Patricia Cristina Baleeiro Beltrão Braga
CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Biologist, with master's degree in Virology and PhD in Molecular Biology, both from the Federal University of São Paulo (UNIFESP). She did two postdoctoral fellows in Brazil, one at School of Medicine (Cell Biology) and another at School of Veterinary Medicine (Cell Biology and Cell Therapy), both from University of São Paulo. Additionaly, she did a sabbatical postdoctoral fellowship in Neuroscience at the University of California San Diego (UCSD). She is currently an Associate Professor at the Biomedical Sciences Institute of the University of São Paulo, teaching Embryology, Genetics and Microbiology. As a research line, she investigates the mechanisms of genetic and infectious diseases that affect the CNS, using disease modeling from human iPSC cells, with the main targets being Autism and Congenital Syndrome caused by the Zika virus. Among her projects at the Laboratory of Disease Modeling at the Institute of Biomedical Sciences at USP, Dr. Patrícia is responsible for the "The Tooth Fairy Project", a Brazilian initiative that uses stem cells from the teeth of autistic children to study the mechanisms involved in Autism. Her group was responsible for proving the causal relationship of the Zika virus with microcephaly using cerebral organoids and animal models. (Source: Lattes Curriculum)
- Investigation of Zika Virus action in central nervous system cells: modeling infection in human astrocytes derived from induced pluripotent cells, AP.R
Abstract
The Zika virus (ZIKV) is a flavivirus capable of causing infection in humans after the bite by mosquitoes of the genus Aedes contaminated with the virus. In 2015, the Brazilian strain of this virus - ZIKVBR caused an epidemic in Brazil, causing a congenital infection with the generation of several cases of cerebral malformation in infants of mothers infected by ZIKVBR. Through the study...
- 47th Annual Meeting of the society for neuroscience - neuroscience 2017, AR.EXT
- The viteline enigma, AP.TEM
Abstract
The successive different phases of gestation are characterized by two clearly distinct parts. The first one is related to the beginning of the gestation and means the first three months of pregnancy in human important events just as embryogenesis, placentation and organogenesis occur during this period. Some evidence found in animal models suggests problems could reflect early or late i...
- Infection of aminiotic menbrance cells from Golden retriever muscular dystrophic dogs (GRMD) with a recombinant retrovirus carrying lacZ gene, AR.EXT
- Investigation of the role of microglia derived from iPSC in Autism Spectrum Disorder, BP.MS
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with high functional impairment, where the patients present behavioral changes such as repetitive and stereotyped movements, communication deficits and socialization problems. The worldwide prevalence of ASD is very high, with about 1-2% of the world population. The diagnosis of ASD patients usually occurs at thr...
- Cell modeling Autism Spectrum Disorder patients using induced pluripotent stem cells (iPSC), BP.PD
Abstract
Studying autism biology is a challenge due to the lack of access to patients cells from the central nervous system (CNS). Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with high functional impairment, where patients exhibit behavioral changes as repetitive and ste-reotyped movements, communication deficits and socialization problems. The worldwide prevalence...
- Generation of induced pluripotent cells of patients with autistic disorder, BP.DR
Abstract
The elucidation of genetic disease whose cause is not fully established is mainly hampered by poor or lack of adequate models for such studies. In 2006 a group of researchers, using an ingenious protocol, managed to reprogram differentiated adult cells, turning them into cells with characteristics similar to embryonic cells using genes that are expressed in pluripotent stem cells by tra...
- Histological analysis of teratoma formed in immunodeficient mice after implant of induced pluripotent stem cell (IPS) derived from human dental pulp, BP.IC
- Morphological and functional research of neurons derived from induced pluripotent stem cells from autistic spectrum disorder patients, BE.EP.DR
Abstract
The idiopathic autism is a disorder classified within the Autism Spectrum Disorder (ASD) affects the development psychoneurological and the ability to communicate, understand and speak thus affecting your social life. It is a disease even without genetic causes as well elucidated and pediatric of major concern, with increasing incidence. Currently, it is estimated that 1% of all school-...
| 1 / 1 | Ongoing research grants |
| 4 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 5 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 12 / 9 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 6 |
| Citations | 75 |
| Cit./Article | 12.5 |
| Data from Web of Science | |
RUSSO, FABIELE BALDINO; BRITO, ANITA; DE FREITAS, ARIANE MIRANDA; CASTANHA, ANDRELISSA; DE FREITAS, BEATRIZ C.; BALEEIRO BELTRAO-BRAGA, PATRICIA CRISTINA. The use of iPSC technology for modeling Autism Spectrum Disorders. Neurobiology of Disease, v. 130, OCT 2019. Web of Science Citations: 0.
RUSSO, FABIELE BALDINO; FREITAS, BEATRIZ CAMILLE; PIGNATARI, GRACIELA CONCEICAO; FERNANDES, ISABELLA RODRIGUES; SEBAT, JONATHAN; MUOTRI, ALYSSON RENATO; BALEEIRO BELTRAO-BRAGA, PATRICIA CRISTINA. Modeling the Interplay Between Neurons and Astrocytes in Autism Using Human Induced Pluripotent Stem Cells. BIOLOGICAL PSYCHIATRY, v. 83, n. 7, p. 569-578, APR 1 2018. Web of Science Citations: 14.
BRITO, ANITA; RUSSO, FABIELE BALDINO; MUOTRI, ALYSSON RENATO; BALEEIRO BELTRAO-BRAGA, PATRICIA CRISTINA. Autism spectrum disorders and disease modeling using stem cells. Cell and Tissue Research, v. 371, n. 1, p. 153-160, JAN 2018. Web of Science Citations: 3.
BELTRAO-BRAGA, PATRICIA C. B.; PIGNATARI, GRACIELA C.; MAIORKA, PAULO C.; OLIVEIRA, NELIO A. J.; LIZIER, NELSON F.; WENCESLAU, CRISTIANE V.; MIGLINO, MARIA A.; MUOTRI, ALYSSON R.; KERKIS, IRINA. Feeder-Free Derivation of Induced Pluripotent Stem Cells From Human Immature Dental Pulp Stem Cells. CELL TRANSPLANTATION, v. 20, n. 11-12, p. 1707-1719, 2011. Web of Science Citations: 57.
ROSA-FERNANDES, LIVIA; CUGOLA, FERNANDA RODRIGUES; RUSSO, FABIELE BALDINO; KAWAHARA, REBECA; DE MELO FREIRE, CAIO CESAR; CORREA LEITE, PAULO EMLIO; BASSI STERN, ANA CAROLINA; ANGELI, CLAUDIA BLANES; LEAL DE OLIVEIRA, DANIELLE BRUNA; MELO, STELLA REZENDE; et al. Zika Virus Impairs Neurogenesis and Synaptogenesis Pathways in Human Neural Stem Cells and Neurons. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 13, MAR 15 2019. Web of Science Citations: 1.
YDE OHKI, CRISTINE MARIE; BENAZZATO, CECILIA; RUSSO, FABIELE BALDINO; BALEEIRO BELTRAO-BRAGA, PATRICIA CRISTINA. Developing animal models of Zika virus infection for novel drug discovery. EXPERT OPINION ON DRUG DISCOVERY, v. 14, n. 6, APR 2019. Web of Science Citations: 0.
(References retrieved automatically from State of São Paulo Research Institutions)
RUSSO, Fabiele Baldino. Geração de células pluripotentes induzidas de pacientes com transtorno do espectro autista. 2015. Tese (Doutorado) – Faculdade de Medicina Veterinária e Zootecnia. Universidade de São Paulo (USP). São Paulo.