CV Lattes
ORCID
Abstract
Application of technical resource reservation for improving institutional research activities at the Institute Butantan (AU)
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She holds a bachelor's degree in Biomedicine from the University of Santo Amaro (1996), a Master's degree (2000) and a PhD (2004) in Pharmacology from the University of São Paulo and a PhD in the Department of Cellular Biology and Development at the University of São Paulo. It investigates the action of Crotoxin (CTX), the main toxin isolated from Crotalus durissus terrificus (rattlesnake) venom on immunometolism, particularly on the function and energetic metabolism of macrophages, and how this immunomodulatory action of CTX can control the inflammatory events associated with Tumor progression. In this context, it investigates the direct effect of this toxin on tumor cells, endothelial cells and fibroblasts in three-dimensional extracellular matrix, in vitro biomimetic system to the tumor microenvironment and the main intracellular signaling pathways involved. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Butantan’s dengue vaccine is 80% effective |
| La vacuna contra el dengue producida en Brasil por el Instituto Butantan de São Paulo posee una eficacia del 80 % |
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| News published in Agência FAPESP Newsletter about the researcher |
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Research grants
- Application of technical resource reservation for improving institutional research activities at the Institute Butantan, AP.RT.INST
- EMU Technological: Acquisition of a High Performance Computing System for Health and Life Sciences, AP.INFRA7.TECIN
Abstract
In this project, we will gather skills from several researchers in the areas of Health Science, Biological Science and Computer Science aiming at the area of Life Sciences and high performance computing (HPC). The advancement of biotechnology and molecular technologies, integrated with developments in the latest technologies in the area of Bioinformatics and Computational Biology, has ope…
- Continuous improvement of vaccines: Center for Viral Surveillance and Serological Assessment (CeVIVAS), AP.CCD
Abstract
Vaccination is the touchstone of public health policies. The history of vaccination shows that vaccines have been empirically developed; therefore, many studies are still needed for the continuous development of this biological product. The effectiveness of vaccines is evaluated through the reduction of the infection or illness among vaccinated individuals, and it is influenced by many fa…
- Hands on training on Infectious Diseases detection methods, AO.R
- Emerging infectious diseases: biology, prevention and treatment, AO.R
- application of technical resource reservation for improving institutional research activities at the Institute Butantan, AP.RT.INST
Abstract
application of technical resource reservation for improving institutional research activities at the Institute Butantan (AU)
(Only some records are available in English at this moment)
Scholarships in Brazil
- HPC Infrastructure Management and Application Development for Scientific Portal for Integration of Bioinformatics Applications into NBBC-HPC, BP.TT
- Continuous improvement of vaccines: Center for Viral Surveillance and Serological Assessment (CeVIVAS), BP.TT
- Impact of different dengue genotypes on the pathophysiology and severity of the disease: a multi-omics approach to the disease and which biological factors lead to its worsening., BP.DR
Abstract
The project "Impact of different dengue genotypes on the pathophysiology and severity of the disease: a multi-omics approach" aims to understand the changes in the dengue pathogen-host interaction, investigate whether there is any genetic factor, whether from the host or the virus, responsible for the severity of the disease, and understand if there are any proteins, peptides, or smaller …
(Only some records are available in English at this moment)
- Reprogramming of Macrophage Metabolism and Function by Crotoxin, BP.DR
Abstract
Macrophages (MØ) are cells with high plasticity that can be reprogrammed into two distinct phenotypes - MØ M1 (pro-inflammatory) and MØ M2 (anti-inflammatory) - according to the nature of the disorder detected in the organism. Experimentally, it is possible to induce reprogramming of macrophages to M1 and M2 and the functional and metabolic status of both phenotypes have already been char…
- Crotoxin-induced macrophage secretory activity on fibroblast functions involved with the wound healing process. in vitro studies, BP.MS
Abstract
Several studies have shown that Crotoxin (CTX), the major toxin of the Crotalus durissus terrificus Venom (CdtV), has anti-inflammatory and immunomodulatory actions in vivo and in vitro. As regards immuno-modulatory activities, CTX stimulates, particularly, the metabolism of macrophages and the production of cytokines, lipoxin A4 and analogue 15-Epi-LXA4, by these cells, leading to inhibi…
- Effect of crotoxin on the modulating action of macrophages on angiogenesis: in vitro assays, BP.MS
Abstract
Studies have shown that Crotoxin (CTX), majority toxin from Crotalus durissus terrificus snake venom presents suppressive action on the immune response and on tumor growth, besides causing inhibition of the events of the inflammatory response by modulating, in particular macrophages functions, cells critical to the mechanisms of innate defense. Studies by our group have shown that CTX sti…
(Only some records are available in English at this moment)
Total / Available in English
| 3 / 3 | Ongoing research grants |
| 13 / 11 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 8 / 4 | Completed scholarships in Brazil |
| 28 / 22 | All research grants and scholarships |
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