bachelor's at Ciências Biológicas - Modalidade Médica from Universidade Estadual Paulista Júlio de Mesquita Filho (1994), master's at General Biology from Universidade Estadual de Campinas (1997) and doctorate at Pathological Anatomy and Clinical Pathology from Universidade Estadual Paulista Júlio de Mesquita Filho (2002). Has experience in Morphology, focusing on Histology, acting on the following subjects: hepatocarcinogênese química, ratos, quimioprevenção, diuron and ratos wistar. (Source: Lattes Curriculum)
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Hepatocellular carcinoma (HCC) features as the 6th/3rd most incident and deadliest, respectively, among all kinds of cancers worldwide, and it has been linked to chronic liver diseases like non-alcoholic fatty liver disease (NAFLD). NAFLD affects ~25% of the global population and contributes to increasing the HCC-related incidence by 26%. Adherence to a western diet (WD) - mostly composed…
Considered a modern disease, the non-alcoholic fatty liver disease (NAFLD) affects around 25% of the world's population, respectively. Its complex development is associated to dietary factors, obesity, sedentarism and metabolic disorders, involving molecular alterations and the crosstalk between liver, adipose tissue and the intestinal microbiota. In preclinical studies, the herbicides gl…
Recently, hepatic fibrosis and carcinogenesis have been linked to altered expression of several miRNAs. In contrast, studies indicate that coffee drinking is associated with a 40% lower risk of developing fibrosis or liver cancer, while decaf drinking is not. Thus, the present project will evaluate whether caffeine alone or associated with trigoneline and/or chlorogenic acid (CGA), abunda…
The present study aims to evaluate the preventive effect of administration of synbiotic (prebiotic inulin associated with the probiotic Bifidobacterium bifidus) and indole-3-carbinol on the chemical process of colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats fed a diet containing heme. The animals will be allocated into seven groups with 10 to 22 animals eac…
(Only some records are available in English at this moment)
Non-alcoholic fatty liver disease (NAFLD) affects ~25% of the world's population, and it is closely associated with metabolic disorders, justifying NAFLD renomenclature to MAFLD (metabolic associated fatty liver disease). Furthermore, this complex condition - which has no approved medical treatment other than dietary re-education - is caused by western diet (WD), involving alterations not…
Irinotecan hydrochloride (CPT-11) is widely used for the treatment of various malignant neoplasms. CPT-11 is responsible for several side effects, including intestinal mucositis (IM). During CPT-11-induced MI, it would be important to assess how foods or bioactive/nutraceutical compounds can influence its evolution. Wasabi (Wasabia japonica), especially its rhizome, is widely used as an i…
Malignant neoplasms hold the second place among the main causes of mortality worldwide, and the main therapeutic alternatives include surgical interventions, radiotherapy and chemotherapy. Although these interventions are beneficial, they result in many side effects that reduce their efficiency and increase treatment costs. Among the adverse effects of the use of chemotherapy drugs, the i…
The hepatocellular carcinoma (HCC) features as the 6th/3rd most incident and deadliest, respectively, among all kind of cancers worldwide, and it has been linked to chronic liver diseases like non-alcoholic fatty liver disease (NAFLD). Nowadays, NAFLD is the most common cause of chronic liver disease worldwide and affects almost 25% of the global population, also contributing for increasi…
(Only some records are available in English at this moment)
Hepatocellular carcinoma (HCC) has become a major public health issue worldwide, corresponding to the 3rd deadliest and 6th most incident type of cancer. In the past few decades, the growing incidence of non-communicable diseases (e.g.: obesity and type 2 diabetes) was followed by an overwhelming epidemiological relevance of non-viral aetiologies-derived HCC, especially metabolic dysfunct…
Colorectal cancer (CRC) is one of most recurrent cancer worldwide within high mortality rates. Moreover, available cytotoxic options in cancer therapy show low response rates and modest impact on survival, mainly due primary or acquired resistance to conventional treatments as result of cancer stem cell-like exposition. Besides the in vitro studies demonstrate antiproliferative, antioxida…
| 1 / 1 | Ongoing grants |
| 8 / 7 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 46 / 32 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 58 / 43 | All research grants and scholarships |
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CV Lattes
ORCID