Taiza Stumpp Teixeira
CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Is graduated in Biology (Federal University of Juiz de Fora), with post-graduation (Masters and Ph.D.) in Sciences at the Federal Univesity of Sao Paulo and post-doctorate at the Medical Research Council - Human Genetics Unit (MRC-HGU) of the University of Edinburgh (Scotland). Has a permanent position (Associate Professor) at the Federal University of Sao Paulo (EPM-UNIFESP) since 2006 and has been dedicated to the study of paternal epigenetic inheritance of psychiatric disorders as well as of genome defense mechanisms against retrotransposons. (Source: Lattes Curriculum)
- Expression of sncRNA related to schizophrenia in the sperm of an experimental model - SHR - for this disorder, AP.R
Abstract
The transgenerational epigenetic inheritance has been an issue of great interest recently, including those regarding schizophrenia (SCZ). Besides the genetic predisposition, epigenetic aspects seem to be involved in this psychiatric disorder. Studies have been showing, for example, that miRNA expression is altered in post mortem brains of SCZ patients. In experimental models for stress,...
- An initial investigation of an alternative model to study rat primordial germ cell epigenetic reprogramming, PUB.ART
Abstract
Background: Primordial germ cells (PGC) are the precursors of the gametes. During pre-natal development, PGC undergo an epigenetic reprogramming when bulk DNA demethylation occurs. This has been widely studied in mice but not in rats probably due to the lack of genetic and molecular information available about germ cell development in this species when compared to mice. However, we have...
- Bioinformatics analysis, manuscript ending and discussion of ongoing projects, AV.EXT
Abstract
Dr. Ian Adams group, at the Medical Research Council - Human Genetics Unit/University of Edinburgh, and our group work in a very similar research area which principal focus is the embryonic development of primordial germ cells (PGC) in mice and rats, respectively. The methods and aims of both groups are also very similar and include: epigenetic analyses of PGC (DNA methylation and histo...
- Genome defense mechanisms against retrotransposon expression in rat primordial germ cells and its relationship with their pluripotency, AP.R
Abstract
Germ cells are responsible for transmitting genetic and epigenetic information throughout the generations. These cells emerge from the epiblast as primordial germ cells (PGC) and undergo genome-wide epigenetic reprogramming that establish their identity and sex determination. This epigenetic reprogramming also lead to a pluripotency condition that is fundamental for the embryo formation...
(Only some records are available in English at this moment)
- Investigation of miRNA expression in blood cells from individuals diagnosed with Autism Spectrum Disorder (ASD) and from their fathers, BP.IC
Abstract
The sncRNAs compose one of epigenetic regulatory mechanisms of genetic expression. The miRNAs are examples of sncRNA and dysregulation of their levels were already found in patients with psychiatric disorders, including autism spectrum disorder (ASD). ASD is characterized by communication and social interaction impairments, repetitive behaviors and restricted interests. This disorder pr...
- Initial investigation of the role of melatonin in the epigenetic reprogramming of primordial germ cells in embryos of pinealectomized rats, BP.IC
Abstract
Primordial germ cells (PGCs) are precursors of gametes and are the only way of transmitting the genetic and epigenetic information to the next generation. As PGC migrate and colonize the future gonads, the expression of germ cell-specific genes, like Mvh (Mouse Vasa Homologue), appear. Also at this stage, epigenetic reprogramming is important for the ultimate differentiation of these ce...
- Association of the 5hmC epigentic mark with the retrotransposons IAP and LINE1 and Tet1 and TDG expression in rat primordial germ cells during the epigenetic reprogramming, BP.IC
Abstract
Primordial germ cells (PGC) derive from the epiblast and migrate through the primitive hindgut to reach the gonadal ridges. During this process, PGC undergo an epigenetic reprogramming that is marked by bulk DNA demethylation. This demethylation contributes to the reduction of potential epimutations and to paternal imprinting erasure. The ten-eleven translocation (TET) and thymine-DNA g...
- Possible role for DAZL protein in retrotransposon silencing, BP.IC
Abstract
Primordial germ cells (PGC) are the precursors of the gametes, which are responsible for the transmission of the genetic and epigenetic information to the next generations. The normal development of PGC depends on a process called epigenetic reprogramming,during which the DNA is widely demethylated, permitting the expression of a variety of genes. Some of these genes are DNA sequences t...
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 8 / 7 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 8 / 8 | Completed scholarships in Brazil |
| 18 / 17 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 3 |
| Citations | 14 |
| Cit./Article | 4.7 |
| Data from Web of Science | |
ROCHA-DA-SILVA, LETICIA; ARMELIN-CORREA, LUCIA; CANTAO, ISABELLE HERNANDEZ; FLAIZ FLISTER, VERENA JULIA; NUNES, MARINA; STUMPP, TAIZA. Expression of genome defence protein members in proliferating and quiescent rat male germ cells and the Nuage dynamics. PLoS One, v. 14, n. 6, JUN 10 2019. Web of Science Citations: 1. (14/19123-8, 16/07782-2, 14/00934-6)
CANTAO, ISABELLE HERNANDEZ; TESSER, RENATO BORGES; STUMPP, TAIZA. An Initial Investigation of an Alternative Model to Study rat Primordial Germ Cell Epigenetic Reprogramming. BIOLOGICAL PROCEDURES ONLINE, v. 19, AUG 3 2017. Web of Science Citations: 1. (12/01024-8, 12/25087-9, 11/07078-0)
ENCINAS, GISELLY; ZOGBI, CAMILA; STUMPP, TAIZA. Detection of Four Germ Cell Markers in Rats during Testis Morphogenesis: Differences and Similarities with Mice. Cells Tissues Organs, v. 195, n. 5, p. 443-455, 2012. Web of Science Citations: 12. (09/07170-3)