Adelino Sanchez Ramos da Silva
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Universidade de São Paulo (USP). Escola de Educação Física e Esporte de Ribeirão Preto (EEFERP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
He is a member of the Brazilian Society of Physiology (SBFis) and the International Society of Exercise and Immunology. He is currently associate professor (RDIDP) at the University of São Paulo (USP) - School of Physical Education and Sport of Ribeirão Preto (EEFERP). He has experience in the evaluation of molecular responses to acute and / or chronic physical exercise in different rodent tissues and in skeletal muscle of human beings with or without chronic diseases. degenerative diseases. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| Overtraining produces negative alterations in several organs |
- Effects of physical exercise on the autophagy pathway, AP.R SPRINT
Abstract
Autophagy is a cellular degradation mechanism that aids in the removal of cytoplasmic contents such as macromolecules and organelles. Currently, Dr. Adelino Sanchez Ramos da Silva is the principal investigator of five projects that are supported by the São Paulo Research Foundation (FAPESP) which aim to evaluate the effects of physical exercise on the autophagy in multiple tissues. The ...
- Sarcopenia, nutrition, and physical activity, AV.EXT
Abstract
Dr. Donato Americo Rivas is a Scientist II and Professor of Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA), Tufts University (Boston, USA). Dr. Rivas investigates the role of substrates in cell signaling pathways that control the metabolism and growth of skeletal muscle and how nutrition, aging, and physical ex...
- Effects of regular physical exercise and overtraining on the behavior of the autophagic pathway in different tissues of mice, AP.R
Abstract
The imbalance between excessive training and inadequate recovery periods is linked to the performance decrement and to the states of functional overreaching (FOR), nonfunctional overreaching (NFOR) and/or overtraining syndrome (OTS). Mice submitted to an overtraining protocol (OT) based on chronic eccentric exercise sessions (OTR/down) showed hepatic activation of the mTORC1 pathway and...
- Levels of hepatic ATF-6 and caspase-3 are downregulated in mice after excessive training, PUB.ART
Abstract
Recently, we demonstrated that different running overtraining (OT) protocols with the same external load, but performed downhill (OTR/down), uphill (OTR/up), and without inclination (OTR), led to hepatic fat accumulation. As the disruption of endoplasmic reticulum (ER) homeostasis is linked to animal models of fatty liver disease, we investigated the effects of these OT models on the pr...
(Only some records are available in English at this moment)
- Physical exercise as a non-pharmacological strategy in the prevention and treatment of Alzheimer Disease, BP.DR
Abstract
The number of people with Dementia is increasing substantially around the world, having a global cost similar to GDP of countries like Netherlands. Brazil occupies the ninth place in this ranking. Alzheimer Disease (AD) is the most prevalent among the neurodegenerative diseases (Dementias), having the formation of ²-amiloide plaques in the brain tissue as a characteristic. One of the fa...
- Role of interleukin-6 in the responses of the autophagic pathway in the heart of mice submitted in acute exhaustive physical exercise, BP.MS
Abstract
Our research group verified that the imbalance between the excess of physical exercise and the adequate period of rest is linked with signals of pathological hypertrophy cardiac, lower phosphorylation of protein AMP-activated protein kinase (AMPK) in tyrosine 172, and higher concentrations of interleukin-6 (IL-6) in serum and cardiac tissue in mice. As known, which the increase in IL-6 ...
- Effects of the combination of intermittent fasting with physical exercise on the hypothalamic autophagy pathway in obese mice, BP.DR
Abstract
The medial basal hypothalamus is composed of AgRP orexigenic neurons and POMC anorectic neurons, which are involved in the regulation of food intake and energy expenditure. It is known that obese individuals present impaired hypothalamic neuronal caused by the increased expression of inflammatory proteins in this region leading to impairment in leptin and insulin signaling. Thus, the ex...
(Only some records are available in English at this moment)
- Effects of regular physical exercise and overtraining on the behavior of the autophagic pathway in different tissues of mice, BP.TT
- Response of NR1D1 to the different acute physical exercise models in mice skeletal muscle, BP.IC
Abstract
Different physical exercise models lead to innumerable benefits in the organism, being able to help in the treatment of diseases and increase performance in sports. Each model of exercise use majorly different types of muscle fiber, energetic system, and signaling pathways activating, for example, the mammalian target of rapamycin (mTOR) pathway, and the AMP-activated protein kinase (AM...
- Molecular mechanisms related to increased hepatic fat content in response to excessive physical exercise, BP.DR
Abstract
The association between Excessive Physical Exercise (EPE) and inadequate recovery is related to the increase in the major proteins of the mammalian target of rapamycin complex 1 (mTORC1), induction of signs of cellular edema, acute inflammation, and accumulation of fat in the hepatic tissue of mice. However, the EPE model based on chronic downhill running sessions (EPE/down) was also ab...
(Only some records are available in English at this moment)
- Role of autophagy in muscle stem cell differentiation, BE.EP.DR
Abstract
The satellite cells (SCS) or skeletal muscle steam cells are responsible for growth and regeneration of muscle fibers. The SCs are located between the basement membrane and the sarcolemma in muscle fibers. Several signaling pathways regulate SCs proliferation and differentiation. It has been demonstrated that autophagy is involved in the proper function and maintenance of stem cells pop...
- Circulating microRNA as novel predictors of skeletal muscle anabolic response in aged humans, BE.PQ
Abstract
Elderly individuals present a reduction in skeletal muscle adaptability in response to resistance exercise. Recently, this anabolic resistance was associated with dysregulation of microRNA expression in skeletal muscle of elderly individuals. Although microRNA expression in skeletal muscle provides important data regarding molecular mechanisms responsible for anabolic resistance and sar...
- Excess of eccentric exercise, mechanical load on the knee joint and osteoarthritis in C57BL/6 mice, BE.EP.MS
Abstract
Osteoarthritis (OA) is a degenerative chronic disease that induces cartilage degradation and is very common in the knee joint. OA progression occurs due to excess load in the joint as well as systemic or local inflammation. Physical exercise is a commonly used therapy to prevent and treat this illness, attenuating the symptoms, however studies that exhibit controversial results still ex...
| 2 / 1 | Ongoing research grants |
| 11 / 9 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 16 / 13 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 36 / 30 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 24 |
| Citations | 199 |
| Cit./Article | 8.3 |
| Data from Web of Science | |
PEREIRA, B. C.; LUCAS, G.; DA ROCHA, A. L.; PAULI, J. R.; ROPELLE, E. R.; CINTRA, D.; DE SOUZA, C. T.; BUENO, C. R.; DA SILVA, A. S.. Eccentric Exercise Leads to Glial Activation but not Apoptosis in Mice Spinal Cords. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 36, n. 5, p. 378-385, MAY 2015. Web of Science Citations: 17. (13/22737-5, 13/19985-7, 13/20591-3)
MORAIS, G. P.; DA ROCHA, A.; PINTO, A. P.; OLIVEIRA, L. DA C.; DE VICENTE, L. G.; FERREIRA, G. N.; DE FREITAS, E. C.; DA SILVA, A. S. R.. Uphill Running Excessive Training Increases Gastrocnemius Glycogen Content in C57BL/6 Mice. Physiological Research, v. 67, n. 1, p. 107-115, 2018. Web of Science Citations: 0. (14/25459-9, 13/20591-3, 15/08013-0)
PEREIRA, BRUNO C.; DA ROCHA, ALISSON L.; PINTO, ANA P.; PAULI, JOSE R.; DE SOUZA, CLAUDIO T.; CINTRA, DENNYS E.; ROPELLE, EDUARDO R.; DE FREITAS, ELLEN C.; ZAGATTO, ALESSANDRO M.; DA SILVA, ADELINO S. R.. Excessive eccentric exercise-induced overtraining model leads to endoplasmic reticulum stress in mice skeletal muscles. Life Sciences, v. 145, p. 144-151, JAN 15 2016. Web of Science Citations: 14. (13/19985-7, 13/20591-3, 15/08013-0, 14/25459-9)
DA ROCHA, ALISSON L.; PEREIRA, BRUNO C.; TEIXEIRA, GIOVANA R.; PINTO, ANA P.; FRANTZ, FABIANI G.; ELIAS, LUCILA L. K.; LIRA, FABIO S.; PAULI, JOSE R.; CINTRA, DENNYS E.; ROPELLE, EDUARDO R.; et al. Treadmill slope Modulates inflammation, Fiber Type composition, androgen, and glucocorticoid receptors in the skeletal Muscle of Overtrained Mice. FRONTIERS IN IMMUNOLOGY, v. 8, OCT 25 2017. Web of Science Citations: 7. (13/19985-7, 13/20591-3)
DA ROCHA, ALISSON L.; PINTO, ANA P.; KOHAMA, EIKE B.; PAULI, JOSE R.; DE MOURA, LEANDRO P.; CINTRA, DENNYS E.; ROPELLE, EDUARDO R.; DA SILVA, ADELINO S. R.. The proinflammatory effects of chronic excessive exercise. CYTOKINE, v. 119, p. 57-61, JUL 2019. Web of Science Citations: 4. (13/19985-7, 14/25459-9, 17/09038-1, 10/08239-4, 13/20591-3, 12/23258-0, 17/19869-8, 13/22737-5, 17/12765-2, 11/02652-0, 15/08013-0)
PINTO, ANA PAULA; DA ROCHA, ALISSON LUIZ; PEREIRA, BRUNO CESAR; OLIVEIRA, LUCIANA DA COSTA; MORAIS, GUSTAVO PAROSCHI; MOURA, LEANDRO PEREIRA; ROPELLE, EDUARDO ROCHETE; PAULI, JOSE RODRIGO; RAMOS DA SILVA, ADELINO SANCHEZ. Excessive training is associated with endoplasmic reticulum stress but not apoptosis in the hypothalamus of mice. APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, v. 42, n. 4, p. 354-360, APR 2017. Web of Science Citations: 5. (13/19985-7, 13/20591-3, 15/13275-3, 15/08013-0, 14/25459-9)
PINTO, ANA P.; DA ROCHA, ALISSON L.; OLIVEIRA, LUCIANA DA C.; MORAIS, GUSTAVO P.; DE VICENTE, LARISSA G.; CINTRA, DENNYS E.; PAULI, JOSE R.; MOURA, LEANDRO P.; ROPELLE, EDUARDO R.; DA SILVA, ADELINO S. R.. Levels of Hepatic Activating Transcription Factor 6 and Caspase-3 Are Downregulated in Mice after Excessive Training. FRONTIERS IN ENDOCRINOLOGY, v. 8, SEP 26 2017. Web of Science Citations: 2. (13/20591-3, 15/08013-0)
DA SILVA, ADELINO S. R.; PAULI, JOSE R.; ROPELLE, EDUARDO R.; OLIVEIRA, ALEXANDRE G.; CINTRA, DENNYS E.; DE SOUZA, CLAUDIO T.; VELLOSO, LICIO A.; CARVALHEIRA, JOSE B. C.; SAAD, MARIO J. A.. Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 42, n. 12, p. 2180-2188, DEC 2010. Web of Science Citations: 21.
PINTO, ANA P.; DA ROCHA, ALISSON L.; CABRERA, ELISA M. B.; MARAFON, BRUNO B.; KOHAMA, EIKE B.; ROVINA, RAFAEL L.; SIMABUCO, FERNANDO M.; BUENO JUNIOR, CARLOS R.; DE MOURA, LEANDRO P.; PAULI, JOSE R.; et al. Role of interleukin-6 in inhibiting hepatic autophagy markers in exercised mice. CYTOKINE, v. 130, JUN 2020. Web of Science Citations: 0. (17/09038-1, 18/14818-9, 18/12519-4, 17/19869-8, 17/12765-2, 19/10875-0)
PINTO, ANA P.; VIEIRA, TALES S.; MARAFON, BRUNO B.; BATITUCCI, GABRIELA; CABRERA, ELISA M. B.; DA ROCHA, ALISSON L.; KOHAMA, EIKE B.; RODRIGUES, KELLEN C. C.; DE MOURA, LEANDRO P.; PAULI, JOSE R.; et al. The Combination of Fasting, Acute Resistance Exercise, and Protein Ingestion Led to Different Responses of Autophagy Markers in Gastrocnemius and Liver Samples. NUTRIENTS, v. 12, n. 3, MAR 2020. Web of Science Citations: 0. (17/09038-1)
PEREIRA, B. C.; DA ROCHA, A. L.; PAULI, J. R.; ROPELLE, E. R.; DE SOUZA, C. T.; CINTRA, D. E.; SANT'ANA, M. R.; DA SILVA, A. S. R.. EXCESSIVE ECCENTRIC EXERCISE LEADS TO TRANSITORY HYPOTHALAMIC INFLAMMATION, WHICH MAY CONTRIBUTE TO THE LOW BODY WEIGHT GAIN AND FOOD INTAKE IN OVERTRAINED MICE. Neuroscience, v. 311, p. 231-242, DEC 17 2015. Web of Science Citations: 17. (14/25459-9, 13/20591-3, 13/19985-7)
PEREIRA, B. C.; PAULI, J. R.; DE SOUZA, C. T.; ROPELLE, E. R.; CINTRA, D. E.; ROCHA, E. M.; FREITAS, E. C.; PAPOTI, M.; DA SILVA, L.; LIRA, F. S.; et al. Nonfunctional Overreaching Leads to Inflammation and Myostatin Upregulation in Swiss Mice. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 35, n. 2, p. 139-146, FEB 2014. Web of Science Citations: 18. (10/08239-4, 11/02652-0)
DA ROCHA, ALISSON L.; PEREIRA, BRUNO C.; PAULI, JOSE R.; CINTRA, DENNYS E.; DE SOUZA, CLAUDIO T.; ROPELLE, EDUARDO R.; DA SILVA, ADELINO S. R.. Downhill Running-Based Overtraining Protocol Improves Hepatic Insulin Signaling Pathway without Concomitant Decrease of Inflammatory Proteins. PLoS One, v. 10, n. 10, OCT 7 2015. Web of Science Citations: 9. (13/22737-5, 14/25459-9, 13/20591-3, 13/19985-7)
ALEX ZELANTI ROSEGUINI; ADELINO SANCHEZ RAMOS DA SILVA; CLAUDIO ALEXANDRE GOBATTO. Determinações e relações dos parâmetros anaeróbios do RAST, do limiar anaeróbio e da resposta lactacidemica obtida no início, no intervalo e ao final de uma partida oficial de handebol. Revista Brasileira de Medicina do Esporte, v. 14, n. 1, p. -, Fev. 2008.
PINTO, ANA P.; DA ROCHA, ALISSON L.; KOHAMA, EIKE B.; GASPAR, RAFAEL C.; SIMABUCO, FERNANDO M.; FRANTZ, FABIANI G.; DE MOURA, LEANDRO P.; PAULI, JOSE R.; CINTRA, DENNYS E.; ROPELLE, EDUARDO R.; et al. Exhaustive acute exercise-induced ER stress is attenuated in IL-6-knockout mice. Journal of Endocrinology, v. 240, n. 2, p. 181-193, FEB 2019. Web of Science Citations: 1. (17/12765-2, 17/19869-8, 12/13558-7, 17/09038-1)
DA ROCHA, ALISSON L.; PINTO, ANA P.; PEREIRA, BRUNO C.; KOHAMA, EIKE B.; MORAIS, GUSTAVO P.; DE VICENTE, LARISSA G.; PAULI, JOSE R.; CINTRA, DENNYS E.; ROPELLE, EDUARDO R.; DE MOURA, LEANDRO P.; et al. Positive effects of total recovery period on anti- and pro-inflammatory cytokines are not linked to performance re-establishment in overtrained mice. CYTOKINE, v. 103, p. 69-76, MAR 2018. Web of Science Citations: 1. (13/19985-7, 13/20591-3)
MORAIS, G. P.; DA ROCHA, A.; PINTO, A. P.; OLIVEIRA, L. DA C.; DE VICENTE, L. G.; FERREIRA, G. N.; DE FREITAS, E. C.; DA SILVA, A. S. R.. Uphill Running Excessive Training Increases Gastrocnemius Glycogen Content in C57BL/6 Mice. Physiological Research, v. 67, n. 1, p. 107-115, 2018. Web of Science Citations: 0. (14/25459-9, 13/20591-3, 15/08013-0)
PEREIRA, BRUNO C.; DA ROCHA, ALISSON L.; PINTO, ANA P.; PAULI, JOSE R.; DE SOUZA, CLAUDIO T.; CINTRA, DENNYS E.; ROPELLE, EDUARDO R.; DE FREITAS, ELLEN C.; ZAGATTO, ALESSANDRO M.; DA SILVA, ADELINO S. R.. Excessive eccentric exercise-induced overtraining model leads to endoplasmic reticulum stress in mice skeletal muscles. Life Sciences, v. 145, p. 144-151, JAN 15 2016. Web of Science Citations: 14. (13/19985-7, 13/20591-3, 15/08013-0, 14/25459-9)
PINTO, ANA PAULA; DA ROCHA, ALISSON LUIZ; PEREIRA, BRUNO CESAR; OLIVEIRA, LUCIANA DA COSTA; MORAIS, GUSTAVO PAROSCHI; MOURA, LEANDRO PEREIRA; ROPELLE, EDUARDO ROCHETE; PAULI, JOSE RODRIGO; RAMOS DA SILVA, ADELINO SANCHEZ. Excessive training is associated with endoplasmic reticulum stress but not apoptosis in the hypothalamus of mice. APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, v. 42, n. 4, p. 354-360, APR 2017. Web of Science Citations: 5. (13/19985-7, 13/20591-3, 15/13275-3, 15/08013-0, 14/25459-9)
PINTO, ANA P.; DA ROCHA, ALISSON L.; OLIVEIRA, LUCIANA DA C.; MORAIS, GUSTAVO P.; DE VICENTE, LARISSA G.; CINTRA, DENNYS E.; PAULI, JOSE R.; MOURA, LEANDRO P.; ROPELLE, EDUARDO R.; DA SILVA, ADELINO S. R.. Levels of Hepatic Activating Transcription Factor 6 and Caspase-3 Are Downregulated in Mice after Excessive Training. FRONTIERS IN ENDOCRINOLOGY, v. 8, SEP 26 2017. Web of Science Citations: 2. (13/20591-3, 15/08013-0)
DA ROCHA, ALISSON L.; PEREIRA, BRUNO C.; TEIXEIRA, GIOVANA R.; PINTO, ANA P.; FRANTZ, FABIANI G.; ELIAS, LUCILA L. K.; LIRA, FABIO S.; PAULI, JOSE R.; CINTRA, DENNYS E.; ROPELLE, EDUARDO R.; et al. Treadmill slope Modulates inflammation, Fiber Type composition, androgen, and glucocorticoid receptors in the skeletal Muscle of Overtrained Mice. FRONTIERS IN IMMUNOLOGY, v. 8, OCT 25 2017. Web of Science Citations: 7. (13/19985-7, 13/20591-3)
PEREIRA, B. C.; LUCAS, G.; DA ROCHA, A. L.; PAULI, J. R.; ROPELLE, E. R.; CINTRA, D.; DE SOUZA, C. T.; BUENO, C. R.; DA SILVA, A. S.. Eccentric Exercise Leads to Glial Activation but not Apoptosis in Mice Spinal Cords. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 36, n. 5, p. 378-385, MAY 2015. Web of Science Citations: 17. (13/22737-5, 13/19985-7, 13/20591-3)
DA SILVA, ADELINO S. R.; PAULI, JOSE R.; ROPELLE, EDUARDO R.; OLIVEIRA, ALEXANDRE G.; CINTRA, DENNYS E.; DE SOUZA, CLAUDIO T.; VELLOSO, LICIO A.; CARVALHEIRA, JOSE B. C.; SAAD, MARIO J. A.. Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 42, n. 12, p. 2180-2188, DEC 2010. Web of Science Citations: 21.
DA ROCHA, ALISSON L.; PINTO, ANA P.; KOHAMA, EIKE B.; PAULI, JOSE R.; DE MOURA, LEANDRO P.; CINTRA, DENNYS E.; ROPELLE, EDUARDO R.; DA SILVA, ADELINO S. R.. The proinflammatory effects of chronic excessive exercise. CYTOKINE, v. 119, p. 57-61, JUL 2019. Web of Science Citations: 4. (13/19985-7, 14/25459-9, 17/09038-1, 10/08239-4, 13/20591-3, 12/23258-0, 17/19869-8, 13/22737-5, 17/12765-2, 11/02652-0, 15/08013-0)
PINTO, ANA P.; VIEIRA, TALES S.; MARAFON, BRUNO B.; BATITUCCI, GABRIELA; CABRERA, ELISA M. B.; DA ROCHA, ALISSON L.; KOHAMA, EIKE B.; RODRIGUES, KELLEN C. C.; DE MOURA, LEANDRO P.; PAULI, JOSE R.; et al. The Combination of Fasting, Acute Resistance Exercise, and Protein Ingestion Led to Different Responses of Autophagy Markers in Gastrocnemius and Liver Samples. NUTRIENTS, v. 12, n. 3, MAR 2020. Web of Science Citations: 0. (17/09038-1)
PINTO, ANA P.; DA ROCHA, ALISSON L.; CABRERA, ELISA M. B.; MARAFON, BRUNO B.; KOHAMA, EIKE B.; ROVINA, RAFAEL L.; SIMABUCO, FERNANDO M.; BUENO JUNIOR, CARLOS R.; DE MOURA, LEANDRO P.; PAULI, JOSE R.; et al. Role of interleukin-6 in inhibiting hepatic autophagy markers in exercised mice. CYTOKINE, v. 130, JUN 2020. Web of Science Citations: 0. (17/09038-1, 18/14818-9, 18/12519-4, 17/19869-8, 17/12765-2, 19/10875-0)
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Adelino Sanchez Ramos da. Respostas de alguns marcadores bioquímicos de overtraining ao longo de uma periodização no futebol, relações com as performances aeróbia e anaeróbia. 239 f. Tese (Doutorado) - Instituto de Biociências de Rio Claro. Universidade Estadula Paulista. Rio Claro. (04/15241-4)