CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences from the Federal University of Juiz de Fora (1999), Master (2002) and PhD (2006) in Sciences from the Federal University of São Paulo and Post-Doctorate in Genetics from the Medical Research Council - Human Genetics Unit (University of Edinburgh ) -2007/2008). She is currently Associate Professor at Escola Paulista de Medicina-Federal University of São Paulo and leader of the study group on Biopsychosocial Epigenetics and its Heritage (BEpI). He has experience in the area of #8203;#8203;Epigenetics and paternal epigenetic inheritance, participating mainly in the following topics: germ cell development, DNA methylation, sncRNA profile and retrotransposons. He has been dedicated to studying the epigenetic inheritance of autism and related conditions, as well as understanding epigenetics as a mechanism for biological incorporation of the psychosocial context. She also works on developing strategies for Higher Education, being the creator and coordinator of the OrganicaMente Project. Coordinator of the Unifesp Mental Health Observatory (OSMU). (Source: Lattes Curriculum)
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Currently, the BepI group (Biopsychosocial Epigenetics and its Inheritance) is developing a research project funded by FAPESP (Proc. 2022/14195-7), which aims to study the expression of microRNAs in blood samples and oral mucosa cells of autistic individuals, as well as in the sperm of parents of autistic individuals. One of the great challenges of this type of study in the autistic commu…
Epigenetics refers to the modulation on gene expression and on DNA structure that are not related to alterations of base sequence. These type of modulation of gene expression include DNA methylation and regulation through short non-coding RNAs (sncRNA). The sncRNA have been pointed as potential biomarkers for psychiatric disorders. The Autism Spectrum Disorder (ASD) is developmental neuro…
The transgenerational epigenetic inheritance has been an issue of great interest recently, including those regarding schizophrenia (SCZ). Besides the genetic predisposition, epigenetic aspects seem to be involved in this psychiatric disorder. Studies have been showing, for example, that miRNA expression is altered in post mortem brains of SCZ patients. In experimental models for stress, t…
Background: Primordial germ cells (PGC) are the precursors of the gametes. During pre-natal development, PGC undergo an epigenetic reprogramming when bulk DNA demethylation occurs. This has been widely studied in mice but not in rats probably due to the lack of genetic and molecular information available about germ cell development in this species when compared to mice. However, we have p…
Dr. Ian Adams group, at the Medical Research Council - Human Genetics Unit/University of Edinburgh, and our group work in a very similar research area which principal focus is the embryonic development of primordial germ cells (PGC) in mice and rats, respectively. The methods and aims of both groups are also very similar and include: epigenetic analyses of PGC (DNA methylation and histone…
(Only some records are available in English at this moment)
Autism, defined in disease classification manuals as autism spectrum disorder (ASD), is a condition related to neurodevelopment, characterized by difficulties in the areas of communication and social interaction, and may exhibit repetitive behaviors. The inheritance of autism is still not understood and research seeks to explain this condition through the interaction between genetic and e…
Autism spectrum disorder (ASD) is a neurodevelopment disorder that has an important environmental component. Thus, in addition to genetic predisposition, epigenetic aspects seem to be involved with this disorder. Some studies have shown, for example, alteration of the expression of microRNAs (miRNAs) in the post-mortem brain of ASD patients. Our group demonstrated that the valproic acid e…
Autism Spectrum Disorder (ASD) refers to a group of neurodevelopmental disorders with a broad spectrum of clinical phenotypes, characterized by deficits in social interaction, repetitive/stereotyped behaviors, problems in perception, interpretation, and elaboration of verbal and nonverbal communication and little or no eye contact. Such symptoms may be noticed in the first months of life,…
(Only some records are available in English at this moment)
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| 12 / 12 | Completed scholarships in Brazil |
| 24 / 22 | All research grants and scholarships |
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