Sergio Marangoni
CV Lattes
Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at Biologia Modalidade Bacharelado from Universidade Estadual Paulista Júlio de Mesquita Filho (1972), master's at Microbiology from Universidade Federal de São Paulo (1979) and doctorate at Ciências Biológicas (Bioquímica) from Universidade Estadual de Campinas (1983). Has experience in Biochemistry, focusing on Chemistry of Macromolecules, acting on the following subjects: fosfolipase a2, inibidor de protease, lectina, phospholipase a2 and inibidor de tripsina. (Source: Lattes Curriculum)
- Chemical modifications by mass spectrometry from the PLA2 Bbil-TX isolated from the Bothriopsis bilineata venom: 'de novo' sequencing using the merge of different kinds of fragmentation and an overlaping of the peptides from a new PLA2 from B. taeniata, AP.R
Abstract
The snake venoms are a complex functional molecules and manly a protein mixture, which along of the evolution trough of mutations and the natural selection for the species maintenance inside of the micro-evolution it was created a several toxins with a high functional complexity and high structural similarity. These toxins has different pharmacological effects such as neurotoxicity and ...
- Rapid purification, pro-coagulant and platelet aggregating activities of Rhombeobin (LMR-47), a Thrombin-like/gyroxin enzyme from Lachesis muta rhombeata snake venom, PUB.ART
Abstract
In this article we report a rapid purification method using one step chromatography of SVSP Rombeobin (LMR-47) from Lachesis muta rhombeata venom and its pro-coagulant activities and effects on platelet aggregation. The venom was fractionated by a single chromatographic step in RP-HPLC on a C-8 Discovery® Bio Wide column, showing high degree of molecular homogeneity with molecular mass ...
- Chemical modifications of myotoxic PLA2 from Porthidium hyoprora: evaluation of catalytic effect and the myotoxic, neurotoxic and inflammatory activities, AP.R
Abstract
The snake venom has a mixture of functional molecules can be compared by analogy to a natural laboratory that develops and improves toxins through mutations and natural selection to maintain their species microevolution (defense and food). These toxins affect the prey's physiological system making it become paralyzed (neurotoxycity and myotoxicity) and do not run away from the place of ...
(Only some records are available in English at this moment)
- Biochemical characterization and study of the pharmacological activi in the junction neuromuscular of an isolated miotoxina from the Bothriopsis bilineata venom, BP.MS
- Structure-function study of Lachesis muta rhombeata venom toxin active in thrombus formation in vivo, BP.PD
Abstract
The snake venom of the family Viperidae is characterized by its rich protein/peptides content, able to interfere in specific stages of the haemostatic system. In general, these components stimulate or they inhibit stages key in the cascade of the clotting, fibrinolises, vascular permeability and platelets function. Venom proteins affecting blood coagulation have been classified in sever...
- Proteome analysis of schizophrenia human brain tissue from posterior superior temporal gyrus, BP.PD
| 25 / 4 | Completed research grants |
| 24 / 3 | Completed scholarships in Brazil |
| 49 / 7 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 16 |
| Citations | 213 |
| Cit./Article | 13.3 |
| Data from Web of Science | |
RAMALHO DE OLIVEIRA, CAIO FERNANDO; MARANGONI, SERGIO; RODRIGUES MACEDO, MARIA LIGIA. The trypsin inhibitor from Entada acaciifolia seeds affects negatively the development of Mediterranean flour moth, Anagasta kuehniella. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, v. 108, p. 74-79, JAN 2014. Web of Science Citations: 12. (11/09361-0)
HUANCAHUIRE-VEGA, SALOMON; PONCE-SOTO, LUIS ALBERTO; MARTINS-DE-SOUZA, DANIEL; MARANGONI, SERGIO. Biochemical and pharmacological characterization of PhTX-I a new myotoxic phospholipase A(2) isolated from Porthidium hyoprora snake venom. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, v. 154, n. 2, p. 108-119, AUG 2011. Web of Science Citations: 10.
HUANCAHUIRE-VEGA, SALOMON; CORREA, DANIEL H. A.; HOLLANDA, LUCIANA M.; LANCELLOTTI, MARCELO; RAMOS, CARLOS H. I.; PONCE-SOTO, LUIS ALBERTO; MARANGONI, SERGIO. Chemical Modi cations of PhTX-I Myoto in from Porthidium hyoprora Snake Venom: Effects on Structural, Enzymatic, and Pharmacological Properties. BIOMED RESEARCH INTERNATIONAL, 2013. Web of Science Citations: 4.
TOYAMA, DANIELA DE OLIVEIRA; DOS SANTOS DIZ FILHO, EDUARDO BRITTO; CAVADA, BENILDO SOUSA; MATIAS DA ROCHA, BRUNO ANDERSON; BUZZO DE OLIVEIRA, SIMONE CRISTINA; COTRIM, CAMILA APARECIDA; GOMES SOARES, VERONICA CRISTINA; DELATORRE, PLINIO; MARANGONI, SERGIO; TOYAMA, MARCOS HIKARI. Umbelliferone induces changes in the structure and pharmacological activities of Bn IV, a phospholipase A(2) isoform isolated from Bothrops neuwiedi. Toxicon, v. 57, n. 6, p. 851-860, MAY 2011. Web of Science Citations: 14.
FAGUNDES, F. H. R.; OLIVEIRA, M.; HUANCAHUIRE-VEGA, S.; ROMERO-VARGAS, F. F.; PONCE-SOTO, L. A.; MARANGONI, S.. cDNA and deduced primary structure of basic phospholipase A(2) with neurotoxic activity from the venom secretion of the Crotalus durissus collilineatus rattlesnake. Brazilian Journal of Medical and Biological Research, v. 43, n. 3, p. 262-270, MAR 2010. Web of Science Citations: 1.
PONCE-SOTO, L. A.; MARTINS-DE-SOUZA, D.; MARANGONI, S.. Neurotoxic, Myotoxic and Cytolytic Activities of the New Basic PLA(2) Isoforms BmjeTX-I and BmjeTX-II Isolated from the Bothrops marajoensis (Maraj Lancehead) Snake Venom. The Protein Journal, v. 29, n. 2, p. 103-113, FEB 2010. Web of Science Citations: 15.
VILCA-QUISPE, AUGUSTO; PONCE-SOTO, LUIS ALBERTO; WINCK, FLAVIA VISCHI; MARANGONI, SERGIO. Isolation and characterization of a new serine protease with thrombin-like activity (TLBm) from the venom of the snake Bothrops marajoensis. Toxicon, v. 55, n. 4, p. 745-753, APR 1 2010. Web of Science Citations: 23.
TOYAMA, D. O.; MARANGONI, S.; DIZ-FILHO, E. B. S.; OLIVEIRA, S. C. B.; TOYAMA, M. H.. Effect of umbelliferone (7-hydroxycoumarin, 7-HOC) on the enzymatic, edematogenic and necrotic activities of secretory phospholipase A2 (sPLA2) isolated from Crotalus durissus collilineatus venom. Toxicon, v. 53, n. 4, p. 417-426, MAR 15 2009. Web of Science Citations: 33.
DANTZGER, MIRIAM; VASCONCELOS, ILKA MARIA; SCORSATO, VALERIA; APARICIO, RICARDO; MARANGONI, SERGIO; RODRIGUES MACEDO, MARIA LIGIA. Bowman-Birk proteinase inhibitor from Clitoria fairchildiarta seeds: Isolation, biochemical properties and insecticidal potential. Phytochemistry, v. 118, p. 224-235, OCT 2015. Web of Science Citations: 13. (11/09361-0)
TORRES-HUACO, FRANK DENIS; WERNECK, CLAUDIO C.; VICENTE, CRISTINA PONTES; VASSEQUI-SILVA, TALITA; COELHO NERY-DIEZ, ANA CLAUDIA; MENDES, CAMILA B.; ANTUNES, EDSON; MARANGONI, SERGIO; DAMICO, DANIELA C. S.. Rapid Purification and Procoagulant and Platelet Aggregating Activities of Rhombeobin: A Thrombin-Like/Gyroxin-Like Enzyme from Lachesis muta rhombeata Snake Venom. BIOMED RESEARCH INTERNATIONAL, 2013. Web of Science Citations: 5. (09/02299-8)
RAMALHO DE OLIVEIRA, CAIO FERNANDO; VASCONCELOS, ILKA MARIA; APARICIO, RICARDO; MACHADO FREIRE, MARIA DAS GRACAS; BALDASSO, PAULO APARECIDO; MARANGONI, SERGIO; RODRIGUES MACEDO, MARIA LIGIA. Purification and biochemical properties of a Kunitz-type trypsin inhibitor from Entada acaciifolia (Benth.) seeds. Process Biochemistry, v. 47, n. 6, p. 929-935, JUN 2012. Web of Science Citations: 27. (11/09361-0)
TORRES-HUACO, FRANK DENIS; PONCE-SOTO, LUIS ALBERTO; MARTINS-DE-SOUZA, DANIEL; MARANGONI, SERGIO. Purification and Characterization of a New Weak Hemorrhagic Metalloproteinase BmHF-1 from Bothrops marajoensis Snake Venom. The Protein Journal, v. 29, n. 6, p. 407-416, AUG 2010. Web of Science Citations: 8.
DAMICO, DANIELA C. S.; VASSEQUI-SILVA, T.; TORRES-HUACO, F. D.; NERY-DIEZ, A. C. C.; DE SOUZA, R. C. G.; DA SILVA, S. L.; VICENTE, C. P.; MENDES, C. B.; ANTUNES, E.; WERNECK, C. C.; et al. LmrTX, a basic PLA(2) (D49) purified from Lachesis muta rhombeata snake venom with enzymatic-related antithrombotic and anticoagulant activity. Toxicon, v. 60, n. 5, p. 773-781, OCT 2012. Web of Science Citations: 13. (10/19916-7, 09/02299-8)
KRAUCHENCO‚ S.; NAGEM‚ R.A.P.; DA SILVA‚ J.A.; MARANGONI‚ S.; POLIKARPOV‚ I.. Three-dimensional structure of an unusual Kunitz (STI) type trypsin inhibitor from Copaifera langsdorffii. Biochimie, v. 86, n. 3, p. 167-172, 2004. (99/03387-4)
FLORIANO, RAFAEL STUANI; ROCHA, THALITA; CARREGARI, VICTOR CORASOLLA; MARANGONI, SERGIO; DA CRUZ-HOEFLING, MARIA ALICE; HYSLOP, STEPHEN; RODRIGUES-SIMIONI, LEA; ROWAN, EDWARD G.. The neuromuscular activity of Bothriopsis bilineata smaragdina (forest viper) venom and its toxin Bbil-TX (Asp49 phospholipase A(2)) on isolated mouse nerve-muscle preparations. Toxicon, v. 96, p. 24-37, MAR 2015. Web of Science Citations: 5. (09/04127-0)
RAMALHO DE OLIVEIRA, CAIO FERNANDO; SOUZA, THAIS DE PAULA; POSTALI PARRA, JOSE ROBERTO; MARANGONI, SERGIO; SILVA-FILHO, MARCIO C.; RODRIGUES MACEDO, MARIA LIGIA. Insensitive trypsins are differentially transcribed during Spodoptera frugiperda adaptation against plant protease inhibitors. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, v. 165, n. 1, p. 19-25, MAY 2013. Web of Science Citations: 26. (11/09361-0)
HUANCAHUIRE-VEGA, SALOMON; PONCE-SOTO, LUIS ALBERTO; MARANGONI, SERGIO. PhTX-II a Basic Myotoxic Phospholipase A(2) from Porthidium hyoprora Snake Venom, Pharmacological Characterization and Amino Acid Sequence by Mass Spectrometry. TOXINS, v. 6, n. 11, p. 3077-3097, NOV 2014. Web of Science Citations: 4.
(References retrieved automatically from State of São Paulo Research Institutions)
BEGHINI, Daniela Gois. Neutralização de atividades farmacológicas e enzimáticas de venenos crotálicos perante antivenenos. 2005. 87f. Tese (Doutorado) – Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). Campinas. (01/14163-1)
TOYAMA, Daniela de Oliveira. Estudo das frações protéicas derivadas do veneno de serpentes crotálicas e bothropicas com atividade antibacteriana, isolamento, purificação e caracterização bioquímica e biológica. 2004. 202f. Tese (Doutorado) – Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). Campinas. (00/14050-0)
QUISPE, Augusto Vilca. Caracterização estrutural e funcional de uma serinoprotease TLBm, isolada a partir do veneno total de Bothrops marajoensis. 2008. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (06/54275-7)
CARREGARI, Victor Corasolla. Caracterização bioquímica e estudo da atividade farmacológica na junção neuromuscular de uma fosfolipase A2 isolada do veneno de Bothriopsis bilineata. 2011. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (09/04127-0)
VEGA, Salomon Huancahuire. Modificações químicas e caracterização farmacológica das miotoxinas PhTX-I e PhTX-II isoladas do veneno de Porthidium hyoprora. 2012. Tese (Doutorado) – Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (09/51207-9)
CALGAROTTO, Andrana Karla. Caracterização fisico-quimica e biologica de uma fosfolipase A2 isolada do veneno de Bothrops moojeni. 2008. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (06/52309-1)
BEGHINI, Daniela Gois. Isolamento e purificação de uma neurotoxina crotoxina do veneno de Crotalus durissus cascavella : caracterização bioquimica e biologica / c Daniela Gois Beghini. 2001. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas. (99/10557-3)
SILVA, José Antônio da. Aspectos estruturais, funcionais e conformacionais do inibidor de tripsina CTI de sementes de Copaifera Iangsdorffii. 2004. Tese (Doutorado) – Instituto de Biologia. Universidade Estadual de Campinas. (00/02317-1)
SOTO, Luis Alberto Ponce. Estudos estrutura-função de neurotoxinas isoladas de veneno crotálico e botrópico : análise comparativa de neurotoxicidade e mitoxicidade. 2005. Tese (Doutorado) – Instituto de Biologia. Universidade Estadual de Campinas. (02/01058-8)
SILVA, José Antônio da. Isolamento e caracterização bioquimica de inibidores de proteinases serinicas de sementes de Copaifera Iangsdorffii : estudo da resistencia contra o Callosobruchus maculatus. 2004. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas. (98/00578-0)
TOYAMA, Marcos Hikari. Miotoxinas PLA2 "like" de Bothrops pirajai : caracterização molecular e funcional. 2000. Tese (Doutorado) – Instituto de Biologia. Universidade Estadual de Campinas. (95/03149-5)
SOTO, Luis Alberto Ponce. Caracterização bioquimica e biologica de uma crotoxina "like" do veneno total de Crotalus durissus collilineatus. 2001. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas. (99/10259-2)