CV Lattes
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Ministério da Ciência, Tecnologia e Inovação (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Researcher in the fields of biotechnology, biocatalysis, and synthetic biology. His work focuses on the discovery and molecular elucidation of the genomic dark matter of microbial life from Brazilian biodiversity, as well as the development of microbial biofactories for the production of enzymes and other bioproducts, which, when combined, have the potential to revolutionize biotechnology. He coordinates institutional interdisciplinary scientific programs to address strategic national challenges in bioenergy and biorenewables, as well as large-scale RD projects in partnership with biotechnology companies. Discoveries from these studies have led to paradigm shifts in biotechnology, with results published in journals such as Nature, Nature Chemical Biology, and Nature Communications. The biotechnological platforms developed in these institutional programs are being validated at large scale, including pilot plant and field experiments, and are being customized through collaborations with the private sector.Since 2008 at CNPEM, he has coordinated major scientific facilities, including the MX1 and MX2 beamlines for Macromolecular Crystallography at LNLS and LNBio, and the ROBOLAB facility for macromolecular crystallization. He has also held leadership roles such as Coordinator of the Molecular Division at CTBE (20162017), Scientific Director of LNBR (20182025), and is currently Executive Director of LNBR. He has served on the National Technical Biosafety Commission (CTNBio) since 2021, currently holding the position of Vice President since September 2024 and Coordinator of the Animal Subsector since February 2025.In recognition of his scientific contributions and support for innovation in biotechnology, he was elected an Affiliate Member of the Brazilian Academy of Sciences (2020present) and received the EMBRAPII Outstanding Researcher Award, selected among more than 15,000 researchers in the EMBRAPII network. (Source: Lattes Curriculum)
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This project aims to elucidate enzymatic systems and molecular mechanisms associated with the depolymerization and metabolism of complex carbohydrates by microorganisms present in the gut microbiota of herbivores. The processing of carbohydrates by the gut microbiota plays a central role in the generation of energy (nutrition) for the host, in addition to other functions such as modulatio…
The plant cell wall is an important physical barrier to pathogens, and to chemical and physical stress for plants and it is essentially composed of polysaccharides of great biological and industrial importance. However, the challenge to deconstruct the plant cell wall into simple sugars is not a fully consolidated and economically viable process for many industrial applications as, for ex…
In this next project we will continue our studies regarding the class V myosins (MyoVs). The combination of structural and functional approaches will be maintained as in the previous project and our goal will be to answer new questions that arose during these two years of work. First, we want to know what the role of phosphorylation in regulating the CBD function of mammalian MyoVs. To th…
(Only some records are available in English at this moment)
Aquatic environments of tropical forests are rich in organic plant matter, coming from aquatic and semi-aquatic plants, algae and decomposing wood. These vegetables serve as food for various animals such as fish, birds and aquatic mammals, being processed mainly by their intestinal microbiota. In this project, enzymes active on carbohydrates prospected from the intestinal microbiota of Am…
Multi-omics studies of environments not yet explored have revealed new strategies for the degradation of lignocellulosic biomass, revealing new enzymes, often from unprecedented families, whose molecular mechanisms remain unknown. In this doctoral project, we intend to understand with a high level of detail and precision the mechanisms of enzymes potentially belonging to new families or s…
The production of bioactive compounds, alternative chemicals and biofuels from lignocellulosic materials is considered one of the most promising strategies to replace current non-renewable petrochemical routes. One of the main challenges encountered is the depolymerization of its components, such as cellulose and hemicellulose, into fermentable sugars. Microorganisms present in natural en…
(Only some records are available in English at this moment)
Microorganisms capability to act in complex carbohydrates feedstocks and catalyze theirdepolymerization in diverse conditions is a synergistic feature of their enzymatic apparatus.However, due to these systems diversity and complexity, the elucidation of their molecularmechanisms is limited in comparison with the number of enzyme sequences available. Thisphenomenon is even more pronounced…
The genus Xanthomonas is composed of gram-negative bacteria capable of infecting different plant species, many of them of great economic and social importance, such as rice and orange. Brazil as the second largest producer of citrus fruits in the world for decades is concerned with Citrus Canker disease, caused by the presence of the bacterium Xanthomonas citri subsp. citri, which has har…
(Only some records are available in English at this moment)
Primary cell walls of plants are mainly composed by cellulose and hemicellulose, having xyloglucan (XyG) as the main hemicellulosic polysaccharide. The XyG structure and composition largely varies according to plant type and tissue requiring a diverse and complex repertoire of glycosyl hydrolases to be depolymerized. The genus Xanthomonas poses as one of the most widespread pathogenic bac…
Glycoside hydrolases from family 43 (GH43) act on the degradation of key polysaccharides that constitute the hemicellulose such as xylan and arabinans. However, despite this family having a strong correlation with plant cell wall deconstruction and being ubiquitous in plant biomass maceration specialized organisms, it is still poorly explored. GH43 is a very polyspecific family, divided i…
The family 5 of glycoside hydrolases (GH5) consists of more than 12000 members that recognize and hydrolyze a broad range of carbohydrates. For a better understanding of the great diversity of its enzymatic repertoire, Asperborg et al. (2012) classified the GH5 family into 51 subfamilies, from which 20 did not have available characterization data so far. In the current FAPESP doctoral pro…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 8 / 8 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 27 / 23 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 46 / 42 | All research grants and scholarships |
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