CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Faculdade de Odontologia (FOA) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Faculdade de Odontologia do Campus de Araçatuba from Universidade Estadual Paulista Júlio de Mesquita Filho (1991), master's at Physiology from Universidade de São Paulo (1996) and ph.d. at Physiology from Universidade de São Paulo (2000). Has experience in Physiology, focusing on Physiology, acting on the following subjects: insulin, insulin signal transduction, meal feeding, insulin sensitivity and glut4. (Source: Lattes Curriculum)
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Apical periodontitis (AP) and smoking may be associated with metabolic syndrome, diabetes mellitus and insulin resistance (IR). Melatonin (MEL) is a hormone with antioxidant and anti-inflammatory properties and with participation in bone remodeling. Previous studies show that MEL improves insulin sensitivity and insulin signaling skeletal muscle of rats with AP. In this context, we hypoth…
Apical periodontitis (AP) and smoking may be associated with metabolic syndrome, diabetes mellitus and insulin resistance (IR). Melatonin (MEL) is a hormone with antioxidant and anti-inflammatory properties and with participation in bone remodeling. Previous studies show that MEL improves insulin sensitivity and insulin signaling in skeletal muscle of rats with AP. In this context, we hyp…
The association between oral inflammation and systemic health has become a subject of great interest to the medical and dental community, as the number of publications on this topic has increased considerably in recent years. Apical periodontitis (PEA) is related to the increase of proinflammatory cytokines that may act locally and systemically. In addition, this oral inflammation is asso…
Currently, there is some consensus within the dentistry area related to the fact that chronic inflammation in teeth may eventually lead to systemic disorders. Periapical lesion (PL) is characterized as an oral inflammation and it is associated with increased levels of proinflammatory cytokines such as IL-6 and TNF-alpha, that possibly induce insulin resistance. Insulin resistance can be d…
(Only some records are available in English at this moment)
Currently, it is well established in the literature that chronic inflammations in the teeth such as Apical Periodontitis (AP) and Periodontal Disease (PD) can cause systemic disorders. AP is an inflammation at the apex of the dental root, generally caused by infection by bacteria originating from the root canal system. The inflammatory response generated by this infection promotes an incr…
Fetal programming suggests that adverse stimuli when applied during early fetal development can alter the offspring's metabolism, increasing the risk of disease in their adult life. The true endo-periodontal lesion (EPL) is an infectious process that extends to the pulp and periodontal tissue simultaneously, each with its origin. It was found that this pathology is related to more express…
Apical periodontitis (AP) and smoking may be associated with metabolic syndrome, diabetes mellitus and insulin resistance (IR). Melatonin (MEL) is a hormone with antioxidant and anti-inflammatory properties and with participation in bone remodeling on periapical lesions. In this context, we hypothesize that the changes in bone remodeling in rats with AP are more pronounced with passive in…
(Only some records are available in English at this moment)
An association between oral inflammation and systemic disease is well established in the literature. Several studies have shown that maternal periodontal disease (PD) is associated with adverse pregnancy outcomes such as low birth weight and preterm delivery. In addition, periodontal pathogens are known to induce changes in placental structure. In addition, there is a paucity of studies i…
Apical periodontitis (AP) and smoking may be associated with metabolic syndrome, diabetes mellitus and insulin resistance (IR). Melatonin (MEL) is a hormone with antioxidant, anti-inflammatory properties and participation in bone remodeling. Previous studies show that MEL improves insulin sensitivity and insulin signaling in skeletal muscle of rats with AP. It is known that inflammatory p…
The fetal programming hypothesis suggests that stimuli or aggression during intrauterine life may result in permanent alterations in the physiology and metabolism of the offspring, increasing the risk of diseases in adult life. Changes in miRNA expression patterns are considered molecular mechanisms responsible for this programming. Previous studies have shown that maternal periodontal di…
(Only some records are available in English at this moment)
Overnutrition and physical inactivity promote the accumulation of sphingolipids such as ceramides which block insulin signaling and anabolic metabolism. Implementation of pharmacological or genetic interventions to reduce sphingolipid levels in rodents prevents or reverses an impressive array of metabolic pathologies (e.g. insulin resistance, diabetes, steatohepatitis, hypertension, cardi…
Cardiovascular complications are the leading causes of morbidity and mortality in individuals with obesity, type 2 diabetes mellitus (T2DM), and insulin resistance. Complications include pathologies specific to large (atherosclerosis, cardiomyopathy) and small (retinopathy, nephropathy, neuropathy) blood vessels. Common among all of these diseases is an altered endothelial cell phenotype …
Circulating sphingolipids are associated with insulin resistance and type 2 diabetes in humans. Plasma ceramides are higher in obese children and diabetic adults and correlate with the severity of insulin resistance. Therefore to explore the hypothesis that ceramides or related sphingolipids serve as nutritional cues to alter mitochondrial function and substrate preference is very importa…
| 1 / 1 | Ongoing grants |
| 8 / 8 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 53 / 42 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 70 / 59 | All research grants and scholarships |
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