CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences at the Federal University of Juiz de Fora (1999), Master (2002) and Doctorate (2006) in Sciences at the Federal University of São Paulo and Post-Doctorate in Genetics at the Medical Research Council - Human Genetics Unit (University of Edinburgh -2007/2008). Associate Professor at the Paulista School of Medicine at the Federal University of São Paulo. Has experience in the field of Epigenetics and Developmental Disorders, acting mainly on the following themes: germ cell development, paternal epigenetic inheritance and sncRNA. Has been dedicated to the study of the epigenetic inheritance of psychiatric disorders in humans and animal models and to the study of retrotransposons in this inheritance. Also works in the development of strategies for Higher Education improvement, being the creator and organizer of the Humana Educação Project. (Source: Lattes Curriculum)
The transgenerational epigenetic inheritance has been an issue of great interest recently, including those regarding schizophrenia (SCZ). Besides the genetic predisposition, epigenetic aspects seem to be involved in this psychiatric disorder. Studies have been showing, for example, that miRNA expression is altered in post mortem brains of SCZ patients. In experimental models for stress, t…
Background: Primordial germ cells (PGC) are the precursors of the gametes. During pre-natal development, PGC undergo an epigenetic reprogramming when bulk DNA demethylation occurs. This has been widely studied in mice but not in rats probably due to the lack of genetic and molecular information available about germ cell development in this species when compared to mice. However, we have p…
Dr. Ian Adams group, at the Medical Research Council - Human Genetics Unit/University of Edinburgh, and our group work in a very similar research area which principal focus is the embryonic development of primordial germ cells (PGC) in mice and rats, respectively. The methods and aims of both groups are also very similar and include: epigenetic analyses of PGC (DNA methylation and histone…
(Only some records are available in English at this moment)
Autism spectrum disorder (ASD) is a neurodevelopment disorder that has an important environmental component. Thus, in addition to genetic predisposition, epigenetic aspects seem to be involved with this disorder. Some studies have shown, for example, alteration of the expression of microRNAs (miRNAs) in the post-mortem brain of ASD patients. Our group demonstrated that the valproic acid e…
Autism Spectrum Disorder (ASD) refers to a group of neurodevelopmental disorders with a broad spectrum of clinical phenotypes, characterized by deficits in social interaction, repetitive/stereotyped behaviors, problems in perception, interpretation, and elaboration of verbal and nonverbal communication and little or no eye contact. Such symptoms may be noticed in the first months of life,…
The sncRNAs compose one of epigenetic regulatory mechanisms of genetic expression. The miRNAs are examples of sncRNA and dysregulation of their levels were already found in patients with psychiatric disorders, including autism spectrum disorder (ASD). ASD is characterized by communication and social interaction impairments, repetitive behaviors and restricted interests. This disorder pres…
Primordial germ cells (PGCs) are precursors of gametes and are the only way of transmitting the genetic and epigenetic information to the next generation. As PGC migrate and colonize the future gonads, the expression of germ cell-specific genes, like Mvh (Mouse Vasa Homologue), appear. Also at this stage, epigenetic reprogramming is important for the ultimate differentiation of these cell…
Primordial germ cells (PGC) derive from the epiblast and migrate through the primitive hindgut to reach the gonadal ridges. During this process, PGC undergo an epigenetic reprogramming that is marked by bulk DNA demethylation. This demethylation contributes to the reduction of potential epimutations and to paternal imprinting erasure. The ten-eleven translocation (TET) and thymine-DNA gly…
Primordial germ cells (PGC) are the precursors of the gametes, which are responsible for the transmission of the genetic and epigenetic information to the next generations. The normal development of PGC depends on a process called epigenetic reprogramming,during which the DNA is widely demethylated, permitting the expression of a variety of genes. Some of these genes are DNA sequences tha…
(Only some records are available in English at this moment)
| 9 / 8 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 8 / 8 | Completed scholarships in Brazil |
| 20 / 19 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 3 |
| Citations | 14 |
| Cit./Article | 4.7 |
| Data from Web of Science | |
ROCHA-DA-SILVA, LETICIA; ARMELIN-CORREA, LUCIA; CANTAO, ISABELLE HERNANDEZ; FLAIZ FLISTER, VERENA JULIA; NUNES, MARINA; STUMPP, TAIZA. Expression of genome defence protein members in proliferating and quiescent rat male germ cells and the Nuage dynamics. PLoS One, v. 14, n. 6, JUN 10 2019. Web of Science Citations: 1. (14/00934-6, 14/19123-8, 16/07782-2)
ENCINAS, GISELLY; ZOGBI, CAMILA; STUMPP, TAIZA. Detection of Four Germ Cell Markers in Rats during Testis Morphogenesis: Differences and Similarities with Mice. Cells Tissues Organs, v. 195, n. 5, p. 443-455, 2012. Web of Science Citations: 12. (09/07170-3)
CANTAO, ISABELLE HERNANDEZ; TESSER, RENATO BORGES; STUMPP, TAIZA. An Initial Investigation of an Alternative Model to Study rat Primordial Germ Cell Epigenetic Reprogramming. BIOLOGICAL PROCEDURES ONLINE, v. 19, AUG 3 2017. Web of Science Citations: 1. (12/25087-9, 12/01024-8, 11/07078-0)