Roberta Okamoto
CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Faculdade de Odontologia (FOA) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Odontologia from Universidade Estadual Paulista Júlio de Mesquita Filho (1994), master's at Physiology from Universidade de São Paulo (1997) and ph.d. at Physiology from Universidade de São Paulo (2001). Has experience in Odontology, focusing on Bucomaxilofacial Surgery, acting on the following subjects: nts, nmda, ampa, imunocitoquímica and reparo alveolar. (Source: Lattes Curriculum)
- Association of systemic and local medicament treatment during the PERIMPLANTAR repair process in ovariectomized rats carriers of metabolic syndrome, AP.R
Abstract
This study will investigate the action of the association between systemic medication (oral bisphosphonate) an several medicines that will be locally applied in the surface of implants that will be installed in rat' maxilla. The medicines that will be used this study in order to functionalism the implant's surface will be Terpy (nitric oxide donator), teriparatide and genisteine. This ...
- Characterization of bone tissue formed during the alveolar bone repair and osseointegration process in rats submited to anti-osteoporosis therapy. histological, histometrical, immunohistochemical, molecular and tridimensional aspects, AP.R
Abstract
Osteoporosis is the most common bone tissue metabolic disorder in women in the postmenopausal period, caused by estrogen deficiency. Also affects men, but in a lower incidence and usually occurs by reducing the production of testosterone, which suffer the flavoring process into estrogen. In order to understand the alveolar bone and the bone around dental implants healing behavior , t...
- Analysis of the bone repair of critical defects filled with bone ceramic associated or not to BMP2: a histometrical and immunohistochemical study, AP.R
Abstract
The loss of alveolar bone is a limitation for insertion of dental implants. This defect is usually caused by dentoalveolar trauma, traumatic exodontia, congenitally missing tooth, or maxillary and mandibular pathologies. Large bone defects may result in longer healing process, which decreases the success rate. Thus, biomaterials have been used to accelerate or allow the normal and compl...
- Evaluation of bone repair in the bone / implant interface in osteoporotic rats treated with raloxifene or alendronate: a histometrical, immunohistochemical, epifluorescence and biomecanical analysis, AP.R
Abstract
The present project has the aim ot evaluate the bone repair process in the bone/implant interface of rats with induced osteoporosis and treated with raloxifene or alendronate through histometrical, immunohistochemical, epifluorescence and biomechanical analysis. To perform this study, 80 rats (Rattus novergicus albinus, Wistar), with the 200g weight were divided in 3 groups, according t...
(Only some records are available in English at this moment)
- Evaluation of bone repair after the installation of functionalized implants with anabolic medication associated with systemic administration of antiresorptive in estrogen deficient rats and metabolic syndrome, BP.MS
Abstract
Studies show a relationship between osteoporosis and metabolic syndrome, both conditions being present in a large part of the population. However, more studies are necessary, so that this correlation is better characterized. Many therapies are currently available for the treatment of osteoporosis, however, they may present some problems regarding long-term efficacy and safety. Thus, the...
- Perimplantar repair in rats type 2 diabetics treated with the combination of antimicrobial photodynamic therapy and polyphenol compounds: biomechanical, histometric, microtomographic and molecular characterization, BP.MS
Abstract
Type 2 diabetes is a metabolic disease caused by the accumulation of blood glucose due to the inability of insulin to exert its effects on the body. With the advancement of dentistry, and with the increasing use of dental implants in the population, it is necessary each day more the search for alternatives that help in a better treatment for the population, such as photodynamic therapy ...
- Characterization of peri-implant bone tissue in hypertensive and estrogen-deficient rats after the synergistic action of losartan and alendronate sodium, BP.DR
Abstract
This study aims to characterize morphologically and structurally the tissue produced at the bone-implant interface in spontaneously hypertensive ovariectomized rats that will have implants placed in their tibiae, and to analyze how the associated treatment of systemic losartan and local sodium alendronate might influence the peri-implant bone healing. Material and methods: 96 spontaneou...
(Only some records are available in English at this moment)
- Alveolar repair process evaluation in estrogen-deficient rats treated with OPG-Fc: immunohistochemistry, computerized microtomography and confocal microscopy analysis, BP.IC
Abstract
The present project aims to evaluate the alveolar repair process after the upper incisor extraction of ovariectomized rats that will be treated with OPG-Fc, mimicking the action of Denosumab, medicine used in anti-osteoporosis therapy. For the development of this project, 36 rats of 3 months will be divided into 3 experimental groups (SHAM, OVX/ST, OVX/OPG-Fc) that will be first submitt...
- Alveolar repair process evaluation in rats with type 2 diabetes, induced by high-fat diet and low dose of streptozotocin: morphometric, immunohistochemistry and birefringence microscopy analysis , BP.IC
Abstract
Most diabetic patients are classified with type II of the disease, which is a syndrome of multiple etiology due to lack of insulin and/or the inability of insulin to properly exert its effects, resulting in the resistance of this hormone. Authors show that diabetes mellitus interferes in bone metabolism influencing tooth loss and that these losses could directly influence the type of di...
- Evaluation of bone repair in the bone/implant interface in estrogen deficient famale rats untreated and treated with strontium ranelate - analysis three dimensional microtomography and immunohistochemistry, BP.IC
Abstract
The purpose of this study is to evaluate the peri implant bone repair in rats submitted to ovariectomy and treated with Strontium ranelate (625mg / kg / day). Thirty-six (36) female rats, weighing approximately 300 grams, will be divided into 3 groups according to drug treatment: SHAM group, 12 rats submitted to sham surgery; OVX group, 12 rats submitted to ovariectomy surgery and witho...
(Only some records are available in English at this moment)
- Histomorphometric analysis of peri-implant bone healing in spontaneously hipertensive rats (SHR) treated with losartan, BE.EP.MS
Abstract
The aim of this study is to evaluate the peri-implant bone healing process by histomorphometric analysis and investigate the influences that losartan treatment may lead to peri-implant bone healing. The influence of losartan in the peri-implant bone healing will be investigated in 32 tibias of male rats; tibias was collected from 16 spontaneously hypertensive rats (SHR) and 48 normotens...
| 1 / 1 | Ongoing research grants |
| 4 / 4 | Completed research grants |
| 8 / 8 | Ongoing scholarships in Brazil |
| 26 / 21 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 40 / 35 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 18 |
| Citations | 190 |
| Cit./Article | 10.6 |
| Data from Web of Science | |
PALIN, LETICIA PITOL; BRAGA POLO, TARIK OCON; DE SOUZA BATISTA, FABIO ROBERTO; SILVA GOMES-FERREIRA, PEDRO HENRIQUE; GARCIA JUNIOR, IDELMO RANGEL; ROSSI, ANA CLAUDIA; FREIRE, ALEXANDRE; FAVERANI, LEONARDO PEREZ; SUMIDA, DORIS HISSAKO; OKAMOTO, ROBERTA. Daily melatonin administration improves osseointegration in pinealectomized rats. Journal of Applied Oral Science, v. 26, 2018. Web of Science Citations: 0. (14/11920-6, 14/15396-0)
RAMALHO-FERREIRA, GABRIEL; FAVERANI, LEONARDO PEREZ; GROSSI-OLIVEIRA, GUSTAVO AUGUSTO; OKAMOTO, TETUO; OKAMOTO, ROBERTA. Alveolar bone dynamics in osteoporotic rats treated with raloxifene or alendronate: confocal microscopy analysis. Journal of Biomedical Optics, v. 20, n. 3, MAR 2015. Web of Science Citations: 6. (10/13971-6, 12/15912-2)
DE OLIVEIRA, DANILA; HASSUMI, JAQUELINE SUEMI; DA SILVA GOMES-FERREIRA, PEDRO HENRIQUE; BRAGA POLO, TARIK OCON; FERREIRA, GABRIEL RAMALHO; FAVERANI, LEONARDO PEREZ; OKAMOTO, ROBERTA. Short term sodium alendronate administration improves the per. implant bone quality in osteoporotic animals. Journal of Applied Oral Science, v. 25, n. 1, p. 42-52, JAN-FEB 2017. Web of Science Citations: 7. (13/11299-7)
ANDRÉ LUIS DA SILVA FABRIS; LEONARDO PEREZ FAVERANI; PEDRO HENRIQUE SILVA GOMES-FERREIRA; TÁRIK OCON BRAGA POLO; JOEL FERREIRA SANTIAGO-JÚNIOR; ROBERTA OKAMOTO. Bone repair access of BoneCeramic™ in 5-mm defects: study on rat calvaria. Journal of Applied Oral Science, v. 26, p. -, 2018. (13/01903-4)
GEALH, WALTER CRISTIANO; SILVA PEREIRA, CASSIANO COSTA; LUVIZUTO, ELOA RODRIGUES; GARCIA-JUNIOR, IDELMO RANGEL; ANTONIALI, CRISTINA; OKAMOTO, ROBERTA. Healing Process of Autogenous Bone Graft in Spontaneously Hypertensive Rats Treated With Losartan: An Immunohistochemical and Histomorphometric Study. JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, v. 72, n. 12, p. 2569-2581, DEC 2014. Web of Science Citations: 6. (09/11227-0)
RAMALHO-FERREIRA, G.; FAVERANI, L. P.; PRADO, F. B.; GARCIA, JR., I. R.; OKAMOTO, R.. Raloxifene enhances peri-implant bone healing in osteoporotic rats. International Journal of Oral and Maxillofacial Surgery, v. 44, n. 6, p. 798-805, JUN 2015. Web of Science Citations: 20. (12/15748-8, 12/15912-2)
LUVIZUTO, ELOA R.; TANGL, STEFAN; DOBSAK, TONI; REICH, KAROLINE; GRUBER, REINHARD; SONODA, CELSO K.; OKAMOTO, ROBERTA. Effect of recombinant PDGF-BB on bone formation in the presence of beta-tricalcium phosphate and bovine bone mineral matrix: a pilot study in rat calvarial defects. BMC ORAL HEALTH, v. 16, MAY 4 2016. Web of Science Citations: 2. (12/15181-8)
DA SILVA DE OLIVEIRA, JULIO CESAR; LUVIZUTO, ELOA RODRIGUES; SONODA, CELSO KOOGI; OKAMOTO, ROBERTA; GARCIA-JUNIOR, IDELMO RANGEL. Immunohistochemistry evaluation of BMP-2 with beta-tricalcium phosphate matrix, polylactic and polyglycolic acid gel, and calcium phosphate cement in rats. ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG, v. 21, n. 2, p. 247-258, JUN 2017. Web of Science Citations: 1. (08/10516-6)
YOGUI, FERNANDA COSTA; CORREA MOMESSO, GUSTAVO ANTONIO; FAVERANI, LEONARDO PEREZ; BRAGA POLO, TARIK OCON; RAMALHO-FERREIRA, GABRIEL; HASSUMI, JAQUELINE SUEMI; ROSSI, ANA CLAUDIA; FREIRE, ALEXANDRE RODRIGUES; PRADO, FELIPPE BEVILACQUA; OKAMOTO, ROBERTA. A SERM increasing the expression of the osteoblastogenesis and mineralization-related proteins and improving quality of bone tissue in an experimental model of osteoporosis. Journal of Applied Oral Science, v. 26, 2018. Web of Science Citations: 6. (13/11277-3, 12/15912-2)
DA SILVA FABRIS, ANDRE LUIS; FAVERANI, LEONARDO PEREZ; SILVA GOMES-FERREIRA, PEDRO HENRIQUE; BRAGA POLO, TARIK OCON; SANTIAGO-JUNIOR, JOEL FERREIRA; OKAMOTO, ROBERTA. Bone repair access of BoneCeramic (TM) in 5-mm defects: study on rat calvaria. Journal of Applied Oral Science, v. 26, 2018. Web of Science Citations: 0. (12/06309-0, 13/01903-4)
FAVERANI, LEONARDO PEREZ; BRAGA POLO, TARIK OCON; RAMALHO-FERREIRA, GABRIEL; CORREA MOMESSO, GUSTAVO ANTONIO; HASSUMI, JAQUELINE SUEMI; ROSSI, ANA CLAUDIA; FREIRE, ALEXANDRE RODRIGUES; PRADO, FELIPPE BEVILACQUA; LUVIZUTO, ELOA RODRIGUES; GRUBER, REINHARD; et al. Raloxifene but not alendronate can compensate the impaired osseointegration in osteoporotic rats. CLINICAL ORAL INVESTIGATIONS, v. 22, n. 1, p. 255-265, JAN 2018. Web of Science Citations: 7. (12/15748-8, 12/15912-2)
SILVA DE OLIVEIRA, JULIO CESAR; OKAMOTO, ROBERTA; SONODA, CELSO KOOGI; POI, WILSON ROBERTO; GARCIA JUNIOR, IDELMO RANGEL; LUVIZUTO, ELOA RODRIGUES. Evaluation of the Osteoinductive Effect of PDGF-BB Associated With Different Carriers in Bone Regeneration in Bone Surgical Defects in Rats. IMPLANT DENTISTRY, v. 26, n. 4, p. 559-566, AUG 2017. Web of Science Citations: 2. (12/15181-8)
SILVA GOMES-FERREIRA, PEDRO HENRIQUE; LISBOA-FILHO, PAULO NORONHA; DA SILVA, ANA CAROLINA; BIM-JUNIOR, ODAIR; DE SOUZA BATISTA, FABIO ROBERTO; ERVOLINO-SILVA, ANA CLAUDIA; GARCIA-JUNIOR, IDELMO RANGEL; OKAMOTO, ROBERTA. Sonochemical time standardization for bioactive materials used in periimplantar defects filling. ULTRASONICS SONOCHEMISTRY, v. 56, p. 437-446, SEP 2019. Web of Science Citations: 0. (17/08187-3)
LUVIZUTO, ELOA R.; TANGL, STEFAN; ZANONI, GERALD; OKAMOTO, TETUO; SONODA, CELSO K.; GRUBER, REINHARD; OKAMOTO, ROBERTA. The effect of BMP-2 on the osteoconductive properties of beta-tricalcium phosphate in rat calvaria defects. Biomaterials, v. 32, n. 15, p. 3855-3861, MAY 2011. Web of Science Citations: 60. (08/10516-6)
LUVIZUTO, ELOA RODRIGUES; DAMASIO DIAS, SHEILA MONICA; QUEIROZ, THALLITA PEREIRA; OKAMOTO, TETUO; GARCIA, JR., IDELMO RANGEL; OKAMOTO, ROBERTA; MENEGATI DORNELLES, RITA CASSIA. Osteocalcin immunolabeling during the alveolar healing process in ovariectomized rats treated with estrogen or raloxifene. BONE, v. 46, n. 4, p. 1021-1029, APR 2010. Web of Science Citations: 27.
LUVIZUTO, ELOA R.; DIAS, SHEILA S. M. D.; OKAMOTO, TETUO; DORNELLES, RITA C. M.; OKAMOTO, ROBERTA. Raloxifene therapy inhibits osteoclastogenesis during the alveolar healing process in rats. ARCHIVES OF ORAL BIOLOGY, v. 56, n. 10, p. 984-990, OCT 2011. Web of Science Citations: 18.
LUVIZUTO, ELOA RODRIGUES; QUEIROZ, THALLITA PEREIRA; DAMASIO DIAS, SHEILA MONICA; OKAMOTO, TETUO; MENEGATI DORNELLES, RITA CASSIA; GARCIA, JR., IDELMO RANGEL; OKAMOTO, ROBERTA. Histomorphometric analysis and immunolocalization of RANKL and OPG during the alveolar healing process in female ovariectomized rats treated with oestrogen or raloxifene. ARCHIVES OF ORAL BIOLOGY, v. 55, n. 1, p. 52-59, JAN 2010. Web of Science Citations: 26.
MULINARI-SANTOS, GABRIEL; DE SOUZA BATISTA, FABIO ROBERTO; KIRCHWEGER, FRANZISKA; TANGL, STEFAN; GRUBER, REINHARD; OKAMOTO, ROBERTA. Losartan reverses impaired osseointegration in spontaneously hypertensive rats. Clinical Oral Implants Research, v. 29, n. 11, p. 1126-1134, NOV 2018. Web of Science Citations: 1. (16/03245-2, 17/08081-0)
DE OLIVEIRA, DANILA; PUTTINI, IGOR DE OLIVEIRA; SILVA GOMES-FERREIRA, PEDRO HENRIQUE; PALIN, LETICIA PITOL; MATSUMOTO, MARIZA AKEMI; OKAMOTO, ROBERTA. Effect of intermittent teriparatide (PTH 1-34) on the alveolar healing process in orchiectomized rats. CLINICAL ORAL INVESTIGATIONS, v. 23, n. 5, p. 2313-2322, MAY 2019. Web of Science Citations: 1. (15/20203-9, 15/14688-0)
(References retrieved automatically from State of São Paulo Research Institutions)
COUTINHO, Carolina Chiantelli Cláudio. Expressão das proteínas osteoprotegerina, RANK e RANKL durante o processo de reparo alveolar em ratos : estudo imunoistoquímico. 2005. 63f. Dissertação (Mestrado) - Faculdade de Odontologia de Araçatuba. Universidade Estadual Paulista. Araçatuba. (04/01959-0)
COUTINHO, Carolina Chiantelli Cláudio. Análise da dinâmica do processo de reparo de alvéolos preenchidos com coágulo sanguineo e vidro bioativo (Perioglass®) em ratos não diabéticos, diabéticos controlados e não controlados : estudo histológico, histométrico e imunoistoquímico. 2009. 202f. Tese (Doutorado) – Faculdade de Odontologia de Araçatuba. Universidade Estadual Paulista. Araçatuba. (06/04929-0)
GEALH, Walter Cristiano. Análise do processo de reparo de enxerto ósseo autógeno em mandíbula de ratos espontaneamente hipertensos (SHR) não tratados e tratados com losartan : estudo imunoistoquímico e histomorfométrico. 2010. 77f. Dissertação (Mestrado) - Faculdade de Odontologia de Araçatuba. Universidade Estadual Paulista. Araçatuba. (08/52576-5)
LUVIZUTO, Eloá Rodrigues. O efeito da BMP-2 sobre as propriedades osteocondutoras do beta-tricálcio fosfato em defeitos de calvária de ratos. 2011. 60f. Tese (Doutorado) – Faculdade de Odontologia de Araçatuba. Universidade Estadual Paulista. Araçatuba. (08/10516-6)
FERREIRA, Gabriel Ramalho. Análise histomorfométrica e imunoistoquímica do processo de reparo alveolar de ratas ovariectomizadas com dieta pobre em cálcio e submetidas à terapia com raloxifeno ou com alendronato. 2012. 82f. Dissertação (Mestrado) - Faculdade de Odontologia de Araçatuba. Universidade Estadual Paulista. Araçatuba. (10/04366-1)
FERREIRA, Pedro Henrique Silva Gomes. Efeito da teriparatida (PTH 1-34) no reparo ósseo periimplantar em ratos submetidos à orquiectomia. 2017. 74f. Dissertação (Mestrado) - Universidade Estadual Paulista (Unesp) Faculdade de Odontologia. (15/04649-7)
MOMESSO, Gustavo Antonio Correa. Strontium ranelate improves alveolar bone healing in osteopenic rats. 2017. 56f. Dissertação (Mestrado) - Universidade Estadual Paulista (Unesp) Faculdade de Odontologia. (15/08456-9)
FERREIRA, Gabriel Ramalho. Avaliação do reparo ósseo na interface osso/implante em ratas com osteoporose induzida tratadas com raloxifeno ou alendronato : análise histométrica, imunoistoquímica, por epifluorescência e biomecânica. 2014. Tese (Doutorado) – Universidade Estadual Paulista (Unesp) Faculdade de Odontologia. (12/15748-8)
SANTOS, Gabriel Mulinari dos. Reparo ósseo peri-implantar em tíbias de ratos espontaneamente hipertensos (SHR) tratados com losartan : análise biomecânica, molecular, microtomográfica, dinâmica óssea por fluorocromos, imunoistoquímica e histológica. 2018. 45f. Dissertação (Mestrado) - Universidade Estadual Paulista (Unesp) Faculdade de Odontologia. (16/03245-2)
COLÉTE, Juliana Zorzi. Avaliação do reparo ósseo na interface ossoimplante em ratas com deficiência de estrógeno tratadas com opg-fc humano ou ranelato de estrôncio. Análise histométrica, imunoistoquímica, biomecânica, por microtomografia computadorizada e microscopia confocal. 2018. 109f. Tese (Doutorado) – Universidade Estadual Paulista (Unesp) Faculdade de Odontologia. (15/13712-4)
POLO, Tárik Ocon Braga. Avaliação do reparo ósseo na interface osso/implante em ratos pinealectomizados : análise histológica, imunoistoquimica, histométrica, biomecânica e por microct. 2016. Dissertação (Mestrado) - . Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Odontologia (Campus de Araçatuba). (14/11920-6)
FABRIS, André Luis da Silva. Análise do processo de reparo de defeitos ósseos críticos em calvária de ratos preenchidos com osso autógeno ou Bone Ceramic : um estudo histométrico e imunoistoquímico. 2014. Dissertação (Mestrado) - . Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Odontologia (Campus de Araçatuba). (12/06309-0)
PEREIRA, Cassiano Costa Silva. Análise do processo de reparo alveolar em ratos espontaneamente hipertensos (SHR) não tratados e tratados com Losartan : estudo imunoistoquímico e histomorfométrico. 2013. 120f. Tese (Doutorado) – Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Odontologia (Campus de Araçatuba). (10/00173-4)