Both innate and adaptive immunity may be involved in this process. Systemic inflammation is a key feature in PE and is represented by excessive concentrations of pro-inflammatory c…
Preeclampsia (PE) is an obstetric pathology which affects between 3% and 8% of pregnancies and is considered as a major cause of morbidity and mortality, both maternal and fetal. The literature suggests that PE is characterized by a state of maladaptive immune tolerance in maternal-fetal interface, determining low uteroplacental blood flow that results in placental hypoxia / ischemia, oxi…
(Only some records are available in English at this moment)
Preeclampsia is a specific manifestation of pregnancy characterized by an intense systemic inflammatory response, arteriolar spasm and endothelial dysfunction, resulting from genetic, immunological and endocrine factors. Between 10 and 15% of maternal deaths are associated with hypertensive diseases of pregnancy, 10% of which are associated with eclampsia, defined as manifestation of gene…
Pregnancies complicated by preeclampsia (PE) are associated with placental ischemia/hypoxia, oxidative stress, and elevated levels of proinflammatory cytokines. These physiological changes can trigger cell death due to apoptosis, an essential process for the maintenance of homeostasis in human tissues, including the placenta and considered an intermediate event in the generation of pregna…
Preeclampsia (PE) is a gestational specific syndrome characterized by a maladaptation state of the immunological tolerance, identified by oxidative stress and abnormal activation of the innate immune system. In plasma of pregnant women with PE there are elevated levels of molecular structures associated with stress and cell death, called damage-associated molecular patterns (DAMPs) such a…
(Only some records are available in English at this moment)
Preeclampsia (PE) is a gestational specific syndrome associated with endothelial celldysfunction, elevated serum levels of inflammatory cytokines and oxidative stress. Previousresults from our research group showed that PE is marked by oxidative stress and the monocytesfrom maternal peripheral blood might be an important source of free radicals and inflammatorycytokines in this disease. N…
Preeclampsia (PE) is an exclusive syndrome of human gestation that is beginning withlocal placental dysfunction and develops into a disease identified by maternal hypertension and/or proteinuria. Nitric oxide (NO) is a biological mediator able to participate in the process related to gestation, representing the main vasodilator in theplacenta.Disturbances in NO system is responsible for t…
Autophagy is an intracellular catabolic process which removes damaged organelles and cytoplasmatic proteins in order to maintain cellular homeostasis. However, autophagy is also involved in the regulation of immune function and inflammation. Two distinct maternal diseases, antiphospholipid syndrome (APS) and diabetes, are associated with placental inflammation and are clinical risk factor…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 6 / 4 | Completed research grants |
| 33 / 18 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 46 / 29 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 17 |
| Citations | 158 |
| Cit./Article | 9.3 |
| Data from Web of Science | |
WEEL, INGRID C.; ROMAO-VEIGA, MARIANA; MATIAS, MARIANA L.; FIORATTI, EDUARDO G.; PERACOLI, JOSE C.; BORGES, VERA T.; ARAUJO, JR., JOAN P.; PERACOLI, MARIA T.. Increased expression of NLRP3 inflammasome in placentas from pregnant women with severe preeclampsia. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, v. 123, p. 40-47, SEP 2017. Web of Science Citations: 17. (12/24697-8)
MEDEIROS, LEONARDO T. L.; PERACOLI, JOSE C.; BANNWART-CASTRO, CAMILA F.; ROMAO, MARIANA; WEEL, INGRID C.; GOLIM, MARJORIE A.; DE OLIVEIRA, LEANDRO G.; KUROKAWA, CILMERY S.; MEDEIROS BORGES, VERA T.; PERACOLI, MARIA T. S.. Monocytes from Pregnant Women with Pre-Eclampsia are Polarized to a M1 Phenotype. American Journal of Reproductive Immunology, v. 72, n. 1, p. 5-13, JUL 2014. Web of Science Citations: 23. (09/11924-3)
MATIAS, MARIANA LETICIA; ROMAO-VEIGA, MARIANA; RIBEIRO, VANESSA ROCHA; NUNES, PRISCILA REZECK; GOMES, VIRGINIA JULIANI; DEVIDES, AMANDA CARREIRA; BORGES, VERA THEREZINHA; ROMAGNOLI, GRAZIELA GORETTI; PERACOLI, JOSE CARLOS; PERACOLI, MARIA TEREZINHA. Progesterone and vitamin D downregulate the activation of the NLRP1/ NLRP3 inflammasomes and TLR4-MyD88-NF-kappa B pathway in monocytes from pregnant women with preeclampsia. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, v. 144, APR 2021. Web of Science Citations: 0. (15/26147-3, 16/18155-9)
NUNES, PRISCILA R.; ROMAO-VEIGA, MARIANA; PERACOLI, JOSE C.; ARAUJO COSTA, ROBERTO A.; DE OLIVEIRA, LEANDRO G.; BORGES, VERA THEREZINHA M.; PERACOLI, MARIA TEREZINHA. Downregulation of CD163 in monocytes and its soluble form in the plasma is associated with a pro-inflammatory profile in pregnant women with preeclampsia. IMMUNOLOGIC RESEARCH, v. 67, n. 2-3, p. 194-201, JUN 2019. Web of Science Citations: 0. (10/20207-0, 13/12260-7)
INNOCENTI GIORGI, VANESSA S.; PERACOLI, MARIA TEREZINHA S.; PERACOLI, JOSE C.; WITKIN, STEVEN S.; BANNWART-CASTRO, CAMILA F.. Silibinin modulates the NF-kappa b pathway and pro-inflammatory cytokine production by mononuclear cells from preeclamptic women. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, v. 95, n. 1-2, p. 67-72, SEP 2012. Web of Science Citations: 35. (10/00776-0)
BANNWART, C. F.; PERACOLI, J. C.; NAKAIRA-TAKAHAGI, E.; PERACOLI, M. T. S.. Inhibitory effect of silibinin on tumour necrosis factor-alpha and hydrogen peroxide production by human monocytes. NATURAL PRODUCT RESEARCH, v. 24, n. 18, p. 1747-1757, 2010. Web of Science Citations: 13.
BANNWART, CAMILA FERREIRA; NAKAIRA-TAKAHAGI, ERIKA; GOLIM, MARJORIE ASSIS; LOPES DE MEDEIROS, LEONARDO TEIXEIRA; ROMAO, MARIANA; WEEL, INGRID CRISTINA; SERRAO PERACOLI, MARIA TEREZINHA. Downregulation of nuclear factor-kappa B (NF-kappa B) pathway by silibinin in human monocytes challenged with Paracoccidioides brasiliensis. Life Sciences, v. 86, n. 23-24, p. 880-886, JUN 5 2010. Web of Science Citations: 18. (08/08374-9)
SIQUEIRA, KEILA ZANIBONI; VICTORIANO DE CAMPOS SOARES, ANGELA MARIA; DIAS-MELICIO, LUCIANE ALARCAO; CALVI, SUELI APARECIDA; SERRAO PERACOLI, MARIA TEREZINHA. Interleukin-6 treatment enhances human monocyte permissiveness for Paracoccidioides brasiliensis growth by modulating cytokine production. Medical Mycology, v. 47, n. 3, p. 259-267, 2009. Web of Science Citations: 8.
GOMES, VIRGINIA JULIANI; NUNES, PRISCILA REZECK; HAWORTH, SARAH MCCANN; SANDRIM, VALERIA CRISTINA; PERACOLI, JOSE CARLOS; PERACOLI, MARIA TEREZINHA S.; CARLSTROM, MATTIAS. Monocytes from preeclamptic women previously treated with silibinin attenuate oxidative stress in human endothelial cells. HYPERTENSION IN PREGNANCY, v. 40, n. 2, FEB 2021. Web of Science Citations: 0. (19/10250-0)
NUNES, P. R.; GOMES, V. J.; SANDRIM, V. C.; PERACOLI, J. C.; PERACOLI, M. T. S.; CARLSTROM, M.. Effects of vitamin D-induced supernatant of placental explants from preeclamptic women on oxidative stress and nitric oxide bioavailability in human umbilical vein endothelial cells. Brazilian Journal of Medical and Biological Research, v. 54, n. 8, 2021. Web of Science Citations: 0. (16/23452-2, 19/00234-8)
ROMAO-VEIGA, MARIANA; MATIAS, MARIANA LETICIA; RIBEIRO, VANESSA ROCHA; NUNES, PRISCILA REZECK; BORGES, VERA THEREZINHA M.; PERACOLI, JOSE CARLOS; PERACOLI, MARIA TEREZINHA S.. Induction of systemic inflammation by hyaluronan and hsp70 in women with pre-eclampsia. CYTOKINE, v. 105, p. 23-31, MAY 2018. Web of Science Citations: 6. (12/24697-8, 13/00534-5)
RIBEIRO, VANESSA R.; ROMAO-VEIGA, MARIANA; ROMAGNOLI, GRAZIELA G.; MATIAS, MARIANA L.; NUNES, PRISCILA R.; BORGES, VERA THEREZINHA M.; PERACOLI, JOSE C.; PERACOLI, MARIA TEREZINHA S.. Association between cytokine profile and transcription factors produced by T-cell subsets in early- and late-onset pre-eclampsia. IMMUNOLOGY, v. 152, n. 1, p. 163-173, SEP 2017. Web of Science Citations: 17. (14/25124-7, 12/24697-8)
NAKAIRA-TAKAHAGI‚ E.; GOLIM‚ M.A.; BANNWART‚ C.F.; PUCCIA‚ R.; PERAÇOLI‚ M.T.S.. Interactions between TLR2‚ TLR4‚ and mannose receptors with gp43 from Paracoccidioides brasiliensis induce cytokine production by human monocytes. Medical Mycology, n. 0, p. 1-10, 2011.
NAKAIRA-TAKAHAGI, ERIKA; GOLIM, MARJORIE A.; BANNWART, CAMILA F.; PUCCIA, ROSANA; PERACOLI, MARIA T. S.. Interactions between TLR2, TLR4, and mannose receptors with gp43 from Paracoccidioides brasiliensis induce cytokine production by human monocytes. Medical Mycology, v. 49, n. 7, p. 694-703, OCT 2011. Web of Science Citations: 18.
DO NASCIMENTO‚ M.P.P.; DE CAMPOS SOARES‚ A.M.V.; DIAS-MELICIO‚ L.A.; PARISE-FORTES‚ M.R.; MARTINS‚ R.A.R.; NAKAIRA‚ E.T.; PERAÇOLI‚ M.T.S.. Fungicidal activity of human monocyte-derived multinucleated giant cells induced in vitro by Paracoccidioides brasiliensis antigen. Mycopathologia, v. 166, n. 1, p. 25-33, 2008.
MATIAS, MARIANA LETICIA; GOMES, VIRGINIA JULIANI; ROMAO-VEIGA, MARIANA; RIBEIRO, VANESSA ROCHA; NUNES, PRISCILA REZECK; ROMAGNOLI, GRAZIELA GORETE; PERACOLI, JOSE CARLOS; SERRAO PERACOLI, MARIA TEREZINHA. Silibinin Downregulates the NF-B Pathway and NLRP1/NLRP3 Inflammasomes in Monocytes from Pregnant Women with Preeclampsia. Molecules, v. 24, n. 8, APR 2 2019. Web of Science Citations: 3. (15/26147-3, 16/18155-9, 16/22854-0)
ROMAO-VEIGA, MARIANA; BANNWART-CASTRO, CAMILA FERREIRA; BORGES, VERA THEREZINHA MEDEIROS; GOLIM, MARJORIE ASSIS; PERACOLI, JOSE CARLOS; PERACOLI, MARIA TEREZINHA SERRAO. Increased TLR4 pathway activation and cytokine imbalance led to lipopolysaccharide tolerance in monocytes from preeclamptic women. PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, v. 21, p. 159-165, JUL 2020. Web of Science Citations: 0. (10/20207-0, 10/12893-1)
GOMES, VIRGINIA JULIANI; NUNES, PRISCILA REZECK; MATIAS, MARIANA LETICIA; RIBEIRO, VANESSA ROCHA; DEVIDES, AMANDA CARREIRA; BANNWART-CASTRO, CAMILA FERREIRA; ROMAGNOLI, GRAZIELA GORETE; PERACOLI, JOSE CARLOS; SERRAO PERACOLI, MARIA TEREZINHA; ROMAO-VEIGA, MARIANA. Silibinin induces in vitro M2-like phenotype polarization in monocytes from preeclamptic women. International Immunopharmacology, v. 89, n. A, DEC 2020. Web of Science Citations: 0. (17/26053-4, 16/18155-9)
NUNES, PRISCILA REZECK; ROMAO-VEIGA, MARIANA; BORGES, VERA THEREZINHA MEDEIROS; MATIAS, MARIANA LETICIA; RIBEIRO, VANESSA ROCHA; COSTA, ROBERTO ANTONIO ARAUJO; PERACOLI, MARIA TEREZINHA SERRAO; PERACOLI, JOSE CARLOS. Association between Adverse Maternal Clinical Outcomes and Imbalance of Cytokines and Angiogenic Factors in Preterm Preeclampsia. Revista Brasileira de Ginecologia e Obstetrícia, v. 43, n. 09, p. 669-675, SEP 2021. Web of Science Citations: 0. (10/20207-0)
(References retrieved automatically from State of São Paulo Research Institutions)
WEEL, Ingrid Cristina. Alterações histopatológicas e expressão de citocinas e de fatores angiogênicos em placenta de gestantes portadoras de pré-eclâmpsia. 68 f. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina. Botucatu. (10/12892-5)
VEIGA, Mariana Romão. Determinação da ativação de monócitos e de biomarcadores celulares em gestantes portadoras de pré-eclâmpsia. 75 f. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina. (10/12893-1)
CRISTOFALO, Renata. Efeito da silibinina sobre o metabolismo oxidativo e produção de citocinas por monócitos em gestantes portadores de pré-eclâmpsia. 84 f. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu). Botucatu. (06/54030-4)
TAKAHAGI, Erika Nakaira. Envolvimento de receptores celulares TLR2 e TLR4 e MR na produção in vitro de citocinas por monócitos humanos estimulados com Paracoccidioides brasiliensis. 70 f. Tese (Doutorado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu). Botucatu. (06/53366-9)
MATIAS, Mariana Leticia. Efeito modulador da progesterona, vitamina D e silibinina sobre inflamassomas em monócitos de gestantes portadoras de pré-eclâmpsia. Tese (Doutorado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina. (15/26147-3)
KUROKAWA, Cilmery Suemi. Produção de citocinas inflamatórias e anti-inflamatórias em pacientes com paracoccidioidomicose e após infecção in vitro de monócitos com amostras de Paracoccidioides brasiliensis. 133 f. Tese (Doutorado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina. Botucatu. (98/13380-4)
WEEL, Ingrid Cristina. Avaliação do inflamassoma NLRP3 e autofagia em placentas de gestantes portadoras de pré-eclâmpsia. Tese (Doutorado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu). (13/00535-1)
RIBEIRO, Vanessa Rocha. Associação entre perfil de citocinas e fatores de transcrição produzidos por subpopulações de células T na pré-eclâmpsia precoce e tardia. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina. (14/25124-7)
MATIAS, Mariana Leticia. Análise de inflamassoma induzido por urato monossódico em monócitos de gestantes portadoras de pré-eclampsia. 98 f. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina. (12/21287-3)
SIQUEIRA, Keila Zaniboni. Efeito da Interleucina-6 sobre a atividade fungicida e produção de citocinas por monócitos humanos, infectados in vitro com cepa virulenta de Paracoccidioides brasiliensis. 52 f. Dissertação (Mestrado) - Campus de Botucatu. Universidade Estadual Paulista (UNESP). Botucatu. (01/12418-2)
MATIAS, Mariana Leticia. Efeito modulador da progesterona, vitamina D e silibinina sobre inflamassomas em monócitos de gestantes portadoras de pré-eclâmpsia. Tese (Doutorado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina. (15/26147-3)
KUROKAWA, Cilmery Suemi. Produção de citocinas inflamatórias e anti-inflamatórias em pacientes com paracoccidioidomicose e após infecção in vitro de monócitos com amostras de Paracoccidioides brasiliensis. 133 f. Tese (Doutorado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina. Botucatu. (98/13380-4)
WEEL, Ingrid Cristina. Avaliação do inflamassoma NLRP3 e autofagia em placentas de gestantes portadoras de pré-eclâmpsia. Tese (Doutorado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu). (13/00535-1)