graduate at Licenciatura Em Ciências Biológicas from Instituto de Biociências Letras E Ciências Exatas (1996), master's at Morphology from Universidade Federal de São Paulo (1999) and ph.d. at Ciências (Morfologia) from Universidade Federal de São Paulo (2005). Has experience in Morphology, focusing on Embryology, acting on the following subjects: microtomia, métodos de coloração, fixação, inclusão em parafina and preparado histológico permanente. (Source: Lattes Curriculum)
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One of the focuses of our research group has been to investigate the pathophysiological relevance of the anti-inflammatory protein annexin A1 (AnxA1) and its mimetic peptides in different models of inflammation through a combination of histopathological, pharmacological, and ultrastructural analyses. On the other hand, we also seek to identify targets that mediate endogenous anti-inflamma…
Annexin A1 (AnxA1) is a 37 kDa protein capable of regulating various cellular and molecular stages of the inflammatory response and is involved in endogenous mechanisms that are activated to obtain an adequate resolution. In addition, some synthetic peptides derived from the N-terminal domain of AnxA1 mimic the pharmacological property of the total protein, especially its anti-inflammator…
In the last years, the research by our group has been focused the role of proteins with anti and proinflammatory activities, specially the galectins-1, -3 and annexin A1 (ANXA1), using different experimental models of inflammation. Thus, these investigations have been expanded with a dual approach: 1) on one hand, the patho-physiological relevance of these mediators in different models of…
Galectins-1 and -3 (Gal-1 e Gal-3), 14.5 and 29 kDa proteins, respectively, operate as potent endogenous mediators of inflammation by controlling leukocyte transmigration process, release of cytokines and mast cell degranulation, thus contributing to homeostasis of the inflammatory reaction. However, the molecular mechanisms by which these lectins modulate cellular responses, particularly…
(Only some records are available in English at this moment)
Diabetic retinopathy (DR) is one of the most serious and common complications of diabetes and considered the leading cause of acquired blindness. During the development of DR, there are morphological changes in the retina and activation of Müller glial cells that contribute to the inflammatory process, which may lead to retinal degeneration. For relevance to this project and the lack of s…
Citrus pectin is a complex polysaccharide, derived from citrus fruit peels, which can be modified through a specific pH and enzymatic treatment that makes it low molecular weight and easily absorbed in the intestine. Modified citrus pectin (MCP) produces pleiotropic effects, including anti-proliferative, anti-metastatic, and immunomodulatory effects. MCP also antagonizes the effects of th…
Parkinson's Disease (PD) is a neurodegenerative disorder of high incidence in the global population, which affects men and women mainly between 45 - 54 years-old. Recent studies demonstrate that neuroinflammation is a crucial condition of PD, prompting the search for more effective treatments with a focus on inflammation. In this context, we highlight Annexin A1 (AnxA1), an anti-inflammat…
(Only some records are available in English at this moment)
Annexin A1 (ANXA1) is an anti-inflammatory and pro-resolving protein in the inflammatory response by controlling the migration of leukocytes, release of pro-inflammatory cytokines, and phagocytosis by macrophages. In addition, ANXA1 regulates the activation of the NLRP3 inflammasome in inflammatory cells, but this relationship has not been explored in cells related to inflammatory bowel d…
Annexin A1 (ANXA1) is an anti-inflammatory protein and has a decisive role in the inflammatory response through the control of leukocyte migration, the release of pro-inflammatory cytokines, and the phagocytosis of macrophages. In allergic processes, this protein also regulates the production of IgE, the release of Th2 profile cytokines, and mast cell degranulation. In addition, ANXA1 reg…
Galectin-3 (Gal-3) is a ²-galactoside-binding protein that is associated with heart fibrosis due to its positive regulation of the inflammatory response and oxidative stress. However, the cellular and molecular mechanisms involved in the role of Gal-3 in the heart in a cardiotoxicity model are not well determined. Thus, this study will evaluate the effect of pharmacological inhibition of …
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 9 / 6 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 17 / 16 | Completed scholarships in Brazil |
| 32 / 28 | All research grants and scholarships |
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CV Lattes
ORCID