CV Lattes
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Universidade de São Paulo (USP). Escola de Educação Física e Esporte de Ribeirão Preto (EEFERP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
He is a member of the Brazilian Society of Physiology (SBFis), Society for Endocrinology, and International Society of Exercise and Immunology. He is currently Associate Professor at the University of São Paulo (USP) - School of Physical Education and Sport of Ribeirão Preto (EEFERP). He has experience in the evaluation of molecular responses to acute and / or chronic physical exercise in different rodent tissues and in skeletal muscle of human beings with or without chronic diseases. degenerative diseases. (Source: Lattes Curriculum)
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The potential benefits of PGC-1 alpha on the mitochondrial function of skeletal muscle are known to be mediated by adaptations induced by physical exercise. However, the interplay of PGC-1alpha with other molecules has not yet been fully elucidated and described in the literature. Therefore, it is essential to unravel the mechanisms by which muscle homeostasis is regulated and which are t…
Recently, the World Health Organization classified sarcopenia as a disease, which will allow the establishment of universal clinical guidelines for its diagnosis and treatment. In this sense, the rev-erb-alpha protein is a promising molecular target for the prevention and treatment of sarcopenia, since it plays an essential role in the regulation of autophagy, mitochondrial content, oxida…
Recently, the World Health Organization classified Sarcopenia as a disease, which will allow the establishment of universal clinical guidelines for its diagnosis and treatment. In this sense, the rev-erb-alpha protein is a promising molecular target for the prevention and treatment of Sarcopenia, since it plays an essential role in the regulation of autophagy, mitochondrial content, oxida…
The regulation of food intake and control of energy expenditure occur in the hypothalamus through orexigenic and anorexigenic neurons. Hypothalamic inflammation induced by obesity is associated with resistance to insulin and leptin, which impairs the actions of these hormones in the autophagy pathway, causing hyperphagia and increasing body adiposity. It is known that intermittent fasting…
Dr. Donato Americo Rivas is a Scientist II and Professor of Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA), Tufts University (Boston, USA). Dr. Rivas investigates the role of substrates in cell signaling pathways that control the metabolism and growth of skeletal muscle and how nutrition, aging, and physical exer…
Autophagy is a cellular degradation mechanism that aids in the removal of cytoplasmic contents such as macromolecules and organelles. Currently, Dr. Adelino Sanchez Ramos da Silva is the principal investigator of five projects that are supported by the São Paulo Research Foundation (FAPESP) which aim to evaluate the effects of physical exercise on the autophagy in multiple tissues. The pr…
(Only some records are available in English at this moment)
It is well known that the liver plays a fundamental role in metabolism, being responsible for the synthesis of various substances essential for metabolic activities. Among these substances, interleukins are notable, with this study focusing especially on interleukin-10 (IL-10), recognized as an anti-inflammatory cytokine that plays a crucial role in modulating the hepatic response to infl…
Aging is a multifactorial process marked by several epigenetic and molecular changes: telomere shortening, DNA exposure to damage, mitochondrial dysfunction and oxidative stress. Such changes lead to the degeneration of cells and molecules, which affects tissues, organs and systems over time, reducing the human body's ability to resist damage and favoring the development of chronic diseas…
(Only some records are available in English at this moment)
During aging, there is a loss of muscle mass and strength, also known as sarcopenia. Furthermore, skeletal muscles are constantly challenged with a multitude of mechanical, thermal, and oxidative stresses, which can result in cell damage and death. Two pathways affected by aging are the Notch and autophagy pathways. Notch signaling aids in muscle development, as well as proliferation and …
Almost all over the world, the largest growing contingent is people aged 60 or over. Due to population aging, the high prevalence of neurodegenerative diseases becomes more worrying, such as dementia. Alzheimer's disease (AD) is the most common form of dementia, characterized by the formation of senile A² plaque (²-amyloid plaque). In addition to AD, another problem observed in the elderl…
(Only some records are available in English at this moment)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the loss of motor neurons, leading to severe muscle atrophy, paralysis, and, ultimately, death due to respiratory failure. Genetic mutations are a major etiopathogenic factor in ALS and have led to the development of animal models, such as the SOD1G93A transgenic mouse, which replicates the dis…
Recently it was demonstrated that the nuclear receptor Rev-erb±, codified by the Nr1d1 gene, plays an important role in the skeletal muscle, regulating exercise capacity and atrophy-related genes. It was shown that this molecule is highly sensitive to endurance chronic training, but until the present moment, few data are available about Rev-erb± responses in skeletal muscle to resistance …
Proteostatic quality control mechanisms fail with advancing age, resulting in the accumulation of damaged and dysfunctional proteins. However, our understanding is limited because the prior investigations treated tissues as a homogenous collection of cells. Therefore, a critical unknown is how individual cell types within a tissue influence overall tissue proteostasis. The overall goal of…
Insulin resistance is a major risk factor for type 2 diabetes (T2D) and metabolic syndrome. Environmental factors, such as feeding patterns and physical activity levels, can favor insulin resistance development. However, in some cases, skeletal muscle insulin sensitivity alterations can occur many years before changes in glucose tolerance. In addition, induced pluripotent stem cells (iPSC…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing grants |
| 17 / 11 | Completed research grants |
| 10 / 10 | Ongoing scholarships in Brazil |
| 24 / 21 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 61 / 52 | All research grants and scholarships |
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