CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Biologist, with a master's degree in Virology and a PhD in Molecular Biology, both from the Federal University of São Paulo (UNIFESP). He did two post-doctorates in Brazil, one at the Medical Schools (Cell Biology) and the other at the Faculty of Veterinary Medicine (Cell Biology and Cell Therapy) at the University of São Paulo. He did a sabbatical postdoctoral in Neuroscience at the University of California San Diego (UCSD). She is currently an Associate Professor in the Department of Microbiology at the Institute of Biomedical Sciences at the University (ICB) of São Paulo and Principal Investigator at the Scientific Platform Pasteur-USP (SPPU), an international member of the Pasteur Institutes. As a line of research, he works investigating the mechanisms of genetic and infectious diseases that affect the CNS, using disease modeling from human iPSC cells, with the main targets of Autism and the Congenital Syndrome caused by the Zika virus. Among her projects at the Disease Modeling Laboratory of the Institute of Biomedical Sciences at USP, Drª Patrícia is the creator and the responsible for the "A Fada do Dente Project", a Brazilian initiative that uses stem cells from the milk teeth of autistic children to study the mechanisms involved in Autism. His group was responsible for proving the causal relationship between Zika virus and microcephaly using brain organoids and animal models. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Otra causa posible del autismo |
The Zika virus (ZIKV) is a flavivirus capable of causing infection in humans after the bite by mosquitoes of the genus Aedes contaminated with the virus. In 2015, the Brazilian strain of this virus - ZIKVBR caused an epidemic in Brazil, causing a congenital infection with the generation of several cases of cerebral malformation in infants of mothers infected by ZIKVBR. Through the study o…
The successive different phases of gestation are characterized by two clearly distinct parts. The first one is related to the beginning of the gestation and means the first three months of pregnancy in human important events just as embryogenesis, placentation and organogenesis occur during this period. Some evidence found in animal models suggests problems could reflect early or late int…
Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with high functional impairment, where the patients present behavioral changes such as repetitive and stereotyped movements, communication deficits and socialization problems. The worldwide prevalence of ASD is very high, with about 1-2% of the world population. The diagnosis of ASD patients usually occurs at three…
Studying autism biology is a challenge due to the lack of access to patients cells from the central nervous system (CNS). Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with high functional impairment, where patients exhibit behavioral changes as repetitive and ste-reotyped movements, communication deficits and socialization problems. The worldwide prevalence o…
The elucidation of genetic disease whose cause is not fully established is mainly hampered by poor or lack of adequate models for such studies. In 2006 a group of researchers, using an ingenious protocol, managed to reprogram differentiated adult cells, turning them into cells with characteristics similar to embryonic cells using genes that are expressed in pluripotent stem cells by trans…
(Only some records are available in English at this moment)
The idiopathic autism is a disorder classified within the Autism Spectrum Disorder (ASD) affects the development psychoneurological and the ability to communicate, understand and speak thus affecting your social life. It is a disease even without genetic causes as well elucidated and pediatric of major concern, with increasing incidence. Currently, it is estimated that 1% of all school-ag…
| 1 / 1 | Ongoing research grants |
| 4 / 3 | Completed research grants |
| 6 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 12 / 9 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 7 |
| Citations | 82 |
| Cit./Article | 11.7 |
| Data from Web of Science | |
YDE OHKI, CRISTINE MARIE; BENAZZATO, CECILIA; RUSSO, FABIELE BALDINO; BALEEIRO BELTRAO-BRAGA, PATRICIA CRISTINA. Developing animal models of Zika virus infection for novel drug discovery. EXPERT OPINION ON DRUG DISCOVERY, v. 14, n. 6, APR 2019. Web of Science Citations: 1. (16/02978-6, 18/16748-8)
ROSA-FERNANDES, LIVIA; CUGOLA, FERNANDA RODRIGUES; RUSSO, FABIELE BALDINO; KAWAHARA, REBECA; DE MELO FREIRE, CAIO CESAR; CORREA LEITE, PAULO EMLIO; BASSI STERN, ANA CAROLINA; ANGELI, CLAUDIA BLANES; LEAL DE OLIVEIRA, DANIELLE BRUNA; MELO, STELLA REZENDE; et al. Zika Virus Impairs Neurogenesis and Synaptogenesis Pathways in Human Neural Stem Cells and Neurons. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 13, MAR 15 2019. Web of Science Citations: 1. (13/08844-3, 18/16748-8, 15/02866-0, 16/02978-6, 11/20683-0, 14/06863-3)
BELTRAO-BRAGA, PATRICIA C. B.; PIGNATARI, GRACIELA C.; MAIORKA, PAULO C.; OLIVEIRA, NELIO A. J.; LIZIER, NELSON F.; WENCESLAU, CRISTIANE V.; MIGLINO, MARIA A.; MUOTRI, ALYSSON R.; KERKIS, IRINA. Feeder-Free Derivation of Induced Pluripotent Stem Cells From Human Immature Dental Pulp Stem Cells. CELL TRANSPLANTATION, v. 20, n. 11-12, p. 1707-1719, 2011. Web of Science Citations: 56.
DIAS, THOMAZ LUSCHER; SCHUCH, VIVIANE; BALEEIRO BELTRAO-BRAGA, PATRICIA CRISTINA; MARTINS-DE-SOUZA, DANIEL; BRENTANI, HELENA PAULA; FRANCO, GLORIA REGINA; NAKAYA, HELDER IMOTO. Drug repositioning for psychiatric and neurological disorders through a network medicine approach. TRANSLATIONAL PSYCHIATRY, v. 10, n. 1, MAY 12 2020. Web of Science Citations: 0. (17/25588-1, 18/03673-0, 14/10068-4, 19/00098-7, 18/16748-8)
RUSSO, FABIELE BALDINO; BRITO, ANITA; DE FREITAS, ARIANE MIRANDA; CASTANHA, ANDRELISSA; DE FREITAS, BEATRIZ C.; BALEEIRO BELTRAO-BRAGA, PATRICIA CRISTINA. The use of iPSC technology for modeling Autism Spectrum Disorders. Neurobiology of Disease, v. 130, OCT 2019. Web of Science Citations: 0. (11/20683-0, 16/02978-6)
RUSSO, FABIELE BALDINO; FREITAS, BEATRIZ CAMILLE; PIGNATARI, GRACIELA CONCEICAO; FERNANDES, ISABELLA RODRIGUES; SEBAT, JONATHAN; MUOTRI, ALYSSON RENATO; BALEEIRO BELTRAO-BRAGA, PATRICIA CRISTINA. Modeling the Interplay Between Neurons and Astrocytes in Autism Using Human Induced Pluripotent Stem Cells. BIOLOGICAL PSYCHIATRY, v. 83, n. 7, p. 569-578, APR 1 2018. Web of Science Citations: 21. (16/02978-6, 11/20683-0)
BRITO, ANITA; RUSSO, FABIELE BALDINO; MUOTRI, ALYSSON RENATO; BALEEIRO BELTRAO-BRAGA, PATRICIA CRISTINA. Autism spectrum disorders and disease modeling using stem cells. Cell and Tissue Research, v. 371, n. 1, p. 153-160, JAN 2018. Web of Science Citations: 3. (11/20683-0)
(References retrieved automatically from State of São Paulo Research Institutions)
RUSSO, Fabiele Baldino. Geração de células pluripotentes induzidas de pacientes com transtorno do espectro autista. Tese (Doutorado) - Faculdade de Medicina Veterinária e Zootecnia. Universidade de São Paulo (USP). São Paulo. (11/20683-0)