Abstract
This study will evaluate the importance of chronic stress (EC) in stimulation of the sympathetic nervous system and explore the pathogenic mechanisms underlying periapical lesions. Animal model of chronic stress and periapical lesion as well as cultured human fibroblasts will be used. The expression of tyrosine hydroxylase, the ±1-adrenergic (±1-AR) and ²2-adrenergic (²2-AR) receptors wil…