Wellerson Rodrigo Scarano
CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at Ciências Biomédicas from Universidade Estadual Paulista Júlio de Mesquita Filho (1999), master's at General Biology from Universidade Estadual de Campinas (2002) and doctorate at General Biology from Universidade Estadual de Campinas (2006). He is currently full professor at Universidade Estadual Paulista Júlio de Mesquita Filho. Has experience in Morphology, focusing on Embryology, acting on the following subjects: histologia, próstata, sistema reprodutor masculino, camundongo and pele. (Source: Lattes Curriculum)
- A collaborative study between Brazilian and US scientists: the effects of environmental chemical exposures on reproduction, AP.R
Abstract
The incidence of chronic diseases such as diabetes and obesity, as well as genetic diseases such as cancer, has increased in recent decades due to several socio-economic and environmental factors. Thus, interest in environmental factors that interfere without intra-uterine development and rnorphofunctional, genetic and epigenetic promovamzy, including how they can be transmitted to offs...
- Oncotoxicological programming by the material exposure to the mixture of different fatalatos: multigenerational effect on prostate of rats and gene and epigenetic aspects related to prostate adenocarcinoma, AP.R
Abstract
The incidence of chronic diseases such as diabetes and obesity, as well as genetic diseases such as cancer, has increased in recent decades due to several socioeconomic and environmental factors that seem to interfere in the development, incidence and prognosis of these diseases. With regard to cancer, the temporal factor distances in up to 50-60 years the stages of initiation and tumor...
- Experimental prostatic carcinogenesis: molecular targets and therapeutic perspectives, AP.R
Abstract
Prostate cancer is related to the endocrine system and its progression involves changes in estrogen and androgen signaling pathways. Therefore the investigation of drugs that interfere in these pathways creates perspective for discovery of novel therapeutic targets.In this scenario, androgen deprivation has been used as the main treatment for tumor reduction.The antiandrogen abiraterone...
- Methylation pattern of the imprinting controlling regions and expression of the H19 and IGF-2 genes and androgenic response in human Sertoli cells after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TDCC), AP.R
Abstract
Infertility affects 10-15% of couples on reproductive age and male factor may be responsible for 30-50% of cases. Male fertility and the spermatogenesis process are directly related to the ability of Sertoli cells to produce factors for the development of germ cells. Only Sertoli cells have receptors for testosterone and FSH, and therefore, these cells are the main regulators of spermat...
- Carcinogenic potential of the plasticizer Di-n-butyl-phthalate (DBP) on the prostate of adult rats exposed from the fetal period, initiated by N-methyl-N-nitrosourea (MNU), AP.R
Abstract
In view of the world problem related to the plastics degradation and its environmental dispersion and before our previous study which histopathological and biochemical changes in the prostate of animals exposed to DBP (Di-n-butyl-phthalate) in the perinatal period were observed, this study aims to evaluate the carcinogenic potential of DBP administered from the fetal period and after th...
- Consequences of exposure of human Sertoli cells to TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin): evaluation of the aryl hydrocarbon receptor pathway and response to stress, BP.IC
Abstract
Infertility affects 10-15% of couples on reproductive age and male factor may be responsible for 30-50% of cases. Studies suggest that 60-70% male infertility cases are considered idiophatic, once the molecular mechanisms involved in spermatogenesis are still unknown. Male fertility and spermatogenesis process are directly related to the ability of Sertoli cells to produce factors for g...
- Zinc modulation in the diet during the prostatic morphogenesis and the consequences on the development and glandular differentiation, BP.IC
Abstract
Zinc is an essential trace element for living organisms due to its numerous biological activities. It acts as a growth factor and immunoregulatory and presents antioxidant and anti-inflammatory properties. To be involved in many aspects of cellular physiology, including structural and functional conditions, the change in their levels during normal sexual development can modulate a serie...
- Characterization of the cellular effects of the mono-n-butyl phthalate (MBP) mediated by non-genomic estrogen pathway activated by GPR30 in human prostate tumor cells, BP.MS
Abstract
The mono-n-butyl phthalate (MBP) - active metabolite of di-n-butyl phthalate, a plasticizer commonly used in many products, including medical devices, cosmetics and flexible plastics - has estrogenic effect, changing the estrogen dependent and/or independent signaling pathways during development of the male reproductive system. Recently, it is believed that the effects of endocrine disr...
(Only some records are available in English at this moment)
- Oncotoxicological programming by the maternal exposure to the mixture of different phthalates: integration of the miRNAs and mRNAs expression profile for the reconstruction of gene regulation networks associated with oncogenesis, BE.PQ
Abstract
The incidence of chronic diseases such as diabetes and obesity, as well as genetic diseases such as cancer, has increased in recent decades due to several socioeconomic and environmental factors that seem to interfere in the development, incidence and prognosis of these diseases. Regarding cancer, the temporal factor distances up to 50-60 years the stages of initiation and tumor progres...
- Profile integration expression of microRNAs and mRNAs for reconstruction of gene regulatory networks in human Sertoli cells exposed to 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD), BE.EP.DR
Abstract
Male fertility and spermatogenesis process are directly related to the ability of Sertoli cells to produce factors associated with germ cells development. Only the Sertoli cells have receptors for FSH and testosterone, and therefore these cells are the major spermatogenesis regulators. Studies suggest that 60-70% male infertility cases are considered idiophatic, since the molecular mech...
*Updated May 18, 2019
| 2 / 2 | Ongoing research grants |
| 4 / 3 | Completed research grants |
| 18 / 15 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 26 / 22 | All Research Grants and Scholarships |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 10 |
| Citations | 69 |
| Cit./Article | 6.9 |
| Data from Web of Science | |
BRANDT, JOYCE ZALOTTI; SILVEIRA, LIVIA TERESA R.; GRASSI, TONY FERNANDO; ANSELMO-FRANCI, JANETE A.; FAVARO, WAGNER JOSE; FELISBINO, SERGIO LUIS; BARBISAN, LUIS FERNANDO; SCARANO, WELLERSON RODRIGO. Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats. REPRODUCTIVE TOXICOLOGY, v. 43, p. 56-66, JAN 2014. Web of Science Citations: 16. (10/14110-4, 10/17262-0, 11/01954-2)
SANTANA, VIVIANE P.; SALLES, EVILA S.; CORREA, DEBORAH E.; GONCALVES, BIANCA F.; CAMPOS, SILVANA G.; JUSTULIN, LUIZ A.; GODINHO, ANTONIO F.; SCARANO, WELLERSON R.. Long-term effects of perinatal exposure to low doses of cadmium on the prostate of adult male rats. International Journal of Experimental Pathology, v. 97, n. 4, p. 310-316, AUG 2016. Web of Science Citations: 2. (10/05979-7)
PEIXOTO, ANDRE R.; SANTOS, TALITA M.; BRANDT, JOYCE Z.; DELELLA, FLAVIA K.; GONCALVES, BIANCA F.; CAMPOS, SILVANA G. P.; TABOGA, SEBASTIAO R.; FAVARO, WAGNER J.; DOMENICONI, RAQUEL F.; SCARANO, WELLERSON R.. Gestational and lactational exposition to Di-N-butyl-phthalate (DBP) increases inflammation and preneoplastic lesions in prostate of wistar rats after carcinogenic N-methyl-N-nitrosourea (MNU) plus testosterone protocol. ENVIRONMENTAL TOXICOLOGY, v. 31, n. 10, p. 1185-1195, OCT 2016. Web of Science Citations: 3. (11/06633-0, 11/10105-9, 10/01143-1)
CAMORA, LUCAS F.; SILVA, ANA PRISCILA G.; SANTOS, SERGIO A. A.; JUSTULIN, LUIS A.; PEROBELLI, JULIANA E.; BARBISAN, LUIS FERNANDO; SCARANO, WELLERSON R.. Impact of maternal and postnatal zinc dietary status on the prostate of pubescent and adult rats. Cell Biology International, v. 41, n. 11, SI, p. 1203-1213, NOV 2017. Web of Science Citations: 1. (14/25932-6)
GONCALVES, BIANCA FACCHIM; PEGORIN DE CAMPOS, SILVANA GISELE; FAVARO, WAGNER JOSE; BRANDT, JOYCE ZALOTTI; PINHO, CRISTIANE FIGUEIREDO; JUSTULIN, LUIS ANTONIO; TABOGA, SEBASTIAO ROBERTO; SCARANO, WELLERSON RODRIGO. Combinatorial Effect of Abiraterone Acetate and NVP-BEZ235 on Prostate Tumor Progression in Rats. HORMONES & CANCER, v. 9, n. 3, p. 175-187, JUN 2018. Web of Science Citations: 0. (14/14202-7, 13/22604-5)
RIBEIRO, MARIANA ANTUNES; DOS REIS, MARIANA BISARRO; DE MORAES, LEONARDO NAZARIO; BRITON-JONES, CHRISTINE; RAINHO, CLAUDIA APARECIDA; SCARANO, WELLERSON RODRIGO. Defining suitable reference genes for RT-qPCR analysis on human sertoli cells after 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure. MOLECULAR BIOLOGY REPORTS, v. 41, n. 11, p. 7063-7066, NOV 2014. Web of Science Citations: 4. (11/04202-1, 12/00253-3)
AQUINO GONCALVES DE FREITAS, ANDRE TEVES; RIBEIRO, MARIANA ANTUNES; PINHO, CRISTIANE FIGUEIREDO; PEIXOTO, ANDRE REBELO; DOMENICONI, RAQUEL FANTIN; SCARANO, WELLERSON R.. Regulatory and junctional proteins of the blood-testis barrier in human Sertoli cells are modified by monobutyl phthalate (MBP) and bisphenol A (BPA) exposure. TOXICOLOGY IN VITRO, v. 34, p. 1-7, AUG 2016. Web of Science Citations: 7. (12/00253-3)
SCARANO, WELLERSON RODRIGO; DE TOLEDO, FABIOLA CHOQUETA; GUERRA, MARINA TREVIZAN; PEGORIN DE CAMPOS, SILVANA GISELE; JUSTULIN JUNIOR, LUIS ANTONIO; FELISBINO, SERGIO LUIS; ANSELMO-FRANCI, JANETE A.; TABOGA, SEBASTIAO ROBERTO; KEMPINAS, WILMA DE GRAVA. Long-term effects of developmental exposure to di-n-butyl-phthalate (DBP) on rat prostate: Proliferative and inflammatory disorders and a possible role of androgens. Toxicology, v. 262, n. 3, p. 215-223, AUG 21 2009. Web of Science Citations: 31.
PINHO, CRISTIANE F.; RIBEIRO, MARIANA A.; RINALDI, JAQUELINE C.; FELISBINO, SERGIO L.; PINHEIRO, PATRICIA F.; DOMENICONI, RAQUEL F.; FOCHI, RICARDO A.; BOER, PATRICIA A.; SCARANO, WELLERSON R.. Gestational protein restriction delays prostate morphogenesis in male rats. REPRODUCTION FERTILITY AND DEVELOPMENT, v. 26, n. 7, p. 967-973, 2014. Web of Science Citations: 5. (11/09061-7)
SCARANO‚ W.R.; CORDEIRO‚ R.S.; GÓES‚ R.M.; CARVALHO‚ H.F.; TABOGA‚ S.R.. Tissue remodeling in Guinea pig lateral prostate at different ages after estradiol treatment. Cell Biology International, v. 29, n. 9, p. 778-784, 2005.
RIBEIRO, MARIANA A.; ESTILL, MOLLY S.; FERNANDEZ, GEYSSON J.; MORAES, LEONARDO N.; KRAWETZ, STEPHEN A.; SCARANO, WELLERSON R.. Integrative transcriptome and microRNome analysis identifies dysregulated pathways in human Sertoli cells exposed to TCDD. Toxicology, v. 409, p. 112-118, NOV 1 2018. Web of Science Citations: 0. (13/12154-2)