CV Lattes
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Universidade Federal do ABC (UFABC). Centro de Ciências Naturais e Humanas (CCNH) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full Professor at the Centre for Natural Sciences and Humanities at the Federal University of ABC UFABC. He has a bachelor?s in Chemistry from University of São Paulo USP end obtained his Ph.D. in Molecular Biological from Federal University of São Paulo UNIFESP, where he studied the action of peptides in Central Nervous System , to obtain the obesity control. Prior to joining at Federal University of ABC in August 2006, he studied the renin-angiotensin-aldosterone system, using analogues of the angiotensin II, as a postdoctoral researcher at Federal University of São Paulo. Dr. Oliveira is currently developing studies on malaria, in order to obtain active peptides against this disease, on development of new antimicrobial peptides and their antitumoral action. Dr. Oliveira is a professor in the postgraduate courses of Science and Technology - Chemistry of UFABC and in Biological Sciences (Molecular Biology) of UNIFESP. http://pesquisa.ufabc.edu.br/lacomb/ (Source: Lattes Curriculum)
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Antimicrobial peptides (PAMs) are biomolecules with less than 100 amino acid residues that play an important role in the immune response of various microorganisms such as bacteria, fungi and viruses, as well as being potential anticancer agents. Thus, it is very important searching new bioactive compounds. The present project proposes the synthesis of new AMPs, analogues of VmCT1 and Poly…
The peptides are versatile molecules, which can be used for various purposes and applications. In this project we propose a study about the effects of synthetic peptides on different micro-organisms. The first target is the protozoa that cause malaria, which still affects 300 million people each year, and even then, does not have an effective drug in the treatment, or with a suitable prev…
Malaria affects 300 million people annually. Nevertheless, this disease has neither an effective drug treatment nor an appropriate preventive. Our research group has showed a new perspective to strive against this disease, when we related the anti-sporozoite action of angiotensin II (AII) and its inhibitory effect on the development of Plasmodium gallinaceum in Aedes aegypti. Recently, we…
(Only some records are available in English at this moment)
The increase in population longevity and the consequent overuse of antibiotics has led to the emergence of bacteria resistant to conventional treatments and has threatened the success of treatments for diseases caused by microorganisms, requiring the search for new pharmacotherapeutic options. In this regard, antimicrobial peptides (AMPs) have aroused great interest in the scientific comm…
Antimicrobial peptides (PAMs) are bioactive molecules produced by various organisms. They are also good candidates for the fight against microorganisms pathogenic to the human body as an essential component of the immune system. One class of these PAMs, the Megainins, has shown low hemolytic activity while possessing good activity against Gram-positive and Gram-negative resistant bacteria…
The antiplasmodial activity of angiotensin II has been studied. Due to its vasoconstrictor properties this hormone cannot be used as an antimalarial drug. Previous works performed at Laboratório de Compostos Bioativos presented the obtainment of different angiotensin II derivatives aiming to understand the role of each amino acid residue and their interaction with the parasite membrane, a…
(Only some records are available in English at this moment)
The increase in multidrug-resistant pathogens has led to the search for new antibiotics. Antimicrobial peptides represent promising alternatives to conventional antibiotics due to their broad-spectrum activity, their potency at low concentrations, and their multifunctional mode of action that decreases the likelihood of resistance development. This research project aims to search for new …
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