CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Researcher in the field of Psychiatric Genetics. Graduated in Biomedical Science, Master's and PhD in Human and Medical Genetics from the Federal University of São Paulo (UNIFESP) with internship at the University of Pennsylvania (USA), Post-Doctorate by Department of Psychiatry at UNIFESP and Associate Professor at the Department of Morphology and Genetics at UNIFESP. She is an Associate Professor in the Department of Morphology and Genetics at the Federal University of São Paulo (UNIFESP) and leads a research group on Genetics Applied to Mental Disorders. She currently coordinates the Laboratory of Integrative Neuroscience (LINC) at UNIFESP and coordinates the Genetics and Biorepository Area of the National Institute of Developmental Psychiatry (INPD). She is the Latin American representative on the schizophrenia group of the PGC (Psychiartic Genomics Consortium) and coordinates the schizophrenia working group within the LAGC (Latin America Genomics Consortium). He has focused on investigating the genetic and epigenetic mechanisms that contribute to the development of psychiatric disorders, showing direct applications to the field of mental health. It has been analyzing large-scale genetic and epigenetic data from patients with schizophrenia, post-traumatic stress disorder, depression and other mental illnesses to identify the supposed genetic factors that underlie mental disorders and their symptoms/dimensions in children and adults. Her goal is to find genetic markers, methylation and gene expression profiles that can predict the disease as early as possible and provide more information on the response to treatment. She has extensive experience in human genetics, further applied to mental health and is particularly interested in finding markers, understanding pathophysiology, progression and response to treatment, as well as how trauma and adverse life experiences interact with the genome, transcriptome and epigenome. (Source: Lattes Curriculum)
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Internalizing problems such as emotional dysregulation and externalizing behaviors like aggression often manifest early in life, correlating with adverse outcomes in adulthood. Genetic influences are substantial in developing these symptoms, contributing significantly to their variance, yet the complete genetic landscape and environmental triggers remain elusive.The study aims to investig…
Psychiatric disorders are among the main causes of socio-occupational disability in western countries and their impact grows every year. Most of these psychiatric disorders begin in childhood or adolescence, with about one in ten children worldwide diagnosed with a psychiatric disorder. However, little investment in research is devoted to the study of mental disorders in this age group. V…
Adverse childhood experiences (ACEs) - which includes physical/sexual abuse, neglect or parental mental illness - confer risk for psychiatric dysfunction not only to those directly exposed, but also to the next generation. However, mechanisms underlying these ACE-related intergenerational effects are unclear, significantly limiting a unique prevention opportunity. Our study aims to examin…
(Only some records are available in English at this moment)
Psychoses characterize a group of severe and disabling mental disorders. The delay in providing adequate treatment, the duration of the first episode of psychosis (FEP) and the low response to the initial treatment are among the main factors of poor prognosis. Recently, the largest genome-wide association study (GWAS) in schizophrenia found 108 regions associated with the disease. In a pr…
Schizophrenia is currently seen as a disease of neurodevelopment that determines high rates of morbidity and mortality. Only prevention strategies, including identification of risk factors and early intervention may reduce these rates. This project focuses on identifying genetic markers of risk, progression and response to treatment to promote primary, secondary, tertiary schizophrenia pr…
Posttraumatic stress disorder is triggered by an external event that threatening individual physical integrity, leading to characteristics symptoms of reviviscence, avoidance/numbing and hyperarousal. Despite the external adverse event, some predisposing factors are present presupposing multicausality. Once PTSD is installed, it has chronic features leading to important functional impairm…
(Only some records are available in English at this moment)
The DEEP-MIND project aims to apply deep-learning techniques to integrate genomic and clinical data within the Brazilian High-Risk Cohort (BHRC), with the goal of identifying genetic variants associated with major mental disorders and functional deviations. This initiative, resulting from a collaboration between the University of São Paulo (USP), Federal University of São Paulo (UNIFESP),…
Advances in molecular and diagnostic techniques have improved our understanding of the etiology of psychiatric conditions, but the diagnosis and management of individuals with psychiatric conditions remains a major challenge. From a biological point of view, psychiatric disorders have a considerable genetic component, with heritability ranging from 0.37 to 0.85, depending on the disorder,…
Internalizing problems such as emotional dysregulation and externalizing behaviors like aggression often manifest early in life, correlating with adverse outcomes in adulthood. Genetic influences are substantial in developing these symptoms, contributing significantly to their variance, yet the complete genetic landscape and environmental triggers remain elusive. The study aims to investi…
(Only some records are available in English at this moment)
MicroRNAs (miRNAs) are small molecules of endogenous regulatory non-coding RNAs that provide an epigenetic mechanism for the regulation of protein expression levels of target genes. They can be detected peripherally and carried by extracellular vesicles (EVs), which can be released by virtually any cell type, including neural cells, and are able to cross the blood-brain barrier functionin…
Psychiatric disorders are multifactorial diseases, resulting from the interplay between genetic and environmental risk factors. However, it is underlying causal mechanisms linking them to the psychopathology spectrum. Traumatic experiences can be considered one of the main environmental risk factors across multiple mental illnesses. This widespread effect is probably due to the impact of…
(Only some records are available in English at this moment)
Schizophrenia, one the most well-characterized psychiatric disorders, presents symptoms such as psychosis, cognitive impairment, and social dysfunction. It has a very impactful genetic component, with heritability estimated at around 70%. Despite extensive genomic and transcriptomic research, only a few genes have been consistently linked with schizophrenia. Variability in results can be …
Schizophrenia (SCZ) is a multifactorial disease comprising a set of signs and symptoms of unknown origin. Modeling SCZ using human induced pluripotent stem cells (iPS cells) offers an emerging opportunity to examine the mechanisms underlying complex disease pathogenesis. We aim to evaluate the expression of miRNAs in neural cells of FEP patients with and without treatment with risperidone…
This study aims to characterize the admixture of a longitudinal cohort of children and adolescents (Instituto Nacional da Psiquiatria do Desenvolvimento - INPD) and understand how ancestry influences the polygenic risk scores (PRS) of psychiatric disorders (PDs) in this cohort. Besides, we will simulate latin american genotypes in order to find which is the best reference panel to charact…
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing grants |
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| 5 / 5 | Ongoing scholarships in Brazil |
| 20 / 19 | Completed scholarships in Brazil |
| 7 / 7 | Completed scholarships abroad |
| 42 / 41 | All research grants and scholarships |
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