CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences from the Federal University of Juiz de Fora (1999), Master (2002) and PhD (2006) in Sciences from the Federal University of São Paulo and Post-Doctorate in Genetics from the Medical Research Council - Human Genetics Unit (University of Edinburgh ) -2007/2008). She is currently Associate Professor at Escola Paulista de Medicina-Federal University of São Paulo and leader of the study group on Biopsychosocial Epigenetics and its Heritage (BEpI). He has experience in the area of #8203;#8203;Epigenetics and paternal epigenetic inheritance, participating mainly in the following topics: germ cell development, DNA methylation, sncRNA profile and retrotransposons. He has been dedicated to studying the epigenetic inheritance of autism and related conditions, as well as understanding epigenetics as a mechanism for biological incorporation of the psychosocial context. She also works on developing strategies for Higher Education, being the creator and coordinator of the OrganicaMente Project. Coordinator of the Unifesp Mental Health Observatory (OSMU). (Source: Lattes Curriculum)
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The dysregulation of miRNA expression in samplesfrom autistic individuals indicates that they are involved in autism. The participationof miRNAs in paternal epigenetic inheritance has also been reported. This study usedbioinformatics tools to analyze the literature and genetic databases to search for miRNAsassociated with autism, aiming to explore their suitability to investigate paternal…
Currently, the BepI group (Biopsychosocial Epigenetics and its Inheritance) is developing a research project funded by FAPESP (Proc. 2022/14195-7), which aims to study the expression of microRNAs in blood samples and oral mucosa cells of autistic individuals, as well as in the sperm of parents of autistic individuals. One of the great challenges of this type of study in the autistic commu…
Epigenetics refers to the modulation on gene expression and on DNA structure that are not related to alterations of base sequence. These type of modulation of gene expression include DNA methylation and regulation through short non-coding RNAs (sncRNA). The sncRNA have been pointed as potential biomarkers for psychiatric disorders. The Autism Spectrum Disorder (ASD) is developmental neuro…
Environment is crucial for manifestation and development of schizophrenia, bringing to light epigenetic mechanisms involved, such as post-transcriptional control of gene expression by miRNA, in this disorder. MiRNAs participate in physiological processes such as neurogenesis, behavioral manifestations as well as in adverse conditions like psychiatric disorders. Experimental models are ess…
(Only some records are available in English at this moment)
Autism, defined in disease classification manuals as autism spectrum disorder (ASD), is a condition related to neurodevelopment, characterized by difficulties in the areas of communication and social interaction, and may exhibit repetitive behaviors. The inheritance of autism is still not understood and research seeks to explain this condition through the interaction between genetic and e…
Autism spectrum disorder (ASD) is a neurodevelopment disorder that has an important environmental component. Thus, in addition to genetic predisposition, epigenetic aspects seem to be involved with this disorder. Some studies have shown, for example, alteration of the expression of microRNAs (miRNAs) in the post-mortem brain of ASD patients. Our group demonstrated that the valproic acid e…
Autism Spectrum Disorder (ASD) refers to a group of neurodevelopmental disorders with a broad spectrum of clinical phenotypes, characterized by deficits in social interaction, repetitive/stereotyped behaviors, problems in perception, interpretation, and elaboration of verbal and nonverbal communication and little or no eye contact. Such symptoms may be noticed in the first months of life,…
(Only some records are available in English at this moment)