Biologist, with a master's degree in Virology and a PhD in Molecular Biology, both from the Federal University of São Paulo (UNIFESP). He did two post-doctorates in Brazil, one at the Medical Schools (Cell Biology) and the other at the Faculty of Veterinary Medicine (Cell Biology and Cell Therapy) at the University of São Paulo. He did a sabbatical postdoctoral in Neuroscience at the University of California San Diego (UCSD). She is currently an Associate Professor in the Department of Microbiology at the Institute of Biomedical Sciences at the University (ICB) of São Paulo and Principal Investigator at the Scientific Platform Pasteur-USP (SPPU), an international member of the Pasteur Institutes. As a line of research, he works investigating the mechanisms of genetic and infectious diseases that affect the CNS, using disease modeling from human iPSC cells, with the main targets of Autism and the Congenital Syndrome caused by the Zika virus. Among her projects at the Disease Modeling Laboratory of the Institute of Biomedical Sciences at USP, Drª Patrícia is the creator and the responsible for the "A Fada do Dente Project", a Brazilian initiative that uses stem cells from the milk teeth of autistic children to study the mechanisms involved in Autism. His group was responsible for proving the causal relationship between Zika virus and microcephaly using brain organoids and animal models. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Otra causa posible del autismo |
| News published in Agência FAPESP Newsletter about the researcher |
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The Zika virus (ZIKV) is a flavivirus capable of causing infection in humans after the bite by mosquitoes of the genus Aedes contaminated with the virus. In 2015, the Brazilian strain of this virus - ZIKVBR caused an epidemic in Brazil, causing a congenital infection with the generation of several cases of cerebral malformation in infants of mothers infected by ZIKVBR. Through the study o…
The successive different phases of gestation are characterized by two clearly distinct parts. The first one is related to the beginning of the gestation and means the first three months of pregnancy in human important events just as embryogenesis, placentation and organogenesis occur during this period. Some evidence found in animal models suggests problems could reflect early or late int…
(Only some records are available in English at this moment)
Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with high functional impairment, where the patients present behavioral changes such as repetitive and stereotyped movements, communication deficits and socialization problems. The worldwide prevalence of ASD is very high, with about 1-2% of the world population. The diagnosis of ASD patients usually occurs at three…
Studying autism biology is a challenge due to the lack of access to patients cells from the central nervous system (CNS). Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with high functional impairment, where patients exhibit behavioral changes as repetitive and ste-reotyped movements, communication deficits and socialization problems. The worldwide prevalence o…
The elucidation of genetic disease whose cause is not fully established is mainly hampered by poor or lack of adequate models for such studies. In 2006 a group of researchers, using an ingenious protocol, managed to reprogram differentiated adult cells, turning them into cells with characteristics similar to embryonic cells using genes that are expressed in pluripotent stem cells by trans…
(Only some records are available in English at this moment)
The idiopathic autism is a disorder classified within the Autism Spectrum Disorder (ASD) affects the development psychoneurological and the ability to communicate, understand and speak thus affecting your social life. It is a disease even without genetic causes as well elucidated and pediatric of major concern, with increasing incidence. Currently, it is estimated that 1% of all school-ag…
| 5 / 4 | Completed research grants |
| 6 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 12 / 9 | All research grants and scholarships |
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