She holds a bachelor's degree in Biomedicine from the University of Santo Amaro (1996), a Master's degree (2000) and a PhD (2004) in Pharmacology from the University of São Paulo and a PhD in the Department of Cellular Biology and Development at the University of São Paulo. It investigates the action of Crotoxin (CTX), the main toxin isolated from Crotalus durissus terrificus (rattlesnake) venom on immunometolism, particularly on the function and energetic metabolism of macrophages, and how this immunomodulatory action of CTX can control the inflammatory events associated with Tumor progression. In this context, it investigates the direct effect of this toxin on tumor cells, endothelial cells and fibroblasts in three-dimensional extracellular matrix, in vitro biomimetic system to the tumor microenvironment and the main intracellular signaling pathways involved. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Butantan’s dengue vaccine is 80% effective |
| La vacuna contra el dengue producida en Brasil por el Instituto Butantan de São Paulo posee una eficacia del 80 % |
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Vaccination is the touchstone of public health policies. The history of vaccination shows that vaccines have been empirically developed; therefore, many studies are still needed for the continuous development of this biological product. The effectiveness of vaccines is evaluated through the reduction of the infection or illness among vaccinated individuals, and it is influenced by many fa…
application of technical resource reservation for improving institutional research activities at the Institute Butantan (AU)
application of technical resource reservation for improving institutional research activities at the Butantan Institute (AU)
The expansion and adequacy of the infrastructure for connectivity and the institutional database are extremely relevant actions to allow the scientific activities of Instituto Butantan to be executed with maximum support. These actions allow the implementation of new and better technologies, as well as reduce the obsolescence of equipment and infrastructure. (AU)
(Only some records are available in English at this moment)
Macrophages (MØ) are cells with high plasticity that can be reprogrammed into two distinct phenotypes - MØ M1 (pro-inflammatory) and MØ M2 (anti-inflammatory) - according to the nature of the disorder detected in the organism. Experimentally, it is possible to induce reprogramming of macrophages to M1 and M2 and the functional and metabolic status of both phenotypes have already been char…
Several studies have shown that Crotoxin (CTX), the major toxin of the Crotalus durissus terrificus Venom (CdtV), has anti-inflammatory and immunomodulatory actions in vivo and in vitro. As regards immuno-modulatory activities, CTX stimulates, particularly, the metabolism of macrophages and the production of cytokines, lipoxin A4 and analogue 15-Epi-LXA4, by these cells, leading to inhibi…
Studies have shown that Crotoxin (CTX), majority toxin from Crotalus durissus terrificus snake venom presents suppressive action on the immune response and on tumor growth, besides causing inhibition of the events of the inflammatory response by modulating, in particular macrophages functions, cells critical to the mechanisms of innate defense. Studies by our group have shown that CTX sti…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 11 / 9 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 8 / 4 | Completed scholarships in Brazil |
| 22 / 16 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID