CV Lattes
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ORCID
Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Biomedical, Master and PhD in Human Genetics from the Federal University of São Paulo (UNIFESP) with an internship at the University of Pennsylvania (USA) and post-doctorate from the Department of Psychiatry at UNIFESP.Acts as Associate Professor in the Department of Morphology and Genetics at the Federal University of São Paulo (UNIFESP).She is a Researcher and leads a research group on Genetics Applied to Mental Diseases. She is Coordinator of the Graduate Program in Structural and Functional Biology at Escola Paulista de Medicina (UNIFESP), Coordinator of the Genetics Area of #8203;#8203;the Laboratory of Integrative Neuroscience (LINC) at UNIFESP and Coordinator of the Genetics and Biorepository of #8203;#8203;the National Institute of Psychiatry Development (INPD).She has focused on investigating the genetic and epigenetic mechanisms that contribute to the development of psychiatric disorders, showing direct applications to the field of mental health. It has been analyzing large-scale genetic and epigenetic data from patients with schizophrenia, post-traumatic stress disorder, depression and other mental illnesses to identify the genetic factors that underlie mental disorders and their symptoms / dimensions in children and adults.Her aims are to find genetic markers, methylation and gene expression profiles able to predict mental disease as early as possible and providing more information for the response to treatment.She has extensive experience in human genetics, even more applied in mental health and is particularly interested in finding markers, understanding the pathophysiology, progression and response to treatment, in addition to how trauma and adverse life experiences interact with the genome, transcriptome and epigenome. (Source: Lattes Curriculum)
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Psychiatric disorders are among the main causes of socio-occupational disability in western countries and their impact grows every year. Most of these psychiatric disorders begin in childhood or adolescence, with about one in ten children worldwide diagnosed with a psychiatric disorder. However, little investment in research is devoted to the study of mental disorders in this age group. V…
Traumatic brain injury (TBI) is a public health problem, with considerable social and economic burden. TBI is one of the most important causes of secondary epilepsy. TBI leads to post-traumatic epilepsy (PTE) most likely by means of direct damage to the brain parenchyma, which in turn leads to neurodegeneration and inflammatory responses, as well as molecular, structural and electrophysio…
Adverse childhood experiences (ACEs) - which includes physical/sexual abuse, neglect or parental mental illness - confer risk for psychiatric dysfunction not only to those directly exposed, but also to the next generation. However, mechanisms underlying these ACE-related intergenerational effects are unclear, significantly limiting a unique prevention opportunity. Our study aims to examin…
Psychoses characterize a group of severe and disabling mental disorders. The delay in providing adequate treatment, the duration of the first episode of psychosis (FEP) and the low response to the initial treatment are among the main factors of poor prognosis. Recently, the largest genome-wide association study (GWAS) in schizophrenia found 108 regions associated with the disease. In a pr…
Schizophrenia is currently seen as a disease of neurodevelopment that determines high rates of morbidity and mortality. Only prevention strategies, including identification of risk factors and early intervention may reduce these rates. This project focuses on identifying genetic markers of risk, progression and response to treatment to promote primary, secondary, tertiary schizophrenia pr…
Posttraumatic stress disorder is triggered by an external event that threatening individual physical integrity, leading to characteristics symptoms of reviviscence, avoidance/numbing and hyperarousal. Despite the external adverse event, some predisposing factors are present presupposing multicausality. Once PTSD is installed, it has chronic features leading to important functional impairm…
(Only some records are available in English at this moment)
Traumatic brain injury (TBI) is highly frequent in Brazil, with more than 150,000 cases per year, and is a major risk factor for the development of post-traumatic epilepsy (PTE). However, the treatment of TBI-derived PTE is still ineffective. Therefore, it is necessary to investigate new approaches, such as the use of biperiden, an anticholinergic drug. MicroRNAs (miRNAs) from extracellul…
MicroRNAs (miRNAs) are small molecules of endogenous regulatory, non-coding RNAs that provide an epigenetic mechanism for regulating protein expression levels of target genes. miRNAs are considered as serum diagnostic biomarkers for various diseases due to their stability and detection in minute amounts. These small regulators can be found in fluids such as blood, serum, saliva, urine, an…
Psychiatric disorders are multifactorial diseases, resulting from the interplay between genetic and environmental risk factors. However, it is underlying causal mechanisms linking them to the psychopathology spectrum. Traumatic experiences can be considered one of the main environmental risk factors across multiple mental illnesses. This widespread effect is probably due to the impact of…
MicroRNAs (miRNAs) are small molecules of endogenous regulatory non-coding RNAs that provide an epigenetic mechanism for the regulation of protein expression levels of target genes. They can be detected peripherally and carried by extracellular vesicles (EVs), which can be released by virtually any cell type, including neural cells, and are able to cross the blood-brain barrier functionin…
Psychiatric Disorders (PD) are severe public health problems. These disorders are highly heritable and have a complex, overlapping polygenic architecture. Besides, they include a combination of genetic and environmental factors. Because of this, it is important to examine shared genetic risk factors for polygenic prediction of PD. Aim: This study aims to identify patterns among psychiatri…
(Only some records are available in English at this moment)
Schizophrenia (SCZ) is a multifactorial disease comprising a set of signs and symptoms of unknown origin. Modeling SCZ using human induced pluripotent stem cells (iPS cells) offers an emerging opportunity to examine the mechanisms underlying complex disease pathogenesis. We aim to evaluate the expression of miRNAs in neural cells of FEP patients with and without treatment with risperidone…
This study aims to characterize the admixture of a longitudinal cohort of children and adolescents (Instituto Nacional da Psiquiatria do Desenvolvimento - INPD) and understand how ancestry influences the polygenic risk scores (PRS) of psychiatric disorders (PDs) in this cohort. Besides, we will simulate latin american genotypes in order to find which is the best reference panel to charact…
Women's higher risk for Posttraumatic stress disorder (PTSD) likely arises from biologic and social/environmental factors. The current results of PTSD GWAS have indicated that there are genetic differences between women and men in the predisposition to PTSD. Polimanti and colleagues (2017) observed a strong causal association between female body shape (anthropometric traits) and the risk …
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing research grants |
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| 3 / 3 | Ongoing scholarships in Brazil |
| 19 / 18 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 37 / 36 | All research grants and scholarships |
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